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Volumn 529, Issue 1-2, 2017, Pages 32-43

Ocular disposition of ciprofloxacin from topical, PEGylated nanostructured lipid carriers: Effect of molecular weight and density of poly (ethylene) glycol

Author keywords

Chitosan chloride; Ciprofloxacin; PEG derivatized phospholipids; PEGylation; Surface functionalized NLCs; Topical lipid nanoparticles; Transcorneal penetration

Indexed keywords

CHITOSAN; CIPROFLOXACIN; MACROGOL; NANOCARRIER; NANOSTRUCTURED LIPID CARRIER; PHOSPHOLIPID; UNCLASSIFIED DRUG; DRUG CARRIER; LIPID; MACROGOL DERIVATIVE; NANOPARTICLE;

EID: 85021187743     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2017.06.042     Document Type: Article
Times cited : (56)

References (61)
  • 1
    • 84977517815 scopus 로고    scopus 로고
    • Development and evaluation of prolonged release topical indomethacin formulations for ocular inflammation
    • Adelli, G.R., Balguri, S.P., Punyamurthula, N., Bhagav, P., Majumdar, S., Development and evaluation of prolonged release topical indomethacin formulations for ocular inflammation. Invest. Ophthalmol. Vis. Sci., 55(13), 2014, 463.
    • (2014) Invest. Ophthalmol. Vis. Sci. , vol.55 , Issue.13 , pp. 463
    • Adelli, G.R.1    Balguri, S.P.2    Punyamurthula, N.3    Bhagav, P.4    Majumdar, S.5
  • 2
    • 84944512028 scopus 로고    scopus 로고
    • Effect of cyclodextrins on morphology and barrier characteristics of isolated rabbit corneas
    • Adelli, G.R., Balguri, S.P., Majumdar, S., Effect of cyclodextrins on morphology and barrier characteristics of isolated rabbit corneas. AAPS PharmSciTech 16:5 (2015), 1220–1226.
    • (2015) AAPS PharmSciTech , vol.16 , Issue.5 , pp. 1220-1226
    • Adelli, G.R.1    Balguri, S.P.2    Majumdar, S.3
  • 4
    • 85021229205 scopus 로고    scopus 로고
    • Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery
    • Adelli, G.R., Balguri, S.P., Bhagav, P., Raman, V., Majumdar, S., Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery. Drug Deliv. 24:1 (2017), 370–379.
    • (2017) Drug Deliv. , vol.24 , Issue.1 , pp. 370-379
    • Adelli, G.R.1    Balguri, S.P.2    Bhagav, P.3    Raman, V.4    Majumdar, S.5
  • 5
    • 0025731906 scopus 로고
    • Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
    • Allen, T.M., Hansen, C., Martin, F., Redemann, C., Yau-Young, A., Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim. Biophys. Acta 1066:1 (1991), 29–36.
    • (1991) Biochim. Biophys. Acta , vol.1066 , Issue.1 , pp. 29-36
    • Allen, T.M.1    Hansen, C.2    Martin, F.3    Redemann, C.4    Yau-Young, A.5
  • 6
    • 84879555223 scopus 로고    scopus 로고
    • A comparative study of submicron particle sizing platforms: accuracy, precision and resolution analysis of polydisperse particle size distributions
    • Anderson, W., Kozak, D., Coleman, V.A., Jämting, Å.K., Trau, M., A comparative study of submicron particle sizing platforms: accuracy, precision and resolution analysis of polydisperse particle size distributions. J. Colloid Interface Sci. 405 (2013), 322–330.
    • (2013) J. Colloid Interface Sci. , vol.405 , pp. 322-330
    • Anderson, W.1    Kozak, D.2    Coleman, V.A.3    Jämting, Å.K.4    Trau, M.5
  • 7
    • 67349191957 scopus 로고    scopus 로고
    • Guidance for Industry Bioanalytical Method Validation
    • Available from:
    • Anon, Guidance for Industry Bioanalytical Method Validation. 2013 Available from: https://www.fda.gov/downloads/Drugs/Guidances/ucm368107.pdf.
    • (2013)
    • Anon1
  • 8
    • 85020114239 scopus 로고    scopus 로고
    • Development of nano structured lipid carriers of ciprofloxacin for ocular delivery: characterization, in vivo distribution and effect of PEGylation
    • Balguri, S.P., Adelli, G., Bhagav, P., Repka, M.A., Majumdar, S., Development of nano structured lipid carriers of ciprofloxacin for ocular delivery: characterization, in vivo distribution and effect of PEGylation. Invest. Ophthalmol. Vis. Sci., 56(7), 2015, 2269-.
    • (2015) Invest. Ophthalmol. Vis. Sci. , vol.56 , Issue.7 , pp. 2269-
    • Balguri, S.P.1    Adelli, G.2    Bhagav, P.3    Repka, M.A.4    Majumdar, S.5
  • 9
    • 84994030221 scopus 로고    scopus 로고
    • Topical ophthalmic lipid nanoparticle formulations (SLN NLC) of indomethacin for delivery to the posterior segment ocular tissues
    • Balguri, S.P., Adelli, G.R., Majumdar, S., Topical ophthalmic lipid nanoparticle formulations (SLN NLC) of indomethacin for delivery to the posterior segment ocular tissues. Eur. J. Pharm. Biopharm. 109 (2016), 224–235.
    • (2016) Eur. J. Pharm. Biopharm. , vol.109 , pp. 224-235
    • Balguri, S.P.1    Adelli, G.R.2    Majumdar, S.3
  • 10
    • 84977080654 scopus 로고    scopus 로고
    • Advanced drug delivery and targeting technologies for the ocular diseases
    • Barar, J., Aghanejad, A., Fathi, M., Omidi, Y., Advanced drug delivery and targeting technologies for the ocular diseases. Bioimpacts 6:1 (2016), 49–67.
    • (2016) Bioimpacts , vol.6 , Issue.1 , pp. 49-67
    • Barar, J.1    Aghanejad, A.2    Fathi, M.3    Omidi, Y.4
  • 11
    • 84861669644 scopus 로고    scopus 로고
    • ® — the first FDA-approved nano-drug: lessons learned
    • ® — the first FDA-approved nano-drug: lessons learned. J. Control. Release 160:2 (2012), 117–134.
    • (2012) J. Control. Release , vol.160 , Issue.2 , pp. 117-134
    • Barenholz, Y.1
  • 12
    • 84886492798 scopus 로고    scopus 로고
    • Expression of efflux transporters in human ocular tissues
    • Chen, P., Chen, H., Zang, X., Chen, M., Jiang, H., Han, S., et al. Expression of efflux transporters in human ocular tissues. Drug Metab. Dispos. 41:11 (2013), 1934–1948.
    • (2013) Drug Metab. Dispos. , vol.41 , Issue.11 , pp. 1934-1948
    • Chen, P.1    Chen, H.2    Zang, X.3    Chen, M.4    Jiang, H.5    Han, S.6
  • 13
    • 84903641451 scopus 로고    scopus 로고
    • Cubic and hexagonal liquid crystals as drug delivery systems
    • Chen, Y., Ma, P., Gui, S., Cubic and hexagonal liquid crystals as drug delivery systems. BioMed Res. Int., 2014, 2014, 815981.
    • (2014) BioMed Res. Int. , vol.2014 , pp. 815981
    • Chen, Y.1    Ma, P.2    Gui, S.3
  • 15
    • 79551717015 scopus 로고    scopus 로고
    • Intracellular trafficking of hyaluronic acid-chitosan oligomer-based nanoparticles in cultured human ocular surface cells
    • Contreras-Ruiz, L., de la Fuente, M., Parraga, J.E., Lopez-Garcia, A., Fernandez, I., Seijo, B., et al. Intracellular trafficking of hyaluronic acid-chitosan oligomer-based nanoparticles in cultured human ocular surface cells. Mol. Vis. 17 (2011), 279–290.
    • (2011) Mol. Vis. , vol.17 , pp. 279-290
    • Contreras-Ruiz, L.1    de la Fuente, M.2    Parraga, J.E.3    Lopez-Garcia, A.4    Fernandez, I.5    Seijo, B.6
  • 16
    • 0042834363 scopus 로고    scopus 로고
    • The effect of a PEG versus a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa
    • De Campos, A.M., Sánchez, A., Gref, R., Calvo, P., Alonso, M., et al. The effect of a PEG versus a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa. Eur. J. Pharm. Sci. 20:1 (2003), 73–81.
    • (2003) Eur. J. Pharm. Sci. , vol.20 , Issue.1 , pp. 73-81
    • De Campos, A.M.1    Sánchez, A.2    Gref, R.3    Calvo, P.4    Alonso, M.5
  • 17
    • 0035090503 scopus 로고    scopus 로고
    • Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir
    • Fresta, M., Fontana, G., Bucolo, C., Cavallaro, G., Giammona, G., Puglisi, G., Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir. J. Pharm. Sci. 90:3 (2001), 288–297.
    • (2001) J. Pharm. Sci. , vol.90 , Issue.3 , pp. 288-297
    • Fresta, M.1    Fontana, G.2    Bucolo, C.3    Cavallaro, G.4    Giammona, G.5    Puglisi, G.6
  • 19
    • 0034112393 scopus 로고    scopus 로고
    • Drug delivery for posterior segment eye disease
    • Geroski, D.H., Edelhauser, H.F., Drug delivery for posterior segment eye disease. Invest. Ophthalmol. Vis. Sci. 41:5 (2000), 961–964.
    • (2000) Invest. Ophthalmol. Vis. Sci. , vol.41 , Issue.5 , pp. 961-964
    • Geroski, D.H.1    Edelhauser, H.F.2
  • 20
    • 12444299613 scopus 로고    scopus 로고
    • Influence of preparation conditions on acyclovir-loaded poly-d,l-lactic acid nanospheres and effect of PEG coating on ocular drug bioavailability
    • Giannavola, C., Bucolo, C., Maltese, A., Paolino, D., Vandelli, M.A., Puglisi, G., et al. Influence of preparation conditions on acyclovir-loaded poly-d,l-lactic acid nanospheres and effect of PEG coating on ocular drug bioavailability. Pharm. Res. 20:4 (2003), 584–590.
    • (2003) Pharm. Res. , vol.20 , Issue.4 , pp. 584-590
    • Giannavola, C.1    Bucolo, C.2    Maltese, A.3    Paolino, D.4    Vandelli, M.A.5    Puglisi, G.6
  • 21
    • 77249104877 scopus 로고    scopus 로고
    • Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    • He, C., Hu, Y., Yin, L., Tang, C., Yin, C., Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials 31:13 (2010), 3657–3666.
    • (2010) Biomaterials , vol.31 , Issue.13 , pp. 3657-3666
    • He, C.1    Hu, Y.2    Yin, L.3    Tang, C.4    Yin, C.5
  • 22
    • 77950917976 scopus 로고    scopus 로고
    • Ciprofloxacin as ocular liposomal hydrogel
    • Hosny, K.M., Ciprofloxacin as ocular liposomal hydrogel. AAPS PharmSciTech. 11:1 (2010), 241–246.
    • (2010) AAPS PharmSciTech. , vol.11 , Issue.1 , pp. 241-246
    • Hosny, K.M.1
  • 23
    • 85021184681 scopus 로고    scopus 로고
    • Stabilization and terminal sterilization of phospholipid formulations Google Patents;
    • P.K. Hui, W.R. Diluzio, Stabilization and terminal sterilization of phospholipid formulations Google Patents; 2002.
    • (2002)
    • Hui, P.K.1    Diluzio, W.R.2
  • 24
    • 85011808056 scopus 로고    scopus 로고
    • Bioanalytical method development and validation of ciprofloxacin by RP-HPLC method
    • Hussain, A.H., Muhammad, Shoaib, Muhammad, Harris, Yousuf, Rabia Ismail, Shafi, Nigha, Bioanalytical method development and validation of ciprofloxacin by RP-HPLC method. Asian J. Pharm. Biol. Res., 2(4), 2012, 19.
    • (2012) Asian J. Pharm. Biol. Res. , vol.2 , Issue.4 , pp. 19
    • Hussain, A.H.1    Muhammad, S.2    Muhammad, H.3    Yousuf, R.I.4    Shafi, N.5
  • 26
  • 27
    • 84883219531 scopus 로고    scopus 로고
    • Nanomedicines for back of the eye drug delivery, gene delivery, and imaging
    • Kompella, U.B., Amrite, A.C., Pacha Ravi, R., Durazo, S.A., Nanomedicines for back of the eye drug delivery, gene delivery, and imaging. Prog. Retin. Eye Res. 36 (2013), 172–198.
    • (2013) Prog. Retin. Eye Res. , vol.36 , pp. 172-198
    • Kompella, U.B.1    Amrite, A.C.2    Pacha Ravi, R.3    Durazo, S.A.4
  • 28
    • 84881351706 scopus 로고    scopus 로고
    • The endocytosis and intracellular fate of nanomedicines: implication for rational design
    • Kou, L., Sun, J., Zhai, Y., He, Z., The endocytosis and intracellular fate of nanomedicines: implication for rational design. Asian J. Pharm. Sci. 8:1 (2013), 1–10.
    • (2013) Asian J. Pharm. Sci. , vol.8 , Issue.1 , pp. 1-10
    • Kou, L.1    Sun, J.2    Zhai, Y.3    He, Z.4
  • 29
    • 84883887168 scopus 로고    scopus 로고
    • Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery
    • Kulkarni, S.A., Feng, S.S., Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery. Pharm. Res. 30:10 (2013), 2512–2522.
    • (2013) Pharm. Res. , vol.30 , Issue.10 , pp. 2512-2522
    • Kulkarni, S.A.1    Feng, S.S.2
  • 30
    • 84874391961 scopus 로고    scopus 로고
    • Current drug research on PEGylation with small molecular agents
    • Li, W., Zhan, P., De Clercq, E., Lou, H., Liu, X., Current drug research on PEGylation with small molecular agents. Prog. Polym. Sci. 38:3–4 (2013), 421–444.
    • (2013) Prog. Polym. Sci. , vol.38 , Issue.3-4 , pp. 421-444
    • Li, W.1    Zhan, P.2    De Clercq, E.3    Lou, H.4    Liu, X.5
  • 31
    • 84866737577 scopus 로고    scopus 로고
    • Improvement of drug safety by the use of lipid-based nanocarriers
    • Lim, S.B., Banerjee, A., Onyuksel, H., Improvement of drug safety by the use of lipid-based nanocarriers. J. Control. Release 163:1 (2012), 34–45.
    • (2012) J. Control. Release , vol.163 , Issue.1 , pp. 34-45
    • Lim, S.B.1    Banerjee, A.2    Onyuksel, H.3
  • 32
    • 85017596919 scopus 로고    scopus 로고
    • Comparison of the results of measurements of the sizes of nanoparticles in stable colloidal solutions by the methods of acoustic spectroscopy dynamic light scattering, and transmission electron microscopy
    • Lizunova, A., Loshkarev, A., Tokunov, Y.M., Ivanov, V., Comparison of the results of measurements of the sizes of nanoparticles in stable colloidal solutions by the methods of acoustic spectroscopy dynamic light scattering, and transmission electron microscopy. Meas. Tech., 2017, 1–5.
    • (2017) Meas. Tech. , pp. 1-5
    • Lizunova, A.1    Loshkarev, A.2    Tokunov, Y.M.3    Ivanov, V.4
  • 33
    • 2242472082 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
    • Müller, R.H., Radtke, M., Wissing, S.A., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev. 54:Suppl (2002), S131–S155.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. S131-S155
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 34
    • 60749108001 scopus 로고    scopus 로고
    • Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
    • Maeda, H., Bharate, G.Y., Daruwalla, J., Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect. Eur. J. Pharm. Biopharm. 71:3 (2009), 409–419.
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , Issue.3 , pp. 409-419
    • Maeda, H.1    Bharate, G.Y.2    Daruwalla, J.3
  • 35
    • 41849105252 scopus 로고    scopus 로고
    • Lipid-based colloidal carriers for peptide and protein delivery–liposomes versus lipid nanoparticles
    • Martins, S., Sarmento, B., Ferreira, D.C., Souto, E.B., Lipid-based colloidal carriers for peptide and protein delivery–liposomes versus lipid nanoparticles. Int. J. Nanomed. 2:4 (2007), 595–607.
    • (2007) Int. J. Nanomed. , vol.2 , Issue.4 , pp. 595-607
    • Martins, S.1    Sarmento, B.2    Ferreira, D.C.3    Souto, E.B.4
  • 36
    • 85021204958 scopus 로고    scopus 로고
    • Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations Google Patents;
    • A.K. Mishra, Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations Google Patents; 2013.
    • (2013)
    • Mishra, A.K.1
  • 37
    • 0034120557 scopus 로고    scopus 로고
    • Pharmacokinetics of ciprofloxacin in the human eye: a clinical study and population pharmacokinetic analysis
    • Morlet, N., Graham, G.G., Gatus, B., McLachlan, A.J., Salonikas, C., Naidoo, D., et al. Pharmacokinetics of ciprofloxacin in the human eye: a clinical study and population pharmacokinetic analysis. Antimicrob. Agents Chemother. 44:6 (2000), 1674–1679.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , Issue.6 , pp. 1674-1679
    • Morlet, N.1    Graham, G.G.2    Gatus, B.3    McLachlan, A.J.4    Salonikas, C.5    Naidoo, D.6
  • 39
    • 84894641652 scopus 로고    scopus 로고
    • Effect of polyethyleneglycol (PEG) chain length on the bio-nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells
    • Pozzi, D., Colapicchioni, V., Caracciolo, G., Piovesana, S., Capriotti, A.L., Palchetti, S., et al. Effect of polyethyleneglycol (PEG) chain length on the bio-nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells. Nanoscale 6:5 (2014), 2782–2792.
    • (2014) Nanoscale , vol.6 , Issue.5 , pp. 2782-2792
    • Pozzi, D.1    Colapicchioni, V.2    Caracciolo, G.3    Piovesana, S.4    Capriotti, A.L.5    Palchetti, S.6
  • 40
    • 1842450748 scopus 로고    scopus 로고
    • The characteristics and mechanisms of uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell layers
    • Qaddoumi, M.G., Ueda, H., Yang, J., Davda, J., Labhasetwar, V., Lee, V.H.L., The characteristics and mechanisms of uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell layers. Pharm. Res. 21:4 (2004), 641–648.
    • (2004) Pharm. Res. , vol.21 , Issue.4 , pp. 641-648
    • Qaddoumi, M.G.1    Ueda, H.2    Yang, J.3    Davda, J.4    Labhasetwar, V.5    Lee, V.H.L.6
  • 42
    • 84946222927 scopus 로고    scopus 로고
    • Using solution X-ray scattering to determine the high-resolution structure and morphology of PEGylated liposomal doxorubicin nanodrugs
    • Schilt, Y., Berman, T., Wei, X., Barenholz, Y., Raviv, U., Using solution X-ray scattering to determine the high-resolution structure and morphology of PEGylated liposomal doxorubicin nanodrugs. Biochim. Biophys. Acta 1860:1 Pt A (2016), 108–119.
    • (2016) Biochim. Biophys. Acta , vol.1860 , Issue.1 , pp. 108-119
    • Schilt, Y.1    Berman, T.2    Wei, X.3    Barenholz, Y.4    Raviv, U.5
  • 45
    • 84904053916 scopus 로고    scopus 로고
    • Design of liposomal colloidal systems for ocular delivery of ciprofloxacin
    • Taha, E.I., El-Anazi, M.H., El-Bagory, I.M., Bayomi, M.A., Design of liposomal colloidal systems for ocular delivery of ciprofloxacin. Saudi Pharm. J. 22:3 (2014), 231–239.
    • (2014) Saudi Pharm. J. , vol.22 , Issue.3 , pp. 231-239
    • Taha, E.I.1    El-Anazi, M.H.2    El-Bagory, I.M.3    Bayomi, M.A.4
  • 46
    • 84907273816 scopus 로고    scopus 로고
    • Role of Pluronic F127 micelles in enhancing ocular delivery of ciprofloxacin
    • Taha, E.I., Badran, M.M., El-Anazi, M.H., Bayomi, M.A., El-Bagory, I.M., Role of Pluronic F127 micelles in enhancing ocular delivery of ciprofloxacin. J. Mol. Liq. 199 (2014), 251–256.
    • (2014) J. Mol. Liq. , vol.199 , pp. 251-256
    • Taha, E.I.1    Badran, M.M.2    El-Anazi, M.H.3    Bayomi, M.A.4    El-Bagory, I.M.5
  • 47
    • 79960190356 scopus 로고    scopus 로고
    • Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: comparative analysis of characteristics, pharmacokinetics and tissue uptake
    • Tiwari, R., Pathak, K., Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: comparative analysis of characteristics, pharmacokinetics and tissue uptake. Int. J. Pharm. 415:1–2 (2011), 232–243.
    • (2011) Int. J. Pharm. , vol.415 , Issue.1-2 , pp. 232-243
    • Tiwari, R.1    Pathak, K.2
  • 48
    • 77953478343 scopus 로고    scopus 로고
    • Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: in vivo pharmacological evidence and biodistribution
    • Tosi, G., Vergoni, A.V., Ruozi, B., Bondioli, L., Badiali, L., Rivasi, F., et al. Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: in vivo pharmacological evidence and biodistribution. J. Control. Release 145:1 (2010), 49–57.
    • (2010) J. Control. Release , vol.145 , Issue.1 , pp. 49-57
    • Tosi, G.1    Vergoni, A.V.2    Ruozi, B.3    Bondioli, L.4    Badiali, L.5    Rivasi, F.6
  • 50
    • 51049120877 scopus 로고    scopus 로고
    • Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives
    • Uner, M., Yener, G., Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. Int. J. Nanomed. 2:3 (2007), 289–300.
    • (2007) Int. J. Nanomed. , vol.2 , Issue.3 , pp. 289-300
    • Uner, M.1    Yener, G.2
  • 51
    • 70749114154 scopus 로고    scopus 로고
    • Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution
    • Vergoni, A.V., Tosi, G., Tacchi, R., Vandelli, M.A., Bertolini, A., Costantino, L., Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution. Nanomedicine 5:4 (2009), 369–377.
    • (2009) Nanomedicine , vol.5 , Issue.4 , pp. 369-377
    • Vergoni, A.V.1    Tosi, G.2    Tacchi, R.3    Vandelli, M.A.4    Bertolini, A.5    Costantino, L.6
  • 52
    • 84887192908 scopus 로고    scopus 로고
    • Questioning the use of PEGylation for drug delivery
    • Verhoef, J.J.F., Anchordoquy, T.J., Questioning the use of PEGylation for drug delivery. Drug Deliv. Transl. Res. 3:6 (2013), 499–503.
    • (2013) Drug Deliv. Transl. Res. , vol.3 , Issue.6 , pp. 499-503
    • Verhoef, J.J.F.1    Anchordoquy, T.J.2
  • 53
    • 51549092094 scopus 로고    scopus 로고
    • The impact of PEGylation on biological therapies
    • Veronese, F.M., Mero, A., The impact of PEGylation on biological therapies. BioDrugs 22:5 (2008), 315–329.
    • (2008) BioDrugs , vol.22 , Issue.5 , pp. 315-329
    • Veronese, F.M.1    Mero, A.2
  • 54
    • 26944452043 scopus 로고    scopus 로고
    • PEGylation, successful approach to drug delivery
    • Veronese, F.M., Pasut, G., PEGylation, successful approach to drug delivery. Drug Discov. Today 10:21 (2005), 1451–1458.
    • (2005) Drug Discov. Today , vol.10 , Issue.21 , pp. 1451-1458
    • Veronese, F.M.1    Pasut, G.2
  • 55
    • 77956930518 scopus 로고    scopus 로고
    • Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis
    • Vij, N., Min, T., Marasigan, R., Belcher, C.N., Mazur, S., Ding, H., et al. Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis. J. Nanobiotechnol., 8(1), 2010, 22.
    • (2010) J. Nanobiotechnol. , vol.8 , Issue.1 , pp. 22
    • Vij, N.1    Min, T.2    Marasigan, R.3    Belcher, C.N.4    Mazur, S.5    Ding, H.6
  • 56
    • 0028596084 scopus 로고
    • Sterically stabilized liposomes: physical and biological properties
    • Woodle, M.C., Newman, M.S., Cohen, J.A., Sterically stabilized liposomes: physical and biological properties. J. Drug Target. 2:5 (1994), 397–403.
    • (1994) J. Drug Target. , vol.2 , Issue.5 , pp. 397-403
    • Woodle, M.C.1    Newman, M.S.2    Cohen, J.A.3
  • 57
    • 0029360756 scopus 로고
    • Sterically stabilized liposome therapeutics
    • Woodle, M.C., Sterically stabilized liposome therapeutics. Adv. Drug Deliv. Rev. 16:2 (1995), 249–265.
    • (1995) Adv. Drug Deliv. Rev. , vol.16 , Issue.2 , pp. 249-265
    • Woodle, M.C.1
  • 58
    • 84959337603 scopus 로고    scopus 로고
    • Recent advances in topical ocular drug delivery
    • Yellepeddi, V.K., Palakurthi, S., Recent advances in topical ocular drug delivery. J. Ocul. Pharmacol. Ther. 32:2 (2016), 67–82.
    • (2016) J. Ocul. Pharmacol. Ther. , vol.32 , Issue.2 , pp. 67-82
    • Yellepeddi, V.K.1    Palakurthi, S.2
  • 59
    • 84884571428 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery
    • Yoon, G., Park, J.W., Yoon, I.-S., Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery. J. Pharm. Investig. 43:5 (2013), 353–362.
    • (2013) J. Pharm. Investig. , vol.43 , Issue.5 , pp. 353-362
    • Yoon, G.1    Park, J.W.2    Yoon, I.-S.3
  • 60
    • 84862813598 scopus 로고    scopus 로고
    • Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquid crystalline nanoparticles (LCNPs) for improved bioavailability
    • Zeng, N., Hu, Q., Liu, Z., Gao, X., Hu, R., Song, Q., et al. Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquid crystalline nanoparticles (LCNPs) for improved bioavailability. Int. J. Pharm. 424:1–2 (2012), 58–66.
    • (2012) Int. J. Pharm. , vol.424 , Issue.1-2 , pp. 58-66
    • Zeng, N.1    Hu, Q.2    Liu, Z.3    Gao, X.4    Hu, R.5    Song, Q.6
  • 61
    • 84894626893 scopus 로고    scopus 로고
    • Targeted paclitaxel delivery to tumors using cleavable PEG-conjugated solid lipid nanoparticles
    • Zheng, J., Wan, Y., Elhissi, A., Zhang, Z., Sun, X., Targeted paclitaxel delivery to tumors using cleavable PEG-conjugated solid lipid nanoparticles. Pharm. Res. 31:8 (2014), 2220–2233.
    • (2014) Pharm. Res. , vol.31 , Issue.8 , pp. 2220-2233
    • Zheng, J.1    Wan, Y.2    Elhissi, A.3    Zhang, Z.4    Sun, X.5


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