Neuroprotective Activity of Cerebrosides from Typhonium giganteum by Regulating Caspase-3 and Bax/Bcl-2 Signaling Pathways in PC12 Cells

Journal of Natural Products

Volumn 80, Issue 6, 2017, Pages 1734-1741

  Jin, Yang ^a   Fan, Jun Ting ^a   Gu, Xiao Ling ^a   Zhang, Li Ying ^a   Han, Jing ^b   Du, Shu Hu ^c   Zhang, Ai Xia ^a  

^a School of Pharmacy   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 O BETA DEXTRO GLUCOPYRANOSYL 2 (2' HYDROXYDOCOSANOYLAMINO) 4,8 OCTADECADIENE 1,3 DIOL; 1 O BETA DEXTRO GLUCOPYRANOSYL 2 (2' HYDROXYEICOSANOYLAMINO) 4,8 OCTADECADIENE 1,3 DIOL; 1 O BETA DEXTRO GLUCOPYRANOSYL 2 (2' HYDROXYLEICOSANOYLAMINO) 4,8 OCTADECADIENE 1,3 DIOL; 1 O BETA DEXTRO GLUCOPYRANOSYL 2 (2' HYDROXYOCTADECANOYLAMINO) 4,8 OCTADECADIENE 1,3 DIOL; CASPASE 3; CASPASE 9; CEREBROSIDE; CYTOCHROME C; GLUTAMIC ACID; LONGAN CEREBROSIDE I; LONGAN CEREBROSIDE II; NEUROPROTECTIVE AGENT; NORPHENAZONE; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; SOYA CEREBROSIDE I; SOYA CEREBROSIDE II; TUBULIN; TYPHONOSIDE; TYPHONOSIDE A; TYPHONOSIDE E; TYPHONOSIDE F; UNCLASSIFIED DRUG;

APOPTOSIS; ARACEAE; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; DRUG ISOLATION; DRUG STRUCTURE; EC50; ENZYME REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; PC12 CELL LINE; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RHIZOME; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TYPHONIUM GIGANTEUM; UPREGULATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; RAT; SAPINDACEAE;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CEREBROSIDES; CYTOCHROMES C; GLUTAMIC ACID; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RHIZOME; SAPINDACEAE; SIGNAL TRANSDUCTION;

EID: 85021143908     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/acs.jnatprod.6b00954     Document Type: Article

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