Bioanalytical measurements enabled by Surface-Enhanced Raman Scattering (SERS) probes

Annual Review of Analytical Chemistry

Volumn 10, Issue , 2017, Pages 415-437

  Jamieson, Lauren E ^a   Asiala, Steven M ^a   Gracie, Kirsten ^a   Faulds, Karen ^a   Graham, Duncan ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Bioanalytical; Detection; Diagnostics; Multiplex; Nanoparticle; SERS

Indexed keywords

BIOMOLECULES; CELL CULTURE; CHEMICAL ANALYSIS; ERROR DETECTION; MOLECULAR BIOLOGY; MULTIPLEXING; NANOPARTICLES; PLASMA DIAGNOSTICS; PROBES; RAMAN SCATTERING;

BIOANALYTICAL; BIOLOGICAL ENVIRONMENTS; BIOMOLECULE DETECTION; DETECTION SENSITIVITY; DIAGNOSTIC CAPABILITIES; SERS; SURFACE ENHANCED RAMAN SCATTERING (SERS); SURFACE-ENHANCED RAMAN SCATTERING PROBES;

SURFACE SCATTERING;

BIOLOGICAL MARKER; DNA; LIPID; MOLECULAR PROBE; NANOPARTICLE; PROTEIN;

CHEMISTRY; HUMAN; MOLECULAR PROBE; PROCEDURES; RAMAN SPECTROMETRY;

BIOMARKERS; DNA; HUMANS; LIPIDS; MOLECULAR PROBES; NANOPARTICLES; PROTEINS; SPECTRUM ANALYSIS, RAMAN;

EID: 85020718534     PISSN: 19361327     EISSN: 19361335     Source Type: Book Series    
DOI: 10.1146/annurev-anchem-071015-041557     Document Type: Review

References (125)

1. Raman CV, Krishnan KS. (1928). A new type of secondary radiation. Nature 121: 501-2
2. Fleischmann M, Hendra PJ, McQuillan AJ. (1974). Raman spectra of pyridine adsorbed at a silver electrode. Chem. Phys. Lett. 26: 163-66
3. Jeanmaire DL, Van Duyne RP. (1977). Surface Raman spectroelectrochemistry part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode. J. Electroanal. Chem. 84: 1-20
4. Albrecht MG, Creighton JA. (1977). Anomalously intense Raman spectra of pyridine at a silver electrode. J. Am. Chem. Soc. 99: 5215-17
5. Howard RE, Liao PF, Skocpol WJ, Jackel LD, Craighead HG. (1983). Microfabrication as a scientific tool. Science 221: 117-21
6. Liao PF, Bergman JG, Chemla DS, Wokaun A, Melngailis J, et al. (1981). Surface-enhanced Raman scattering from microlithographic silver particle surfaces. Chem. Phys. Lett. 82: 355-59
7. Asiala SM, Schultz ZD. (2011). Characterization of hotspots in a highly enhancing SERS substrate. Analyst 136: 4472-79
8. Pavel I, McCarney E, Elkhaled A, Morrill A, Plaxco K, Moskovits M. (2008). Label-free SERS detection of small proteins modified to act as bifunctional linkers. J. Phys. Chem. C 112: 4880-83
9. Bell SEJ, Sirimuthu NMS. (2006). Surface-enhanced Raman spectroscopy (SERS) for sub-micromolar detection of DNA/RNA mononucleotides. J. Am. Chem. Soc. 128: 15580-81
10. Papadopoulou E, Bell SEJ. (2011). Label-free detection of single-base mismatches in DNA by surfaceenhanced Raman spectroscopy. Angew. Chem. Int. Ed. 50: 9058-61
11. Knauer M, Ivleva NP, Liu X, Niessner R, Haisch C. (2010). Surface-enhanced Raman scattering-based label-free microarray readout for the detection of microorganisms. Anal. Chem. 82: 2766-72
12. Gautam R, Vanga S, Ariese F, Umapathy S. (2015). Review of multidimensional data processing approaches for Raman and infrared spectroscopy. EPJ Tech. Instrum. 2: 1-38
13. Jamieson LE, Jaworska A, Jiang J, Baranska M, Harrison DJ, Campbell CJ. (2015). Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors. Analyst 140: 2330-35
14. Bonifacio A, Dalla Marta S, Spizzo R, Cervo S, Steffan A, et al. (2014). Surface-enhanced Raman spectroscopy of blood plasma and serum using Ag and Au nanoparticles: a systematic study. Anal. Bioanal. Chem. 406: 2355-65
15. Premasiri WR, Lee JC, Ziegler LD. (2012). Surface-enhanced Raman scattering of whole human blood, blood plasma, and red blood cells: cellular processes and bioanalytical sensing. J. Phys. Chem. B 116: 9376-86
16. Sun F, Ella-Menye J-R, Galvan DD, Bai T, Hung H-C, et al. (2015). Stealth surface modification of surface-enhanced Raman scattering substrates for sensitive and accurate detection in protein solutions. ACS Nano 9: 2668-76
17. Schlücker S. (2009). SERS microscopy: nanoparticle probes and biomedical applications. ChemPhysChem 10: 1344-54
18. Kneipp K, Haka AS, Kneipp H, Badizadegan K, Yoshizawa N, et al. (2002). Surface-enhanced Raman spectroscopy in single living cells using gold nanoparticles. Appl. Spectrosc. 56: 150-54
19. Wang Y, Yan B, Chen L. (2013). SERStags: novel optical nanoprobes for bioanalysis. Chem. Rev. 113: 1391-428
20. Alkilany AM, Murphy CJ. (2010). Toxicity and cellular uptake of gold nanoparticles: What we have learned so far?. J. Nanopart. Res. 12: 2313-33
21. Kennedy DC, Orts-Gil G, Lai C-H, Müller L, Haase A, et al. (2014). Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptake. J. Nanobiotechnol. 12: 1-8
22. Anselmo AC, Mitragotri S. (2016). Nanoparticles in the clinic. Bioeng. Transl. Med. 1: 10-29
23. Graham D, Faulds K, Smith WE. (2006). Biosensing using silver nanoparticles and surface enhanced resonance Raman scattering. Chem. Commun. 42: 4363-71
24. Ahn J-M, Eom H-J, Yang X, Meyer JN, Choi J. (2014). Comparative toxicity of silver nanoparticles on oxidative stress and DNA damage in the nematode, Caenorhabditis elegans. Chemosphere 108: 343-52
25. Graham D, Smith WE, Linacre AMT, Munro CH, Watson ND, White PC. (1997). Selective detection of deoxyribonucleic acid at ultralow concentrations by SERRS. Anal. Chem. 69: 4703-7
26. Harper MM, McKeating KS, Faulds K. (2013). Recent developments and future directions in SERS for bioanalysis. Phys. Chem. Chem. Phys. 15: 5312-28
27. Bartczak D, Kanaras AG. (2011). Preparation of peptide-functionalized gold nanoparticles using one pot EDC/sulfo-NHS coupling. Langmuir 27: 10119-23
28. Ming L, Scott KC, Jianming Z, Jessica L, Zoraida PA, et al. (2012). Shape-dependent surface-enhanced Raman scattering in gold-Raman-probe-silica sandwiched nanoparticles for biocompatible applications. Nanotechnology 23: 115501
29. Gracie K, Moores M, Smith WE, Harding K, Girolami M, et al. (2016). Preferential attachment of specific fluorescent dyes and dye labeledDNAsequences in a surface enhanced Raman scattering multiplex. Anal. Chem. 88: 1147-53
30. Bedics MA, Kearns H, Cox JM, Mabbott S, Ali F, et al. (2015). Extreme red shifted SERS nanotags. Chem. Sci. 6: 2302-6
31. Kearns H, Bedics MA, Shand NC, Faulds K, Detty MR, Graham D. (2016). Sensitive SERS nanotags for use with 1550 nm (retina-safe) laser excitation. Analyst 141: 5062-65
32. Kearns H, Shand NC, Smith WE, Faulds K, Graham D. (2015). 1064 nm SERS of NIR active hollow gold nanotags. Phys. Chem. Chem. Phys. 17: 1980-86
33. Schlücker S. (2009). SERS microscopy: nanoparticle probes and biomedical applications. ChemPhysChem 10: 1344-54
34. Karabeber H, Huang RM, Iacono P, Samii JM, Pitter K, et al. (2014). Guiding brain tumor resection using surface-enhanced Raman scattering nanoparticles and a hand-held Raman scanner. ACS Nano 8: 9755-66
35. Mohs AM, Mancini MC, Singhal S, Provenzale JM, Leyland-Jones B, et al. (2010). Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration. Anal. Chem. 82: 9058-65
36. Zavaleta CL, Garai E, Liu JT, Sensarn S, Mandella MJ, et al. (2013). A Raman-based endoscopic strategy for multiplexed molecular imaging. PNAS 110: E2288-97
37. Garai E, Sensarn S, Zavaleta CL, Loewke NO, Rogalla S, et al. (2015). A real-Time clinical endoscopic system for intraluminal, multiplexed imaging of surface-enhanced Raman scattering nanoparticles. PLOS ONE 10: e0123185
38. Jeong S, Kim YI, Kang H, Kim G, Cha MG, et al. (2015). Fluorescence-Raman dual modal endoscopic system for multiplexed molecular diagnostics. Sci. Rep. 5: 9455
39. Bohndiek SE, Wagadarikar A, Zavaleta CL, Van de Sompel D, Garai E, et al. (2013). A small animal Raman instrument for rapid, wide-Area, spectroscopic imaging. PNAS 110: 12408-13
40. McVeigh PZ, Mallia RJ, Veilleux I, Wilson BC. (2013). Widefield quantitativemultiplex surface enhanced Raman scattering imaging in vivo. J. Biomed. Opt. 18: 046011
41. Matousek P. (2007). Deep non-invasive Raman spectroscopy of living tissue and powders. Chem. Soc. Rev. 36: 1292-304
42. Stone N, Faulds K, Graham D, Matousek P. (2010). Prospects of deep Raman spectroscopy for noninvasive detection of conjugated surface enhanced resonanceRaman scattering nanoparticles buriedwithin 25mm of mammalian tissue. Anal. Chem. 82: 3969-73
43. Stone N, Kerssens M, Lloyd GR, Faulds K, Graham D, Matousek P. (2011). Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging-The next dimension. Chem. Sci. 2: 776-80
44. Sharma B, Ma K, Glucksberg MR, Van Duyne RP. (2013). Seeing through bone with surface-enhanced spatially offset Raman spectroscopy. J. Am. Chem. Soc. 135: 17290-93
45. Kotanen CN, Martinez L, Alvarez R, Simecek JW. (2016). Surface enhanced Raman scattering spectroscopy for detection and identification of microbial pathogens isolated from human serum. Sens. Bio-Sens. Res. 8: 20-26
46. Gracie K, Correa E, Mabbott S, Dougan JA, Graham D, et al. (2014). Simultaneous detection and quantification of three bacterial meningitis pathogens by SERS. Chem. Sci. 5: 1030-40
47. Faulds K, Jarvis R, Smith WE, Graham D, Goodacre R. (2008). Multiplexed detection of six labelled oligonucleotides using surface enhanced resonance Raman scattering (SERRS). Analyst 133: 1505-12
48. McAughtrie S, Lau K, Faulds K, Graham D. (2013). 3D optical imaging of multiple SERS nanotags in cells. Chem. Sci. 4: 3566-72
49. Wang YW, Khan A, Som M, Wang D, Chen Y, et al. (2014). Rapid ratiometric biomarker detection with topically applied SERS nanoparticles. Technology 2: 118-32
50. Kneipp J, Kneipp H, Rice WL, Kneipp K. (2005). Optical probes for biological applications based on surface-enhanced Raman scattering from indocyanine green on gold nanoparticles. Anal. Chem. 77: 2381-85
51. Premasiri WR, Moir DT, Klempner MS, Krieger N, Jones G II, Ziegler LD. (2005). Characterization of the surface enhanced Raman scattering (SERS) of bacteria. J. Phys. Chem. B 109: 312-20
52. Kneipp J, Kneipp H, McLaughlin M, Brown D, Kneipp K. (2006). in Vivo Molecular Probing of Cellular Compartments with Gold Nanoparticles and Nanoaggregates. Nano Lett. 6: 2225-31
53. Zhou H, Wang Q, Yuan D, Wang J, Huang Y, et al. (2016). Early apoptosis real-Time detection by label-free SERS based on externalized phosphatidylserine. Analyst 141: 4293-98
54. Jamieson LE, Byrne HJ. (2016). Vibrational spectroscopy as a tool for studying drug-cell interaction: could high throughput vibrational spectroscopic screening improve drug development?. Vib. Spectrosc. In press. http://dx.doi.org/10.1016/j.vibspec.2016.09.003
55. Lee S, Kim S, Choo J, Soon YS, Lee YH, et al. (2007). Biological imaging of HEK293 cells expressing PLC?1 using surface-enhanced raman microscopy. Anal. Chem. 79: 916-22
56. Park H, Lee S, Chen L, Lee EK, Shin SY, et al. (2009). SERS imaging of HER2-overexpressed MCF7 cells using antibody-conjugated gold nanorods. Phys. Chem. Chem. Phys. 11: 7444-49
57. Lee S, Chon H, Lee J, Ko J, Chung BH, et al. (2014). Rapid and sensitive phenotypic marker detection on breast cancer cells using surface-enhanced Raman scattering (SERS) imaging. Biosens. Bioelectron. 51: 238-43
58. Stevenson R, McAughtrie S, Senior L, Stokes RJ, McGachy H, et al. (2013). Analysis of intracellular enzyme activity by surface enhanced Raman scattering. Analyst 138: 6331-36
59. Bishnoi SW, Rozell CJ, Levin CS, Gheith MK, Johnson BR, et al. (2006). All-optical Nanoscale PH Meter. Nano Lett. 6: 1687-92
60. Kneipp J, Kneipp H, Wittig B, Kneipp K (2007). One- And two-photon excited optical pH probing for cells using surface-enhanced raman and hyper-Raman nanosensors. Nano Lett. 7: 2819-23
61. Mallikarjun V, Clarke DJ, Campbell CJ. (2012). Cellular redox potential and the biomolecular electrochemical series: a systems hypothesis. Free Radic. Biol. Med. 53: 280-88
62. Auchinvole CAR, Richardson P, McGuinnes C, Mallikarjun V, Donaldson K, et al. (2012). Monitoring intracellular redox potential changes using SERS nanosensors. ACS Nano 6: 888-96
63. Jiang J, Auchinvole C, Fisher K, Campbell CJ. (2014). Quantitative measurement of redox potential in hypoxic cells using SERS nanosensors. Nanoscale 6: 12104-10
64. Thomson PIT, Camus VL, Hu Y, Campbell CJ. (2015). Series of quinone-containing nanosensors for biologically relevant redox potential determination by surface-enhanced Raman spectroscopy. Anal. Chem. 87: 4719-25
65. Camus VL, Stewart G, Nailon WH, McLaren DB, Campbell CJ. (2016). Measuring the effects of fractionated radiation therapy in a 3Dprostate cancermodel system using SERS nanosensors. Analyst 141: 5056-61
66. Jamieson LE, Camus VL, Bagnaninchi PO, Fisher KM, Stewart GD, et al. (2016). Targeted SERS nanosensors measure physicochemical gradients and free energy changes in live 3D tumor spheroids. Nanoscale 8: 16710-18
67. Lawson LS, Chan JW, Huser T. (2014). A highly sensitive nanoscale pH-sensor using Au nanoparticles linked by a multifunctional Raman-Active reporter molecule. Nanoscale 6: 7971-80
68. Lee KYJ, Wang Y, Nie S. (2015). In vitro study of a pH-sensitive multifunctional doxorubicin-gold nanoparticle system: therapeutic effect and surface enhanced Raman scattering. RSC Adv. 5: 65651-59
69. Chen Y, Bai X, Su L, Du Z, Shen A, et al. (2016). Combined labelled and label-free SERS probes for triplex three-dimensional cellular imaging. Sci. Rep. 6: 19173
70. Lee M. (2009). Basic Skills in Interpreting Laboratory Data. Bethesda, MD: ASHP. 4th ed.
71. Theodosiou Z, Kasampalidis IN, Livanos G, Zervakis M, Pitas I, Lyroudia K. (2007). Automated analysis of FISH and immunohistochemistry images: a review. Cytometry A 71: 439-50
72. Shafer-Peltier KE, Haynes CL, Glucksberg MR, Van Duyne RP. (2003). Toward a glucose biosensor based on surface-enhanced Raman scattering. J. Am. Chem. Soc. 125: 588-93
73. Rohr TE, Cotton T, Fan N, Tarcha PJ. (1989). Immunoassay employing surface-enhanced Raman spectroscopy. Anal. Biochem. 182: 388-98
74. Schlücker S, Küstner B, Punge A, Bonfig R, Marx A, Ströbel P. (2006). Immuno-Raman microspectroscopy: in situ detection of antigens in tissue specimens by surface-enhanced Raman scattering. J. Raman Spectrosc. 37: 719-21
75. Sinha L, Wang Y, Yang C, Khan A, Brankov JG, et al. (2015). Quantification of the binding potential of cell-surface receptors in fresh excised specimens via dual-probe modeling of SERS nanoparticles. Sci. Rep. 5: 8582
76. Bantz KC, Meyer AF, Wittenberg NJ, Im H, Kurtulus O, et al. (2011). Recent progress inSERSbiosensing. Phys. Chem. Chem. Phys. 13: 11551-67
77. Vo-Dinh T, Hiromoto MYK, Begun GM, Moody RL. (1984). Surface-enhanced Raman spectrometry for trace organic analysis. Anal. Chem. 56: 1667-70
78. Vo-Dinh T, Houck K, Stokes DL. (1994). Surface-enhanced Raman gene probes. Anal. Chem. 66: 3379-83
79. Isola NR, Stokes DL, Vo-Dinh T. (1998). Surface-enhanced Raman gene probe for HIV detection. Anal. Chem. 70: 1352-56
80. Graham D, Mallinder BJ, Smith WE. (2000). Surface-enhanced resonance Raman scattering as a novel method of DNA discrimination. Angew. Chem. Int. Ed. 39: 1061-63
81. Cao YC, Jin R, Mirkin CA. (2002). Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. Science 297: 1536-40
82. Faulds K, Smith WE, Graham D. (2004). Evaluation of surface-enhanced resonance Raman scattering for quantitative DNA analysis. Anal. Chem. 76: 412-17
83. Faulds K, McKenzie F, Smith WE, Graham D. (2007). Quantitative simultaneous multianalyte detection of DNAby dual-wavelength surface-enhanced resonanceRaman scattering. Angew. Chem. Int. Ed. 46: 1829-31
84. White PL, Hibbitts SJ, Perry MD, Green J, Stirling E, et al. (2014). Evaluation of a commercially developed semiautomated PCR-surface-enhanced Raman scattering assay for diagnosis of invasive fungal disease. J. Clin. Microbiol. 52: 3536-43
85. Cui Y, Ren B, Yao J-L, Gu R-A, Tian Z-Q. (2007). Multianalyte immunoassay based on surface-enhanced Raman spectroscopy. J. Raman Spectrosc. 38: 896-902
86. Wang G, Park H-Y, Lipert RJ, Porter MD. (2009). Mixed monolayers on gold nanoparticle labels for multiplexed surface-enhanced Raman scattering based immunoassays. Anal. Chem. 81: 9643-50
87. Wang G, Lipert RJ, Jain M, Kaur S, Chakraboty S, et al. (2011). Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering. Anal. Chem. 83: 2554-61
88. Dou X, Takama T, Yamaguchi Y, Yamamoto H, Ozaki Y. (1997). Enzyme immunoassay utilizing surfaceenhanced Raman scattering of the enzyme reaction product. Anal. Chem. 69: 1492-95
89. Larmour IA, Faulds K, Graham D. (2010). The past, present and future of enzyme measurements using surface enhanced Raman spectroscopy. Chem. Sci. 1: 151-60
90. Moore BD, Stevenson L, Watt A, Flitsch S, Turner NJ, et al. (2004). Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering. Nat. Biotechnol. 22: 1133-38
91. Lutz BR, Dentinger CE, Nguyen LN, Sun L, Zhang J, et al. (2008). Spectral analysis of multiplex Raman probe signatures. ACS Nano 2: 2306-14
92. Sun L, Sung K-B, Dentinger C, Lutz B, Nguyen L, et al (2007). Composite organic-inorganic nanoparticles as Raman labels for tissue analysis. Nano Lett. 7: 351-56
93. Salehi M, Steinigeweg D, Ströbel P, Marx A, Packeisen J, Schlücker S. (2013). Rapid immuno-SERS microscopy for tissue imaging with single-nanoparticle sensitivity. J. Biophotonics 6: 785-92
94. Salehi M, Schneider L, Strobel P, Marx A, Packeisen J, Schlucker S. (2014). Two-color SERS microscopy for protein co-localization in prostate tissue with primary antibody-protein A/G-gold nanocluster conjugates. Nanoscale 6: 2361-67
95. Wang Y, Kang S, Khan A, Ruttner G, Leigh SY, et al. (2016). Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy. Sci. Rep. 6: 21242
96. Stuart DA, Yuen JM, Shah N, Lyandres O, Yonzon CR, et al. (2006). In vivo glucose measurement by surface-enhanced Raman spectroscopy. Anal. Chem. 78: 7211-15
97. Ma K, Yuen JM, Shah NC, Walsh JT Jr., Glucksberg MR, Van Duyne RP. (2011). In vivo, transcutaneous glucose sensing using surface-enhanced spatially offset Raman spectroscopy: multiple rats, improved hypoglycemic accuracy, low incident power, and continuous monitoring for greater than 17 days. Anal. Chem. 83: 9146-52
98. Qian X, Peng XH, Ansari DO, Yin-Goen Q, Chen GZ, et al. (2008). In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nat. Biotechnol. 26: 83-90
99. Keren S, Zavaleta C, Cheng Z, de la Zerda A, Gheysens O, Gambhir SS. (2008). Noninvasive molecular imaging of small living subjects using Raman spectroscopy. PNAS 105: 5844-49
100. Zavaleta CL, Smith BR, Walton I, Doering W, Davis G, et al. (2009). Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy. PNAS 106: 13511-16
101. Kang H, Jeong S, Park Y, Yim J, Jun BH, et al. (2013). Near-infrared SERS nanoprobes with plasmonic Au/Ag hollow-shell assemblies for in vivo multiplex detection. Adv. Funct. Mater. 23: 3719-27
102. Register JK, Fales AM, Wang HN, Norton SJ, Cho EH, et al. (2015). In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models. Anal. Bioanal. Chem. 407: 8215-24
103. Maiti KK, Dinish US, Fu CY, Lee JJ, Soh KS, et al. (2010). Development of biocompatible SERS nanotag with increased stability by chemisorption of reporter molecule for in vivo cancer detection. Biosens. Bioelectron. 26: 398-403
104. Samanta A, Maiti KK, Soh KS, Liao X, Vendrell M, et al. (2011). Ultrasensitive near-infrared Raman reporters for SERS-based in vivo cancer detection. Angew. Chem. Int. Ed. 50: 6089-92
105. Maiti KK, Dinish US, Samanta A, Vendrell M, Soh KS, et al. (2012). Multiplex targeted in vivo cancer detection using sensitive near-infrared SERS nanotags. Nano Today 7: 85-93
106. Dinish US, Balasundaram G, Chang YT, Olivo M. (2014). Actively targeted in vivo multiplex detection of intrinsic cancer biomarkers using biocompatible SERS nanotags. Sci. Rep. 4: 4075
107. McQueenie R, Stevenson R, Benson R, MacRitchie N, McInnes I, et al. (2012). Detection of inflammation in vivo by surface-enhanced Raman scattering provides higher sensitivity than conventional fluorescence imaging. Anal. Chem. 84: 5968-75
108. Wang YW, Kang S, Khan A, Bao PQ, Liu JT. (2015). In vivo multiplexedmolecular imaging of esophageal cancer via spectral endoscopy of topically applied SERS nanoparticles. Biomed. Opt. Express 6: 3714-23
109. Yuen JM, Shah NC, Walsh JT Jr., Glucksberg MR, Van Duyne RP. (2010). Transcutaneous glucose sensing by surface-enhanced spatially offset Raman spectroscopy in a rat model. Anal. Chem. 82: 8382-85
110. Niu XJ, Chen HY, Wang YQ, Wang WH, Sun XY, Chen LX. (2014). Upconversion fluorescence-SERS dual-mode tags for cellular and in vivo imaging. Acs Appl. Mater. Interfaces 6: 5152-60
111. Jeong S, Kim YI, Kang H, Kim G, Cha MG, et al. (2015). Fluorescence-Raman dual modal endoscopic system for multiplexed molecular diagnostics. Sci. Rep. 5: 9455
112. Iacono P, Karabeber H, Kircher MF. (2014). A schizophotonic all-in-one nanoparticle coating for multiplexed SE(R)RS biomedical imaging. Angew. Chem. Int. Ed. 53: 11756-61
113. von Maltzahn G, Centrone A, Park J-H, Ramanathan R, Sailor MJ, et al. (2009). SERS-coded gold nanorods as a multifunctional platform for densely multiplexed near-infrared imaging and photothermal heating. Adv. Mater. 21: 3175-80
114. Park JH, von Maltzahn G, Ong LL, Centrone A, Hatton TA, et al. (2010). Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery. Adv. Mater. 22: 880-85
115. Zeng LY, Pan YW, Wang SJ, Wang X, Zhao XM, et al. (2015). Raman reporter-coupled Agcore@Aushell nanostars for in vivo improved surface enhanced Raman scattering imaging and near-infrared-Triggered photothermal therapy in breast cancers. Acs Appl. Mater. Interfaces 7: 16781-91
116. Liu Y, Chang Z, Yuan HK, Fales AM, Vo-Dinh T. (2013). Quintuple-modality (SERS-MRI-CT-TPLPTT) plasmonic nanoprobe for theranostics. Nanoscale 5: 12126-31
117. Liu Y, Ashton JR, Moding EJ, Yuan H, Register JK, et al. (2015). A plasmonic gold nanostar theranostic probe for in vivo tumor imaging and photothermal therapy. Theranostics 5: 946-60
118. Kircher MF, de la Zerda A, Jokerst JV, Zavaleta CL, Kempen PJ, et al. (2012). A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. Nat. Med. 18: 829-34
119. Amendola V, Scaramuzza S, Litti L, Meneghetti M, Zuccolotto G, et al. (2014). Magneto-plasmonic Au-Fe alloy nanoparticles designed for multimodal SERS-MRI-CT imaging. Small 10: 2476-86
120. Yigit MV, Zhu L, Ifediba MA, Zhang Y, Carr K, et al. (2011). Noninvasive MRI-SERS imaging in living mice using an innately bimodal nanomaterial. ACS Nano 5: 1056-66
121. Tian F, Conde J, Bao C, Chen Y, Curtin J, Cui D. (2016). Gold nanostars for efficient in vitro and in vivo real-Time SERS detection and drug delivery via plasmonic-Tunable Raman/FTIR imaging. Biomaterials 106: 87-97
122. Dinish US, Song ZG, Ho CJH, Balasundaram G, Attia ABE, et al. (2015). Single molecule with dual function on nanogold: biofunctionalized construct for in vivo photoacoustic imaging and SERS biosensing. Adv. Funct. Mater. 25: 2316-25
123. Henry AI, Sharma B, Cardinal MF, Kurouski D, Van Duyne RP. (2016). Surface-enhanced Raman spectroscopy biosensing: in vivo diagnostics and multimodal imaging. Anal. Chem. 88: 6638-47
124. Lee DE, Koo H, Sun IC, Ryu JH, Kim K, Kwon IC. (2012). Multifunctional nanoparticles for multimodal imaging and theragnosis. Chem. Soc. Rev. 41: 2656-72
125. Lane LA, Qian XM, Nie SM. (2015). SERS Nanoparticles in medicine: from label-free detection to spectroscopic tagging. Chem. Rev. 115: 10489-529