Vibrational spectroscopy as a tool for studying drug-cell interaction: Could high throughput vibrational spectroscopic screening improve drug development?

Vibrational Spectroscopy

Volumn 91, Issue , 2017, Pages 16-30

  Jamieson, Lauren E ^a   Byrne, Hugh J ^b  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

Drug screening; FTIR; HTS; Nonlinear Raman; Raman; SERS

Indexed keywords

BINDING ENERGY; BIOINFORMATICS; CELLS; CYTOLOGY; DIAGNOSIS; DRUG PRODUCTS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; INTERACTIVE COMPUTER SYSTEMS; MEDICAL APPLICATIONS; PATHOLOGY; RAMAN SPECTROSCOPY; SPECTROSCOPY; THROUGHPUT; VIBRATIONAL SPECTROSCOPY;

DRUG SCREENING; FTIR; NONLINEAR RAMAN; RAMAN; SERS;

DRUG INTERACTIONS;

EID: 85008620715     PISSN: 09242031     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vibspec.2016.09.003     Document Type: Article

References (97)

1. [1] Almond, L.M., Hutchings, J., Lloyd, G., Barr, H., Shepherd, N., Day, J., Stevens, O., Sanders, S., Wadley, M., Stone, N., Kendall, C., Endoscopic Raman spectroscopy enables objective diagnosis of dysplasia in Barrett's esophagus. Gastrointest. Endosc. 79 (2014), 37–45, 10.1016/j.gie.2013.05.028.
2. [2] Fernandez, D.C., Bhargava, R., Hewitt, S.M., Levin, I.W., Infrared spectroscopic imaging for histopathologic recognition. Nat. Biotechnol. 23 (2005), 469–474, 10.1038/nbt1080.
3. [3] Khoshmanesh, A., Dixon, M.W.A., Kenny, S., Tilley, L., McNaughton, D., Wood, B.R., Detection and quantification of early-stage malaria parasites in laboratory infected erythrocytes by attenuated total reflectance infrared spectroscopy and multivariate analysis. Anal. Chem. 86 (2014), 4379–4386, 10.1021/ac500199x.
4. [4] Lovergne, L., Clemens, G., Untereiner, V., Lukaszweski, R.A., Sockalingum, G.D., Baker, M.J., Investigating optimum sample preparation for infrared spectroscopic serum diagnostics. Anal. Methods 7 (2015), 7140–7149, 10.1039/C5AY00502G.
5. [5] Lyng, F.M., Traynor, D., Ramos, I.R.M., Bonnier, F., Byrne, H.J., Raman spectroscopy for screening and diagnosis of cervical cancer. Anal. Bioanal. Chem. 407 (2015), 8279–8289, 10.1007/s00216-015-8946-1.
6. [6] Byrne, H.J., Baranska, M., Puppels, G.J., Stone, N., Wood, B., Gough, K.M., Lasch, P., Heraud, P., Sulé-Suso, J., Spectropathology for the next generation: quo vaids?. Analyst 140 (2015), 2066–2073, 10.1039/c4an02036g.
7. [7] The International Society for Clinical Spectroscopy, http://clirspec.org (accessed 08.04.16).
8. [8] Raman4Clinics, https://www.raman4clinics.eu (accessed 24.05.16).
9. [9] Laser detects brain tumour cells during surgery, http://www.bbc.co.uk/news/health-34041863 (accessed 06.09.15).
10. [10] Jermyn, M., Mok, K., Mercier, J., Desroches, J., Pichette, J., Saint-Arnaud, K., Bernstein, L., Guiot, M.-C., Petrecca, K., Leblond, F., Intraoperative brain cancer detection with Raman spectroscopy in humans. Sci. Transl. Med., 7, 2015, 10.1126/scitranslmed.aaa2384 274ra19–274ra19.
11. [11] Infrared light puts malaria to the test, http://monash.edu/news/show/infrared-light-puts-malaria-to-the-test (accessed 06.09.15).
12. [12] Legislation for the protection of animals used for scientific purposes, http://ec.europa.eu/environment/chemicals/lab_animals/legislation_en.htm (accessed15.05.16).
13. [13] Public Law 106–387 106th Congress An Act, (2001).
14. [14] Hajare, A.A., Salunkhe, S.S., Mali, S.S., Gorde, S.S., Nadaf, S.J., Pishawikar, S.A., Review on: high-throughput screening is an approach to drug discovery. Am. J. Pharm. Tech. Res. 4 (2013), 112–129.
15. [15] Hughes, C., Clemens, G., Baker, M.J., Preclinical screening of anticancer drugs using infrared (IR) microspectroscopy. Trends Biotechnol. 33 (2015), 429–430, 10.1016/j.tibtech.2015.03.010.
16. [16] Nawaz, H., Bonnier, F., Knief, P., Howe, O., Lyng, F.M., Meade, A.D., Byrne, H.J., Evaluation of the potential of Raman microspectroscopy for prediction of chemotherapeutic response to cisplatin in lung adenocarcinoma. Analyst 135 (2010), 3070–3076, 10.1039/c0an00541j.
17. [17] Derenne, A., Gasper, R., Goormaghtigh, E., The FTIR spectrum of prostate cancer cells allows the classification of anticancer drugs according to their mode of action. Analyst 136 (2011), 1134–1141, 10.1039/c0an00872a.
18. [18] Stevenson, R., McAughtrie, S., Senior, L., Stokes, R.J., McGachy, H., Tetley, L., Nativo, P., Brewer, J.M., Alexander, J., Faulds, K., Graham, D., Analysis of intracellular enzyme activity by surface enhanced Raman scattering. Analyst 138 (2013), 6331–6336, 10.1039/c3an00729d.
19. [19] Austin, L.A., Kang, B., El-Sayed, M.A., A new nanotechnology technique for determining drug efficacy using targeted plasmonically enhanced single cell imaging spectroscopy. J. Am. Chem. Soc. 135 (2013), 4688–4691, 10.1021/ja4011145.
20. [20] Tipping, W.J., Lee, M., Serrels, A., Brunton, V.G., Hulme, A.N., Stimulated Raman scattering microscopy: an emerging tool for drug discovery. Chem. Soc. Rev. 45 (2016), 2075–2089, 10.1039/C5CS00693G.
21. [21] Szymański, P., Markowicz, M., Mikiciuk-Olasik, E., Adaptation of high-throughput screening in drug discovery-toxicological screening tests. Int. J. Mol. Sci. 13 (2012), 427–452, 10.3390/ijms13010427.
22. [22] Boger, D.L., Fink, B.E., Hedrick, M.P., Total synthesis of distamycin A and 2640 analogues: a solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents and development of a rapid, high-throughput screen for determining relative DNA binding affinity or DNA binding selectivity. J.Am. Chem. Soc. 122 (2000), 6382–6394, 10.1021/ja994192d.
23. [23] Torjesen, I., Drug development: the journey of a medicine from lab to shelf. Pharm. J., 2015 article (accessed 08.04.16) http://www.pharmaceutical-journal.com/publications/tomorrows-pharmacist/drug-development-the-journey-of-a-medicine-from-lab-to-shelf/20068196.
24. [24] Barata, D., van Blitterswijk, C., Habibovic, P., High-throughput screening approaches and combinatorial development of biomaterials using microfluidics. Acta Biomater. 34 (2015), 1–20, 10.1016/j.actbio.2015.09.009.
25. [25] Boute, N., Jockers, R., Issad, T., The use of resonance energy transfer in high-throughput screening: BRET versus FRET. Trends Pharmacol. Sci. 23 (2002), 351–354, 10.1016/S0165-6147(02)02062-X.
26. [26] Smith, D.S., Eremin, S.A., Fluorescence polarization immunoassays and related methods for simple, high-throughput screening of small molecules. Anal. Bioanal. Chem. 391 (2008), 1499–1507, 10.1007/s00216-008-1897-z.
27. [27] Jia, Y., Quinn, C.M., Gagnon, A.I., Talanian, R., Homogeneous time-resolved fluorescence and its applications for kinase assays in drug discovery. Anal. Biochem. 356 (2006), 273–281, 10.1016/j.ab.2006.05.006.
28. [28] Auer, M., Moore, K.J., Meyer-Almes, F.J., Guenther, R., Pope, A.J., Stoeckli, K.A., Fluorescence correlation spectroscopy: lead discovery by miniaturized HTS. Drug Discov. Today 3 (1998), 457–465, 10.1016/S1359-6446(98)01240-9.
29. [29] Inglese, J., Johnson, R.L., Simeonov, A., Xia, M., Zheng, W., Austin, C.P., Auld, D.S., High-throughput screening assays for the identification of chemical probes. Nat. Chem. Biol. 3 (2007), 466–479, 10.1038/nchembio.2007.17.
30. [30] Maffia, A.M. III, Kariv, I., Oldenburg, K.R., Miniaturization of a mammalian cell-based assay: luciferase reporter gene readout in a 3 microliter 1536-well plate. J. Biomol. Screen 4 (1999), 137–142, 10.1177/108705719900400307.
31. [31] Collins, L.A., Torrero, M.N., Franzblau, S.G., Green fluorescent protein reporter microplate assay for high-throughput screening of compounds against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 42 (1998), 344–347.
32. [32] Berg, M., Undisz, K., Thiericke, R., Moore, T., Posten, C., Miniaturization of an enzyme assay (β-galactosidase) in the 384- and 1536-well plate format. J. Assoc. Lab. Autom. 4 (1999), 64–67, 10.1016/S1535-5535(04)00042-5.
33. [33] Go, Y.-M., Jones, D.P., Redox compartmentalization in eukaryotic cells. Biochim. Biophys. Acta 1780 (2009), 1273–1290, 10.1016/j.bbagen.2008.01.011.
34. [34] Hamid, R., Rotshteyn, Y., Rabadi, L., Parikh, R., Bullock, P., Comparison of alamar blue and MTT assays for high through-put screening. Toxicol. Vitro 18 (2004), 703–710, 10.1016/j.tiv.2004.03.012.
35. [35] Vichai, V., Kirtikara, K., Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat. Protoc. 1 (2006), 1112–1116, 10.1038/nprot.2006.179.
36. [36] High Throughput Raman Spectrometer, http://www.is-instruments.com/high-throughput-raman-spectrometer.html (accessed 25.04.16).
37. [37] Stevenson, R., Ingram, A., Leung, H., McMillan, D.C., Graham, D., Quantitative SERRS immunoassay for the detection of human PSA. Analyst 134 (2009), 842–844, 10.1039/b902174d.
38. [38] Laing, S., Gracie, K., Faulds, K., Multiplex in vitro detection using SERS. Chem. Soc. Rev. 45 (2016), 1901–1918, 10.1039/C5CS00644A.
39. [39] Byrne, H.J., Knief, P., Keating, M.E., Bonnier, F., Spectral pre and post processing for infrared and Raman spectroscopy of biological tissues and cells. Chem. Soc. Rev. 45 (2016), 1865–1878, 10.1039/C5CS00440C.
40. [40] Bassan, P., Kohler, A., Martens, H., Lee, J., Byrne, H.J., Dumas, P., Gazi, E., Brown, M., Clarke, N., Gardner, P., Resonant mie scattering (RMieS) correction of infrared spectra from highly scattering biological samples. Analyst 135 (2010), 268–277, 10.1039/b921056c.
41. [41] Bruun, S.W., Kohler, A., Adt, I., Sockalingum, G.D., Manfait, M., Martens, H., Correcting attenuated total reflection-fourier transform infrared spectra for water vapor and carbon dioxide. Appl. Spectrosc. 60 (2006), 1029–1039, 10.1366/000370206778397371.
42. [42] Kerr, L.T., Byrne, H., Hennelly, B.M., Optimal choice of sample substrate and laser wavelength for Raman spectroscopic analysis of biological specimen. Anal. Methods 7 (2015), 5041–5052, 10.1039/C5AY00327J.
43. [43] Liland, K.H., Kohler, A., Afseth, N.K., Model-based pre-processing in Raman spectroscopy of biological samples. J. Raman Spectrosc., 2016, 10.1002/jrs.4886.
44. [44] Baker, M.J., Hughes, C.S., Hollywood, K.A., Biophotonics Vibrational Spectroscopic Diagnostics. 2016, Morgan & Claypool Publishers, 10.1088/978-1-6817-4071-3.
45. [45] Bird, B., Baker, M.J., Quantum cascade lasers in biomedical infrared imaging. Trends Biotechnol. 33 (2015), 557–558, 10.1016/j.tibtech.2015.07.003.
46. [46] El-Mashtoly, S.F., Petersen, D., Yosef, H.K., Mosig, A., Reinacher-Schick, A., Kötting, C., Gerwert, K., Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy. Analyst 139 (2014), 1155–1161, 10.1039/c3an01993d.
47. [47] Farhane, Z., Bonnier, F., Casey, A., Byrne, H.J., Raman micro spectroscopy for in vitro drug screening: subcellular localisation and interactions of doxorubicin. Analyst 140 (2015), 4212–4223, 10.1039/c5an00256g.
48. [48] Nawaz, H., Bonnier, F., Knief, P., Howe, O., Lyng, F.M., Meade, A.D., Byrne, H.J., Evaluation of the potential of Raman microspectroscopy for prediction of chemotherapeutic response to cisplatin in lung adenocarcinoma. Analyst 135 (2010), 3070–3076, 10.1039/c0an00541j.
49. [49] Miljković, M., Chernenko, T., Romeo, M.J., Bird, B., Matthäus, C., Diem, M., Label-free imaging of human cells: algorithms for image reconstruction of Raman hyperspectral datasets. Analyst 135 (2010), 2002–2013, 10.1039/c0an00042f.
50. [50] Keating, M.E., Bonnier, F., Byrne, H.J., Spectral cross-correlation as a supervised approach for the analysis of complex Raman datasets: the case of nanoparticles in biological cells. Analyst 137 (2012), 5792–5802, 10.1039/c2an36169h.
51. [51] Lasch, P., Diem, M., Hänsch, W., Naumann, D., Artificial neural networks as supervised techniques for FT-IR microspectrocopic imaging. J. Chemom. 20 (2006), 209–220, 10.1002/cem993.
52. [52] Gaigneaux, A., Ruysschaert, J.M., Goormaghtigh, E., Infrared spectroscopy as a tool for discrimination between sensitive and multiresistant K562 cells. Eur. J. Biochem. 269 (2002), 1968–1973, 10.1046/j.1432-1327.2002.02841.x.
53. [53] Miller, L.M., Dumas, P., Chemical imaging of biological tissue with synchrotron infrared light. Biochim. Biophys. Acta Biomembr. 1758 (2006), 846–857, 10.1016/j.bbamem.2006.04.010.
54. [54] Derenne, A., Van Hemelryck, V., Lamoral-Theys, D., Kiss, R., Goormaghtigh, E., FTIR spectroscopy: a new valuable tool to classify the effects of polyphenolic compounds on cancer cells. Biochim. Biophys. Acta Mol. Basis Dis. 1832 (2013), 46–56, 10.1016/j.bbadis.2012.10.010.
55. [55] Gasper, R., Mijatovic, T., Bénard, A., Derenne, A., Kiss, R., Goormaghtigh, E., FTIR spectral signature of the effect of cardiotonic steroids with antitumoral properties on a prostate cancer cell line. Biochim. Biophys. Acta Mol. Basis Dis. 1802 (2010), 1087–1094, 10.1016/j.bbadis.2010.07.012.
56. [56] Nie, F., Yu, X.-L., Wang, X.-G., Tang, Y.-F., Wang, L.-L., Ma, L., Down-regulation of CacyBP is associated with poor prognosis and the effects on COX-2 expression in breast cancer. Int. J. Oncol. 37 (2010), 1261–1269, 10.3892/ijo.
57. [57] Berger, G., Leclercqz, H., Derenne, A., Gelbcke, M., Goormaghtigh, E., Nève, J., Mathieu, V., Dufrasne, F., Synthesis and in vitro characterization of platinum(II) anticancer coordinates using FTIR spectroscopy and NCI COMPARE: a fast method for new compound discovery. Bioorg. Med. Chem. 22 (2014), 3527–3536, 10.1016/j.bmc.2014.04.017.
58. [58] Baker, M.J., Trevisan, J., Bassan, P., Bhargava, R., Butler, H.J., Dorling, K.M., Fielden, P.R., Fogarty, S.W., Fullwood, N.J., Heys, K.A., Hughes, C., Lasch, P., Martin-Hirsch, P.L., Obinaju, B., Sockalingum, G.D., Sulé-Suso, J., Strong, R.J., Walsh, M.J., Wood, B.R., Gardner, P., Martin, F.L., Using Fourier transform IR spectroscopy to analyze biological materials. Nat. Protoc. 9 (2014), 1771–1791, 10.1038/nprot.2014.110.
59. [59] Elmer, Perkin, The effects of varying force and contact on ATR spectra. Tech. Note, 2012, 4–6.
60. [60] Levenson, E., Lerch, P., Martin, M.C., Spatial resolution limits for synchrotron-based spectromicroscopy in the mid- and near-infrared. J. Synchrotron Radiat. 15 (2008), 323–328, 10.1107/S0909049508004524.
61. [61] Hughes, C., Henderson, A., Kansiz, M., Dorling, K., Jimenez-Hernandez, M., Brown, M.D., Clarke, N.W., Gardner, P., Enhanced FTIR benchtop imaging of single biological cells. Analyst, 2015, 2080–2085, 10.1039/C4AN02053G.
62. [62] Draux, F., Jeannesson, P., Gobinet, C., Sulé-Suso, J., Pijanka, J., Sandt, C., Dumas, P., Manfait, M., Sockalingum, G.D., IR spectroscopy reveals effect of non-cytotoxic doses of anti-tumour drug on cancer cells. Anal. Bioanal. Chem. 395 (2009), 2293–2301, 10.1007/s00216-009-3140-y.
63. [63] Hughes, C., Brown, M.D., Ball, F.J., Monjardez, G., Clarke, N.W., Flower, K.R., Gardner, P., Highlighting a need to distinguish cell cycle signatures from cellular responses to chemotherapeutics in SR-FTIR spectroscopy. Analyst 137 (2012), 5736–5742, 10.1039/c2an35633c.
64. [64] Derenne, A., Mignolet, A., Goormaghtigh, E., FTIR spectral signature of anticancer drug effects on PC-3 cancer cells: is there any influence of the cell cycle?. Analyst 138 (2013), 3998–4005, 10.1039/c3an00225j.
65. [65] Holman, H.-Y.N., Martin, M.C., Blakely, E.A., Bjornstad, K., McKinney, W.R., IR spectroscopic characteristics of cell cycle and cell death probed by synchrotron radiation based fourier transform IR spectromicroscopy. Biopolymers 57 (2000), 329–335, 10.1002/1097-0282.
66. [66] Jimenez-Hernandez, M., Brown, M.D., Hughes, C., Clarke, N.W., Gardner, P., Characterising cytotoxic agent action as a function of the cell cycle using fourier transform infrared microspectroscopy. Analyst 140 (2015), 4453–4464, 10.1039/c5an00671f.
67. [67] Gaudenzi, S., Pozzi, D., Toro, P., Silvestri, I., Morrone, S., Castellano, A.C., Cell apoptosis specific marker found by Fourier transform infrared spectroscopy. Spectroscopy 18 (2004), 415–422, 10.1155/2004/483591.
68. [68] Lui, K.-Z., Li, J., Kelsey, S.M., Mantsch, H.H., Quantitative determination of apoptosis on leukaemia cells by infrared spectroscopy. Apoptosis 6 (2001), 267–276, 10.1023/A:1011383408381.
69. [69] Rutter, A.V., Siddique, M.R., Filik, J., Sandt, C., Dumas, P., Cinque, G., Sockalingum, G.D., Yang, Y., Sulé-Suso, J., Study of gemcitabine-sensitive/resistant cancer cells by cell cloning and synchrotron FTIR microspectroscopy. Cytometry A 85 (2014), 688–697, 10.1002/cyto.a.22488.
70. [70] Bonnier, F., Ali, S.M., Knief, P., Lambkin, H., Flynn, K., McDonagh, V., Healy, C., Lee, T.C., Lyng, F.M., Byrne, H.J., Analysis of human skin tissue by Raman microspectroscopy: dealing with the background. Vib. Spectrosc. 61 (2012), 124–132, 10.1016/j.vibspec.2012.03.009.
71. [71] Buckmaster, R., Asphahani, F., Thein, M., Xu, J., Zhang, M., Detection of drug-induced cellular changes using confocal Raman spectroscopy on patterned single-cell biosensors. Analyst 134 (2009), 1440–1446, 10.1039/b900420c.
72. [72] Farhane, Z., Bonnier, F., Casey, A., Byrne, H., Raman micro spectroscopy for in vitro drug screening: subcellular localisation and interactions of Doxorubicin. Analyst 140 (2015), 4212–4223, 10.1039/c5an00256g.
73. [73] Farhane, Z., Bonnier, F., Marcus Alexander, B., Jane, Maher, Alan, C., Byrne, H.J., Differentiating responses of lung cancer cell lines to Doxorubicin exposure: in vitro Raman micro spectroscopy, oxidative stress and bcl-2 protein expression. J. Biophotonics, 2016, 1–15, 10.1002/jbio.201600019.
74. [74] Keating, M.E., Nawaz, H., Bonnier, F., Byrne, H.J., Multivariate statistical methodologies applied in biomedical Raman spectroscopy: assessing the validity of partial least squares regression using simulated model datasets. Analyst 140 (2015), 2482–2492, 10.1039/c4an02167c.
75. [75] Le Ru, E.C., Etchegoin, P.G., Principles of surface-enhanced Raman spectroscopy. SERS Enhancement Factors and Related Topics, 2009, Elsevier, 10.1016/B978-0-444-52779-0.00009-X (Chapter 4).
76. [76] Tian, Z.Q., Surface-enhanced Raman spectroscopy: advancements and applications. J. Raman Spectrosc. 36 (2005), 466–470, 10.1002/jrs.1378.
77. [77] Moore, B.D., Stevenson, L., Watt, A., Flitsch, S., Turner, N.J., Cassidy, C., Graham, D., Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering. Nat. Biotechnol. 22 (2004), 1133–1138, 10.1038/nbt1003.
78. [78] Kneipp, K., Haka, A.S., Kneipp, H., Badizadegan, K., Yoshizawa, N., Boone, C., Shafer-Peltier, K.E., Motz, J.T., Dasari, R.R., Feld, M.S., Surface-enhanced raman spectroscopy in single living cells using gold nanoparticles. Appl. Spectrosc. 56 (2002), 150–154, 10.1366/0003702021954557.
79. [79] T. Vo-Dinh, Nanoprobe for surface-enhanced Raman spectroscopy in medical diagnostic and drug screening, 2001, US 6,219,137 B1, filed 3rd Dec 1998 (issued 17.04.01).
80. [80] Grubisha, D.S., Lipert, R.J., Park, H.Y., Driskell, J., Porter, M.D., Femtomolar detection of prostate-specific antigen: an immunoassay based on surface-enhanced Raman scattering and immunogold labels. Anal. Chem. 75 (2003), 5936–5943, 10.1021/ac034356f.
81. [81] Ni, J., Lipert, R.J., Dawson, G.B., Porter, M.D., Immunoassay readout method using extrinsic Raman labels adsorbed on immunogokld collids. Anal. Chem. 71 (1999), 4903–4908, 10.1021/ac990616a.
82. [82] Han, X.X., Zhao, B., Ozaki, Y., Surface-enhanced Raman scattering for protein detection. Anal. Bioanal. Chem. 394 (2009), 1719–1727, 10.1007/s00216-009-2702-3.
83. [83] Jaworska, A., Jamieson, L.E., Malek, K., Campbell, C.J., Choo, J., Chlopicki, S., Baranska, M., SERS-based monitoring of the intracellular pH in endothelial cells: the influence of the extracellular environment and tumour necrosis factor-α. Analyst 140 (2015), 2321–2329, 10.1039/c4an01988a.
84. [84] Bishnoi, S.W., Rozell, C.J., Levin, C.S., Gheith, M.K., Johnson, B.R., Johnson, D.H., Halas, N.J., All-optical nanoscale pH meter. Nano Lett. 6 (2006), 1687–1692, 10.1021/nl060865w.
85. [85] Ochsenkuehn, M.A., Jess, P.R.T., Stoquert, H., Dholakia, K., Campbell, C.J., Nanoshells for surface-enhanced raman. ACS Nano 3 (2009), 3613–3621, 10.1021/nn900681c.
86. [86] Kneipp, J., Kneipp, H., Wittig, B., Kneipp, K., Following the dynamics of ph in endosomes of live cells with SERS nanosensors. J. Phys. Chem. C 114 (2010), 7421–7426, 10.1021/jp910034z.
87. [87] Kneipp, J., Kneipp, H., Wittig, B., Kneipp, K., One- and two-photon excited optical pH probing for cells using surface-enhanced Raman and hyper-Raman nanosensors. Nano Lett. 7 (2007), 2819–2823, 10.1021/nl071418z.
88. [88] Auchinvole, C.A.R., Richardson, P., McGuinnes, C., Mallikarjun, V., Donaldson, K., McNab, H., Campbell, C.J., Monitoring intracellular redox potential changes using SERS nanosensors. ACS Nano 6 (2012), 888–896, 10.1021/nn204397q.
89. [89] Jiang, J., Auchinvole, C., Fisher, K., Campbell, C.J., Quantitative measurement of redox potential in hypoxic cells using SERS nanosensors. Nanoscale 6 (2014), 12104–12110, 10.1039/c4nr01263a.
90. [90] Thomson, P.I.T., Camus, V.L., Hu, Y., Campbell, C.J., Series of quinone-containing nanosensors for biologically relevant redox potential determination by surface-enhanced Raman spectroscopy. Anal. Chem. 87 (2015), 4719–4725, 10.1021/ac504795s.
91. [91] Jamieson, L.E., Jaworska, A., Jiang, J., Baranska, M., Harrison, D.J., Campbell, C.J., Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors. Analyst 140 (2015), 2330–2335, 10.1039/c4an02365j.
92. [92] Folick, A., Min, W., Wang, M.C., Label-free imaging of lipid dynamics using coherent anti-stokes Raman scattering (CARS) and stimulated Raman scattering (SRS) microscopy. Curr. Opin. Genet. Dev. 21 (2011), 585–590, 10.1016/j.gde.2011.09.003.
93. [93] Pezacki, J.P., Blake, J.A., Danielson, D.C., Kennedy, D.C., Lyn, R.K., Singaravelu, R., Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy. Nat. Chem. Biol. 7 (2011), 137–145, 10.1038/nchembio.525.
94. [94] Freudiger, C.W., Min, W., Holtom, G.R., Xu, B., Dantus, M., Sunney Xie, X., Xie, X.S., Highly specific label-free molecular imaging with spectrally tailored excitation-stimulated Raman scattering (STE-SRS) microscopy. Nat. Photonics 5 (2011), 103–109, 10.1038/nphoton.2010.294.
95. [95] Hellerer, T., Axäng, C., Brackmann, C., Hillertz, P., Pilon, M., Enejder, A., Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-stokes Raman scattering (CARS) microscopy. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 14658–14663, 10.1073/pnas.0703594104.
96. [96] Kang, E., Wang, H., Kwon, I.K., Robinson, J., Park, K., Cheng, J., In Situ visualization of paclitaxel distribution and release by coherent anti-Stokes Raman scattering microscopy. Anal. Chem. 78 (2006), 8036–8043, 10.1021/ac061218s.
97. [97] Fu, D., Zhou, J., Zhu, W.S., Manley, P.W., Wang, Y.K., Hood, T., Wylie, A., Xie, X.S., Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering. Nat. Chem. 6 (2014), 614–622, 10.1038/nchem.1961.