The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells

Immunity

Volumn 46, Issue 6, 2017, Pages 983-991.e4

  Iwata, Shigeru ^a,e   Mikami, Yohei ^a   Sun, Hong Wei ^a   Brooks, Stephen R ^a   Jankovic, Dragana ^b   Hirahara, Kiyoshi ^c   Onodera, Atsushi ^c   Shih, Han Yu ^a   Kawabe, Takeshi ^b   Jiang, Kan ^a   Nakayama, Toshinori ^c,d   Sher, Alan ^b   O'Shea, John J ^a   Davis, Fred P ^a   Kanno, Yuka ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c CHIBA UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

ChIP seq; immunoregulation; interferon gamma; JAK STAT pathway; RNA seq; signal transducer and activator of transcription; STAT; T helper cells; T bet; transcription; type I interferons

Indexed keywords

GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 7; STAT1 PROTEIN; STAT2 PROTEIN; TRANSCRIPTION FACTOR T BET; TRANSCRIPTOME; INTERFERON; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ARTICLE; CD4+ T LYMPHOCYTE; GENOTYPE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TH1 CELL; VIRUS INFECTION; ANIMAL; AUTOCRINE EFFECT; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTIC CHORIOMENINGITIS; METABOLISM; MICROBIOLOGY; MOUSE; TOXOPLASMA; TOXOPLASMOSIS; VIROLOGY;

ANIMALS; AUTOCRINE COMMUNICATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; HUMANS; INTERFERON TYPE I; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; TH1 CELLS; TOXOPLASMA; TOXOPLASMOSIS; TRANSCRIPTOME;

EID: 85020642282     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.05.005     Document Type: Article

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