-
1
-
-
84940462680
-
Refining the treatment of NSCLC according to histological and molecular subtypes
-
Thomas A, Liu SV, Subramaniam DS, Giaccone G. Refining the treatment of NSCLC according to histological and molecular subtypes. Nat Rev Clin Oncol 2015; 12: 511-526.
-
(2015)
Nat Rev Clin Oncol
, vol.12
, pp. 511-526
-
-
Thomas, A.1
Liu, S.V.2
Subramaniam, D.S.3
Giaccone, G.4
-
3
-
-
79960085862
-
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling
-
Chmielecki J, Foo J, Oxnard GR, Hutchinson K, Ohashi K, Somwar R et al. Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. Sci Transl Med 2011; 3: 90ra59.
-
(2011)
Sci Transl Med
, vol.3
, pp. 90ra59
-
-
Chmielecki, J.1
Foo, J.2
Oxnard, G.R.3
Hutchinson, K.4
Ohashi, K.5
Somwar, R.6
-
4
-
-
84944463598
-
A decade of EGFR inhibition in EGFR-mutated non small cell lung cancer (NSCLC): Old successes and future perspectives
-
Russo A, Franchina T, Ricciardi GR, Picone A, Ferraro G, Zanghi M et al. A decade of EGFR inhibition in EGFR-mutated non small cell lung cancer (NSCLC): old successes and future perspectives. Oncotarget 2015; 6: 26814-26825.
-
(2015)
Oncotarget
, vol.6
, pp. 26814-26825
-
-
Russo, A.1
Franchina, T.2
Ricciardi, G.R.3
Picone, A.4
Ferraro, G.5
Zanghi, M.6
-
5
-
-
84883556206
-
Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non-small cell lung cancer: Focus on epidermal growth factor receptor mutation testing and mutation-positive patients
-
Roengvoraphoj M, Tsongalis GJ, Dragnev KH, Rigas JR. Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non-small cell lung cancer: focus on epidermal growth factor receptor mutation testing and mutation-positive patients. Cancer Treat Rev 2013; 39: 839-850.
-
(2013)
Cancer Treat Rev
, vol.39
, pp. 839-850
-
-
Roengvoraphoj, M.1
Tsongalis, G.J.2
Dragnev, K.H.3
Rigas, J.R.4
-
6
-
-
84940489292
-
Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer
-
Tan CS, Gilligan D, Pacey S. Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer. Lancet Oncol 2015; 16: e447-e459.
-
(2015)
Lancet Oncol
, vol.16
, pp. e447-e459
-
-
Tan, C.S.1
Gilligan, D.2
Pacey, S.3
-
7
-
-
84950341627
-
Targeted therapies for treatment of non-small cell lung cancer-recent advances and future perspectives
-
Minguet J, Smith KH, Bramlage P. Targeted therapies for treatment of non-small cell lung cancer-recent advances and future perspectives. Int J Cancer 2015; 138: 2549-2561.
-
(2015)
Int J Cancer
, vol.138
, pp. 2549-2561
-
-
Minguet, J.1
Smith, K.H.2
Bramlage, P.3
-
8
-
-
84960090500
-
New strategies in immunotherapy for non-small cell lung cancer
-
Carrizosa DR, Gold KA. New strategies in immunotherapy for non-small cell lung cancer. Transl Lung Cancer Res 2015; 4: 553-559.
-
(2015)
Transl Lung Cancer Res
, vol.4
, pp. 553-559
-
-
Carrizosa, D.R.1
Gold, K.A.2
-
9
-
-
84941800472
-
Adaptive immune resistance: How cancer protects from immune attack
-
Ribas A. Adaptive immune resistance: how cancer protects from immune attack. Cancer Discov 2015; 5: 915-919.
-
(2015)
Cancer Discov
, vol.5
, pp. 915-919
-
-
Ribas, A.1
-
10
-
-
33748987908
-
Cancer despite immunosurveillance: Immunoselection and immunosubversion
-
Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol 2006; 6: 715-727.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 715-727
-
-
Zitvogel, L.1
Tesniere, A.2
Kroemer, G.3
-
11
-
-
33244463813
-
Complex networks orchestrate epithelial-mesenchymal transitions
-
Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006; 7: 131-142.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 131-142
-
-
Thiery, J.P.1
Sleeman, J.P.2
-
12
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-1428.
-
(2009)
J Clin Invest
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
13
-
-
0034798707
-
Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition
-
Savagner P. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays 2001; 23: 912-923.
-
(2001)
Bioessays
, vol.23
, pp. 912-923
-
-
Savagner, P.1
-
14
-
-
44449144396
-
Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
-
Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008; 14: 818-829.
-
(2008)
Dev Cell
, vol.14
, pp. 818-829
-
-
Yang, J.1
Weinberg, R.A.2
-
15
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-890.
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
Nieto, M.A.4
-
16
-
-
77951058591
-
Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells
-
Reiman JM, Knutson KL, Radisky DC. Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells. Cancer Res 2010; 70: 3005-3008.
-
(2010)
Cancer Res
, vol.70
, pp. 3005-3008
-
-
Reiman, J.M.1
Knutson, K.L.2
Radisky, D.C.3
-
17
-
-
84876954094
-
Epithelial-tomesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis
-
Akalay I, Janji B, Hasmim M, Noman MZ, Andre F, De Cremoux P et al. Epithelial-tomesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis. Cancer Res 2013; 73: 2418-2427.
-
(2013)
Cancer Res
, vol.73
, pp. 2418-2427
-
-
Akalay, I.1
Janji, B.2
Hasmim, M.3
Noman, M.Z.4
Andre, F.5
De Cremoux, P.6
-
18
-
-
84900021817
-
WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition
-
Hamilton DH, Huang B, Fernando RI, Tsang KY, Palena C. WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition. Cancer Res 2014; 74: 2510-2519.
-
(2014)
Cancer Res
, vol.74
, pp. 2510-2519
-
-
Hamilton, D.H.1
Huang, B.2
Fernando, R.I.3
Tsang, K.Y.4
Palena, C.5
-
19
-
-
84897532715
-
Tumor plasticity interferes with anti-tumor immunity
-
Chouaib S, Janji B, Tittarelli A, Eggermont A, Thiery JP. Tumor plasticity interferes with anti-tumor immunity. Crit Rev Immunol 2014; 34: 91-102.
-
(2014)
Crit Rev Immunol
, vol.34
, pp. 91-102
-
-
Chouaib, S.1
Janji, B.2
Tittarelli, A.3
Eggermont, A.4
Thiery, J.P.5
-
20
-
-
84904741452
-
EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition
-
Claperon A, Mergey M, Nguyen Ho-Bouldoires TH, Vignjevic D, Wendum D, Chretien Y et al. EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition. J Hepatol 2014; 61: 325-332.
-
(2014)
J Hepatol
, vol.61
, pp. 325-332
-
-
Claperon, A.1
Mergey, M.2
Nguyen Ho-Bouldoires, T.H.3
Vignjevic, D.4
Wendum, D.5
Chretien, Y.6
-
21
-
-
84921592131
-
Epidermal growth factor signaling in transformed cells
-
Lindsey S, Langhans SA. Epidermal growth factor signaling in transformed cells. Int Rev Cell Mol Biol 2015; 314: 1-41.
-
(2015)
Int Rev Cell Mol Biol
, vol.314
, pp. 1-41
-
-
Lindsey, S.1
Langhans, S.A.2
-
22
-
-
35148832569
-
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
-
Lo HW, Hsu SC, Xia W, Cao X, Shih JY, Wei Y et al. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res 2007; 67: 9066-9076.
-
(2007)
Cancer Res
, vol.67
, pp. 9066-9076
-
-
Lo, H.W.1
Hsu, S.C.2
Xia, W.3
Cao, X.4
Shih, J.Y.5
Wei, Y.6
-
23
-
-
27144477683
-
Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition
-
Thomson S, Buck E, Petti F, Griffin G, Brown E, Ramnarine N et al. Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res 2005; 65: 9455-9462.
-
(2005)
Cancer Res
, vol.65
, pp. 9455-9462
-
-
Thomson, S.1
Buck, E.2
Petti, F.3
Griffin, G.4
Brown, E.5
Ramnarine, N.6
-
24
-
-
31544452076
-
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
-
Witta SE, Gemmill RM, Hirsch FR, Coldren CD, Hedman K, Ravdel L et al. Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res 2006; 66: 944-950.
-
(2006)
Cancer Res
, vol.66
, pp. 944-950
-
-
Witta, S.E.1
Gemmill, R.M.2
Hirsch, F.R.3
Coldren, C.D.4
Hedman, K.5
Ravdel, L.6
-
25
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, Fidias P et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011; 3: 75ra26.
-
(2011)
Sci Transl Med
, vol.3
, pp. 75ra26
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
Digumarthy, S.4
Turke, A.B.5
Fidias, P.6
-
26
-
-
84871998076
-
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance
-
Byers LA, Diao L, Wang J, Saintigny P, Girard L, Peyton M et al. An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res 2013; 19: 279-290.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 279-290
-
-
Byers, L.A.1
Diao, L.2
Wang, J.3
Saintigny, P.4
Girard, L.5
Peyton, M.6
-
27
-
-
85040539674
-
IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib
-
Fernando RI, Hamilton DH, Dominguez C, David JM, McCampbell KK, Palena C. IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib. Oncotarget 2016; 7: 42031-42044.
-
(2016)
Oncotarget
, vol.7
, pp. 42031-42044
-
-
Fernando, R.I.1
Hamilton, D.H.2
Dominguez, C.3
David, J.M.4
McCampbell, K.K.5
Palena, C.6
-
28
-
-
84880890008
-
EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction
-
Akalay I, Janji B, Hasmim M, Noman MZ, Thiery JP, Mami-Chouaib F et al. EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction. Autophagy 2013; 9: 1104-1106.
-
(2013)
Autophagy
, vol.9
, pp. 1104-1106
-
-
Akalay, I.1
Janji, B.2
Hasmim, M.3
Noman, M.Z.4
Thiery, J.P.5
Mami-Chouaib, F.6
-
29
-
-
84896702989
-
EGFR-mediated tumor immunoescape: The imbalance between phosphorylated STAT1 and phosphorylated STAT3
-
Concha-Benavente F, Srivastava RM, Ferrone S, Ferris RL. EGFR-mediated tumor immunoescape: The imbalance between phosphorylated STAT1 and phosphorylated STAT3. Oncoimmunology 2013; 2: e27215.
-
(2013)
Oncoimmunology
, vol.2
, pp. e27215
-
-
Concha-Benavente, F.1
Srivastava, R.M.2
Ferrone, S.3
Ferris, R.L.4
-
30
-
-
84886944522
-
EGFR inhibitors, MHC expression and immune responses: Can EGFR inhibitors be used as immune response modifiers
-
Pollack BP. EGFR inhibitors, MHC expression and immune responses: can EGFR inhibitors be used as immune response modifiers Oncoimmunology 2012; 1: 71-74.
-
(2012)
Oncoimmunology
, vol.1
, pp. 71-74
-
-
Pollack, B.P.1
-
31
-
-
84929645752
-
EMT, CTCs and CSCs in tumor relapse and drug-resistance
-
Mitra A, Mishra L, Li S. EMT, CTCs and CSCs in tumor relapse and drug-resistance. Oncotarget 2015; 6: 10697-10711.
-
(2015)
Oncotarget
, vol.6
, pp. 10697-10711
-
-
Mitra, A.1
Mishra, L.2
Li, S.3
-
32
-
-
84960358236
-
Therapies targeting cancer stem cells: Current trends and future challenges
-
Dragu DL, Necula LG, Bleotu C, Diaconu CC, Chivu-Economescu M. Therapies targeting cancer stem cells: Current trends and future challenges. World J Stem Cells 2015; 7: 1185-1201.
-
(2015)
World J Stem Cells
, vol.7
, pp. 1185-1201
-
-
Dragu, D.L.1
Necula, L.G.2
Bleotu, C.3
Diaconu, C.C.4
Chivu-Economescu, M.5
-
33
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-715.
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.J.3
Eaton, E.N.4
Ayyanan, A.5
Zhou, A.Y.6
-
34
-
-
84907494586
-
EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling
-
Arasada RR, Amann JM, Rahman MA, Huppert SS, Carbone DP. EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling. Cancer Res 2014; 74: 5572-5584.
-
(2014)
Cancer Res
, vol.74
, pp. 5572-5584
-
-
Arasada, R.R.1
Amann, J.M.2
Rahman, M.A.3
Huppert, S.S.4
Carbone, D.P.5
-
35
-
-
0042197268
-
Are p27 and p21 cytoplasmic oncoproteins
-
Blagosklonny MV. Are p27 and p21 cytoplasmic oncoproteins Cell Cycle 2002; 1: 391-393.
-
(2002)
Cell Cycle
, vol.1
, pp. 391-393
-
-
Blagosklonny, M.V.1
-
36
-
-
18544367664
-
Paradoxical expression of cell cycle inhibitor p27 in endometrioid adenocarcinoma of the uterine corpus-correlation with proliferation and clinicopathological parameters
-
Watanabe J, Sato H, Kanai T, Kamata Y, Jobo T, Hata H et al. Paradoxical expression of cell cycle inhibitor p27 in endometrioid adenocarcinoma of the uterine corpus-correlation with proliferation and clinicopathological parameters. Br J Cancer 2002; 87: 81-85.
-
(2002)
Br J Cancer
, vol.87
, pp. 81-85
-
-
Watanabe, J.1
Sato, H.2
Kanai, T.3
Kamata, Y.4
Jobo, T.5
Hata, H.6
-
37
-
-
70349859809
-
Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells
-
Kurrey NK, Jalgaonkar SP, Joglekar AV, Ghanate AD, Chaskar PD, Doiphode RY et al. Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells 2009; 27: 2059-2068.
-
(2009)
Stem Cells
, vol.27
, pp. 2059-2068
-
-
Kurrey, N.K.1
Jalgaonkar, S.P.2
Joglekar, A.V.3
Ghanate, A.D.4
Chaskar, P.D.5
Doiphode, R.Y.6
-
38
-
-
84863707423
-
Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment
-
Palena C, Hamilton DH, Fernando RI. Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment. Future Oncol 2012; 8: 713-722.
-
(2012)
Future Oncol
, vol.8
, pp. 713-722
-
-
Palena, C.1
Hamilton, D.H.2
Fernando, R.I.3
-
39
-
-
84929591022
-
IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer
-
Liu YN, Chang TH, Tsai MF, Wu SG, Tsai TH, Chen HY et al. IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer. Oncotarget 2015; 6: 10415-10431.
-
(2015)
Oncotarget
, vol.6
, pp. 10415-10431
-
-
Liu, Y.N.1
Chang, T.H.2
Tsai, M.F.3
Wu, S.G.4
Tsai, T.H.5
Chen, H.Y.6
-
40
-
-
79955607323
-
EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells
-
Kim H, Kim SH, Kim MJ, Kim SJ, Park SJ, Chung JS et al. EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells. J Immunother 2011; 34: 372-381.
-
(2011)
J Immunother
, vol.34
, pp. 372-381
-
-
Kim, H.1
Kim, S.H.2
Kim, M.J.3
Kim, S.J.4
Park, S.J.5
Chung, J.S.6
-
41
-
-
80054722876
-
EGFR inhibitors sensitize non-small cell lung cancer cells to TRAIL-induced apoptosis
-
Xu F, Tian Y, Huang Y, Zhang LL, Guo ZZ, Huang JJ et al. EGFR inhibitors sensitize non-small cell lung cancer cells to TRAIL-induced apoptosis. Chin J Cancer 2011; 30: 701-711.
-
(2011)
Chin J Cancer
, vol.30
, pp. 701-711
-
-
Xu, F.1
Tian, Y.2
Huang, Y.3
Zhang, L.L.4
Guo, Z.Z.5
Huang, J.J.6
-
42
-
-
0035826778
-
Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
-
Zhang D, Beresford PJ, Greenberg AH, Lieberman J. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci U S A 2001; 98: 5746-5751.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 5746-5751
-
-
Zhang, D.1
Beresford, P.J.2
Greenberg, A.H.3
Lieberman, J.4
-
43
-
-
84911486852
-
Pharmacotherapy targeting the EGFR oncogene in NSCLC
-
Landi L, Cappuzzo F. Pharmacotherapy targeting the EGFR oncogene in NSCLC. Expert Opin Pharmacother 2014; 15: 2293-2305.
-
(2014)
Expert Opin Pharmacother
, vol.15
, pp. 2293-2305
-
-
Landi, L.1
Cappuzzo, F.2
-
44
-
-
84929248179
-
EGFR-TKI resistance in NSCLC patients: Mechanisms and strategies
-
Lin Y, Wang X, Jin H. EGFR-TKI resistance in NSCLC patients: mechanisms and strategies. Am J Cancer Res 2014; 4: 411-435.
-
(2014)
Am J Cancer Res
, vol.4
, pp. 411-435
-
-
Lin, Y.1
Wang, X.2
Jin, H.3
-
45
-
-
84943758352
-
EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition
-
Sato F, Kubota Y, Natsuizaka M, Maehara O, Hatanaka Y, Marukawa K et al. EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition. Cancer Biol Ther 2015; 16: 933-940.
-
(2015)
Cancer Biol Ther
, vol.16
, pp. 933-940
-
-
Sato, F.1
Kubota, Y.2
Natsuizaka, M.3
Maehara, O.4
Hatanaka, Y.5
Marukawa, K.6
-
46
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 2015; 373: 1627-1639.
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
Spigel, D.R.4
Steins, M.5
Ready, N.E.6
-
47
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 2015; 372: 2018-2028.
-
(2015)
N Engl J Med
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
Leighl, N.4
Balmanoukian, A.S.5
Eder, J.P.6
-
48
-
-
84860188105
-
Therapeutic cancer vaccines: Current status and moving forward
-
Schlom J. Therapeutic cancer vaccines: current status and moving forward. J Natl Cancer Inst 2012; 104: 599-613.
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 599-613
-
-
Schlom, J.1
-
49
-
-
34247887629
-
The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy
-
Palena C, Polev DE, Tsang KY, Fernando RI, Litzinger M, Krukovskaya LL et al. The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy. Clin Cancer Res 2007; 13: 2471-2478.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2471-2478
-
-
Palena, C.1
Polev, D.E.2
Tsang, K.Y.3
Fernando, R.I.4
Litzinger, M.5
Krukovskaya, L.L.6
-
50
-
-
84886745437
-
Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine
-
Hamilton DH, Litzinger MT, Jales A, Huang B, Fernando RI, Hodge JW et al. Immunological targeting of tumor cells undergoing an epithelial-mesenchymal transition via a recombinant brachyury-yeast vaccine. Oncotarget 2013; 4: 1777-1790.
-
(2013)
Oncotarget
, vol.4
, pp. 1777-1790
-
-
Hamilton, D.H.1
Litzinger, M.T.2
Jales, A.3
Huang, B.4
Fernando, R.I.5
Hodge, J.W.6
-
51
-
-
76649138588
-
The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells
-
Fernando RI, Litzinger M, Trono P, Hamilton DH, Schlom J, Palena C. The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells. J Clin Invest. 2010; 120: 533-544.
-
(2010)
J Clin Invest
, vol.120
, pp. 533-544
-
-
Fernando, R.I.1
Litzinger, M.2
Trono, P.3
Hamilton, D.H.4
Schlom, J.5
Palena, C.6
-
52
-
-
84863955851
-
Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: An opportunity for novel interventions against lung cancer
-
Roselli M, Fernando RI, Guadagni F, Spila A, Alessandroni J, Palmirotta R et al. Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer. Clin Cancer Res 2012; 18: 3868-3879.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 3868-3879
-
-
Roselli, M.1
Fernando, R.I.2
Guadagni, F.3
Spila, A.4
Alessandroni, J.5
Palmirotta, R.6
-
53
-
-
84892818249
-
Expression of brachyury gene is a significant prognostic factor for primary lung carcinoma
-
Haro A, Yano T, Kohno M, Yoshida T, Koga T, Okamoto T et al. Expression of brachyury gene is a significant prognostic factor for primary lung carcinoma. Ann Surg Oncol 2013; 20: S509-S516.
-
(2013)
Ann Surg Oncol
, vol.20
, pp. S509-S516
-
-
Haro, A.1
Yano, T.2
Kohno, M.3
Yoshida, T.4
Koga, T.5
Okamoto, T.6
-
54
-
-
84905171394
-
Overexpression of the EMT driver brachyury in breast carcinomas: Association with poor prognosis
-
Palena C, Roselli M, Litzinger MT, Ferroni P, Costarelli L, Spila A et al. Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis. J Natl Cancer Inst 2014; 106: dju054.
-
(2014)
J Natl Cancer Inst
, vol.106
, pp. dju054
-
-
Palena, C.1
Roselli, M.2
Litzinger, M.T.3
Ferroni, P.4
Costarelli, L.5
Spila, A.6
-
55
-
-
79953690193
-
Brachyury expression predicts poor prognosis at early stages of colorectal cancer
-
Kilic N, Feldhaus S, Kilic E, Tennstedt P, Wicklein D, Wasielewski R et al. Brachyury expression predicts poor prognosis at early stages of colorectal cancer. Eur J Cancer 2011; 47: 1080-1085.
-
(2011)
Eur J Cancer
, vol.47
, pp. 1080-1085
-
-
Kilic, N.1
Feldhaus, S.2
Kilic, E.3
Tennstedt, P.4
Wicklein, D.5
Wasielewski, R.6
-
56
-
-
84945561165
-
Phase i trial of a yeast-based therapeutic cancer vaccine (GI-6301) targeting the transcription factor brachyury
-
Heery CR, Singh BH, Rauckhorst M, Marte JL, Donahue RN, Grenga I et al. Phase I trial of a yeast-based therapeutic cancer vaccine (GI-6301) targeting the transcription factor brachyury. Cancer Immunol Res 2015; 3: 1248-1256.
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 1248-1256
-
-
Heery, C.R.1
Singh, B.H.2
Rauckhorst, M.3
Marte, J.L.4
Donahue, R.N.5
Grenga, I.6
-
57
-
-
85020867508
-
-
http://www.clinicaltrials.gov/. Safety and Tolerability of a Modified Vaccinia Ankara (MVA)-Based Vaccine Modified to Express Brachyury and T-cell Costimulatory Molecules (MVA-Brachyury-TRICOM)
-
http://www.clinicaltrials.gov/. Safety and Tolerability of a Modified Vaccinia Ankara (MVA)-Based Vaccine Modified to Express Brachyury and T-cell Costimulatory Molecules (MVA-Brachyury-TRICOM) 2014. Available from: http://www.clinicaltrials.gov/ct2/show/ NCT02179515.
-
(2014)
-
-
-
58
-
-
77957787538
-
Therapeutic cancer vaccines in prostate cancer: The paradox of improved survival without changes in time to progression
-
Madan RA, Gulley JL, Fojo T, Dahut WL. Therapeutic cancer vaccines in prostate cancer: the paradox of improved survival without changes in time to progression. Oncologist 2010; 15: 969-975.
-
(2010)
Oncologist
, vol.15
, pp. 969-975
-
-
Madan, R.A.1
Gulley, J.L.2
Fojo, T.3
Dahut, W.L.4
-
59
-
-
84916220460
-
Identification and characterization of a cytotoxic T-lymphocyte agonist epitope of brachyury, a transcription factor involved in epithelial to mesenchymal transition and metastasis
-
Tucker JA, Jochems C, Boyerinas B, Fallon J, Greiner JW, Palena C et al. Identification and characterization of a cytotoxic T-lymphocyte agonist epitope of brachyury, a transcription factor involved in epithelial to mesenchymal transition and metastasis. Cancer Immunol Immunother 2014; 63: 1307-1317.
-
(2014)
Cancer Immunol Immunother
, vol.63
, pp. 1307-1317
-
-
Tucker, J.A.1
Jochems, C.2
Boyerinas, B.3
Fallon, J.4
Greiner, J.W.5
Palena, C.6
-
60
-
-
84894457863
-
Identification and characterization of agonist epitopes of the MUC1-C oncoprotein
-
Jochems C, Tucker JA, Vergati M, Boyerinas B, Gulley JL, Schlom J et al. Identification and characterization of agonist epitopes of the MUC1-C oncoprotein. Cancer Immunol Immunother 2014; 63: 161-174.
-
(2014)
Cancer Immunol Immunother
, vol.63
, pp. 161-174
-
-
Jochems, C.1
Tucker, J.A.2
Vergati, M.3
Boyerinas, B.4
Gulley, J.L.5
Schlom, J.6
-
61
-
-
84924955938
-
Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody
-
Hamilton DH, Fernando RI, Schlom J, Palena C. Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody. Oncotarget 2015; 6: 4853-4862.
-
(2015)
Oncotarget
, vol.6
, pp. 4853-4862
-
-
Hamilton, D.H.1
Fernando, R.I.2
Schlom, J.3
Palena, C.4
-
62
-
-
33744814638
-
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors
-
Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev 2006; 20: 1496-1510.
-
(2006)
Genes Dev
, vol.20
, pp. 1496-1510
-
-
Politi, K.1
Zakowski, M.F.2
Fan, P.D.3
Schonfeld, E.A.4
Pao, W.5
Varmus, H.E.6
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