Absorption, Distribution and Excretion of Four Forms of Titanium Dioxide Pigment in the Rat

Journal of Food Science

Volumn 82, Issue 8, 2017, Pages 1985-1993

  Farrell, Thomas P ^a   Magnuson, Berna ^b  

^a Colorcon Inc ^*  (United States)

^b Health Science Consultants Inc   (Canada)

Author keywords

absorption; food safety; particle size distribution; trace metals

Indexed keywords

FOOD DYE; TITANIUM; TITANIUM DIOXIDE;

ANIMAL; BIOAVAILABILITY; CHEMISTRY; FEMALE; KIDNEY; LIVER; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; RAT; SPRAGUE DAWLEY RAT; URINE;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; FEMALE; FOOD COLORING AGENTS; KIDNEY; LIVER; MALE; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; TITANIUM;

EID: 85020540393     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/1750-3841.13791     Document Type: Article

References (21)

1. Braun JH. 1997. Titanium dioxide – A Review. J. Coat. Technol. 69:59–72.
2. CDC. 2012. Method number DLS 3016.9, blood metals panel 2 (BMP 2) ICP-DRC-MS (https://www.cdc.gov/nchs/data/nhanes/nhanes_11_12/pbcd_g_met_blood-metals.pdf). Accessed March 24, 2017.
3. EFSA. 2004. Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food on a request from the commission related to the safety in use of rutile titanium dioxide as an alternative to the presently permitted anatase form (Question No. EFSA-Q-2004-103; adopted on 7 december 2004). The EFSA Journal 163:1–12.
4. EFSA. 2009. The potential risks arising from nanoscience and nanotechnologies on food and feed safety - scientific opinion of the scientific committee on the potential risks arising from nanoscience and nanotechnologies on food and feed safety (Question No EFSA-Q-2007-124a; adopted on 10 February 2009). The EFSA Journal 958:1–39.
5. EFSA. 2016. EFSA ANS panel (EFSA Panel on Food Additives and Nutrient Sources added to food), 2016. Scientific opinion on the Re-evaluation of titanium dioxide (E 171) as a food additive. EFSA Journal 14(9):4545, 83 pp.
6. Geraets L, Oomen AG, Krystek P, Jacobsen NR, Wallin H, Laurentie M, Verharen HW, Brandon EF, de Jong WH. 2014. Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Particle and Fibre Toxicology 3:11–30.
7. Guo Z, Martucci NJ, Moreno-Olivas F, Takob E, Mahler GJ. 2017. Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine. NanoImpact 5:70-82.
8. Heringa MB, Geraets L, van Eijkeren JCH, Vandebriel RJ, de Jong WH, Oomen AG. 2016. Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations. Nanotoxicology 10(10):1515–1525.
9. Hong J, Zhang Y. 2016. Murine liver damage caused by exposure to Nano-Titanium dioxide. Nanotechnology 27(11):14 pp. Published online (http://iopscience.iop.org/article/10.1088/0957-4484/27/11/112001/meta;jsessionid=1DF88AE2B82D0B5ACA5EEAD35AA4ACAD.c2.iopscience.cld.iop.org). Accessed March 24, 2017.
10. Hong F, Yu X, Wu N, Zhang Y. 2017. Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles. Tox. Res. 6:115–133.
11. Jani PU, McCarthy DE, Florence, AT. 1994. Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration. International Journal of Pharmaceutics 105:157–168.
12. JECFA (1970) Toxicological evaluation of some food colors, emulsifiers, stabilizers, anti-caking agents and certain other substances. FAO Nutr. Mtgs. Rept. Ser. No. 46A; WHO Food Add 70:36.
13. Jones K, Morton J, Smith I, Jurkschat K, Harding A, Evans G. 2015. Human in vivo and in vitro studies on gastrointestinal absorption of titanium dioxide nanoparticles. Tox. Letters 233:95–101.
14. OECD Guideline for the Testing of Chemical. OECD 417 Toxicokinetics.
15. MacNicoll A, Kelly M, Aksoy H, Kramer E, Bouwmeester H, Chaudhry Q. 2015. A study of the uptake and biodistribution of nano-titanium dioxide using in vitro and in vivo models of oral intake. J Nanopart Res 17:66 https://doi.org/10.1007/s11051-015-2862-3.
16. Peters RJB, van Bemmel G, Herrera-Rivera Z, Helsper HPFG, Marvin HJP, Weigel S, Tromp PC, Oomen AG, Rietveld AG, Bouwmeester H. 2014. Characterization of titanium dioxide nanoparticles in food products: analytical methods to define nanoparticles. J. Agric. Food Chem. 62(27):6285–6293.
17. Theissman R, Kluwig M, Koch T. 2014. A reproducible Number-Based sizing method for pigment-grade titanium dioxide. Beilstein J. Nanotechnol 5:1815–1822.
18. Warheit DB, Donner EM. 2015. Risk assessment strategies for nanoscale and fine-sized titanium dioxide particles: recognizing hazard and exposure issues. Food Chem Toxicol 85:138–47.
19. Weir A, Westerhoff P, Fabricius L, Hristovski K, von Goetz N, 2012. Titanium dioxide nanoparticles in food and personal care products. Environ. Sci. Tech. 46:2242–2250.
20. US FDA/Center for Drug Evaluation and Research Office of Pharmaceutical Quality. Inactive Ingredient Database.(http://www.accessdata.fda.gov/scripts/cder/iig/index.Cfm). Accessed Oct 5, 2016.
21. Yang Y, Doudrick K, Bi X, Hristovski K, Herckes, WP, Kaegi R. 2014. Characterization of food-grade titanium dioxide: The presence of nanosized particles. Environ. Sci. Tech. 48:6391–6400.