Sitagliptin ameliorates oxidative stress in experimental diabetic nephropathy by diminishing the miR-200a/Keap-1/Nrf2 antioxidant pathway

Diabetes, Metabolic Syndrome and Obesity

Volumn 10, Issue , 2017, Pages 207-222

  Civantos, Esther ^a,b   Bosch, Enrique ^a   Ramirez, Elisa ^a   Zhenyukh, Olha ^a   Egido, Jesús ^a,b   Lorenzo, Oscar ^a,b   Mas, Sebastián ^a,b  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Diabetes; GK rats; Keap 1; miRNAs; Nrf2; Sitagliptin

Indexed keywords

GLUTATHIONE PEROXIDASE 3; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MICRORNA; MICRORNA 200A; MICRORNA 21; PEROXIREDOXIN 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); SITAGLIPTIN; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOINFORMATICS; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; EXPERIMENTAL DIABETIC NEPHROPATHY; GEL ELECTROPHORESIS; GOTO KAKIZAKI RAT; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY INTERSTITIUM; KIDNEY TUBULE CELL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEINURIA; PROTEOMICS; QUANTITATIVE ANALYSIS; RAT; RENAL PROTECTION; TRANSCRIPTOMICS; TREATMENT DURATION; WESTERN BLOTTING;

EID: 85020529382     PISSN: None     EISSN: 11787007     Source Type: Journal    
DOI: 10.2147/DMSO.S132537     Document Type: Article

References (43)

1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047–1053.
2. Subbarayan S, Kipnes M. Sitagliptin: a review. Expert Opin Pharmacother. 2011;12(10):1613–1622.
3. Ruggenenti P, Cravedi P, Remuzzi G. The RAAS in the pathogenesis and treatment of diabetic nephropathy. Nat Rev Nephrol. 2010;6(6): 319–330.
4. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813–820.
5. Sharma K. Mitochondrial hormesis and diabetic complications. Diabetes. 2015;64(3):663–672.
6. Liu W, Du Y, Liu J, et al. Effects of atrazine on the oxidative damage of kidney in Wister rats. Int J Clin Exp Med. 2014;7(10):3235–3243.
7. Pergola PE, Raskin P, Toto RD, et al; BEAM Study Investigators. Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med. 2011;365(4):327–336.
8. de Zeeuw D, Akizawa T, Audhya P, et al; BEACON Trial Investigators. Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease. N Engl J Med. 2013;369(26):2492–2503.
9. Eligar VS, Bain SC. A review of sitagliptin with special emphasis on its use in moderate to severe renal impairment. Drug Des Devel Ther. 2013;7:893–903.
10. Muskiet MH, Smits MM, Morsink LM, Diamant M. The gut-renal axis: do incretin-based agents confer renoprotection in diabetes? Nat Rev Nephrol. 2014;10(2):88–103.
11. Bergenstal RM, Wysham C, Macconell L, et al; DURATION-2 Study Group. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet. 2010;376(9739):431–439.
12. Mega C, de Lemos ET, Vala H, et al. Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat). Exp Diabetes Res. 2011;2011:162092.
13. Goto Y, Kakizaki M, Masaki N. Production of spontaneous diabetic rats by repetition of selective breeding. Tohoku J Exp Med. 1976;119(1):85–90.
14. Kelleni MT, Amin EF, Abdelrahman AM. Effect of metformin and sitagliptin on doxorubicin-induced cardiotoxicity in rats: impact of oxidative stress, inflammation, and apoptosis. J Toxicol. 2015;2015:424813.
15. Cook HC. A histochemical characterization of malignant tumour mucins as a possible aid in the identification of metastatic deposits. Med Lab Technol. 1973;30(3):217–224.
16. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254.
17. Duran MC, Mas S, Martin-Ventura JL, et al. Proteomic analysis of human vessels: application to atherosclerotic plaques. Proteomics. 2003;3(6):973–978.
18. Martinez-Pinna R, Ramos-Mozo P, Madrigal-Matute J, et al. Identification of peroxiredoxin-1 as a novel biomarker of abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 2011;31(4):935–943.
19. Pérez V, Navarro-Muñoz M, Mas S, et al. Proteomic approach to the study of statin pleiotropy in kidney transplant patients. Pharmacology. 2011;87(3–4):161–168.
20. Rodriguez-Porcel M, Gheysens O, Paulmurugan R, et al. Antioxidants improve early survival of cardiomyoblasts after transplantation to the myocardium. Mol Imaging Biol. 2010;12(3):325–334.
21. Chua S, Sheu JJ, Chen YL, et al. Sitagliptin therapy enhances the number of circulating angiogenic cells and angiogenesis-evaluations in vitro and in the rat critical limb ischemia model. Cytotherapy. 2013;15(9):1148–1163.
22. Srinivasan K, Ramarao P. Animal models in type 2 diabetes research: an overview. Indian J Med Res. 2007;125(3):451–472.
23. Zhang Z, Peng H, Chen J, et al. MicroRNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice. FEBS Lett. 2009;583(12):2009–2014.
24. Mori H, Okada Y, Arao T, Tanaka Y. Sitagliptin improves albuminuria in patients with type 2 diabetes mellitus. J Diabetes Investig. 2014;5(3):313–319.
25. Hsu YC, Lei CC, Ho C, Shih YH, Lin CL. Potential biomarkers associated with diabetic glomerulopathy through proteomics. Ren Fail. 2015;37(8):1308–1315.
26. Liu X, Yang G, Fan Q, Wang L. Proteomic profile in glomeruli of type-2 diabetic KKAy mice using 2-dimensional differential gel electrophoresis. Med Sci Monit. 2014;20:2705–2713.
27. Barati MT, Merchant ML, Kain AB, Jevans AW, McLeish KR, Klein JB. Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice. Am J Physiol Renal Physiol. 2007;293(4):F1157–F1165.
28. Fiorentino L, Cavalera M, Mavilio M, et al. Regulation of TIMP3 in diabetic nephropathy: a role for microRNAs. Acta Diabetol. 2013;50(6):965–969.
29. Zhong X, Chung AC, Chen HY, et al. miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes. Diabetologia. 2013;56(3):663–674.
30. Dey N, Das F, Mariappan MM, et al. MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes. J Biol Chem. 2011;286(29):25586–25603.
31. Wang J, Gao Y, Ma M, et al. Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic nephropathy mice. Cell Biochem Biophys. 2013;67(2):537–546.
32. Lin Q, Gao Z, Alarcon RM, Ye J, Yun Z. A role of miR-27 in the regulation of adipogenesis. FEBS J. 2009;276(8):2348–2358.
33. Zhou R, Li X, Hu G, Gong AY, Drescher KM, Chen XM. miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene. PLoS One. 2012;7(1):e30772.
34. Wang B, Koh P, Winbanks C, et al. miR-200a prevents renal fibrogenesis through repression of TGF-β2 expression. Diabetes. 2011;60(1):280–287.
35. Xiong M, Jiang L, Zhou Y, et al. The miR-200 family regulates TGF-β1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression. Am J Physiol Renal Physiol. 2012;302(3):F369–F379.
36. Wei J, Zhang Y, Luo Y, et al. Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgfβ1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice. Free Radic Biol Med. 2014;67:91–102.
37. Wu H, Zhou S, Kong L, et al. Metallothionein deletion exacerbates intermittent hypoxia-induced renal injury in mice. Toxicol Lett. 2015;232(2):340–348.
38. Yang X, Wang D, Ma Y, et al. Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells. Toxicol Appl Pharmacol. 2015;289(2):231–239.
39. Liu L, Liu J, Tian XY, et al. Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress. Antioxid Redox Signal. 2014;21(11):1571–1581.
40. Patel V, Joharapurkar A, Dhanesha N, et al. Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice. Pharmacol Rep. 2013;65(4):927–936.
41. Pujadas G, De Nigris V, Prattichizzo F, La Sala L, Testa R, Ceriello A. The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin functions as antioxidant on human endothelial cells exposed to chronic hyperglycemia and metabolic high-glucose memory. Endocrine. Epub 2016 Aug 16.
42. Femia AP, Raimondi L, Maglieri G, Lodovici M, Mannucci E, Caderni G. Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats. Int J Cancer. 2013;133(10): 2498–2503.
43. Franceschini A, Szklarczyk D, Frankild S, et al. STRING v9.1: proteinprotein interaction networks, with increased coverage and integration. Nucleic Acids Res. 2013;41:D808–815.