Sitagliptin therapy enhances the number of circulating angiogenic cells and angiogenesis-evaluations in vitro and in the rat critical limb ischemia model

Cytotherapy

Volumn 15, Issue 9, 2013, Pages 1148-1163

  Chua, Sarah ^a   Sheu, Jiunn Jye ^a   Chen, Yung Lung ^a   Chang, Li Teh ^c   Sun, Cheuk Kwan ^b   Leu, Steve ^a   Sung, Hsin Ching ^d   Tsai, Tzu Hsien ^a   Chung, Sheng Ying ^a   Yeh, Kuo Ho ^a   Cho, Chung Lung ^e   Kao, Ying Hsien ^b   Yip, Hon Kan ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b I SHOU UNIVERSITY   (Taiwan)

^c MEIHO UNIVERSITY   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

^e NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; Endothelial progenitor cells; Laser Doppler blood flow; Sitagliptin

Indexed keywords

ATAXIN 1; BIOLOGICAL MARKER; CD31 ANTIGEN; CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; SITAGLIPTIN; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1ALPHA; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; CELL COUNT; CONTROLLED STUDY; CRITICAL LIMB ISCHEMIA; CULTURE MEDIUM; DRUG EFFECT; ENDOTHELIAL PROGENITOR CELL; FEMORAL ARTERY; FLOW CYTOMETRY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LASER DOPPLER FLOWMETRY; LIMB BLOOD FLOW; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TISSUE CULTURE; WESTERN BLOTTING;

RATTUS;

ANGIOGENESIS; ENDOTHELIAL PROGENITOR CELLS; LASER DOPPLER BLOOD FLOW; SITAGLIPTIN;

ADIPOSE TISSUE; ANIMALS; ARTERIES; BIOLOGICAL MARKERS; CELL MOVEMENT; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HINDLIMB; ISCHEMIA; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; PYRAZINES; RATS; RATS, INBRED F344; REGIONAL BLOOD FLOW; STEM CELLS; TRIAZOLES;

EID: 84881116229     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2013.05.005     Document Type: Article

References (32)

1. Hristov M., Heussen N., Schober A., Weber C. Intracoronary infusion of autologous bone marrow cells and left ventricular function after acute myocardial infarction: a meta-analysis. JCell Mol Med 2006, 10:727-733.
2. Yip H.K., Chang L.T., Sun C.K., Sheu J.J., Chiang C.H., Youssef A.A., et al. Autologous transplantation of bone marrow-derived endothelial progenitor cells attenuates monocrotaline-induced pulmonary arterial hypertension in rats. Crit Care Med 2008, 36:873-880.
3. Yip H.K., Chang L.T., Wu C.J., Sheu J.J., Youssef A.A., Pei S.N., et al. Autologous bone marrow-derived mononuclear cell therapy prevents the damage of viable myocardium and improves rat heart function following acute anterior myocardial infarction. Circ J 2008, 72:1336-1345.
4. Turan R.G., Bozdag T.I., Turan C.H., Ortak J., Akin I., Kische S., et al. Enhanced mobilisation of the bone marrow derived circulating progenitor cells by intracoronary freshly isolated bone marrow cells transplantation in patients with acute myocardial infarction. J Cell Mol Med 2012, 16:852-864.
5. Dai W., Hale S.L., Martin B.J., Kuang J.Q., Dow J.S., Wold L.E., et al. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation 2005, 112:214-223.
6. Tse H.F., Kwong Y.L., Chan J.K., Lo G., Ho C.L., Lau C.P. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 2003, 361:47-49.
7. Leu S., Sun C.K., Sheu J.J., Chang L.T., Yuen C.M., Yen C.H., et al. Autologous bone marrow cell implantation attenuates left ventricular remodeling and improves heart function in porcine myocardial infarction: an echocardiographic, six-month angiographic, and molecular-cellular study. Int J Cardiol 2011, 150:156-168.
8. Yeh K.H., Sheu J.J., Lin Y.C., Sun C.K., Chang L.T., Kao Y.H., et al. Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats. Crit Care Med 2012, 40:169-177.
9. Shantsila E., Watson T., Lip G.Y. Endothelial progenitor cells in cardiovascular disorders. JAm Coll Cardiol 2007, 49:741-752.
10. Hill J.M., Zalos G., Halcox J.P., Schenke W.H., Waclawiw M.A., Quyyumi A.A., et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. NEngl J Med 2003, 348:593-600.
11. Yip H.K., Chang L.T., Chang W.N., Lu C.H., Liou C.W., Lan M.Y., et al. Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke. Stroke 2008, 39:69-74.
12. Valgimigli M., Rigolin G.M., Fucili A., Porta M.D., Soukhomovskaia O., Malagutti P., et al. CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. Circulation 2004, 110:1209-1212.
13. Yip H.K., Tsai T.H., Lin H.S., Chen S.F., Sun C.K., Leu S., et al. Effect of erythropoietin on level of circulating endothelial progenitor cells and outcome in patients after acute ischemic stroke. Crit Care 2011, 15:R40.
14. Herrera C., Morimoto C., Blanco J., Mallol J., Arenzana F., Lluis C., et al. Comodulation of CXCR4 and CD26 in human lymphocytes. JBiol Chem 2001, 276:19532-19539.
15. De Falco E., Porcelli D., Torella A.R., Straino S., Iachininoto M.G., Orlandi A., et al. SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood 2004, 104:3472-3482.
16. Zheng H., Fu G., Dai T., Huang H. Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha/CXCR4 via PI3K/Akt/eNOS signal transduction pathway. JCardiovasc Pharmacol 2007, 50:274-280.
17. Yin Y., Zhao X., Fang Y., Yu S., Zhao J., Song M., et al. SDF-1alpha involved in mobilization and recruitment of endothelial progenitor cells after arterial injury in mice. Cardiovasc Pathol 2010, 19:218-227.
18. Wang C.H., Verma S., Hsieh I.C., Chen Y.J., Kuo L.T., Yang N.I., et al. Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system. JMol Cell Cardiol 2006, 41:34-43.
19. Moore M.A., Hattori K., Heissig B., Shieh J.H., Dias S., Crystal R.G., et al. Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF, and angiopoietin-1. Ann N Y Acad Sci 2001, 938:36-45.
20. Imanishi T., Tsujioka H., Akasaka T. Endothelial progenitor cells dysfunction and senescence: contribution to oxidative stress. Curr Cardiol Rev 2008, 4:275-286.
21. Scheen A.J. Dipeptidylpeptidase-4 inhibitors (gliptins): focus ondrug-drug interactions. Clin Pharmacokinet 2010, 49:573-588.
22. Fadini G.P., Boscaro E., Albiero M., Menegazzo L., Frison V., de Kreutzenberg S., et al. The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha. Diabetes Care 2010, 33:1607-1609.
23. Huang C.Y., Shih C.M., Tsao N.W., Lin Y.W., Huang P.H., Wu S.C., et al. Dipeptidyl peptidase-4 inhibitor improves neovascularization by increasing circulating endothelial progenitor cells. Br J Pharmacol 2012, 167:1506-1519.
24. Leu S., Lin Y.C., Yuen C.M., Yen C.H., Kao Y.H., Sun C.K., et al. Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. JTransl Med 2010, 8:63.
25. Beconi M.G., Reed J.R., Teffera Y., Xia Y.Q., Kochansky C.J., Liu D.Q., et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptinin rats and dogs. Drug Metab Dispos 2007, 35:525-532.
26. Horwitz E.M., Le Blanc K., Dominici M., Mueller I., Slaper-Cortenbach I., Marini F.C., et al. Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement. Cytotherapy 2005, 7:393-395.
27. Christopherson K.W., Hangoc G., Mantel C.R., Broxmeyer H.E. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004, 305:1000-1003.
28. Mu J., Woods J., Zhou Y.P., Roy R.S., Li Z., Zycband E., et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in arodent model of type 2 diabetes. Diabetes 2006, 55:1695-1704.
29. Iwasaki H., Kawamoto A., Tjwa M., Horii M., Hayashi S., Oyamada A., et al. PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors. PLoS One 2011, 6:e24872.
30. Cianfarani F., Zambruno G., Brogelli L., Sera F., Lacal P.M., Pesce M., et al. Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am J Pathol 2006, 169:1167-1182.
31. Ceradini D.J., Kulkarni A.R., Callaghan M.J., Tepper O.M., Bastidas N., Kleinman M.E., et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 2004, 10:858-864.
32. Van de Velde S., Hogan M.F., Montminy M. mTOR links incretin signaling to HIF induction in pancreatic beta cells. Proc Natl Acad Sci U S A 2011, 108:16876-16882.