The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis

Critical Care Medicine

Volumn 43, Issue 9, 2015, Pages 1907-1915

  Sterling, Sarah A ^a   Miller, W Ryan ^a   Pryor, Jason ^a   Puskarich, Michael A ^a   Jones, Alan E ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Antibacterial agents; antibiotics; septic shock; severe sepsis; shock recognition; timing of antibiotics

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ANTIBIOTIC THERAPY; ARTICLE; EARLY DIAGNOSIS; EARLY INTERVENTION; EMERGENCY HEALTH SERVICE; EMERGENCY WARD; HUMAN; INFORMATION RETRIEVAL; META ANALYSIS; MORTALITY; PRIORITY JOURNAL; PUBLICATION; SEPSIS; SEPTIC SHOCK; SYSTEMATIC REVIEW; TREATMENT OUTCOME; LENGTH OF STAY; SHOCK, SEPTIC;

ANTI-BACTERIAL AGENTS; EMERGENCY SERVICE, HOSPITAL; HOSPITAL MORTALITY; HUMANS; LENGTH OF STAY; SEPSIS; SHOCK, SEPTIC; TRIAGE;

EID: 84947039569     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001142     Document Type: Article

References (39)

1. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the Unit States: Analysis of incidence, outcome, and associat costs of care. Crit Care M 2001; 29:1303-1310
2. Wang HE, Shapiro NI, Angus DC, et al: National estimates of severe sepsis in Unit States emergency departments. Crit Care M 2007; 35:1928-1936
3. Rivers E, Nguyen B, Havstad S, et al; Early Goal-Direct Therapy Collaborative Group: Early goal-direct therapy in the treatment of severe sepsis and septic shock. N Engl J M 2001; 345:1368-1377
4. Jones AE, Focht A, Horton JM, et al: Prospective external validation of the clinical effectiveness of an emergency department-bas early goal-direct therapy protocol for severe sepsis and septic shock. Chest 2007; 132:425-432
5. Jones AE, Brown MD, Trzeciak S, et al; Emergency Micine Shock Research Network Investigators: The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: A meta-analysis. Crit Care M 2008; 36:2734-2739
6. Nguyen HB, Corbett SW, Steele R, et al: Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associat with decreas mortality. Crit Care M 2007; 35:1105-1112
7. Puskarich MA, Marchick MR, Kline JA, et al: One year mortality of patients treat with an emergency department bas early goal direct therapy protocol for severe sepsis and septic shock: A before and after study. Crit Care 2009; 13:R167
8. Ferrer R, Martin-Loeches I, Phillips G, et al: Empiric antibiotic treatment ruces mortality in severe sepsis and septic shock from the first hour: Results from a guideline-bas performance improvement program. Crit Care M 2014; 42:1749-1755
9. Gaieski DF, Mikkelsen ME, Band RA, et al: Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-direct therapy was initiat in the emergency department. Crit Care M 2010; 38:1045-1053
10. Kumar A, Roberts D, Wood KE, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care M 2006; 34:1589-1596
11. Puskarich MA, Trzeciak S, Shapiro NI, et al; Emergency Micine Shock Research Network (EMSHOCKNET): Association between timing of antibiotic administration and mortality from septic shock in patients treat with a quantitative resuscitation protocol. Crit Care M 2011; 39:2066-2071
12. Venkatesh AK, Avula U, Bartimus H, et al: Time to antibiotics for septic shock: Evaluating a propos performance measure. Am J Emerg M 2013; 31:680-683
13. Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including the Piatric Subgroup: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care M 2013; 41:580-637
14. Vilella AL, Seifert CF: Timing and appropriateness of initial antibiotic therapy in newly presenting septic patients. Am J Emerg M 2014; 32:7-13
15. Institute for Healthcare Improvement: Sepsis resuscitation bundle: Timing of antibiotics. May 13, 2013. Available at: http://www.ihi. org/resources/Pages/Measures/TimingofAntibiotics.aspx. Access June 5, 2015
16. Moher D, Liberati A, Tetzlaff J, et al; PRISMA Group: Preferr reporting items for systematic reviews and meta-analyses: The PRISMA statement. J Clin Epidemiol 2009; 62:1006-1012
17. Reeves BC, Deeks JJ, Higgins JPT, et al: Chapter 13: Including nonrandomiz studies. In: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Higgins JPT, Green S (s). The Cochrane Collaboration, 2011. Available at: http://www.cochranehandbook. org. Access June 5, 2015
18. Borenstein M, Hges LV, Higgines JPT, et al: Fix-Effect Versus Random-Effects Models. Introduction to Meta-Analysis. John Wiley & Sons, 2009
19. Hutchison RW, Govathoti DA, Fehlis K, et al: Improving severe sepsis outcomes: Cost and time to first antibiotic dose. Dimens Crit Care Nurs 2011; 30:277-282
20. Siddiqui S, Razzak J: Early versus late pre-intensive care unit admission broad spectrum antibiotics for severe sepsis in adults. Cochrane Database Syst Rev 2010; 10:CD007081
21. Yealy DM, Kellum JA, Huang DT, et al: A randomiz trial of protocol-bas care for early septic shock. N Engl J M 2014; 370:1683-1693
22. Shenep JL, Mogan KA: Kinetics of endotoxin release during antibiotic therapy for experimental gram-negative bacterial sepsis. J Infect Dis 1984; 150:380-388
23. Peng ZY, Wang HZ, Srisawat N, et al: Bactericidal antibiotics temporarily increase inflammation and worsen acute kidney injury in experimental sepsis. Crit Care M 2012; 40:538-543
24. Lepper PM, Held TK, Schneider EM, et al: Clinical implications of antibiotic-induc endotoxin release in septic shock. Intensive Care M 2002; 28:824-833
25. Mignon F, Piagnerelli M, Van Nuffelen M, et al: Effect of empiric antibiotic treatment on plasma endotoxin activity in septic patients. Infection 2014; 42:521-528
26. Villar J, Clement JP, Stotts J, et al: Many emergency department patients with severe sepsis and septic shock do not meet diagnostic criteria within 3 hours of arrival. Ann Emerg M 2014; 64:48-54
27. Kirn TJ, Weinstein MP: Update on blood cultures: How to obtain, process, report, and interpret. Clin Microbiol Infect 2013; 19:513-520
28. Kerremans JJ, Verboom P, Stijnen T, et al: Rapid identification and antimicrobial susceptibility testing ruce antibiotic use and accelerate pathogen-direct antibiotic use. J Antimicrob Chemother 2008; 61:428-435
29. Bloos F, Thomas-Ruddel D, Ruddel H, et al: Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: A prospective observational multi-center study. Crit Care 2014; 18:R42
30. Bruce HR, Maiden J, Fullo PF, et al: Impact of nurse-initiat sepsis protocol on compliance with sepsis bundles, time to initial antibiotic administration, and in-hospital mortality. J Emerg Nurs 2015; 41:130-137
31. Cullen M, Fogg T, Delaney A: Timing of appropriate antibiotics in patients with septic shock: A retrospective cohort study. Emerg M Australas 2013; 25:308-315
32. Gurnani PK, Patel GP, Crank CW, et al: Impact of the implementation of a sepsis protocol for the management of fluid-refractory septic shock: A single-center, before-and-after study. Clin Ther 2010; 32:1285-1293
33. Hitti EA, Lewin JJ III, Lopez J, et al: Improving door-to-antibiotic time in severely septic emergency department patients. J Emerg M 2012; 42:462-469
34. Ferrer R, Artigas A, Suarez D, et al: Effectiveness of treatments for severe sepsis: A prospective, multicenter, observational study. Am J Respir Crit Care M 2009; 180:861-866
35. Joo Y, Chae M, Hwang S, et al: Impact of timely antibioitc administration on outcomes in patients with severe sepsis and septic shock in the emergency department. Clin Exp Emerg M 2014; 1:35-40
36. Mok K, Christian MD, Nelson S, et al: Time to administration of antibiotics among inpatients with severe sepsis or septic shock. Can J Hosp Pharm 2014; 67:213-219
37. Ryoo S, Kim W, Sohn C, et al: Prognostic value of timing of antibiotic administration in patients with septic shock treat with early quantitative resuscitation in emergency department patients. Am J M Sci 2015; 349:328-333
38. Tipler PS, Pamplin J, Mysliwiec V, et al: Use of a protocoliz approach to the management of sepsis can improve time to first dose of antibiotics. J Crit Care 2013; 28:148-151
39. Yokota PK, Marra AR, Martino MD, et al: Impact of appropriate antimicrobial therapy for patients with severe sepsis and septic shock-A quality improvement study. PLoS One 2014; 9:e104475