The timing of early antibiotics and hospital mortality in sepsis: Playing devil’s advocate

American Journal of Respiratory and Critical Care Medicine

Volumn 196, Issue 7, 2017, Pages 934-935

  Chertoff, Jason ^a   Ataya, Ali ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ANTIBIOTIC THERAPY; EMERGENCY CARE; HOSPITAL MORTALITY; HUMAN; LETTER; PRIORITY JOURNAL; SEPSIS; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANTI-BACTERIAL AGENTS; HOSPITAL MORTALITY; HUMANS; SEPSIS;

EID: 85027684363     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201703-0657LE     Document Type: Letter

References (7)

1. Liu VX, Fielding-Singh V, Greene JD, Baker JM, Iwashyna TJ, Bhattacharya J, Escobar GJ. The timing of early antibiotics and hospital mortality in sepsis. Am J Respir Crit Care Med [online ahead of print] 27 Mar 2017; DOI: 10.1164/rccm.201609-1848OC. Published in final form as Am J Respir Crit Care Med 2017;196: 856–863 (this issue).
2. Gaieski DF, Mikkelsen ME, Band RA, Pines JM, Massone R, Furia FF, Shofer FS, Goyal M. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010;38:1045–1053.
3. Puskarich MA, Trzeciak S, Shapiro NI, Arnold RC, Horton JM, Studnek JR, Kline JA, Jones AE; Emergency Medicine Shock Research Network (EMSHOCKNET). Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med 2011;39: 2066–2071.
4. Sterling SA, Miller WR, Pryor J, Puskarich MA, Jones AE. The impact of timing of antibiotics on outcomes in severe sepsis and septic shock: a systematic review and meta-analysis. Crit Care Med 2015;43: 1907–1915.
5. Wisdom A, Eaton V, Gordon D, Daniel S, Woodman R, Phillips C. INITIAT-E.D.: impact of timing of initiation of antibiotic therapy on mortality of patients presenting to an emergency department with sepsis. Emerg Med Australas 2015;27:196–201.
6. van Zanten AR. The golden hour of antibiotic administration in severe sepsis: avoid a false start striving for gold. Crit Care Med 2014;42: 1931–1932.
7. Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf 2014;5:229–241.