Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

European Cells and Materials

Volumn 33, Issue , 2017, Pages 279-293

  Xiao, L ^a   Ding, M ^a,b   Fernandez, A ^a   Zhao, P ^b   Jin, L ^a   Li, Xudong ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Curcumin; Disc herniation; Neuroinflammation; Neuropathic pain; Nociceptive; Oxidative stress; Radiculopathy; Toxicity

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CATALASE; CURCUMIN; CYCLOOXYGENASE 2; HEME OXYGENASE; INTERLEUKIN 6; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SUBSTANCE P; TUMOR NECROSIS FACTOR; NEUROPEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL CULTURE; CELL REGENERATION; CONTROLLED STUDY; EXPLANT; FEMALE; HYPERALGESIA; IN VITRO STUDY; IN VIVO STUDY; LUMBAR DISK HERNIA; LUMBAR RADICULOPATHY; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NERVOUS SYSTEM INFLAMMATION; NOCICEPTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RADICULOPATHY; SPINAL GANGLION; VON FREY TEST; ANIMAL; BAGG ALBINO MOUSE; CELL PROTECTION; COMPLICATION; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; INFLAMMATION; INTERVERTEBRAL DISK HERNIA; LUMBAR VERTEBRA; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; STAINING;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CURCUMIN; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GANGLIA, SPINAL; HYPERALGESIA; INFLAMMATION; INTERVERTEBRAL DISC DISPLACEMENT; LUMBAR VERTEBRAE; MALE; MICE, INBRED BALB C; NEURONS; NEUROPEPTIDES; NOCICEPTION; OXIDATIVE STRESS; RADICULOPATHY; REACTIVE OXYGEN SPECIES; STAINING AND LABELING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85020383456     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v033a21     Document Type: Article

References (56)

1. Andersson GBJ (1999) Epidemiological features of chronic low-back pain. Lancet 354: 581-585.
2. Arulselvan P, Fard MT, Tan WS, Gothai S, Fakurazi S, Norhaizan ME, Kumar SS (2016) Role of antioxidants and natural products in inflammation. Oxid Med Cell Longev 2016: 5276130.
3. Belavý DL, Albracht K, Bruggemann G-P, Vergroesen P-PA, van Dieën JH (2016) Can exercise positively influence the intervertebral disc?. Sports Med 46: 473-485.
4. Bhatia A, Flamer D, Shah P, Cohen SP (2016) Transforaminal epidural steroid injections for treating lumbosacral radicular pain from herniated intervertebral discs: a systematic review and meta-analysis. Anesth Analg 122: 857-870.
5. Biddie SC, Conway-Campbell BL, Lightman SL (2012) Dynamic regulation of glucocorticoid signalling in health and disease. Rheumatology (Oxford) 51: 403-412.
6. Bonin RP, Bories C, De Koninck Y (2014) A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments. Mol Pain 10: 26.
7. Brenna JT, Akomo P, Bahwere P, Berkley JA, Calder PC, Jones KD, Liu L, Manary M, Trehan I, Briend A (2015) Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF). BMC Med 13: 117.
8. Cao H, Zheng J-w, Li J-j, Meng B, Li J, Ge R-s (2014) Effects of curcumin on pain threshold and on the expression of nuclear factor κ B and CX3C receptor 1 after sciatic nerve chronic constrictive injury in rats. Chin J Integr Med 20: 850-856.
9. Chainani-Wu N (2003) Safety and anti-inflammatory activity of curcumin: a component of tumeric (curcuma longa). J Altern Complement Med 9: 161-168.
10. Feldmann M, Maini RN (2003) TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med 9: 1245-1250.
11. Frearson J, Wyatt P (2010) Drug discovery in academia-the third way?. Expert Opin Drug Discov 5: 909-919.
12. Gruber HE, Ingram J, Jr ENH (2002) An improved staining method for intervertebral disc tissue. Biotech Histochem 77: 81-83.
13. Guterl CC, See EY, Blanquer SBG, Pandit A, Ferguson SJ, Benneker LM, Grijpma DW, Sakai D, Eglin D, Alini M, Iatridis JC, Grad S (2013) Challenges and strategies in the repair of ruptured annulus fibrosus. Eur Cells Mater 25: 1-21.
14. Hoy D, March L, Brooks P, Blyth F, Woolf A, Bain C, Williams G, Smith E, Vos T, Barendregt J, Murray C, Burstein R, Buchbinder R (2014) The global burden of low back pain: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis 6: 968-974.
15. Isyar M, Bilir B, Yilmaz I, Cakmak S, Sirin DY, Guzelant AY, Mahirogullari M (2015) Are biological agents toxic to human chondrocytes and osteocytes?. J Orthop Surg Res 10: 118.
16. Jeon Y, Kim C-E, Jung D, Kwak K, Park S, Lim D, Kim S, Baek W (2013) Curcumin could prevent the development of chronic neuropathic pain in rats with peripheral nerve injury. Curr Ther Res Clin Exp 74: 1-4.
17. Jin L, Feng G, Reames DL, Shimer AL, Shen FH, Li X (2013) The effects of simulated microgravity on intervertebral disc degeneration. Spine J 13: 235-242.
18. Jo YY, Lee JY, Park C-K (2016) Resolvin E1 inhibits substance P-induced potentiation of TRPV1 in primary sensory neurons. Mediators Inflamm 2016: 5259321.
19. Joshi RP, Negi G, Kumar A, Pawar YB, Munjal B, Bansal AK, Sharma SS (2013) SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for neuroprotection. Nanomedicine: 9: 776-785.
20. JS J (2009) Anti-inflammatory properties of curcumin, a major constituent of curcuma longa: a review of preclinical and clinical research. Altern Med Rev 14: 141-153.
21. Kepler CK, Ponnappan RK, Tannoury CA, Risbud MV, Anderson DG (2013) The molecular basis of intervertebral disc degeneration. Spine J 13: 318-330.
22. Khatri DK, Juvekar AR (2016) Neuroprotective effect of curcumin as evinced by abrogation of rotenone-induced motor deficits, oxidative and mitochondrial dysfunctions in mouse model of Parkinson’s disease. Pharmacol Biochem Behav 150-151: 39-47.
23. Klawitter M, Quero L, Klasen J, Gloess AN, Klopprogge B, Hausmann O, Boos N, Wuertz K (2012) Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity. J Inflamm (London) 9: 29-29.
24. Krock E, Rosenzweig DH, Chabot-Doré A-J, Jarzem P, Weber MH, Ouellet JA, Stone LS, Haglund L (2014) Painful, degenerating intervertebral discs up-regulate neurite sprouting and CGRP through nociceptive factors. J Cell Mol Med 18: 1213-1225.
25. Krock E, Currie JB, Weber MH, Quellet JA, Stone LS, Rosenzweig DH, Haglund L (2016) Nerve growth factor is regulated by toll-like receptor 2 in human intervertebral disc. J Biol. Chem 291: 3541-3551.
26. Kübra Elçioğlu H, Kabasakal L, Tufan F, Elçioğlu ÖH, Solakoglu S, Kotil T, Karan MA (2015) Effects of systemic thalidomide and intracerebroventricular etanercept and infliximab administration in a streptozotocin induced dementia model in rats. Acta Histochem 117: 176-181.
27. Kunnumakkara AB, Anand P, Aggarwal BB (2008) Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269: 199-225.
28. La Binch A, Cole AA, Breakwell LM, Michael ALR, Chiverton N, Cross AK, Le Maitre CL (2014) Expression and regulation of neurotrophic and angiogenic factorsduring human intervertebral disc degeneration. Arthritis Res Ther 16: 416.
29. Leung L, Cahill CM (2010) TNF-α and neuropathic pain – a review. J Neuroinflammation 7: 27-27.
30. Liu Q, Jin L, Mahon BH, Chordia MD, Shen FH, Li X (2013) A novel treatment of neuroinflammation against low back pain by soluble fullerol nanoparticles. Spine (Phila Pa 1976) 38: 1443-1451.
31. Lories RJ, de Vlam K (2014) Tumour necrosis factor inhibitors in the treatment of psoriatic arthritis: a view on effectiveness, clinical practice and toxicity. Expert Opin Biol Ther 14: 1825-1836.
32. Ma T GC, Zhao X, Wu T, Sun SX, Jin QH (2015) The effect of curcumin on NF-κB expression in rat with lumbar intervertebral disc degeneration. Eur Rev Med Pharmacol Sci 19: 1305-1314.
33. Malin SA, Davis BM, Molliver DC (2007) Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticity. Nat Protoc 2: 152-160.
34. Margină D, Ilie M, Grădinaru D, Androutsopoulos VP, Kouretas D, Tsatsakis AM (2015) Natural products – friends or foes?. Toxicol Lett 236: 154-167.
35. Martinov T, Mack M, Sykes A, Chatterjea D (2013) Measuring changes in tactile sensitivity in the hind paw of mice using an electronic von Frey apparatus. J Vis Exp 82: e51212.
36. Mattei RA, Dalmarco EM, Fröde TS (2015) Etanercept administration prevents the inflammatory response induced by carrageenan in the murine air pouch model. Naunyn Schmiedebergs Arch Pharmacol 388: 1247-1257.
37. McDermott AM, Toelle TR, Rowbotham DJ, Schaefer CP, Dukes EM (2006) The burden of neuropathic pain: results from a cross-sectional survey. Eur J Pain 10: 127-127.
38. Meng B, Shen L-l, Shi X-t, Gong Y-s, Fan X-f, Li J, Cao H (2015) Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain. Neurosci Lett 605: 59-64.
39. Noorafshan A, Omidi A, Karbalay-Doust S (2011a) Curcumin protects the dorsal root ganglion and sciatic nerve after crush in rat. Pathol Res Pract 207: 577-582.
40. Noorafshan A, Omidi A, Karbalay-Doust S, Aliabadi E, Dehghani F (2011b) Effects of curcumin on the dorsal root ganglion structure and functional recovery after sciatic nerve crush in rat. Micron 42: 449-455.
41. Park C-K, Lü N, Xu Z-Z, Liu T, Serhan CN, Ji R-R (2011) Resolving TRPV1 and TNF-α mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. The J Neurosci 31: 15072-15085.
42. Pathak S, Regmi S, Gupta B, Poudel BK, Pham TT, Kim J-R, Park P-H, Yong CS, Kim JO, Bae YK, Kim SK, Jeong J-H (2016) Hybrid congregation of islet single cells and curcumin-loaded polymeric microspheres as an interventional strategy to overcome apoptosis associated with pancreatic islets transplantation. ACS Appl Mater Interfaces 8: 25702-25713.
43. Purmessur D, Freemont AJ, Hoyland JA (2008) Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc. Arthritis Res Ther 10: R99.
44. Rahimifard M, Maqbool F, MoeiniNodeh S, Niaz K, Abdollahi M, Braidy N, Nabavi SM, Nabavi SF (2017) Targeting the TLR4 signaling pathway by polyphenols: a novel therapeutic strategy for neuroinflammation. Ageing Res Rev. 36:11-19.
45. Ramsden CE, Faurot KR, Zamora D, Palsson OS, MacIntosh BA, Gaylord S, Taha AY, Rapoport SI, Hibbeln JR, Davis JM, Mann JD (2015) Targeted alterations in dietary n-3 and n-6 fatty acids improve life functioning and reduce psychological distress among chronic headache patients: secondary analysis of a randomized trial. Pain 156: 587-596.
46. Richardson SM, Doyle P, Minogue BM, Gnanalingham K, Hoyland JA (2009) Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis Res Ther 11: R126.
47. Ringer C, Tune S, Bertoune MA, Schwarzbach H, Tsujikawa K, Weihe E, Schütz B (2016) Disruption of calcitonin gene-related peptide signaling accelerates muscle denervation and dampens cytotoxic neuroinflammation in SOD1 mutant mice. Cell Mol Life Scie 74: 339-358.
48. Rohanizadeh R, Deng Y, Verron E (2016) Therapeutic actions of curcumin in bone disorders. Bonekey Rep 5: 793.
49. Sainoh T, Orita S, Miyagi M, Sakuma Y, Yamauchi K, Suzuki M, Kubota G, Oikawa Y, Inage K, Sato J, Fujimoto K, Shiga Y, Inoue G, Aoki Y, Takahashi K, Ohtori S (2015) Interleukin-6 and interleukin-6 receptor expression, localization, and involvement in pain-sensing neuron activation in a mouse intervertebral disc injury model. J Orthop Res 33: 1508-1514.
50. Shehzad A, Ha T, Subhan F, Lee YS (2011) New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr 50: 151-161.
51. Sinclair SM, Bhattacharyya J, McDaniel JR, Gooden DM, Gopalaswamy R, Chilkoti A, Setton LA (2013) A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation. J Control Release 171: 38-47.
52. Walter BA, Torre OM, Laudier D, Naidich TP, Hecht AC, Iatridis JC (2015) Form and function of the intervertebral disc in health and disease: a morphological and stain comparison study. J Anat 227: 707-716.
53. Xiao L, Ding M, Saadoon O, Vess E, Fernandez A, Zhao P, Jin L, Li X (2016) A novel culture platform for fast proliferation of human annulus fibrosus cells. Cell Tissue Res 367: 1-12.
54. Zammataro M, Sortino MA, Parenti C, Gereau RW, Chiechio S (2014) HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors. Mol Pain 10: 68.
55. Zhao J, Luo D, Liang Z, Lao L, Rong J (2016) Plant Natural Product Puerarin Ameliorates depressive behaviors and chronic pain in mice with spared nerve injury (SNI). Mol Neurobiol 54:2801-2812
56. Zhou H, Beevers CS, Huang S (2011) Targets of curcumin. Current Drug Targets 12: 332-347.