Nerve growth factor is regulated by toll-like receptor 2 in human intervertebral discs

Journal of Biological Chemistry

Volumn 291, Issue 7, 2016, Pages 3541-3551

  Krock, Emerson ^a,b,c   Currie, J Brooke ^a   Weber, Michael H ^c   Ouellet, Jean A ^b,c   Stone, Laura S ^b,c,d,e,f   Rosenzweig, Derek H ^a,c   Haglund, Lisbet ^a,c,g  

^a Faculty of Medicine   (India)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d Integrated Program in Neuroscience   (Canada)

^e Departments of Anesthesiology   (Canada)

^f Department of Psychiatry at UBC   (Canada)

^g RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; COLLAGEN; GENE EXPRESSION; HEALTH; MUSCULOSKELETAL SYSTEM; PATTERN RECOGNITION; TISSUE;

BRAIN-DERIVED NEUROTROPHIC FACTORS; EXTRACELLULAR MATRIX PROTEIN; INTER-VERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISCS; PATTERN RECOGNITION RECEPTORS; SIGNALING MECHANISMS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS;

IMPLANTS (SURGICAL);

ALARMIN; BRAIN DERIVED NEUROTROPHIC FACTOR; COLLAGEN TYPE 1; COLLAGEN TYPE 2; CYTOKINE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NERVE GROWTH FACTOR; PROTEINASE; SCLEROPROTEIN; SYNAPTOTAGMIN I; THROMBOSPONDIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; IL1B PROTEIN, HUMAN; LIGAND; NERVE PROTEIN; NEUTRALIZING ANTIBODY; NGF PROTEIN, HUMAN; NONSTEROID ANTIINFLAMMATORY AGENT; PRO-NERVE GROWTH FACTOR, HUMAN; PROTEIN KINASE INHIBITOR; PROTEIN PRECURSOR; RECOMBINANT PROTEIN; RELA PROTEIN, HUMAN; TLR2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELA;

ADOLESCENT; ADULT; ARTICLE; CELL NUCLEUS; CHRONIC PAIN; CLINICAL ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; INTERVERTEBRAL DISK; LOW BACK PAIN; MALE; ORGAN DONOR; OSTEOARTHRITIS; PATTERN RECOGNITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; ACTIVE TRANSPORT; AGONISTS; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DONOR; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LUMBAR VERTEBRA; METABOLISM; MIDDLE AGED; SECRETION (PROCESS); SIGNAL TRANSDUCTION; YOUNG ADULT;

ACTIVE TRANSPORT, CELL NUCLEUS; ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, NEUTRALIZING; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1BETA; INTERVERTEBRAL DISC; LIGANDS; LUMBAR VERTEBRAE; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; PROTEIN KINASE INHIBITORS; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; TISSUE DONORS; TOLL-LIKE RECEPTOR 2; TRANSCRIPTION FACTOR RELA; YOUNG ADULT;

EID: 84964477852     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.675900     Document Type: Article

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