-
1
-
-
51649127013
-
Multiple system atrophy
-
18617848
-
Bhidayasiri R, Ling H. Multiple system atrophy. Neurologist. 2008;14:224-37.
-
(2008)
Neurologist
, vol.14
, pp. 224-237
-
-
Bhidayasiri, R.1
Ling, H.2
-
2
-
-
84940062763
-
Expanding the spectrum of neuronal pathology in multiple system atrophy
-
25981961 4840945
-
Cykowski MD, Coon EA, Powell SZ, Jenkins SM, Benarroch EE, Low PA, et al. Expanding the spectrum of neuronal pathology in multiple system atrophy. Brain. 2015;138:2293-309.
-
(2015)
Brain
, vol.138
, pp. 2293-2309
-
-
Cykowski, M.D.1
Coon, E.A.2
Powell, S.Z.3
Jenkins, S.M.4
Benarroch, E.E.5
Low, P.A.6
-
4
-
-
84913529632
-
Changes in total cell numbers of the basal ganglia in patients with multiple system atrophy- A stereological study
-
25449905
-
Salvesen L, Ullerup BH, Sunay FB, Brudek T, Lokkegaard A, Agander TK, et al. Changes in total cell numbers of the basal ganglia in patients with multiple system atrophy- A stereological study. Neurobiol Dis. 2015;74:104-13.
-
(2015)
Neurobiol Dis
, vol.74
, pp. 104-113
-
-
Salvesen, L.1
Ullerup, B.H.2
Sunay, F.B.3
Brudek, T.4
Lokkegaard, A.5
Agander, T.K.6
-
5
-
-
84970991878
-
Neocortical Neuronal Loss in Patients with Multiple System Atrophy: A Stereological Study
-
L. Salvesen, K. Winge, T. Brudek, T.K. Agander, A. Lokkegaard, B. Pakkenberg. Neocortical Neuronal Loss in Patients with Multiple System Atrophy: A Stereological Study. Cereb Cortex. 2015.
-
(2015)
Cereb Cortex
-
-
Salvesen, L.1
Winge, K.2
Brudek, T.3
Agander, T.K.4
Lokkegaard, A.5
Pakkenberg, B.6
-
6
-
-
33750440495
-
Hippocampal neuron and glial cell numbers in Parkinson’s disease--a stereological study
-
1:STN:280:DC%2BD28rotFGisw%3D%3D 16941622
-
Joelving FC, Billeskov R, Christensen JR, West M, Pakkenberg B. Hippocampal neuron and glial cell numbers in Parkinson’s disease--a stereological study. Hippocampus. 2006;16:826-33.
-
(2006)
Hippocampus
, vol.16
, pp. 826-833
-
-
Joelving, F.C.1
Billeskov, R.2
Christensen, J.R.3
West, M.4
Pakkenberg, B.5
-
7
-
-
84872729641
-
Parkinson Disease and Parkinsonism: Neuropathology
-
Dickson DW, Parkinson Disease and Parkinsonism: Neuropathology. Cold Spring Harb Perspect Med. 2012;2.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Dickson, D.W.1
-
8
-
-
84930541886
-
Natural history of multiple system atrophy in the USA: a prospective cohort study
-
26025783 4472464
-
Low PA, Reich SG, Jankovic J, Shults CW, Stern MB, Novak P, et al. Natural history of multiple system atrophy in the USA: a prospective cohort study. Lancet Neurol. 2015;14:710-9.
-
(2015)
Lancet Neurol
, vol.14
, pp. 710-719
-
-
Low, P.A.1
Reich, S.G.2
Jankovic, J.3
Shults, C.W.4
Stern, M.B.5
Novak, P.6
-
9
-
-
84938993532
-
Neurodegenerative disease: Multiple system atrophy- new insight from prospective studies
-
26195260
-
Poewe W, Krismer F. Neurodegenerative disease: Multiple system atrophy- new insight from prospective studies. Nat Rev Neurol. 2015;11:430-1.
-
(2015)
Nat Rev Neurol
, vol.11
, pp. 430-431
-
-
Poewe, W.1
Krismer, F.2
-
10
-
-
84887921166
-
Alpha-Synucleinopathy phenotypes
-
24262191
-
McCann H, Stevens CH, Cartwright H, Halliday GM. Alpha-Synucleinopathy phenotypes. Parkinsonism Relat Disord. 2014;20(Supplement 1):S62-7.
-
(2014)
Parkinsonism Relat Disord
, vol.20
, Issue.Supplement 1
, pp. S62-S67
-
-
McCann, H.1
Stevens, C.H.2
Cartwright, H.3
Halliday, G.M.4
-
11
-
-
78649342837
-
LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation
-
1:CAS:528:DC%2BC3cXhsVGitrzN 20728949
-
Kubo M, Kamiya Y, Nagashima R, Maekawa T, Eshima K, Azuma S, et al. LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation. J Neuroimmunol. 2010;229:123-8.
-
(2010)
J Neuroimmunol
, vol.229
, pp. 123-128
-
-
Kubo, M.1
Kamiya, Y.2
Nagashima, R.3
Maekawa, T.4
Eshima, K.5
Azuma, S.6
-
12
-
-
84873486299
-
A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson’s disease
-
The International Parkinson's Disease Genomics Consortium. 1:CAS:528:DC%2BC3sXhvV2qur4%3D 23223016
-
Holmans P, Moskvina V, Jones L, Sharma M, The International Parkinson's Disease Genomics Consortium, Vedernikov A, et al. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson’s disease. Hum Mol Genet. 2013;22:1039-49.
-
(2013)
Hum Mol Genet
, vol.22
, pp. 1039-1049
-
-
Holmans, P.1
Moskvina, V.2
Jones, L.3
Sharma, M.4
Vedernikov, A.5
-
14
-
-
35448937286
-
Naturally occurring B-cell autoreactivity: A critical overview
-
1:CAS:528:DC%2BD2sXht1amsrfM 17888629
-
Avrameas S, Ternynck T, Tsonis IA, Lymberi P. Naturally occurring B-cell autoreactivity: A critical overview. J Autoimmun. 2007;29:213-8.
-
(2007)
J Autoimmun
, vol.29
, pp. 213-218
-
-
Avrameas, S.1
Ternynck, T.2
Tsonis, I.A.3
Lymberi, P.4
-
15
-
-
84875638187
-
Natural IgG Autoantibodies Are Abundant and Ubiquitous in Human Sera, and Their Number Is Influenced By Age, Gender, and Disease
-
1:CAS:528:DC%2BC3sXmtVehtrg%3D 23589757 3617628
-
Nagele EP, Han M, Acharya NK, DeMarshall C, Kosciuk MC, Nagele RG. Natural IgG Autoantibodies Are Abundant and Ubiquitous in Human Sera, and Their Number Is Influenced By Age, Gender, and Disease. PLoS One. 2013;8:e60726.
-
(2013)
PLoS One
, vol.8
, pp. e60726
-
-
Nagele, E.P.1
Han, M.2
Acharya, N.K.3
DeMarshall, C.4
Kosciuk, M.C.5
Nagele, R.G.6
-
16
-
-
84862746963
-
Pathogenic and physiological autoantibodies in the central nervous system
-
22725955
-
Gold M, Pul R, Bach JP, Stangel M, Dodel R. Pathogenic and physiological autoantibodies in the central nervous system. Immunol Rev. 2012;248:68-86.
-
(2012)
Immunol Rev
, vol.248
, pp. 68-86
-
-
Gold, M.1
Pul, R.2
Bach, J.P.3
Stangel, M.4
Dodel, R.5
-
17
-
-
77955349272
-
Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury
-
1:CAS:528:DC%2BC3cXovVartLY%3D 20547838 2900702
-
Vargas ME, Watanabe J, Singh SJ, Robinson WH, Barres BA. Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury. Proc Natl Acad Sci. 2010;107:11993-8.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 11993-11998
-
-
Vargas, M.E.1
Watanabe, J.2
Singh, S.J.3
Robinson, W.H.4
Barres, B.A.5
-
18
-
-
20444413356
-
Effects of Alpha-Synuclein Immunization in a Mouse Model of Parkinson’s Disease
-
1:CAS:528:DC%2BD2MXlvVWjtLg%3D 15953415
-
Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, et al. Effects of Alpha-Synuclein Immunization in a Mouse Model of Parkinson’s Disease. Neuron. 2005;46:857-68.
-
(2005)
Neuron
, vol.46
, pp. 857-868
-
-
Masliah, E.1
Rockenstein, E.2
Adame, A.3
Alford, M.4
Crews, L.5
Hashimoto, M.6
-
19
-
-
84903441419
-
Alpha-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded Alpha-Synuclein and Neurodegeneration
-
1:CAS:528:DC%2BC2cXpvFWmtLo%3D 24931606 4410967
-
Tran H-T, Chung C-HY, Iba M, Zhang B, Trojanowski J-Q, Luk K-C, et al. Alpha-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded Alpha-Synuclein and Neurodegeneration. Cell Rep. 2014;7:2054-65.
-
(2014)
Cell Rep
, vol.7
, pp. 2054-2065
-
-
Tran, H.-T.1
Chung, C.-H.2
Iba, M.3
Zhang, B.4
Trojanowski, J.-Q.5
Luk, K.-C.6
-
20
-
-
84901682081
-
Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
-
1:CAS:528:DC%2BC2cXisFensro%3D 24525765 4034750
-
Mandler M, Valera E, Rockenstein E, Weninger H, Patrick C, Adame A, et al. Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials. Acta Neuropathol. 2014;127:861-79.
-
(2014)
Acta Neuropathol
, vol.127
, pp. 861-879
-
-
Mandler, M.1
Valera, E.2
Rockenstein, E.3
Weninger, H.4
Patrick, C.5
Adame, A.6
-
21
-
-
84928533692
-
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
-
25886309 4411775
-
Mandler M, Valera E, Rockenstein E, Mante M, Weninger H, Patrick C, et al. Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy. Mol Neurodegener. 2015;10:10.
-
(2015)
Mol Neurodegener
, vol.10
, pp. 10
-
-
Mandler, M.1
Valera, E.2
Rockenstein, E.3
Mante, M.4
Weninger, H.5
Patrick, C.6
-
22
-
-
85020251348
-
Development of Passive Immunotherapies for Synucleinopathies
-
n/a
-
A.L. Bergstrom, P. Kallunki, K. Fog. Development of Passive Immunotherapies for Synucleinopathies. Mov. Disord. 2015;n/a.
-
(2015)
Mov. Disord.
-
-
Bergstrom, A.L.1
Kallunki, P.2
Fog, K.3
-
23
-
-
34247402084
-
Autoantibodies to alpha-synuclein in inherited Parkinsons disease
-
1:CAS:528:DC%2BD2sXlsV2ksLg%3D 17448146 3154646
-
Papachroni KK, Ninkina N, Papapanagiotou A, Hadjigeorgiou GM, Xiromerisiou G, Papadimitriou A, et al. Autoantibodies to alpha-synuclein in inherited Parkinsons disease. J Neurochem. 2007;101:749-56.
-
(2007)
J Neurochem
, vol.101
, pp. 749-756
-
-
Papachroni, K.K.1
Ninkina, N.2
Papapanagiotou, A.3
Hadjigeorgiou, G.M.4
Xiromerisiou, G.5
Papadimitriou, A.6
-
24
-
-
84871324721
-
Alpha-Synuclein and Anti-Alpha-Synuclein Antibodies in Parkinsons Disease, Atypical Parkinson Syndromes, REM Sleep Behavior Disorder, and Healthy Controls
-
1:CAS:528:DC%2BC3sXhvF2nsQ%3D%3D 23284971 3524108
-
Smith LM, Schiess MC, Coffey MP, Klaver AC, Loeffler DA. Alpha-Synuclein and Anti-Alpha-Synuclein Antibodies in Parkinsons Disease, Atypical Parkinson Syndromes, REM Sleep Behavior Disorder, and Healthy Controls. PLoS One. 2012;7:e52285.
-
(2012)
PLoS One
, vol.7
, pp. e52285
-
-
Smith, L.M.1
Schiess, M.C.2
Coffey, M.P.3
Klaver, A.C.4
Loeffler, D.A.5
-
25
-
-
0037076503
-
Absence of elevated anti-alpha-synuclein and anti-EBV latent membrane protein antibodies in PD
-
1:STN:280:DC%2BD383ntVKgug%3D%3D 12011302
-
Woulfe JM, Duke R, Middeldorp JM, Stevens S, Vervoort M, Hashimoto M, et al. Absence of elevated anti-alpha-synuclein and anti-EBV latent membrane protein antibodies in PD. Neurology. 2002;58:1435-6.
-
(2002)
Neurology
, vol.58
, pp. 1435-1436
-
-
Woulfe, J.M.1
Duke, R.2
Middeldorp, J.M.3
Stevens, S.4
Vervoort, M.5
Hashimoto, M.6
-
26
-
-
84866175982
-
Correlation between Protective Immunity to Alpha-Synuclein Aggregates, Oxidative Stress and Inflammation
-
1:CAS:528:DC%2BC38XhsFymtr%2FL 22986484
-
Gruden MA, Yanamandra K, Kucheryanu VG, Bocharova OR, Sherstnev VV, Morozova-Roche LA, et al. Correlation between Protective Immunity to Alpha-Synuclein Aggregates, Oxidative Stress and Inflammation. Neuroimmunomodulation. 2012;19:334-42.
-
(2012)
Neuroimmunomodulation
, vol.19
, pp. 334-342
-
-
Gruden, M.A.1
Yanamandra, K.2
Kucheryanu, V.G.3
Bocharova, O.R.4
Sherstnev, V.V.5
Morozova-Roche, L.A.6
-
27
-
-
79953308255
-
Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression
-
1:CAS:528:DC%2BC3MXks1Wluro%3D 21239064
-
Gruden MA, Sewell RDE, Yanamandra K, Davidova TV, Kucheryanu VG, Bocharov EV, et al. Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression. J Neuroimmunol. 2011;233:221-7.
-
(2011)
J Neuroimmunol
, vol.233
, pp. 221-227
-
-
Gruden, M.A.1
Sewell, R.D.E.2
Yanamandra, K.3
Davidova, T.V.4
Kucheryanu, V.G.5
Bocharov, E.V.6
-
28
-
-
79955554760
-
Alpha-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson’s Disease Patients
-
1:CAS:528:DC%2BC3MXlsFemtbY%3D 21541339 3081826
-
Yanamandra K, Gruden MA, Casaite V, Meskys R, Forsgren L, Morozova-Roche LA. Alpha-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson’s Disease Patients. PLoS One. 2011;6:e18513.
-
(2011)
PLoS One
, vol.6
, pp. e18513
-
-
Yanamandra, K.1
Gruden, M.A.2
Casaite, V.3
Meskys, R.4
Forsgren, L.5
Morozova-Roche, L.A.6
-
29
-
-
84873641251
-
Naturally occurring alpha-synuclein autoantibody levels are lower in patients with Parkinson disease
-
1:CAS:528:DC%2BC3sXlt1OitA%3D%3D 23255825
-
Besong-Agbo D, Wolf E, Jessen F, Oechsner M, Hametner E, Poewe W, et al. Naturally occurring alpha-synuclein autoantibody levels are lower in patients with Parkinson disease. Neurology. 2013;80:169-75.
-
(2013)
Neurology
, vol.80
, pp. 169-175
-
-
Besong-Agbo, D.1
Wolf, E.2
Jessen, F.3
Oechsner, M.4
Hametner, E.5
Poewe, W.6
-
30
-
-
0026695663
-
Criteria for diagnosing Parkinson’s disease
-
1510370
-
Calne DB, Snow BJ, Lee C. Criteria for diagnosing Parkinson’s disease. Ann Neurol. 1992;32:S125-7.
-
(1992)
Ann Neurol
, vol.32
, pp. S125-S127
-
-
Calne, D.B.1
Snow, B.J.2
Lee, C.3
-
31
-
-
52449086856
-
Second consensus statement on the diagnosis of multiple system atrophy
-
1:STN:280:DC%2BD1crktlWmsA%3D%3D 18725592 2676993
-
Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology. 2008;71:670-6.
-
(2008)
Neurology
, vol.71
, pp. 670-676
-
-
Gilman, S.1
Wenning, G.K.2
Low, P.A.3
Brooks, D.J.4
Mathias, C.J.5
Trojanowski, J.Q.6
-
32
-
-
84903437288
-
Validation of a multiplex electrochemiluminescent immunoassay platform in human and mouse samples
-
1:CAS:528:DC%2BC2cXnslGrurs%3D 24768796 4120713
-
Bastarache JA, Koyama T, Wickersham NE, Ware LB. Validation of a multiplex electrochemiluminescent immunoassay platform in human and mouse samples. J Immunol Methods. 2014;408:13-23.
-
(2014)
J Immunol Methods
, vol.408
, pp. 13-23
-
-
Bastarache, J.A.1
Koyama, T.2
Wickersham, N.E.3
Ware, L.B.4
-
33
-
-
0037397605
-
Effects of age on antibody affinity maturation
-
1:CAS:528:DC%2BD3sXisFGjt7c%3D 12653658
-
Dunn-Walters DK, Banerjee M, Mehr R. Effects of age on antibody affinity maturation. Biochem Soc Trans. 2003;31:447-8.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 447-448
-
-
Dunn-Walters, D.K.1
Banerjee, M.2
Mehr, R.3
-
34
-
-
0036174010
-
Alpha-Synuclein is phosphorylated in synucleinopathy lesions
-
1:CAS:528:DC%2BD38XhsVKnur4%3D 11813001
-
Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, et al. Alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol. 2002;4:160-4.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
-
35
-
-
59149090357
-
Polo-like Kinase 2 (PLK2) Phosphorylates Alpha-Synuclein at Serine 129 in Central Nervous System
-
1:CAS:528:DC%2BD1MXpsVyqug%3D%3D 19004816 2631975
-
Inglis KJ, Chereau D, Brigham EF, Chiou SS, Schöbel S, Frigon NL, et al. Polo-like Kinase 2 (PLK2) Phosphorylates Alpha-Synuclein at Serine 129 in Central Nervous System. J Biol Chem. 2009;284:2598-602.
-
(2009)
J Biol Chem
, vol.284
, pp. 2598-2602
-
-
Inglis, K.J.1
Chereau, D.2
Brigham, E.F.3
Chiou, S.S.4
Schöbel, S.5
Frigon, N.L.6
-
36
-
-
77949517145
-
Plasma alpha-synuclein in patients with Parkinson’s disease with and without treatment
-
20063406
-
Duran R, Barrero FJ, Morales B, Luna JD, Ramirez M, Vives F. Plasma alpha-synuclein in patients with Parkinson’s disease with and without treatment. Mov Disord. 2010;25:489-93.
-
(2010)
Mov Disord
, vol.25
, pp. 489-493
-
-
Duran, R.1
Barrero, F.J.2
Morales, B.3
Luna, J.D.4
Ramirez, M.5
Vives, F.6
-
37
-
-
82655171636
-
Phosphorylated alpha-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson’s disease
-
1:CAS:528:DC%2BC3MXhs1Wlt73E 21865317
-
Foulds PG, Mitchell JD, Parker A, Turner R, Green G, Diggle P, et al. Phosphorylated alpha-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson’s disease. FASEB J. 2011;25:4127-37.
-
(2011)
FASEB J
, vol.25
, pp. 4127-4137
-
-
Foulds, P.G.1
Mitchell, J.D.2
Parker, A.3
Turner, R.4
Green, G.5
Diggle, P.6
-
38
-
-
84902894449
-
A longitudinal study on alpha-synuclein in blood plasma as a biomarker for Parkinson’s disease
-
23985836 3756331
-
Foulds PG, Diggle P, Mitchell JD, Parker A, Hasegawa M, Masuda-Suzukake M, et al. A longitudinal study on alpha-synuclein in blood plasma as a biomarker for Parkinson’s disease. Sci Rep. 2013;3:2540.
-
(2013)
Sci Rep
, vol.3
, pp. 2540
-
-
Foulds, P.G.1
Diggle, P.2
Mitchell, J.D.3
Parker, A.4
Hasegawa, M.5
Masuda-Suzukake, M.6
-
39
-
-
0032926674
-
Lewy body-type degeneration in cardiac plexus in Parkinson’s and incidental Lewy body diseases
-
1:STN:280:DyaK1M3ivFGluw%3D%3D 10214756
-
Iwanaga K, Wakabayashi K, Yoshimoto M, Tomita I, Satoh H, Takashima H, et al. Lewy body-type degeneration in cardiac plexus in Parkinson’s and incidental Lewy body diseases. Neurology. 1999;52:1269.
-
(1999)
Neurology
, vol.52
, pp. 1269
-
-
Iwanaga, K.1
Wakabayashi, K.2
Yoshimoto, M.3
Tomita, I.4
Satoh, H.5
Takashima, H.6
-
40
-
-
84956885449
-
Gut Feelings About Alpha-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?
-
n/a
-
C. Ruffmann,L. Parkkinen. Gut Feelings About Alpha-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making? Mov. Disord. 2016;n/a.
-
(2016)
Mov. Disord.
-
-
Ruffmann, C.1
Parkkinen, L.2
-
41
-
-
84915805753
-
Alpha-Synuclein inclusions in the skin of Parkinson’s disease and parkinsonism
-
1:CAS:528:DC%2BC2cXht1WmsrzI 25356418 4184776
-
Rodriguez-Leyva I, Calderon-Garciduenas AL, Jimenez-Capdeville ME, Renteria-Palomo AA, Hernandez-Rodriguez HG, Valdes-Rodriguez R, et al. Alpha-Synuclein inclusions in the skin of Parkinson’s disease and parkinsonism. Ann Clin Transl Neurol. 2014;1:471-8.
-
(2014)
Ann Clin Transl Neurol
, vol.1
, pp. 471-478
-
-
Rodriguez-Leyva, I.1
Calderon-Garciduenas, A.L.2
Jimenez-Capdeville, M.E.3
Renteria-Palomo, A.A.4
Hernandez-Rodriguez, H.G.5
Valdes-Rodriguez, R.6
-
42
-
-
84940093905
-
Phosphorylated alpha-synuclein in skin nerve fibres differentiates Parkinson’s disease from multiple system atrophy
-
26017579
-
Zange L, Noack C, Hahn K, Stenzel W, Lipp A. Phosphorylated alpha-synuclein in skin nerve fibres differentiates Parkinson’s disease from multiple system atrophy. Brain. 2015;138:2310-21.
-
(2015)
Brain
, vol.138
, pp. 2310-2321
-
-
Zange, L.1
Noack, C.2
Hahn, K.3
Stenzel, W.4
Lipp, A.5
-
43
-
-
32544442518
-
Gastric alpha-synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson's disease-related brain pathology
-
1:CAS:528:DC%2BD28XhsF2gurc%3D 16330147
-
Braak H, de Vos RAI, Bohl J, Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett. 2006;396:67-72.
-
(2006)
Neurosci Lett
, vol.396
, pp. 67-72
-
-
Braak, H.1
De Vos, R.A.I.2
Bohl, J.3
Del Tredici, K.4
-
44
-
-
56549121613
-
Pathological lesions in colonic biopsies during Parkinson’s disease
-
1:STN:280:DC%2BD1cjlsVWksA%3D%3D 19022934
-
Lebouvier T, Chaumette T, Damier P, Coron E, Touchefeu Y, Vrignaud S, et al. Pathological lesions in colonic biopsies during Parkinson’s disease. Gut. 2008;57:1741.
-
(2008)
Gut
, vol.57
, pp. 1741
-
-
Lebouvier, T.1
Chaumette, T.2
Damier, P.3
Coron, E.4
Touchefeu, Y.5
Vrignaud, S.6
-
45
-
-
77958558412
-
Colonic Biopsies to Assess the Neuropathology of Parkinson’s Disease and Its Relationship with Symptoms
-
20856865 2939055
-
Lebouvier T, Neunlist M, Bruley des Varannes S, Coron E, Drouard A, N’Guyen JM, et al. Colonic Biopsies to Assess the Neuropathology of Parkinson’s Disease and Its Relationship with Symptoms. PLoS One. 2010;5:e12728.
-
(2010)
PLoS One
, vol.5
, pp. e12728
-
-
Lebouvier, T.1
Neunlist, M.2
Bruley Des Varannes, S.3
Coron, E.4
Drouard, A.5
N’Guyen, J.M.6
-
46
-
-
84896717250
-
Accumulation of alpha-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease
-
1:CAS:528:DC%2BC3sXhslylsrjL 24240814
-
Hilton D, Stephens M, Kirk L, Edwards P, Potter R, Zajicek J, et al. Accumulation of alpha-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease. Acta Neuropathol. 2014;127:235-41.
-
(2014)
Acta Neuropathol
, vol.127
, pp. 235-241
-
-
Hilton, D.1
Stephens, M.2
Kirk, L.3
Edwards, P.4
Potter, R.5
Zajicek, J.6
-
47
-
-
84923536410
-
Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease
-
1:CAS:528:DC%2BC2MXislSgsb4%3D 25589666 4335990
-
Visanji NP, Marras C, Kern DS, Al Dakheel A, Gao A, Liu LW, et al. Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease. Neurology. 2015;84:609-16.
-
(2015)
Neurology
, vol.84
, pp. 609-616
-
-
Visanji, N.P.1
Marras, C.2
Kern, D.S.3
Al Dakheel, A.4
Gao, A.5
Liu, L.W.6
-
48
-
-
79953308255
-
Immunoprotection against toxic biomarkers is retained during Parkinson’s disease progression
-
1:CAS:528:DC%2BC3MXks1Wluro%3D 21239064
-
Gruden MA, Sewell RDE, Yanamandra K, Davidova TV, Kucheryanu VG, Bocharov EV, et al. Immunoprotection against toxic biomarkers is retained during Parkinson’s disease progression. J Neuroimmunol. 2011;233:221-7.
-
(2011)
J Neuroimmunol
, vol.233
, pp. 221-227
-
-
Gruden, M.A.1
Sewell, R.D.E.2
Yanamandra, K.3
Davidova, T.V.4
Kucheryanu, V.G.5
Bocharov, E.V.6
-
49
-
-
84866679781
-
Antibody-Aided Clearance of Extracellular Alpha-Synuclein Prevents Cell-to-Cell Aggregate Transmission
-
1:CAS:528:DC%2BC38XhsVKhsrzK 23015436 3752153
-
Bae EJ, Lee HJ, Rockenstein E, Ho DH, Park EB, Yang NY, et al. Antibody-Aided Clearance of Extracellular Alpha-Synuclein Prevents Cell-to-Cell Aggregate Transmission. J Neurosci. 2012;32:13454-69.
-
(2012)
J Neurosci
, vol.32
, pp. 13454-13469
-
-
Bae, E.J.1
Lee, H.J.2
Rockenstein, E.3
Ho, D.H.4
Park, E.B.5
Yang, N.Y.6
-
50
-
-
84863987464
-
Inhibition of Amyloid Formation
-
22244855
-
Hard T, Lendel C. Inhibition of Amyloid Formation. J Mol Biol. 2012;421:441-65.
-
(2012)
J Mol Biol
, vol.421
, pp. 441-465
-
-
Hard, T.1
Lendel, C.2
-
51
-
-
84870607253
-
Rational design of potent domain antibody inhibitors of amyloid fibril assembly
-
1:CAS:528:DC%2BC3sXjslKgtw%3D%3D 23161913 3523860
-
Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, et al. Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci. 2012;109:19965-70.
-
(2012)
Proc Natl Acad Sci
, vol.109
, pp. 19965-19970
-
-
Ladiwala, A.R.1
Bhattacharya, M.2
Perchiacca, J.M.3
Cao, P.4
Raleigh, D.P.5
Abedini, A.6
-
52
-
-
69249139853
-
Monoclonal Antibodies Recognize Distinct Conformational Epitopes Formed by Polyglutamine in a Mutant Huntingtin Fragment
-
1:CAS:528:DC%2BD1MXpt1WisLc%3D 19491400 2755888
-
Legleiter J, Lotz GP, Miller J, Ko J, Ng C, Williams GL, et al. Monoclonal Antibodies Recognize Distinct Conformational Epitopes Formed by Polyglutamine in a Mutant Huntingtin Fragment. J Biol Chem. 2009;284:21647-58.
-
(2009)
J Biol Chem
, vol.284
, pp. 21647-21658
-
-
Legleiter, J.1
Lotz, G.P.2
Miller, J.3
Ko, J.4
Ng, C.5
Williams, G.L.6
-
53
-
-
0042467574
-
A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme
-
1:CAS:528:DC%2BD3sXmt1antrc%3D 12917687
-
Dumoulin M, Last AM, Desmyter A, Decanniere K, Canet D, Larsson G, et al. A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. Nature. 2003;424:783-8.
-
(2003)
Nature
, vol.424
, pp. 783-788
-
-
Dumoulin, M.1
Last, A.M.2
Desmyter, A.3
Decanniere, K.4
Canet, D.5
Larsson, G.6
-
54
-
-
84961162986
-
Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence Alpha-Synuclein Aggregation at Substoichiometric Concentrations
-
1:CAS:528:DC%2BC2MXlslGjs70%3D 25833100
-
Breydo L, Morgan D, Uversky VN. Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence Alpha-Synuclein Aggregation at Substoichiometric Concentrations. Mol Neurobiol. 2016;53:1949-58.
-
(2016)
Mol Neurobiol
, vol.53
, pp. 1949-1958
-
-
Breydo, L.1
Morgan, D.2
Uversky, V.N.3
-
55
-
-
34147130637
-
Isolation of a Human Single Chain Antibody Fragment Against Oligomeric Alpha-Synuclein that Inhibits Aggregation and Prevents Alpha-Synuclein-induced Toxicity
-
1:CAS:528:DC%2BD2sXksFahsr8%3D 17391701 2235820
-
Emadi S, Barkhordarian H, Wang MS, Schulz P, Sierks MR. Isolation of a Human Single Chain Antibody Fragment Against Oligomeric Alpha-Synuclein that Inhibits Aggregation and Prevents Alpha-Synuclein-induced Toxicity. J Mol Biol. 2007;368:1132-44.
-
(2007)
J Mol Biol
, vol.368
, pp. 1132-1144
-
-
Emadi, S.1
Barkhordarian, H.2
Wang, M.S.3
Schulz, P.4
Sierks, M.R.5
-
56
-
-
85020274468
-
et al
-
Gustafsson G, Eriksson F, Moeller C, Fonseca TL, Outeiro TF, Lannfelt L, et al. Cellular Uptake of Alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of Alpha-Synuclein and Mediated via FcGamma Receptors. Cell Mol Neurobiol. 2016:1-11.
-
(2016)
Cellular Uptake of Alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of Alpha-Synuclein and Mediated via FcGamma Receptors. Cell Mol Neurobiol
, pp. 1-11
-
-
Gustafsson, G.1
Eriksson, F.2
Moeller, C.3
Fonseca, T.L.4
Outeiro, T.F.5
Lannfelt, L.6
-
57
-
-
79955757052
-
Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
-
1:CAS:528:DC%2BC3MXls1Kktbs%3D 21559417 3084838
-
Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, et al. Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease. PLoS One. 2011;6:e19338.
-
(2011)
PLoS One
, vol.6
, pp. e19338
-
-
Masliah, E.1
Rockenstein, E.2
Mante, M.3
Crews, L.4
Spencer, B.5
Adame, A.6
-
58
-
-
33748932543
-
The plasma alpha-synuclein levels in patients with Parkinson disease and multiple system atrophy
-
1:CAS:528:DC%2BD28XpvVaqsLY%3D 16465458
-
Lee PH, Lee G, Park HJ, Bang OY, Joo IS, Huh K. The plasma alpha-synuclein levels in patients with Parkinson disease and multiple system atrophy. J Neural Transm. 2006;113:1435-9.
-
(2006)
J Neural Transm
, vol.113
, pp. 1435-1439
-
-
Lee, P.H.1
Lee, G.2
Park, H.J.3
Bang, O.Y.4
Joo, I.S.5
Huh, K.6
-
59
-
-
33947619003
-
Plasma alpha-synduclein is decreased in subjects with Parkinson’s disease
-
1:CAS:528:DC%2BD2sXjslSktbY%3D 17258710
-
Li QX, Mok SS, Laughton KM, McLean CA, Cappai R, Masters CL, et al. Plasma alpha-synduclein is decreased in subjects with Parkinson’s disease. Exp Neurol. 2007;204:583-8.
-
(2007)
Exp Neurol
, vol.204
, pp. 583-588
-
-
Li, Q.X.1
Mok, S.S.2
Laughton, K.M.3
McLean, C.A.4
Cappai, R.5
Masters, C.L.6
-
60
-
-
84951906259
-
Altered Alpha-Synuclein, Parkin, and Synphilin Isoform Levels in Multiple System Atrophy Brains
-
1:CAS:528:DC%2BC2MXhvVSlu7jK 26465922
-
Brudek T, Winge K, Bredo Rasmussen N, Bahl Czarna JM, Tanassi J, Klitmoller Agander T, et al. Altered Alpha-Synuclein, Parkin, and Synphilin Isoform Levels in Multiple System Atrophy Brains. J Neurochem. 2016;136:172-85.
-
(2016)
J Neurochem
, vol.136
, pp. 172-185
-
-
Brudek, T.1
Winge, K.2
Bredo Rasmussen, N.3
Bahl Czarna, J.M.4
Tanassi, J.5
Klitmoller Agander, T.6
-
61
-
-
0031763264
-
The synuclein family
-
1:CAS:528:DyaK1cXmsVWgsro%3D 9750188
-
Lavedan C. The synuclein family. Genome Res. 1998;8:871-80.
-
(1998)
Genome Res
, vol.8
, pp. 871-880
-
-
Lavedan, C.1
-
62
-
-
0036150971
-
The synucleins
-
reviews3002
-
George J. The synucleins. Genome Biol. 2001;3:reviews3002.
-
(2001)
Genome Biol
, vol.3
-
-
George, J.1
-
63
-
-
2642514788
-
Alpha-Synuclein: Normal Function and Role in Neurodegenerative Diseases
-
P.S. Gerald, editor. Academic Press
-
E.H. Norris, B.I. Giasson, and V.M.Y. Lee. Alpha-Synuclein: Normal Function and Role in Neurodegenerative Diseases. In: Current Topics in Developmental Biology, Stem Cells in Development and Disease. P.S. Gerald, editor. Academic Press, 2004, 17-54.
-
(2004)
Current Topics in Developmental Biology, Stem Cells in Development and Disease
, pp. 17-54
-
-
Norris, E.H.1
Giasson, B.I.2
Lee, V.M.Y.3
-
64
-
-
0035409575
-
Alpha-synuclein and neurodegenerative diseases
-
1:CAS:528:DC%2BD3MXlslGls70%3D 11433374
-
Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci. 2001;2:492-501.
-
(2001)
Nat Rev Neurosci
, vol.2
, pp. 492-501
-
-
Goedert, M.1
-
65
-
-
0037023699
-
Biophysical Properties of the Synucleins and Their Propensities to Fibrillate: INHIBITION OF ALPHA-SYNUCLEIN ASSEMBLY BY BETA- AND GAMMA-SYNUCLEINS
-
1:CAS:528:DC%2BD38XivVektrw%3D 11812782
-
Uversky VN, Li J, Souillac P, Millett IS, Doniach S, Jakes R, et al. Biophysical Properties of the Synucleins and Their Propensities to Fibrillate: INHIBITION OF ALPHA-SYNUCLEIN ASSEMBLY BY BETA- AND GAMMA-SYNUCLEINS. J Biol Chem. 2002;277:11970-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 11970-11978
-
-
Uversky, V.N.1
Li, J.2
Souillac, P.3
Millett, I.S.4
Doniach, S.5
Jakes, R.6
-
66
-
-
0037426346
-
Beta-Synuclein Inhibits Formation of Alpha-Synuclein Protofibrils: A Possible Therapeutic Strategy against Parkinson’s Disease
-
1:CAS:528:DC%2BD3sXhvFaqtbk%3D 12667059
-
Park JY, Lansbury PT. Beta-Synuclein Inhibits Formation of Alpha-Synuclein Protofibrils: A Possible Therapeutic Strategy against Parkinson’s Disease. Biochemistry. 2003;42:3696-700.
-
(2003)
Biochemistry
, vol.42
, pp. 3696-3700
-
-
Park, J.Y.1
Lansbury, P.T.2
-
67
-
-
84924042444
-
The ongoing pursuit of neuroprotective therapies in Parkinson disease
-
1:CAS:528:DC%2BC2cXitVemsr%2FJ 25447485
-
Athauda D, Foltynie T. The ongoing pursuit of neuroprotective therapies in Parkinson disease. Nat Rev Neurol. 2015;11:25-40.
-
(2015)
Nat Rev Neurol
, vol.11
, pp. 25-40
-
-
Athauda, D.1
Foltynie, T.2
|