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Volumn 31, Issue 2, 2016, Pages 193-202

Gut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?

Author keywords

biomarker; biopsy; enteric nervous system; Parkinson's disease; synuclein

Indexed keywords

ALPHA SYNUCLEIN; BIOLOGICAL MARKER;

EID: 84956885449     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.26480     Document Type: Review
Times cited : (54)

References (75)
  • 1
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases
    • Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181–184.
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 2
    • 56549121613 scopus 로고    scopus 로고
    • Pathological lesions in colonic biopsies during Parkinson's disease
    • Lebouvier T, Chaumette T, Damier P, et al. Pathological lesions in colonic biopsies during Parkinson's disease. Gut 2008;57:1741–1743.
    • (2008) Gut , vol.57 , pp. 1741-1743
    • Lebouvier, T.1    Chaumette, T.2    Damier, P.3
  • 3
    • 77958558412 scopus 로고    scopus 로고
    • Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms
    • Lebouvier T, Neunlist M, Bruley des Varannes S, et al. Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms. PloS One 2010;5:e12728.
    • (2010) PloS One , vol.5
    • Lebouvier, T.1    Neunlist, M.2    Bruley des Varannes, S.3
  • 4
    • 81955167987 scopus 로고    scopus 로고
    • A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease
    • Pouclet H, Lebouvier T, Coron E, et al. A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease. Neurobiol Dis 2012;45:305–309.
    • (2012) Neurobiol Dis , vol.45 , pp. 305-309
    • Pouclet, H.1    Lebouvier, T.2    Coron, E.3
  • 5
    • 84861692236 scopus 로고    scopus 로고
    • Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease
    • Shannon KM, Keshavarzian A, Mutlu E, et al. Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease. Mov Disord 2012;27:709–715.
    • (2012) Mov Disord , vol.27 , pp. 709-715
    • Shannon, K.M.1    Keshavarzian, A.2    Mutlu, E.3
  • 6
    • 84897432656 scopus 로고    scopus 로고
    • Alimentary, my dear Watson?. The challenges of enteric alpha-synuclein as a Parkinson's disease biomarker
    • Visanji NP, Marras C, Hazrati LN, Liu LW, Lang AE. Alimentary, my dear Watson?. The challenges of enteric alpha-synuclein as a Parkinson's disease biomarker. Mov Disord 2014;29:444–450.
    • (2014) Mov Disord , vol.29 , pp. 444-450
    • Visanji, N.P.1    Marras, C.2    Hazrati, L.N.3    Liu, L.W.4    Lang, A.E.5
  • 7
    • 84896717250 scopus 로고    scopus 로고
    • Accumulation of alpha-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease
    • Hilton D, Stephens M, Kirk L, et al. Accumulation of alpha-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease. Acta Neuropathol 2014;127:235–241.
    • (2014) Acta Neuropathol , vol.127 , pp. 235-241
    • Hilton, D.1    Stephens, M.2    Kirk, L.3
  • 8
    • 84964277355 scopus 로고    scopus 로고
    • In vivo gastric detection of alpha-synuclein inclusions in Parkinson's disease
    • Sanchez-Ferro A, Rabano A, Catalan MJ, et al. In vivo gastric detection of alpha-synuclein inclusions in Parkinson's disease. Mov Disord 2015;30:517–524.
    • (2015) Mov Disord , vol.30 , pp. 517-524
    • Sanchez-Ferro, A.1    Rabano, A.2    Catalan, M.J.3
  • 10
    • 84904421453 scopus 로고    scopus 로고
    • Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders
    • Gelpi E, Navarro-Otano J, Tolosa E, et al. Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders. Mov Disord 2014;29:1010–1018.
    • (2014) Mov Disord , vol.29 , pp. 1010-1018
    • Gelpi, E.1    Navarro-Otano, J.2    Tolosa, E.3
  • 11
    • 84861697687 scopus 로고    scopus 로고
    • Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease?. Evidence from 3 cases
    • Shannon KM, Keshavarzian A, Dodiya HB, Jakate S, Kordower JH. Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease?. Evidence from 3 cases. Mov Disord 2012;27:716–719.
    • (2012) Mov Disord , vol.27 , pp. 716-719
    • Shannon, K.M.1    Keshavarzian, A.2    Dodiya, H.B.3    Jakate, S.4    Kordower, J.H.5
  • 12
    • 61949445069 scopus 로고    scopus 로고
    • Can we image premotor Parkinson disease?
    • Marek K, Jennings D. Can we image premotor Parkinson disease? Neurology 2009;72:S21–S26.
    • (2009) Neurology , vol.72 , pp. S21-S26
    • Marek, K.1    Jennings, D.2
  • 13
    • 84865055362 scopus 로고    scopus 로고
    • Expression pattern and localization of alpha-synuclein in the human enteric nervous system
    • Bottner M, Zorenkov D, Hellwig I, et al. Expression pattern and localization of alpha-synuclein in the human enteric nervous system. Neurobiol Dis 2012;48:474–480.
    • (2012) Neurobiol Dis , vol.48 , pp. 474-480
    • Bottner, M.1    Zorenkov, D.2    Hellwig, I.3
  • 14
    • 84923536410 scopus 로고    scopus 로고
    • Colonic mucosal a-synuclein lacks specificity as a biomarker for Parkinson disease
    • Visanji NP, Marras C, Kern DS, et al. Colonic mucosal a-synuclein lacks specificity as a biomarker for Parkinson disease. Neurology 2015;84:609–616.
    • (2015) Neurology , vol.84 , pp. 609-616
    • Visanji, N.P.1    Marras, C.2    Kern, D.S.3
  • 15
    • 84874210403 scopus 로고    scopus 로고
    • Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease
    • Gold A, Turkalp ZT, Munoz DG. Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease. Mov Disord 2013;28:237–240.
    • (2013) Mov Disord , vol.28 , pp. 237-240
    • Gold, A.1    Turkalp, Z.T.2    Munoz, D.G.3
  • 16
    • 84872870323 scopus 로고    scopus 로고
    • Submandibular gland biopsy for the diagnosis of Parkinson disease
    • Beach TG, Adler CH, Dugger BN, et al. Submandibular gland biopsy for the diagnosis of Parkinson disease. J Neuropathol Exp Neurol 2013;72:130–136.
    • (2013) J Neuropathol Exp Neurol , vol.72 , pp. 130-136
    • Beach, T.G.1    Adler, C.H.2    Dugger, B.N.3
  • 17
    • 0023805080 scopus 로고
    • Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses
    • Wakabayashi K, Takahashi H, Takeda S, Ohama E, Ikuta F. Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses. Acta Neuropathol 1988;76:217–221.
    • (1988) Acta Neuropathol , vol.76 , pp. 217-221
    • Wakabayashi, K.1    Takahashi, H.2    Takeda, S.3    Ohama, E.4    Ikuta, F.5
  • 18
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • Braak H, de Vos RA, Bohl J, Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 2006;396:67–72.
    • (2006) Neurosci Lett , vol.396 , pp. 67-72
    • Braak, H.1    de Vos, R.A.2    Bohl, J.3    Del Tredici, K.4
  • 19
    • 77953021942 scopus 로고    scopus 로고
    • Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders
    • Beach TG, Adler CH, Sue LI, et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol 2010;119:689–702.
    • (2010) Acta Neuropathol , vol.119 , pp. 689-702
    • Beach, T.G.1    Adler, C.H.2    Sue, L.I.3
  • 20
    • 34248205797 scopus 로고    scopus 로고
    • Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage
    • Nakai M, Fujita M, Waragai M, et al. Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage. Biochem Biophys Res Comm 2007;358:104–110.
    • (2007) Biochem Biophys Res Comm , vol.358 , pp. 104-110
    • Nakai, M.1    Fujita, M.2    Waragai, M.3
  • 21
    • 0037150751 scopus 로고    scopus 로고
    • Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels
    • Tamo W, Imaizumi T, Tanji K, et al. Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels. Neurosci Lett 2002;326:5–8.
    • (2002) Neurosci Lett , vol.326 , pp. 5-8
    • Tamo, W.1    Imaizumi, T.2    Tanji, K.3
  • 22
    • 0033934231 scopus 로고    scopus 로고
    • Novel immunolocalization of alpha-synuclein in human muscle of inclusion-body myositis, regenerating and necrotic muscle fibers, and at neuromuscular junctions
    • Askanas V, Engel WK, Alvarez RB, McFerrin J, Broccolini A. Novel immunolocalization of alpha-synuclein in human muscle of inclusion-body myositis, regenerating and necrotic muscle fibers, and at neuromuscular junctions. J Neuropathol Exp Neurol 2000;59:592–598.
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 592-598
    • Askanas, V.1    Engel, W.K.2    Alvarez, R.B.3    McFerrin, J.4    Broccolini, A.5
  • 23
    • 72149119358 scopus 로고    scopus 로고
    • Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
    • Luk KC, Song C, O'Brien P, et al. Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc Natl Acad Sci U S A 2009;106:20051–20056.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 20051-20056
    • Luk, K.C.1    Song, C.2    O'Brien, P.3
  • 24
    • 69149089854 scopus 로고    scopus 로고
    • Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    • Desplats P, Lee HJ, Bae EJ, et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 2009;106:13010–130105.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13010-130105
    • Desplats, P.1    Lee, H.J.2    Bae, E.J.3
  • 25
    • 80053613574 scopus 로고    scopus 로고
    • Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
    • Volpicelli-Daley LA, Luk KC, Patel TP, et al. Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 2011;72:57–71.
    • (2011) Neuron , vol.72 , pp. 57-71
    • Volpicelli-Daley, L.A.1    Luk, K.C.2    Patel, T.P.3
  • 26
    • 84937549571 scopus 로고    scopus 로고
    • Alpha-synuclein immunoreactivity patterns in the enteric nervous system
    • Aldecoa I, Navarro-Otano J, Stefanova N, et al. Alpha-synuclein immunoreactivity patterns in the enteric nervous system. Neurosci Lett 2015;602:145–149.
    • (2015) Neurosci Lett , vol.602 , pp. 145-149
    • Aldecoa, I.1    Navarro-Otano, J.2    Stefanova, N.3
  • 27
    • 84877993385 scopus 로고    scopus 로고
    • A study of calretinin in Hirschsprung pathology, particularly in total colonic aganglionosis
    • Morris MI, Soglio DB, Ouimet A, Aspirot A, Patey N. A study of calretinin in Hirschsprung pathology, particularly in total colonic aganglionosis. J Ped Surg 2013;48:1037–1043.
    • (2013) J Ped Surg , vol.48 , pp. 1037-1043
    • Morris, M.I.1    Soglio, D.B.2    Ouimet, A.3    Aspirot, A.4    Patey, N.5
  • 28
    • 0029097763 scopus 로고
    • Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation
    • Singaram C, Ashraf W, Gaumnitz EA, et al. Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation. Lancet 1995;346:861–864.
    • (1995) Lancet , vol.346 , pp. 861-864
    • Singaram, C.1    Ashraf, W.2    Gaumnitz, E.A.3
  • 30
    • 33846997878 scopus 로고    scopus 로고
    • Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    • Kramer ML, Schulz-Schaeffer WJ. Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 2007;27:1405–1410.
    • (2007) J Neurosci , vol.27 , pp. 1405-1410
    • Kramer, M.L.1    Schulz-Schaeffer, W.J.2
  • 31
    • 83555166040 scopus 로고    scopus 로고
    • Pale neurites, premature alpha-synuclein aggregates with centripetal extension from axon collaterals
    • Kanazawa T, Adachi E, Orimo S, Nakamura A, Mizusawa H, Uchihara T. Pale neurites, premature alpha-synuclein aggregates with centripetal extension from axon collaterals. Brain Pathol 2012;22:67–78.
    • (2012) Brain Pathol , vol.22 , pp. 67-78
    • Kanazawa, T.1    Adachi, E.2    Orimo, S.3    Nakamura, A.4    Mizusawa, H.5    Uchihara, T.6
  • 32
    • 33646112656 scopus 로고    scopus 로고
    • Comparative study of commercially available anti-alpha-synuclein antibodies
    • Croisier E, DE MR, Deprez M, et al. Comparative study of commercially available anti-alpha-synuclein antibodies. Neuropathol Appl Neurobiol 2006;32:351–356.
    • (2006) Neuropathol Appl Neurobiol , vol.32 , pp. 351-356
    • Croisier, E.1    De, M.R.2    Deprez, M.3
  • 33
    • 49049114460 scopus 로고    scopus 로고
    • Evaluation of alpha-synuclein immunohistochemical methods used by invited experts
    • Beach TG, White CL, Hamilton RL, et al. Evaluation of alpha-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol 2008;116:277–288.
    • (2008) Acta Neuropathol , vol.116 , pp. 277-288
    • Beach, T.G.1    White, C.L.2    Hamilton, R.L.3
  • 34
    • 41949092490 scopus 로고    scopus 로고
    • Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium
    • Alafuzoff I, Parkkinen L, Al-Sarraj S, et al. Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol 2008;67:125–143.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 125-143
    • Alafuzoff, I.1    Parkkinen, L.2    Al-Sarraj, S.3
  • 35
    • 84881313560 scopus 로고    scopus 로고
    • Alpha-synuclein expression patterns in the colonic submucosal plexus of the aging Fischer 344 rat: implications for biopsies in aging and neurodegenerative disorders?
    • Phillips RJ, Martin FN, Billingsley CN, Powley TL. Alpha-synuclein expression patterns in the colonic submucosal plexus of the aging Fischer 344 rat: implications for biopsies in aging and neurodegenerative disorders? Neurogastroenterol Motil 2013;25:e621–e633.
    • (2013) Neurogastroenterol Motil , vol.25 , pp. e621-e633
    • Phillips, R.J.1    Martin, F.N.2    Billingsley, C.N.3    Powley, T.L.4
  • 36
    • 0036174010 scopus 로고    scopus 로고
    • alpha-Synuclein is phosphorylated in synucleinopathy lesions
    • Fujiwara H, Hasegawa M, Dohmae N, et al. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biol 2002;4:160–164.
    • (2002) Nature Cell Biol , vol.4 , pp. 160-164
    • Fujiwara, H.1    Hasegawa, M.2    Dohmae, N.3
  • 37
    • 84855188545 scopus 로고    scopus 로고
    • alpha-synuclein phosphorylation and truncation are normal events in the adult human brain
    • Muntane G, Ferrer I, Martinez-Vicente M. alpha-synuclein phosphorylation and truncation are normal events in the adult human brain. Neuroscience 2012;200:106–119.
    • (2012) Neuroscience , vol.200 , pp. 106-119
    • Muntane, G.1    Ferrer, I.2    Martinez-Vicente, M.3
  • 38
    • 0037551741 scopus 로고    scopus 로고
    • Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders
    • Caughey B, Lansbury PT. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 2003;26:267–298.
    • (2003) Annu Rev Neurosci , vol.26 , pp. 267-298
    • Caughey, B.1    Lansbury, P.T.2
  • 39
    • 4344641972 scopus 로고    scopus 로고
    • Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease
    • Rochet JC, Outeiro TF, Conway KA, et al. Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. J Neurosci 2004;23:23–34.
    • (2004) J Neurosci , vol.23 , pp. 23-34
    • Rochet, J.C.1    Outeiro, T.F.2    Conway, K.A.3
  • 40
    • 84929996447 scopus 로고    scopus 로고
    • Generation and characterization of novel conformation-specific monoclonal antibodies for alpha-synuclein pathology
    • Vaikath NN, Majbour NK, Paleologou KE, et al. Generation and characterization of novel conformation-specific monoclonal antibodies for alpha-synuclein pathology. Neurobiol Dis 2015;79:81–99.
    • (2015) Neurobiol Dis , vol.79 , pp. 81-99
    • Vaikath, N.N.1    Majbour, N.K.2    Paleologou, K.E.3
  • 41
    • 0033874288 scopus 로고    scopus 로고
    • The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases
    • Schulz-Schaeffer WJ, Tschoke S, Kranefuss N, et al. The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases. Am J Pathol 2000;156:51–56.
    • (2000) Am J Pathol , vol.156 , pp. 51-56
    • Schulz-Schaeffer, W.J.1    Tschoke, S.2    Kranefuss, N.3
  • 42
    • 0037166267 scopus 로고    scopus 로고
    • Biochemical characterization of the core structure of alpha-synuclein filaments
    • Miake H, Mizusawa H, Iwatsubo T, Hasegawa M. Biochemical characterization of the core structure of alpha-synuclein filaments. J Biol Chem 2002;277:19213–19.
    • (2002) J Biol Chem , vol.277 , pp. 19213-19219
    • Miake, H.1    Mizusawa, H.2    Iwatsubo, T.3    Hasegawa, M.4
  • 43
    • 0037592405 scopus 로고    scopus 로고
    • Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas
    • Fung KM, Rorke LB, Giasson B, Lee VM, Trojanowski JQ. Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas. Acta Neuropathol 2003;106:167–175.
    • (2003) Acta Neuropathol , vol.106 , pp. 167-175
    • Fung, K.M.1    Rorke, L.B.2    Giasson, B.3    Lee, V.M.4    Trojanowski, J.Q.5
  • 44
    • 0033980068 scopus 로고    scopus 로고
    • alpha-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation
    • Kawashima M, Suzuki SO, Doh-ura K, Iwaki T. alpha-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation. Acta Neuropathol 2000;99:154–160.
    • (2000) Acta Neuropathol , vol.99 , pp. 154-160
    • Kawashima, M.1    Suzuki, S.O.2    Doh-ura, K.3    Iwaki, T.4
  • 45
    • 33846471635 scopus 로고    scopus 로고
    • Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis
    • Wu K, Quan Z, Weng Z, et al. Expression of neuronal protein synuclein gamma gene as a novel marker for breast cancer prognosis. Breast Cancer Res Treat 2007;101:259–267.
    • (2007) Breast Cancer Res Treat , vol.101 , pp. 259-267
    • Wu, K.1    Quan, Z.2    Weng, Z.3
  • 46
    • 84861563520 scopus 로고    scopus 로고
    • Direct observation of the interconversion of normal and toxic forms of alpha-synuclein
    • Cremades N, Cohen SI, Deas E, et al. Direct observation of the interconversion of normal and toxic forms of alpha-synuclein. Cell 2012;149:1048–1059.
    • (2012) Cell , vol.149 , pp. 1048-1059
    • Cremades, N.1    Cohen, S.I.2    Deas, E.3
  • 47
    • 0036255761 scopus 로고    scopus 로고
    • Protein detection using proximity-dependent DNA ligation assays
    • Fredriksson S, Gullberg M, Jarvius J, et al. Protein detection using proximity-dependent DNA ligation assays. Nat Biotechnol 2002;20:473–477.
    • (2002) Nat Biotechnol , vol.20 , pp. 473-477
    • Fredriksson, S.1    Gullberg, M.2    Jarvius, J.3
  • 49
    • 33751252292 scopus 로고    scopus 로고
    • Direct observation of individual endogenous protein complexes in situ by proximity ligation
    • Soderberg O, Gullberg M, Jarvius M, et al. Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods 2006;3:995–1000.
    • (2006) Nat Methods , vol.3 , pp. 995-1000
    • Soderberg, O.1    Gullberg, M.2    Jarvius, M.3
  • 50
    • 84938704559 scopus 로고    scopus 로고
    • Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain
    • Roberts RF, Wade-Martins R, Alegre-Abarrategui J. Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain. Brain 2015;138:1642–1657.
    • (2015) Brain , vol.138 , pp. 1642-1657
    • Roberts, R.F.1    Wade-Martins, R.2    Alegre-Abarrategui, J.3
  • 51
    • 0035859102 scopus 로고    scopus 로고
    • Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
    • Saborio GP, Permanne B, Soto C. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 2001;411:810–813.
    • (2001) Nature , vol.411 , pp. 810-813
    • Saborio, G.P.1    Permanne, B.2    Soto, C.3
  • 52
    • 79751535822 scopus 로고    scopus 로고
    • Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion
    • Atarashi R, Satoh K, Sano K, et al. Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med 2011;17:175–178.
    • (2011) Nat Med , vol.17 , pp. 175-178
    • Atarashi, R.1    Satoh, K.2    Sano, K.3
  • 53
    • 84865587647 scopus 로고    scopus 로고
    • Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease
    • McGuire LI, Peden AH, Orru CD, et al. Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease. Ann Neurol 2012;72:278–285.
    • (2012) Ann Neurol , vol.72 , pp. 278-285
    • McGuire, L.I.1    Peden, A.H.2    Orru, C.D.3
  • 54
    • 84872458771 scopus 로고    scopus 로고
    • Aggregation and neurotoxicity of recombinant alpha-synuclein aggregates initiated by dimerization
    • Roostaee A, Beaudoin S, Staskevicius A, Roucou X. Aggregation and neurotoxicity of recombinant alpha-synuclein aggregates initiated by dimerization. Mol Neurodegener 2013;8:5.
    • (2013) Mol Neurodegener , vol.8 , pp. 5
    • Roostaee, A.1    Beaudoin, S.2    Staskevicius, A.3    Roucou, X.4
  • 55
    • 84899422309 scopus 로고    scopus 로고
    • Anti-amyloid compounds inhibit alpha-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA)
    • Herva ME, Zibaee S, Fraser G, Barker RA, Goedert M, Spillantini MG. Anti-amyloid compounds inhibit alpha-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA). J Biol Chem 2014;289:11897–1905.
    • (2014) J Biol Chem , vol.289 , pp. 11897-11905
    • Herva, M.E.1    Zibaee, S.2    Fraser, G.3    Barker, R.A.4    Goedert, M.5    Spillantini, M.G.6
  • 56
    • 0021161884 scopus 로고
    • Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease
    • Qualman SJ, Haupt HM, Yang P, Hamilton SR. Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease. Gastroenterology 1984;87:848–856.
    • (1984) Gastroenterology , vol.87 , pp. 848-856
    • Qualman, S.J.1    Haupt, H.M.2    Yang, P.3    Hamilton, S.R.4
  • 57
    • 0023186176 scopus 로고
    • Parkinson's disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells
    • Kupsky WJ, Grimes MM, Sweeting J, Bertsch R, Cote LJ. Parkinson's disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells. Neurology 1987;37:1253–1255.
    • (1987) Neurology , vol.37 , pp. 1253-1255
    • Kupsky, W.J.1    Grimes, M.M.2    Sweeting, J.3    Bertsch, R.4    Cote, L.J.5
  • 59
    • 23844446448 scopus 로고    scopus 로고
    • Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: ‘permissive templating’ as a general mechanism underlying neurodegeneration
    • Hardy J. Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: ‘permissive templating’ as a general mechanism underlying neurodegeneration. Biochem Soc Trans 2005;33:578–581.
    • (2005) Biochem Soc Trans , vol.33 , pp. 578-581
    • Hardy, J.1
  • 60
    • 84883688262 scopus 로고    scopus 로고
    • Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
    • Jucker M, Walker LC. Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature 2013;501:45–51.
    • (2013) Nature , vol.501 , pp. 45-51
    • Jucker, M.1    Walker, L.C.2
  • 61
    • 84904636970 scopus 로고    scopus 로고
    • Intramuscular injection of alpha-synuclein induces CNS alpha-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
    • Sacino AN, Brooks M, Thomas MA, et al. Intramuscular injection of alpha-synuclein induces CNS alpha-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc Natl Acad Sci U S A 2014;111:10732–10737.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 10732-10737
    • Sacino, A.N.1    Brooks, M.2    Thomas, M.A.3
  • 62
    • 84922092995 scopus 로고    scopus 로고
    • Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
    • Holmqvist S, Chutna O, Bousset L, et al. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats. Acta Neuropath 2014;128:805–820.
    • (2014) Acta Neuropath , vol.128 , pp. 805-820
    • Holmqvist, S.1    Chutna, O.2    Bousset, L.3
  • 63
    • 77649284470 scopus 로고    scopus 로고
    • Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice
    • Pan-Montojo F, Anichtchik O, Dening Y, et al. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PloS One 2010;5:e8762.
    • (2010) PloS One , vol.5
    • Pan-Montojo, F.1    Anichtchik, O.2    Dening, Y.3
  • 64
    • 84870769168 scopus 로고    scopus 로고
    • Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
    • Pan-Montojo F, Schwarz M, Winkler C, et al. Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep 2012;2:898.
    • (2012) Sci Rep , vol.2 , pp. 898
    • Pan-Montojo, F.1    Schwarz, M.2    Winkler, C.3
  • 65
    • 0025185288 scopus 로고
    • Simultaneous labeling of vagal innervation of the gut and afferent projections from the visceral forebrain with dil injected into the dorsal vagal complex in the rat
    • Berthoud HR, Jedrzejewska A, Powley TL. Simultaneous labeling of vagal innervation of the gut and afferent projections from the visceral forebrain with dil injected into the dorsal vagal complex in the rat. J Comp Neurol 1990;301:65–79.
    • (1990) J Comp Neurol , vol.301 , pp. 65-79
    • Berthoud, H.R.1    Jedrzejewska, A.2    Powley, T.L.3
  • 66
    • 0037370875 scopus 로고    scopus 로고
    • Musings on the wanderer: what's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut
    • Chang HY, Mashimo H, Goyal RK. Musings on the wanderer: what's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut. Am J Phys Gastroint Liver Phys 2003;284:G357–G366.
    • (2003) Am J Phys Gastroint Liver Phys , vol.284 , pp. G357-G366
    • Chang, H.Y.1    Mashimo, H.2    Goyal, R.K.3
  • 67
    • 84871004211 scopus 로고    scopus 로고
    • Spinal cord lesions in sporadic Parkinson's disease
    • Del Tredici K, Braak H. Spinal cord lesions in sporadic Parkinson's disease. Acta Neuropath 2012;124:643–664.
    • (2012) Acta Neuropath , vol.124 , pp. 643-664
    • Del Tredici, K.1    Braak, H.2
  • 68
    • 84862501292 scopus 로고    scopus 로고
    • The enteric nervous system and neurogastroenterology
    • Furness JB. The enteric nervous system and neurogastroenterology. Nature Rev Gastroent Hepat 2012;9:286–294.
    • (2012) Nature Rev Gastroent Hepat , vol.9 , pp. 286-294
    • Furness, J.B.1
  • 69
    • 0038748401 scopus 로고    scopus 로고
    • Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
    • Braak H, Rub U, Gai WP, Del Tredici K. Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 2003;110:517–536.
    • (2003) J Neural Transm , vol.110 , pp. 517-536
    • Braak, H.1    Rub, U.2    Gai, W.P.3    Del Tredici, K.4
  • 70
    • 72849139125 scopus 로고    scopus 로고
    • Incidental Lewy body disease restricted to the heart and stellate ganglia
    • Miki Y, Mori F, Wakabayashi K, Kuroda N, Orimo S. Incidental Lewy body disease restricted to the heart and stellate ganglia. Mov Disord 2009;24:2299–2301.
    • (2009) Mov Disord , vol.24 , pp. 2299-2301
    • Miki, Y.1    Mori, F.2    Wakabayashi, K.3    Kuroda, N.4    Orimo, S.5
  • 71
    • 33646082266 scopus 로고    scopus 로고
    • Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
    • Bloch A, Probst A, Bissig H, Adams H, Tolnay M. Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropath App Neurobiol 2006;32:284–295.
    • (2006) Neuropath App Neurobiol , vol.32 , pp. 284-295
    • Bloch, A.1    Probst, A.2    Bissig, H.3    Adams, H.4    Tolnay, M.5
  • 72
    • 78649838939 scopus 로고    scopus 로고
    • The brain to gut pathway: a possible route of prion transmission
    • Lawson VA, Furness JB, Klemm HM, et al. The brain to gut pathway: a possible route of prion transmission. Gut 2010;59:1643–651.
    • (2010) Gut , vol.59 , pp. 1643-1651
    • Lawson, V.A.1    Furness, J.B.2    Klemm, H.M.3
  • 73
    • 84898057951 scopus 로고    scopus 로고
    • Time to redefine PD?. Introductory statement of the MDS Task Force on the definition of Parkinson's disease
    • Berg D, Postuma RB, Bloem B, et al. Time to redefine PD?. Introductory statement of the MDS Task Force on the definition of Parkinson's disease. Mov Disord 2014;29:454–462.
    • (2014) Mov Disord , vol.29 , pp. 454-462
    • Berg, D.1    Postuma, R.B.2    Bloem, B.3
  • 74
    • 84865315472 scopus 로고    scopus 로고
    • Analysis of colonic alpha-synuclein pathology in multiple system atrophy
    • Pouclet H, Lebouvier T, Coron E, et al. Analysis of colonic alpha-synuclein pathology in multiple system atrophy. Parkinsonism Relat Disord 2012;18:893–895.
    • (2012) Parkinsonism Relat Disord , vol.18 , pp. 893-895
    • Pouclet, H.1    Lebouvier, T.2    Coron, E.3


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