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Volumn 2, Issue 3, 2016, Pages 318-329

Highly purified eicosapentaenoic acid ameliorates cardiac injury and adipose tissue inflammation in a rat model of metabolic syndrome

Author keywords

Adiponectin; eicosapentaenoic acid; inflammation; metabolic syndrome

Indexed keywords

ADIPONECTIN; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ICOSAPENTAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID; OMEGA 3 FATTY ACID; SYNAPTOTAGMIN I;

EID: 85020255394     PISSN: None     EISSN: 20552238     Source Type: Journal    
DOI: 10.1002/osp4.50     Document Type: Article
Times cited : (9)

References (49)
  • 1
    • 84864244872 scopus 로고    scopus 로고
    • Metabolic syndrome, insulin resistance, and roles of inflammation – mechanisms and therapeutic targets
    • Romeo GR, Lee J, Shoelson SE. Metabolic syndrome, insulin resistance, and roles of inflammation – mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol 2012; 32: 1771–1776.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1771-1776
    • Romeo, G.R.1    Lee, J.2    Shoelson, S.E.3
  • 2
    • 30544439060 scopus 로고    scopus 로고
    • Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease
    • Matsuzawa Y. Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med 2006; 3: 35–42.
    • (2006) Nat Clin Pract Cardiovasc Med , vol.3 , pp. 35-42
    • Matsuzawa, Y.1
  • 3
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 2012; 18: 363–374.
    • (2012) Nat Med , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 4
    • 0037051975 scopus 로고    scopus 로고
    • Fish and omega-3 fatty acid intake and risk of coronary heart disease in women
    • Hu FB, Bronner L, Willett WC, et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. Jama 2002; 287: 1815–1821.
    • (2002) Jama , vol.287 , pp. 1815-1821
    • Hu, F.B.1    Bronner, L.2    Willett, W.C.3
  • 5
    • 3142712905 scopus 로고    scopus 로고
    • n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored
    • Calder PC. n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci (Lond) 2004; 107: 1–11.
    • (2004) Clin Sci (Lond) , vol.107 , pp. 1-11
    • Calder, P.C.1
  • 7
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    • Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 2007; 369: 1090–1098.
    • (2007) Lancet , vol.369 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3
  • 8
    • 34548274430 scopus 로고    scopus 로고
    • Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects
    • Itoh M, Suganami T, Satoh N, et al. Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Arterioscler Thromb Vasc Biol 2007; 27: 1918–1925.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1918-1925
    • Itoh, M.1    Suganami, T.2    Satoh, N.3
  • 9
    • 57549112337 scopus 로고    scopus 로고
    • In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid
    • Yamada H, Yoshida M, Nakano Y, et al. In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid. Arterioscler Thromb Vasc Biol 2008; 28: 2173–2179.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2173-2179
    • Yamada, H.1    Yoshida, M.2    Nakano, Y.3
  • 10
    • 33750284280 scopus 로고    scopus 로고
    • Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases
    • Simopoulos AP. Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother 2006; 60: 502–507.
    • (2006) Biomed Pharmacother , vol.60 , pp. 502-507
    • Simopoulos, A.P.1
  • 12
    • 0037191503 scopus 로고    scopus 로고
    • Enhancement of lipid peroxidation and of the antitumor effect of hyperthermia upon combination with oral eicosapentaenoic acid
    • Kokura S, Nakagawa S, Hara T, et al. Enhancement of lipid peroxidation and of the antitumor effect of hyperthermia upon combination with oral eicosapentaenoic acid. Cancer Lett 2002; 185: 139–144.
    • (2002) Cancer Lett , vol.185 , pp. 139-144
    • Kokura, S.1    Nakagawa, S.2    Hara, T.3
  • 13
    • 0023603233 scopus 로고
    • Intake of different eicosapentaenoic acid-containing lipids and fatty acid pattern of plasma lipids in the rats
    • Hamazaki T, Urakaze M, Makuta M, et al. Intake of different eicosapentaenoic acid-containing lipids and fatty acid pattern of plasma lipids in the rats. Lipids 1987; 22: 994–998.
    • (1987) Lipids , vol.22 , pp. 994-998
    • Hamazaki, T.1    Urakaze, M.2    Makuta, M.3
  • 14
    • 84946557557 scopus 로고    scopus 로고
    • Blockade of glucocorticoid receptors with RU486 attenuates cardiac damage and adipose tissue inflammation in a rat model of metabolic syndrome
    • Takeshita Y, Watanabe S, Hattori T, et al. Blockade of glucocorticoid receptors with RU486 attenuates cardiac damage and adipose tissue inflammation in a rat model of metabolic syndrome. Hypertens Res 2015; 38: 741–750.
    • (2015) Hypertens Res , vol.38 , pp. 741-750
    • Takeshita, Y.1    Watanabe, S.2    Hattori, T.3
  • 15
    • 0035984393 scopus 로고    scopus 로고
    • AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats
    • Nagata K, Somura F, Obata K, et al. AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats. Hypertension 2002; 40: 168–174.
    • (2002) Hypertension , vol.40 , pp. 168-174
    • Nagata, K.1    Somura, F.2    Obata, K.3
  • 16
    • 84930834818 scopus 로고    scopus 로고
    • Restraint stress exacerbates cardiac and adipose tissue pathology via beta-adrenergic signaling in rats with metabolic syndrome
    • Matsuura N, Nagasawa K, Minagawa Y, et al. Restraint stress exacerbates cardiac and adipose tissue pathology via beta-adrenergic signaling in rats with metabolic syndrome. Am J Physiol Heart Circ Physiol 2015; 308: H1275–1286.
    • (2015) Am J Physiol Heart Circ Physiol , vol.308 , pp. H1275-1286
    • Matsuura, N.1    Nagasawa, K.2    Minagawa, Y.3
  • 17
    • 84924786246 scopus 로고    scopus 로고
    • Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome
    • Hattori T, Murase T, Takatsu M, et al. Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome. J Am Heart Assoc 2014; 3: e001312.
    • (2014) J Am Heart Assoc , vol.3
    • Hattori, T.1    Murase, T.2    Takatsu, M.3
  • 18
    • 51549114941 scopus 로고    scopus 로고
    • Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt
    • Kato MF, Shibata R, Obata K, et al. Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt. J Hypertens 2008; 26: 1669–1676.
    • (2008) J Hypertens , vol.26 , pp. 1669-1676
    • Kato, M.F.1    Shibata, R.2    Obata, K.3
  • 19
    • 64849096300 scopus 로고    scopus 로고
    • Exercise training alters left ventricular geometry and attenuates heart failure in Dahl salt-sensitive hypertensive rats
    • Miyachi M, Yazawa H, Furukawa M, et al. Exercise training alters left ventricular geometry and attenuates heart failure in Dahl salt-sensitive hypertensive rats. Hypertension 2009; 53: 701–707.
    • (2009) Hypertension , vol.53 , pp. 701-707
    • Miyachi, M.1    Yazawa, H.2    Furukawa, M.3
  • 20
    • 84920643340 scopus 로고    scopus 로고
    • Effects of pioglitazone on cardiac and adipose tissue pathology in rats with metabolic syndrome
    • Matsuura N, Asano C, Nagasawa K, et al. Effects of pioglitazone on cardiac and adipose tissue pathology in rats with metabolic syndrome. Int J Cardiol 2015; 179: 360–369.
    • (2015) Int J Cardiol , vol.179 , pp. 360-369
    • Matsuura, N.1    Asano, C.2    Nagasawa, K.3
  • 21
    • 84988483836 scopus 로고    scopus 로고
    • Attenuation of cold stress-induced exacerbation of cardiac and adipose tissue pathology and metabolic disorders in a rat model of metabolic syndrome by the glucocorticoid receptor antagonist RU486
    • Nagasawa K, Matsuura N, Takeshita Y, et al. Attenuation of cold stress-induced exacerbation of cardiac and adipose tissue pathology and metabolic disorders in a rat model of metabolic syndrome by the glucocorticoid receptor antagonist RU486. Nutr Diabetes 2016; 6: e207.
    • (2016) Nutr Diabetes , vol.6
    • Nagasawa, K.1    Matsuura, N.2    Takeshita, Y.3
  • 22
    • 33645816971 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats
    • Nagata K, Obata K, Xu J, et al. Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats. Hypertension 2006; 47: 656–664.
    • (2006) Hypertension , vol.47 , pp. 656-664
    • Nagata, K.1    Obata, K.2    Xu, J.3
  • 23
    • 84865446073 scopus 로고    scopus 로고
    • Comparison of the effects of cilnidipine and amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats
    • Takatsu M, Hattori T, Murase T, et al. Comparison of the effects of cilnidipine and amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats. J Hypertens 2012; 30: 1845–1855.
    • (2012) J Hypertens , vol.30 , pp. 1845-1855
    • Takatsu, M.1    Hattori, T.2    Murase, T.3
  • 24
    • 13144293998 scopus 로고    scopus 로고
    • NADPH oxidase inhibition attenuates oxidative stress but not hypertension produced by chronic ET-1
    • Elmarakby AA, Loomis ED, Pollock JS, Pollock DM. NADPH oxidase inhibition attenuates oxidative stress but not hypertension produced by chronic ET-1. Hypertension 2005; 45: 283–287.
    • (2005) Hypertension , vol.45 , pp. 283-287
    • Elmarakby, A.A.1    Loomis, E.D.2    Pollock, J.S.3    Pollock, D.M.4
  • 25
    • 31544473558 scopus 로고    scopus 로고
    • Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells
    • Miyata K, Rahman M, Shokoji T, et al. Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells. J Am Soc Nephrol 2005; 16: 2906–2912.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2906-2912
    • Miyata, K.1    Rahman, M.2    Shokoji, T.3
  • 26
    • 2442457887 scopus 로고    scopus 로고
    • Activation of matrix metalloproteinases precedes left ventricular remodeling in hypertensive heart failure rats: its inhibition as a primary effect of angiotensin-converting enzyme inhibitor
    • Sakata Y, Yamamoto K, Mano T, et al. Activation of matrix metalloproteinases precedes left ventricular remodeling in hypertensive heart failure rats: its inhibition as a primary effect of angiotensin-converting enzyme inhibitor. Circulation 2004; 109: 2143–2149.
    • (2004) Circulation , vol.109 , pp. 2143-2149
    • Sakata, Y.1    Yamamoto, K.2    Mano, T.3
  • 27
    • 84857542727 scopus 로고    scopus 로고
    • fa rats as a new animal model of metabolic syndrome
    • fa rats as a new animal model of metabolic syndrome. Hypertension 2012; 59: 694–704.
    • (2012) Hypertension , vol.59 , pp. 694-704
    • Murase, T.1    Hattori, T.2    Ohtake, M.3
  • 28
    • 67449142998 scopus 로고    scopus 로고
    • Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats
    • Yamada T, Nagata K, Cheng XW, et al. Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats. Eur J Pharmacol 2009; 615: 163–170.
    • (2009) Eur J Pharmacol , vol.615 , pp. 163-170
    • Yamada, T.1    Nagata, K.2    Cheng, X.W.3
  • 29
    • 84856752080 scopus 로고    scopus 로고
    • fa rats: a new animal model of metabolic syndrome
    • fa rats: a new animal model of metabolic syndrome. Hypertens Res 2012; 35: 186–193.
    • (2012) Hypertens Res , vol.35 , pp. 186-193
    • Murase, T.1    Hattori, T.2    Ohtake, M.3
  • 30
    • 84886433495 scopus 로고    scopus 로고
    • Calorie restriction attenuates cardiac remodeling and diastolic dysfunction in a rat model of metabolic syndrome
    • Takatsu M, Nakashima C, Takahashi K, et al. Calorie restriction attenuates cardiac remodeling and diastolic dysfunction in a rat model of metabolic syndrome. Hypertension 2013; 62: 957–965.
    • (2013) Hypertension , vol.62 , pp. 957-965
    • Takatsu, M.1    Nakashima, C.2    Takahashi, K.3
  • 31
    • 31944447600 scopus 로고    scopus 로고
    • Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats
    • Xu J, Nagata K, Obata K, et al. Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats. Hypertension 2005; 46: 719–724.
    • (2005) Hypertension , vol.46 , pp. 719-724
    • Xu, J.1    Nagata, K.2    Obata, K.3
  • 32
  • 33
    • 79951670918 scopus 로고    scopus 로고
    • Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblasts
    • Chen J, Shearer GC, Chen Q, et al. Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase G signaling in cardiac fibroblasts. Circulation 2011; 123: 584–593.
    • (2011) Circulation , vol.123 , pp. 584-593
    • Chen, J.1    Shearer, G.C.2    Chen, Q.3
  • 34
    • 0023493524 scopus 로고
    • Fructose-induced insulin resistance and hypertension in rats
    • Hwang IS, Ho H, Hoffman BB, Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension 1987; 10: 512–516.
    • (1987) Hypertension , vol.10 , pp. 512-516
    • Hwang, I.S.1    Ho, H.2    Hoffman, B.B.3    Reaven, G.M.4
  • 35
    • 84947242025 scopus 로고    scopus 로고
    • Effects of omega-3 fatty acid supplementation on glucose control and lipid levels in type 2 diabetes: a meta-analysis
    • Chen C, Yu X, Shao S. Effects of omega-3 fatty acid supplementation on glucose control and lipid levels in type 2 diabetes: a meta-analysis. PLoS One 2015; 10: e0139565.
    • (2015) PLoS One , vol.10
    • Chen, C.1    Yu, X.2    Shao, S.3
  • 36
    • 84923791604 scopus 로고    scopus 로고
    • Safety in the hypertriglyceridemia treatment with N-3 polyunsaturated fatty acids on glucose metabolism in subjects with type 2 diabetes mellitus
    • Reis CE, Landim KC, Nunes AC, Dullius J. Safety in the hypertriglyceridemia treatment with N-3 polyunsaturated fatty acids on glucose metabolism in subjects with type 2 diabetes mellitus. Nutr Hosp 2014; 31: 570–576.
    • (2014) Nutr Hosp , vol.31 , pp. 570-576
    • Reis, C.E.1    Landim, K.C.2    Nunes, A.C.3    Dullius, J.4
  • 37
    • 84862006013 scopus 로고    scopus 로고
    • Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model
    • Szkudelski T. Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model. Exp Biol Med (Maywood) 2012; 237: 481–490.
    • (2012) Exp Biol Med (Maywood) , vol.237 , pp. 481-490
    • Szkudelski, T.1
  • 38
    • 49749087978 scopus 로고    scopus 로고
    • A review of islet of Langerhans degeneration in rodent models of type 2 diabetes
    • Nugent DA, Smith DM, Jones HB. A review of islet of Langerhans degeneration in rodent models of type 2 diabetes. Toxicol Pathol 2008; 36: 529–551.
    • (2008) Toxicol Pathol , vol.36 , pp. 529-551
    • Nugent, D.A.1    Smith, D.M.2    Jones, H.B.3
  • 39
    • 44949173089 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus
    • Cd003205
    • Hartweg J, Perera R, Montori V, et al. Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus. Cochrane Database Syst Rev 2008 Cd003205.
    • (2008) Cochrane Database Syst Rev
    • Hartweg, J.1    Perera, R.2    Montori, V.3
  • 40
    • 84864193051 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acid supplementation does not influence body composition, insulin resistance, and lipemia in women with type 2 diabetes and obesity
    • Crochemore IC, Souza AF, de Souza AC, Rosado EL. Omega-3 polyunsaturated fatty acid supplementation does not influence body composition, insulin resistance, and lipemia in women with type 2 diabetes and obesity. Nutr Clin Pract 2012; 27: 553–560.
    • (2012) Nutr Clin Pract , vol.27 , pp. 553-560
    • Crochemore, I.C.1    Souza, A.F.2    de Souza, A.C.3    Rosado, E.L.4
  • 41
    • 84655174598 scopus 로고    scopus 로고
    • (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights
    • Kalupahana NS, Claycombe KJ, Moustaid-Moussa N. (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. Adv Nutr 2011; 2: 304–316.
    • (2011) Adv Nutr , vol.2 , pp. 304-316
    • Kalupahana, N.S.1    Claycombe, K.J.2    Moustaid-Moussa, N.3
  • 42
    • 77957606885 scopus 로고    scopus 로고
    • Antiobesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesis
    • Sato A, Kawano H, Notsu T, et al. Antiobesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesis. Diabetes 2010; 59: 2495–2504.
    • (2010) Diabetes , vol.59 , pp. 2495-2504
    • Sato, A.1    Kawano, H.2    Notsu, T.3
  • 43
    • 31844451413 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet
    • Flachs P, Mohamed-Ali V, Horakova O, et al. Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. Diabetologia 2006; 49: 394–397.
    • (2006) Diabetologia , vol.49 , pp. 394-397
    • Flachs, P.1    Mohamed-Ali, V.2    Horakova, O.3
  • 44
    • 19644369581 scopus 로고    scopus 로고
    • Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis
    • Arita M, Yoshida M, Hong S, et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A 2005; 102: 7671–7676.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 7671-7676
    • Arita, M.1    Yoshida, M.2    Hong, S.3
  • 45
    • 79959956336 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan
    • Salminen A, Hyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) 2011; 89: 667–676.
    • (2011) J Mol Med (Berl) , vol.89 , pp. 667-676
    • Salminen, A.1    Hyttinen, J.M.2    Kaarniranta, K.3
  • 46
    • 84867186758 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway
    • Xue B, Yang Z, Wang X, Shi H. Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. PLoS One 2012; 7: e45990.
    • (2012) PLoS One , vol.7
    • Xue, B.1    Yang, Z.2    Wang, X.3    Shi, H.4
  • 47
    • 37349086163 scopus 로고    scopus 로고
    • The ischemic heart: starving to stimulate the adiponectin-AMPK signaling axis
    • Dyck JR. The ischemic heart: starving to stimulate the adiponectin-AMPK signaling axis. Circulation 2007; 116: 2779–2781.
    • (2007) Circulation , vol.116 , pp. 2779-2781
    • Dyck, J.R.1
  • 48
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409–2415.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 49
    • 77950989801 scopus 로고    scopus 로고
    • AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes
    • Wang S, Zhang M, Liang B, et al. AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res 2010; 106: 1117–1128.
    • (2010) Circ Res , vol.106 , pp. 1117-1128
    • Wang, S.1    Zhang, M.2    Liang, B.3


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