Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP

Journal of Cell Science

Volumn 118, Issue 9, 2005, Pages 2057-2065

  Hsiao, Victoria C ^a   Tian, Rujin ^a   Long, Heather ^b   Perng, Ming Der ^b   Brenner, Michael ^c   Quinlan, Roy A ^b   Goldman, James E ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b DURHAM UNIVERSITY   (United Kingdom)

^c University of Alabama at Birmingham   (United States)

Author keywords

Alexander disease; Cytoskeleton; GFAP; Intermediate filaments

Indexed keywords

ALPHA CRYSTALLIN; AMINO ACID; ARGININE; BETA CRYSTALLIN; BUFFER; CYSTEINE; GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT SHOCK PROTEIN 27; MUTANT PROTEIN; POTASSIUM CHLORIDE; TRITON X 100; UBIQUITIN; VIMENTIN;

ALEXANDER DISEASE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CELL INCLUSION; CELL STRUCTURE; CLINICAL FEATURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; GENE MUTATION; GENETIC TRANSFECTION; HETEROZYGOSITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERMEDIATE FILAMENT; NEUROLOGIC DISEASE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN STRUCTURE; RAT; SOLUBILIZATION; WHITE MATTER; WILD TYPE;

ALEXANDER DISEASE; ANIMALS; ASTROCYTES; CELLS, CULTURED; COS CELLS; CYTOPLASM; CYTOSKELETON; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MICROFILAMENTS; MICROSCOPY, ELECTRON; MUTATION; OCTOXYNOL; PLASMIDS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION; VIMENTIN;

ANIMALIA;

EID: 19444366359     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02339     Document Type: Article

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