Fate of edible solid lipid nanoparticles (SLN) in surfactant stabilized o/w emulsions. Part 2: Release and partitioning behavior of lipophilic probes from SLN into different phases of o/w emulsions

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Volumn 558, Issue , 2018, Pages 623-631

  Milsmann, Johanna ^a   Oehlke, Kathleen ^a   Greiner, Ralf ^a   Steffen Heins, Anja ^b  

^a FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Benzoate; CLSM; EPR; Oil in water emulsions; Solid lipid nanoparticles (SLN); TEMPOL hyphen

Indexed keywords

EMULSIFICATION; EMULSIONS; NANOPARTICLES; OILS AND FATS; PARAMAGNETIC RESONANCE; PHASE INTERFACES; PROBES; SPIN DYNAMICS; SURFACE ACTIVE AGENTS;

BENZOATE; CLSM; CONFOCAL LASER SCANNING MICROSCOPY; ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY; ENCAPSULATED COMPOUNDS; OIL-IN-WATER EMULSIONS; SOLID LIPID NANOPARTICLE (SLN); SURFACTANT-STABILIZED;

ELECTRON SPIN RESONANCE SPECTROSCOPY;

BENZOIC ACID; EMULSIFYING AGENT; SOLID LIPID NANOPARTICLE; SURFACTANT; TEMPOL; WATER OIL CREAM;

ARTICLE; CONFOCAL LASER SCANNING MICROSCOPY; ELECTRON SPIN RESONANCE; FOOD; IMAGE ANALYSIS; LIPOPHILICITY; PRIORITY JOURNAL; SOLUBILIZATION;

EID: 85020188822     PISSN: 09277757     EISSN: 18734359     Source Type: Journal    
DOI: 10.1016/j.colsurfa.2017.05.050     Document Type: Article

References (38)

1. Oehlke, K., Adamiuk, M., Behsnilian, D., Graf, V., Mayer-Miebach, E., Walz, E., Greiner, R., Potential bioavailability enhancement of bioactive compounds using food-grade engineered nanomaterials: a review of the existing evidence. Food Funct. 5 (2014), 1341–1359.
2. Weiss, J., Decker, E., McClements, D.J., Kristbergsson, K., Helgason, T., Awad, T., Solid lipid nanoparticles as delivery systems for bioactive food components. Food Biophys. 3 (2008), 146–154.
3. Samtlebe, M., Yucel, U., Weiss, J., Coupland, J., Stability of solid lipid nanoparticles in the presence of liquid oil emulsions. J. Am. Oil Chem. Soc. 89 (2012), 609–617.
4. Luo, Y., Teng, Z., Li, Y., Wang, Q., Solid lipid nanoparticles for oral drug delivery: chitosan coating improves stability, controlled delivery, mucoadhesion and cellular uptake. Carbohydr. Polym. 122 (2015), 221–229.
5. Rivolta, I., Panariti, A., Lettiero, B., Sesana, S., Gasco, P., Gasco, M.R., Masserini, M., Miserocchi, G., Cellular uptake of coumarin-6 as a model drug loaded in solid lipid nanoparticles. J. Physiol. Pharmacol. 62 (2011), 45–53.
6. Ruiz, C.C., Hierrezuelo, J.M., Molina-Bolivar, J.A., Analysis of the photophysical behavior and rotational-relaxation dynamics of coumarin 6 in nonionic micellar environments: the effect of temperature. Molecules 20 (2015), 19343–19360.
7. Finke, J.H., Richter, C., Gothsch, T., Kwade, A., Büttgenbach, S., Müller-Goymann, C.C., Coumarin 6 as a fluorescent model drug: how to identify properties of lipid colloidal drug delivery systems via fluorescence spectroscopy?. Eur. J. Lipid Sci. Technol. 116 (2014), 1234–1246.
8. Krudopp, H., Sonnichsen, F.D., Steffen-Heins, A., Partitioning of nitroxides in dispersed systems investigated by ultrafiltration, EPR and NMR spectroscopy. J. Colloid Interface Sci. 452 (2015), 15–23.
9. Frenzel, M., Steffen-Heins, A., Impact of quercetin and fish oil encapsulation on bilayer membrane and oxidation stability of liposomes. Food Chem. 185 (2015), 48–57.
10. Berton-Carabin, C.C., Coupland, J.N., Elias, R.J., Effect of the lipophilicity of model ingredients on their location and reactivity in emulsions and solid lipid nanoparticles. Coll. Surf. A 431 (2013), 9–17.
11. Yucel, U., Elias, R.J., Coupland, J.N., Localization and reactivity of a hydrophobic solute in lecithin and caseinate stabilized solid lipid nanoparticles and nanoemulsions. J. Colloid Interface Sci. 394 (2013), 20–25.
12. Yucel, U., Elias, R.J., Coupland, J.N., Solute distribution and stability in emulsion-based delivery systems: an EPR study. J. Colloid Interface Sci. 377 (2012), 105–113.
13. Štrancar, J., Koklič, T., Arsov, Z., Filipič, B., Stopar, D., Hemminga, M.A., Spin label EPR-based characterization of biosystem complexity. J. Chem. Inf. Model. 45 (2005), 394–406.
14. Frenzel, M., Krolak, E., Wagner, A.E., Steffen-Heins, A., Physicochemical properties of WPI coated liposomes serving as stable transporters in a real food matrix. LWT – Food Sci. Technol. 63 (2015), 527–534.
15. Yucel, U., Elias, R., Coupland, J., Effect of liquid oil on the distribution and reactivity of a hydrophobic solute in solid lipid nanoparticles. J. Am. Oil Chem. Soc. 90 (2013), 819–824.
16. Ahlin, P., Kristl, J., Šentjurc, M., Štrancar, J., Pečar, S., Influence of spin probe structure on its distribution in SLN dispersions. Int. J. Pharm. 196 (2000), 241–244.
17. Ahlin, P., Sentjurc, M., Stacar, J., Kristl, J., Location of lipophilic substances and ageing of solid lipid nanoparticles. STP Pharma: J. Drug Deliv. Sci. Technol. 10 (2000), 125–132.
18. Jores, K., Mehnert, W., Mäder, K., Physicochemical investigations on solid lipid nanoparticles and on oil-loaded solid lipid nanoparticles: a nuclear magnetic resonance and electron spin resonance study. Pharm. Res. 20 (2003), 1274–1283.
19. Oehlke, K., Behsnilian, D., Mayer-Miebach, E., Weidler, P.G., Greiner, R., Edible solid lipid nanoparticles (SLN) as carrier system for antioxidants of different lipophilicity. PLoS One, 12, 2017 e0171662 https://doi.org/10.1371/journal.pone.0171662.
20. Oehlke, K., Garamus, V.M., Heins, A., Stöckmann, H., Schwarz, K., The partitioning of emulsifiers in o/w emulsions: a comparative study of SANS, ultrafiltration and dialysis. J. Colloid Interface Sci. 322 (2008), 294–303.
21. Heins, A., Garamus, V., Steffen, B., Stöckmann, H., Schwarz, K., Impact of phenolic antioxidants on structural properties of micellar solutions. Food Biophys. 1 (2006), 189–201.
22. Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., Tinevez, J.-Y., White, D.J., Hartenstein, V., Eliceiri, K., Tomancak, P., Cardona, A., Fiji: an open-source platform for biological-image analysis. Nat. Methods 9 (2012), 676–682.
23. Manders, E.M.M., Verbeek, F.J., Aten, J.A., Measurement of co-localization of objects in dual-colour confocal images. J. Microsc. 169 (1993), 375–382.
24. Costes, S.V., Daelemans, D., Cho, E.H., Dobbin, Z., Pavlakis, G., Lockett, S., Automatic and quantitative measurement of protein–protein colocalization in live cells. Biophys. J. 86 (2004), 3993–4003.
25. Tikekar, R.V., Nitin, N., Effect of physical state (solid vs. liquid) of lipid core on the rate of transport of oxygen and free radicals in solid lipid nanoparticles and emulsion. Soft Matter 7 (2011), 8149–8157.
26. Jores, K., Haberland, A., Wartewig, S., Mäder, K., Mehnert, W., Solid lipid nanoparticles (SLN) and oil-loaded SLN studied by spectrofluorometry and raman spectroscopy. Pharm. Res. 22 (2005), 1887–1897.
27. Jenning, V., Schäfer-Korting, M., Gohla, S., Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J. Controlled Release 66 (2000), 115–126.
28. Plajnšek, K.T., Pajk, S., Govedarica, B., Pečar, S., Srčič, S., Kristl, J., A novel fluorescent probe for more effective monitoring of nanosized drug delivery systems within the cells. Int. J. Pharm. 416 (2011), 384–393.
29. Yin Win, K., Feng, S.-S., Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 26 (2005), 2713–2722.
30. Yan, F., Zhang, C., Zheng, Y., Mei, L., Tang, L., Song, C., Sun, H., Huang, L., The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity nanomedicine: nanotechnology. Biol. Med. 6 (2010), 170–178.
31. Ulrih, N.P., Maričić, M., Ota, A., Šentjurc, M., Abram, V., Kaempferol and quercetin interactions with model lipid membranes. Food Res. Int. 71 (2015), 146–154.
32. Nakagawa, K., Diffusion coefficient and relaxation time of aliphatic spin probes in a unique triglyceride membrane. Langmuir 19 (2003), 5078–5082.
33. Horasan, N., Sünnetçioğlu, M.M., Sungur, R., EPR spin label study of walnut oil effects on phosphatidylcholine membranes. Chem. Phys. Lipids 140 (2006), 1–10.
34. Johansson, D., Bergenståhl, B., Lundgren, E., Wetting of fat crystals by triglyceride oil and water. 1. The effect of additives. J. Am. Oil Chem. Soc. 72 (1995), 921–931.
35. Hou, D., Xie, C., Huang, K., Zhu, C., The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials 24 (2003), 1781–1785.
36. Ghosh, S., Peterson, D., Coupland, J., Aroma release from solid droplet emulsions: effect of lipid type. J. Am. Oil Chemists' Soc. 84 (2007), 1001–1014.
37. Müller, R.H., Mäder, K., Gohla, S., Solid lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art. Eur. J. Pharm. Biopharm. 50 (2000), 161–177.
38. Zur Mühlen, A., Mehnert, W., Drug release and release mechanism of prednisolone loaded solid lipid nanoparticles. Pharmazie 53 (1998), 552–555.