Edible solid lipid nanoparticles (SLN) as carrier system for antioxidants of different lipophilicity

PLoS ONE

Volumn 12, Issue 2, 2017, Pages

  Oehlke, Kathleen ^a   Behsnilian, Diana ^a   Mayer Miebach, Esther ^a   Weidler, Peter G ^b   Greiner, Ralf ^a  

^a FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; FERULIC ACID; SOLID LIPID NANOPARTICLE; TOCOPHEROL; COUMARIC ACID; DRUG CARRIER; LIPID; NANOPARTICLE; SCAVENGER;

ANTIOXIDANT ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DELIVERY SYSTEM; ELECTRON SPIN RESONANCE; EMULSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; LIPOPHILICITY; MELTING POINT; MORPHOLOGY; NANOENCAPSULATION; NANOTECHNOLOGY; PARTICLE SIZE; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION; ZETA POTENTIAL; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; DRUG STORAGE; HUMAN; PROCEDURES; TEMPERATURE; ULTRASTRUCTURE;

ANTIOXIDANTS; CALORIMETRY, DIFFERENTIAL SCANNING; COUMARIC ACIDS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; DRUG STABILITY; DRUG STORAGE; FREE RADICAL SCAVENGERS; HUMANS; LIPIDS; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; TEMPERATURE; TOCOPHEROLS; X-RAY DIFFRACTION;

EID: 85012219130     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0171662     Document Type: Article

References (46)

1. Weiss J, Decker EA, McClements DJ, Kristbergsson K, Helgason T, Awad T. Solid lipid nanoparticles as delivery systems for bioactive food components. Food Biophysics. 2008;3(2):146-154.
2. Freitas C, Müller RH. Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase. European Journal of Pharmaceutics and Biopharmaceutics. 1999;47(2):125-132. http://dx.doi.org/10.1016/S0939-6411 (98) 00074-5. PMID: 10234536
3. Hentschel A, Gramdorf S, Müller RH, Kurz T. beta-carotene-loaded nanostructured lipid carriers. J Food Sci. 2008;73(2):N1-N6. doi: 10.1111/j.1750-3841.2007.00641.x PMID: 18298743
4. Helgason T, Awad TS, Kristbergsson K, Decker EA, McClements DJ, Weiss J. Impact of Surfactant Properties on Oxidative Stability of beta-Carotene Encapsulated within Solid Lipid Nanoparticles. J Agric Food Chem. 2009;57(17):8033-8040. doi: 10.1021/jf901682m PMID: 19691283
5. Carvalho SMD, Noronha CM, Floriani CL, Lino RC, Rocha G, Bellettini IC, et al. Optimization of alphatocopherol loaded solid lipid nanoparticles by central composite design. Industrial Crops and Products. 2013;49:278-285.
6. Campos DA, Madureira AR, Gomes AM, Sarmento B, Pintado MM. Optimization of the production of solid Witepsol nanoparticles loaded with rosmarinic acid. Colloids and Surfaces B: Biointerfaces. 2014;115:109-117. doi: 10.1016/j.colsurfb.2013.10.035 PMID: 24413308
7. Jenning V, Schäfer-Korting M, Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: Drug release properties. Journal of Controlled Release. 2000;66(2-3):115-126. doi: 10.1016/S0168-3659 (99) 00223-0 PMID: 10742573
8. Bondi M, Montana G, Craparo E, Picone P, Capuano G, Carlo MD, et al. Ferulic Acid-Loaded Lipid Nanostructures as Drug Delivery Systems for Alzheimer's Disease: Preparation, Characterization and Cytotoxicity Studies. Current Nanoscience. 2009;5(1):26-32.
9. Carbone C, Campisi A, Musumeci T, Raciti G, Bonfanti R, Puglisi G. FA-loaded lipid drug delivery systems: Preparation, characterization and biological studies. European Journal of Pharmaceutical Sciences. 2014;52(1):12-20. doi: 10.1016/j.ejps.2013.10.003 PMID: 24514450
10. Trombino S, Cassano R, Muzzalupo R, Pingitore A, Cione E, Picci N. Stearyl ferulate-based solid lipid nanoparticles for the encapsulation and stabilization of beta-carotene and alpha-tocopherol. Colloids and Surfaces B: Biointerfaces. 2009;72(2):181-187. doi: 10.1016/j.colsurfb.2009.03.032 PMID: 19410436
11. Trombino S, Cassano R, Ferrarelli T, Barone E, Picci N, Mancuso C. Trans-ferulic acid-based solid lipid nanoparticles and their antioxidant effect in rat brain microsomes. Colloids and Surfaces B: Biointerfaces. 2013;109:273-279. doi: 10.1016/j.colsurfb.2013.04.005 PMID: 23668982
12. Korkmaz E, Gokce EH, Ozer O. Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery. Acta Pharmaceutica. 2013;63(4):517-529. doi: 10. 2478/acph-2013-0039 PMID: 24451076
13. Yucel U, Elias RJ, Coupland JN. Localization and reactivity of a hydrophobic solute in lecithin and caseinate stabilized solid lipid nanoparticles and nanoemulsions. Journal of Colloid and Interface Science. 2013;394(1):20-25. doi: 10.1016/j.jcis.2012.12.042 PMID: 23352869
14. Jores K, Mehnert W, Mäder K. Physicochemical investigations on solid lipid nanoparticles and on oilloaded solid lipid nanoparticles: A nuclear magnetic resonance and electron spin resonance study. Pharmaceutical Research. 2003;20(8):1274-1283. PMID: 12948026
15. Ahlin P, Kristl J, Sentjurc M, Strancar J, Pecar S. Influence of spin probe structure on its distribution in SLN dispersions. Int J Pharm. 2000;196(2):241-244. doi: 10.1016/S0378-5173 (99) 00431-7 PMID: 10699727
16. Noack A, Hause G, Mäder K. Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles. International Journal of Pharmaceutics. 2012;423(2):440-451. doi: 10.1016/j.ijpharm.2011. 12.011 PMID: 22197758
17. Heins A, McPhail DB, Sokolowski T, Stoeckmann H, Schwarz K. The location of phenolic antioxidants and radicals at interfaces determines their activity. Lipids. 2007;42(6):573-582. doi: 10.1007/s11745-007-3052-6 PMID: 17473943
18. Berton-Carabin CC, Coupland JN, Elias RJ. Effect of the lipophilicity of model ingredients on their location and reactivity in emulsions and solid lipid nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2013;431(0):9-17. http://dx.doi.org/10.1016/j.colsurfa.2013.04.016.
19. Lacatusu I, Badea N, Murariu A, Oprea O, Bojin D, Meghea A. Antioxidant activity of solid lipid nanoparticles loaded with umbelliferone. Soft Materials. 2013;11(1):75-84. doi: 10.1080/1539445X.2011. 582914
20. Dingler A, Blum RP, Niehus H, Müller RH, Gohla S. Solid lipid nanoparticles (SLN (TM)/Lipopearls (TM)) -a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products. Journal of Microencapsulation. 1999;16(6):751-767. doi: 10.1080/026520499288690 PMID: 10575627
21. Gokce EH, Korkmaz E, Dellera E, Sandri G, Bonferoni MC, Ozer O. Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: Evaluation of antioxidant potential for dermal applications. International Journal of Nanomedicine. 2012;7:1841-1850. doi: 10.2147/IJN. S29710 PMID: 22605933
22. Aditya NP, Macedo AS, Doktorovova S, Souto EB, Kim S, Chang PS, et al. Development and evaluation of lipid nanocarriers for quercetin delivery: A comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE). LWT-Food Science and Technology. 2014;59(1):115-121. doi: 10.1016/j.lwt.2014.04.058
23. Bose S, Du Y, Takhistov P, Michniak-Kohn B. Formulation optimization and topical delivery of quercetin from solid lipid based nanosystems. International Journal of Pharmaceutics. 2013;441(1-2):56-66. doi: 10.1016/j.ijpharm.2012.12.013 PMID: 23262430
24. Helgason T, Awad TS, Kristbergsson K, McClements DJ, Weiss J. Influence of polymorphic transformations on gelation of tripalmitin solid lipid nanoparticle suspensions. Journal of the American Oil Chemists' Society: 85 (6) 501-511. 2008;85(6):501-511. doi: 10.1007/s11746-008-1219-9
25. Seetapan N, Bejrapha P, Srinuanchai W, Ruktanonchai UR. Rheological and morphological characterizations on physical stability of gamma-oryzanol-loaded solid lipid nanoparticles (SLNs). Micron. 2010;41(1):51-58. doi: 10.1016/j.micron. 2009.08.003 PMID: 19726202
26. Zimmermann E, Müller RH. Electrolyte-and pH-stabilities of aqueous solid lipid nanoparticle (SLN) dispersions in artificial gastrointestinal media. European Journal of Pharmaceutics and Biopharmaceutics. 2001;52(2):203-210. doi: 10.1016/S0939-6411 (01) 00167-9 PMID: 11522487
27. Oehlke K, Heins A, Stöckmann H, Schwarz K. Impact of emulsifier microenvironments on acid-base equilibrium and activity of antioxidants. Food Chemistry. 2010;118(1):48-55. doi: 10.1016/j.foodchem. 2009.04.078
28. Heins A, Sokolowski T, Stoeckmann H, Schwarz K. Investigating the location of propyl gallate at surfaces and its chemical microenvironment by 1H NMR. Lipids. 2007;42(6):561-572. doi: 10.1007/s11745-007-3053-5 PMID: 17447096
29. Niculae G, Lacatusu I, Bors A, Stan R. Photostability enhancement by encapsulation of alpha-tocopherol into lipid-based nanoparticles loaded with a UV filter. Comptes Rendus Chimie. 2014;.
30. Oehlke K, Heins A, Stöckmann H, Sönnichsen F, Schwarz K. New insights into the antioxidant activity of Trolox in o/w emulsions. Food Chemistry. 2011;124(3):781-787. doi: 10.1016/j.foodchem.2010.06. 095
31. Sonnen AFP, Bakirci H, Netscher T, Nau WM. Effect of Temperature, Cholesterol Content, and Antioxidant Structure on the Mobility of Vitamin E Constituents in Biomembrane Models Studied by Laterally Diffusion-Controlled Fluorescence Quenching. Journal of the American Chemical Society. 2005;127(44):15575-15584. doi: 10.1021/ja054367l PMID: 16262423
32. Lavigne F, Bourgaux C, Ollivon M. Phase transitions of saturated triglycerides. Journal de Physique IV. 1993;3(C8):C8-137-C8-140. doi: 10.1051/jp4:1993825
33. Rousseau D, Hodge SM, Nickerson MT, Paulson AT. Regulating the β'→β polymorphic transition in food fats. Journal of the American Oil Chemists' Society. 2005;82(1):7-12.
34. Bunjes H, Unruh T. Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering. Advanced Drug Delivery Reviews. 2007;59(6):379-402. doi: 10.1016/j.addr. 2007.04.013 PMID: 17658653
35. Bunjes H, Koch MHJ, Westesen K. Effect of particle size on colloidal solid triglycerides. Langmuir. 2000;16(12):5234-5241. doi: 10.1021/la990856l
36. Unruh T, Bunjes H, Westesen K, Koch MHJ. Investigations on the melting behaviour of triglyceride nanoparticles. Colloid and Polymer Science. 2001;279(4):398. doi: 10.1007/s003960000436
37. Bunjes H. Structural properties of solid lipid based colloidal drug delivery systems. Current Opinion in Colloid & Interface Science. 2011;16(5):405-411. http://dx.doi.org/10.1016/j.cocis.2011.06.007.
38. Oh JH, McCurdy AR, Clark S, Swanson BG. Stabilizing polymorphic transitions of tristearin using diacylglycerols and sucrose polyesters. JAOCS, Journal of the American Oil Chemists' Society. 2005;82(1):13-19. doi: 10.1007/s11746-005-1036-y
39. Elisabettini P, Desmedt A, Durant F. Polymorphism of stabilized and nonstabilized tristearin, pure and in the presence of food emulsifiers. JAOCS, Journal of the American Oil Chemists' Society. 1996;73(2):187-192. doi: 10.1007/BF02523893
40. Helgason T, Awad TS, Kristbergsson K, McClements DJ, Weiss J. Effect of surfactant surface coverage on formation of solid lipid nanoparticles (SLN). Journal of Colloid and Interface Science. 2009;334(1):75-81. doi: 10.1016/j.jcis.2009.03.012 PMID: 19380149
41. Oh JH, McCurdy AR, Clark S, Swanson BG. Characterization and thermal stability of polymorphic forms of synthesized tristearin. Journal of Food Science. 2002;67(8):2911-2917. doi: 10.1111/j.1365-2621.2002.tb08837.x
42. Dijkstra AJ, Quinn PJ, Foubert I, de Walle DV, Dewettinck K. Physical Properties. In: Lipid Handbook. CRC Press; 2007. doi: 10.1201/9781420009675.ch7
43. Jores K, Haberland A, Wartewig S, Mäder K, Mehnert W. Solid lipid nanoparticles (SLN) and oil-loaded SLN studied by spectrofluorometry and raman spectroscopy. Pharmaceutical Research. 2005;22(11):1887-1897. doi: 10.1007/s11095-005-7148-1 PMID: 16132349
44. Westesen K, Bunjes H, Koch MHJ. Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential. Journal of Controlled Release. 1997;48(2-3):223-236. doi: 10.1016/S0168-3659 (97) 00046-1
45. Nik AM, Langmaid S, Wright AJ. Nonionic Surfactant and Interfacial Structure Impact Crystallinity and Stability of beta-Carotene Loaded Lipid Nanodispersions. J Agric Food Chem. 2012;60(16):4126-4135. doi: 10.1021/jf204810m PMID: 22401532
46. Sánchez-Paz V, Pastoriza-Gallego MJ, Losada-Barreiro S, Bravo-Díaz C, Gunaseelan K, Romsted LS. Quantitative determination of α-tocopherol distribution in a tributyrin/Brij 30/water model food emulsion. Journal of Colloid and Interface Science. 2008;320(1):1-8. doi: 10.1016/j.jcis.2007.12.018 PMID: 18206901