Promising Therapeutic Strategies for Mesenchymal Stem Cell-Based Cardiovascular Regeneration: From Cell Priming to Tissue Engineering

Stem Cells International

Volumn 2017, Issue , 2017, Pages

  Ji, Seung Taek ^a   Kim, Hyunyun ^a   Yun, Jisoo ^a   Chung, Joo Seop ^a   Kwon, Sang Mo ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; GLUCAGON LIKE PEPTIDE 1; GOLD NANOPARTICLE; SILICA NANOPARTICLE; SILICON DIOXIDE; VASCULOTROPIN;

ACUTE HEART INFARCTION; ARTICLE; CARDIAC MUSCLE CELL; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CELL BASED GENE THERAPY; CELL DIFFERENTIATION; CELL HOMING; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL STUDY; CORONARY ARTERY ATHEROSCLEROSIS; HEART FAILURE; HUMAN; ISCHEMIC CARDIOMYOPATHY; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PHOTOTHERMAL THERAPY; THREE DIMENSIONAL PRINTING; TISSUE ENGINEERING; TISSUE REGENERATION;

EID: 85020177951     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2017/3945403     Document Type: Article

References (119)

1. GBD 2013 Mortality and Causes of Death Collaborators, "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 cause of death, 1990-2013: A systematic analysis for the global burden of disease study 2013, " The Lancet, vol. 385, no. 9963, pp. 117-171, 2015.
2. A. E. Guttmacher, F. S. Collins, andE. G. Nabel, "Cardiovascular disease, " New England Journal of Medicine, vol. 349, no. 1, pp. 60-72, 2003.
3. C. Meads, C. Cummins, K. Jolly, A. Stevens, A. Burls, and C. Hyde, "Coronary artery stents in the treatment of ischaemic heart disease: A rapid and systematic review, " Health Technology Assessment, vol. 4, no. 23, pp. 1-153, 2000.
4. T. D. Henry, B. H. Annex, G. R. McKendall et al., "The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis, " Circulation, vol. 107, no. 10, pp. 1359-1365, 2003.
5. A. Rozanski, J. A. Blumenthal, and J. Kaplan, "Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy, " Circulation, vol. 99, no. 16, pp. 2192-2217, 1999.
6. V. F. M. Segers and R. T. Lee, "Stem-cell therapy for cardiac disease, " Nature, vol. 451, no. 7181, pp. 937-942, 2008.
7. K. W. Liechty, T. C. MacKenzie, A. F. Shaaban et al., "Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep, " Nature Medicine, vol. 6, no. 11, pp. 1282-1286, 2000.
8. M. F. Pittenger and B. J. Martin, "Mesenchymal stem cells and their potential as cardiac therapeutics, " Circulation Research, vol. 95, no. 1, pp. 9-20, 2004.
9. M. F. Pittenger, A. M. Mackay, S. C. Beck et al., "Multilineage potential of adult human mesenchymal stem cells, " Science, vol. 284, no. 5411, pp. 143-147, 1999.
10. I. Ullah, R. B. Subbarao, and G. J. Rho, "Human mesenchymal stem cells-current trends and future prospective, " Bioscience Reports, vol. 35, Article ID e00191, 2015.
11. C. Nombela-Arrieta, J. Ritz, and L. E. Silberstein, "The elusive nature and function ofmesenchymal stem cells, " Nature Reviews Molecular Cell Biology, vol. 12, no. 2, pp. 126-131, 2011.
12. R. Atoui and R. C. J. Chiu, "Mesenchymal stromal cells as universal donor cells, "ExpertOpiniononBiologicalTherapy, vol. 12, no. 10, pp. 1293-1297, 2012.
13. W. Faiella and R. Atoui, "Therapeutic use of stem cells for cardiovascular disease, "Clinical and TranslationalMedicine, vol. 5, no. 1, article 34, 2016.
14. K. Le Blanc, C. Tammik, K. Rosendahl, E. Zetterberg, and O. Ringdén, "HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells, " Experimental Hematology, vol. 31, no. 10, pp. 890-896, 2003.
15. J. Stagg, S. Pommey, N. Eliopoulos, andJ. Galipeau, "Interferon-stimulated marrow stromal cells: A new type of nonhematopoietic antigen-presenting cell, " Blood, vol. 107, no. 6, pp. 2570-2577, 2006.
16. D. M. Patel, J. Shah, and A. S. Srivastava, "Therapeutic potential of mesenchymal stem cells in regenerative medicine, " StemCells International, vol. 2013, Article ID 496218, 15 pages, 2013.
17. L. Li, X. Chen, W. E. Wang, and C. Zeng, "How to improve the survival of transplanted mesenchymal stem cell in ischemic heart" Stem Cells International, vol. 2016, Article ID 9682757, 14 pages, 2016.
18. J. M. KarpandG. S. L. Teo, "Mesenchymal stemcell homing: The devil is in the details, " Cell Stem Cell, vol. 4, no. 3, pp. 206-216, 2009.
19. P. R. Baraniak and T. C. McDevitt, "Stem cell paracrine actions and tissue regeneration, " RegenerativeMedicine, vol. 5, no. 1, pp. 121-143, 2010.
20. N. Zippel, M. Schulze, and E. Tobiasch, "Biomaterials and mesenchymal stem cells for regenerative medicine, " Recent patents on biotechnology, vol. 4, no. 1, pp. 1-22, 2010.
21. A. I. Caplan, "Mesenchymal stem cells, " Journal of Orthopaedic Research, vol. 9, no. 5, pp. 641-650, 1991.
22. A. J. Friedenstein, R. K. Chailakhjan, and K. S. Lalykina, "The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells, " Cell and Tissue Kinetics, vol. 3, no. 4, pp. 393-403, 1970.
23. A. J. Friedenstein, U. F. Gorskaja, and N. N. Kulagina, "Fibroblast precursors in normal and irradiated mouse hematopoietic organs, " Experimental Hematology, vol. 4, no. 5, pp. 267-274, 1976.
24. R. Hass, C. Kasper, S. Böhm, and R. Jacobs, "Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC, " Cell Communication and Signaling, vol. 9, article 12, 2011.
25. A. P. Franco Lambert, A. Fraga Zandonai, D. Bonatto, D. CantarelliMachado, and J. A. PêgasHenriques, "Differentiation of human adipose-derived adult stemcells into neuronal tissue: does it work" Differentiation, vol. 77, no. 3, pp. 221-228, 2009.
26. S. Gronthos, D. M. Franklin, H. A. Leddy, P. G. Robey, R. W. Storms, and J. M. Gimble, "Surface protein characterization of human adipose tissue-derived stromal cells, " Journal of Cellular Physiology, vol. 189, no. 1, pp. 54-63, 2001.
27. A.-M. Rodriguez, C. Elabd, E.-Z. Amri, G. Ailhaud, and C. Dani, "Thehuman adipose tissue is a source ofmultipotent stem cells, " Biochimie, vol. 87, no. 1, pp. 125-128, 2005.
28. B. Lindroos, S. Boucher, L. Chase et al., "Serum-free, xeno-free culture media maintain the proliferation rate and multipotentiality of adipose stem cells in vitro, " Cytotherapy, vol. 11, no. 7, pp. 958-972, 2009.
29. S. Schreml, P. Babilas, S. Fruth et al., "Harvesting human adipose tissue-derived adult stem cells: resection versus liposuction, " Cytotherapy, vol. 11, no. 7, pp. 947-957, 2009.
30. L. Sensebé and P. Bourin, "Mesenchymal stem cells for therapeutic purposes, " Transplantation, vol. 87, no. 9S, pp. S49-53, 2009.
31. S. Alsalameh, R. Amin, T. Gemba, and M. Lotz, "Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage, " Arthritis and Rheumatism, vol. 50, no. 5, pp. 1522-1532, 2004.
32. K. Hiraoka, S. Grogan, T. Olee, and M. Lotz, "Mesenchymal progenitor cells in adult human articular cartilage, " Biorheology, vol. 43, no. 3-4, pp. 447-454, 2006.
33. M. Secco, Y. B. Moreira, E. Zucconi et al., "Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood, " Stem Cell Reviews and Reports, vol. 5, no. 4, pp. 387-401, 2009.
34. M. Jäger, C. Zilkens, B. Bittersohl, and R. Krauspe, "Cord blood-an alternative source for bone regeneration, " Stem Cell Reviews and Reports, vol. 5, no. 3, pp. 266-277, 2009.
35. K. Bieback and H. Klüter, "Mesenchymal stromal cells from umbilical cord blood, " Current StemCell Research andTherapy, vol. 2, no. 4, pp. 310-323, 2007.
36. C. Campagnoli, I. A. G. Roberts, S. Kumar, P. R. Bennett, I. Bellantuono, and N. M. Fisk, "Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow, " Blood, vol. 98, no. 8, pp. 2396-2402, 2001.
37. N. J. Zvaifler, L. Marinova-Mutafchieva, G. Adams et al., "Mesenchymal precursor cells in the blood of normal individuals, " Arthritis Research, vol. 2, no. 6, pp. 477-488, 2000.
38. L. da Silva Meirelles, P. C. Chagastelles, and N. B. Nardi, "Mesenchymal stem cells reside in virtually all post-natal organs and tissues, " Journal of Cell Science, vol. 119, no. 11, pp. 2204-2213, 2006.
39. M. Dominici, K. Le Blanc, I. Mueller et al., "Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement, " Cytotherapy, vol. 8, no. 4, pp. 315-317, 2006.
40. E. M. Horwitz, K. Le Blanc, M. Dominici et al., "Clarification of the nomenclature for MSC: The International Society for CellularTherapy position statement, " Cytotherapy, vol. 7, no. 5, pp. 393-395, 2005.
41. S. E. Haynesworth, M. A. Barer, and A. I. Caplan, "Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies, " Bone, vol. 13, no. 1, pp. 69-80, 1992.
42. P. A. Conget and J. J. Minguell, "Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells, " Journal of Cellular Physiology, vol. 181, no. 1, pp. 67-73, 1999.
43. J.-H. Hong, E. S. Hwang, M. T. McManus et al., "TAZ, a transcriptional modulator of mesenchymal stem cell differentiation, " Science, vol. 309, no. 5737, pp. 1074-1078, 2005.
44. A. I. Caplan and S. P. Bruder, "Mesenchymal stem cells: building blocks for molecular medicine in the 21st century, " Trends in Molecular Medicine, vol. 7, no. 6, pp. 259-264, 2001.
45. B. Short, N. Brouard, T. Occhiodoro-Scott, A. Ramakrishnan, and P. J. Simmons, "Mesenchymal stem cells, " Archives of Medical Research, vol. 34, no. 6, pp. 565-571, 2003.
46. A. Augello and C. De Bari, "The regulation of differentiation in mesenchymal stem cells, " Human GeneTherapy, vol. 21, no. 10, pp. 1226-1238, 2010.
47. H. Song, W. Chang, B. W. Song, and K. C. Hwang, "Specific differentiation of mesenchymal stem cells by small molecules, " American Journal of Stem Cells, vol. 1, no. 1, pp. 22-30, 2012.
48. I. Mahjneh, M.-R. Passos-Bueno, M. Zatz et al., "The phenotype of chromosome 2p-linked limb-girdle muscular dystrophy, " Neuromuscular Disorders, vol. 6, no. 6, pp. 483-490, 1996.
49. A. M. Mackay, S. C. Beck, J. M. Murphy, F. P. Barry, C. O. Chichester, and M. F. Pittenger, "Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow, " Tissue Engineering, vol. 4, no. 4, pp. 415-428, 1998.
50. Y. Sato, H. Araki, J. Kato et al., "Humanmesenchymal stemcells xenografted directly to rat liver are differentiated into human hepatocytes without fusion, " Blood, vol. 106, no. 2, pp. 756-763, 2005.
51. C. Toma, M. F. Pittenger, K. S. Cahill, B. J. Byrne, and P. D. Kessler, "Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart, " Circulation, vol. 105, no. 1, pp. 93-98, 2002.
52. A. R. Williams and J. M. Hare, "Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease, " Circulation Research, vol. 109, no. 8, pp. 923-940, 2011.
53. W. Xu, X. Zhang, H. Qian et al., "Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro, " Experimental Biology and Medicine, vol. 229, no. 7, pp. 623-631, 2004.
54. Y. S. Kim, J. S. Kwon, M. H. Hong et al., "Promigratory activityof oxytocin on umbilical cord blood-derived mesenchymal stem cells, " Artificial Organs, vol. 34, no. 6, pp. 453-461, 2010.
55. S. Y. Lim, Y. S. Kim, Y. Ahn et al., "The effects of mesenchymal stem cells transduced with Akt in a porcine myocardial infarctionmodel, " Cardiovascular Research, vol. 70, no. 3, pp. 530-542, 2006.
56. H. C. Quevedo, K. E. Hatzistergos, B. N. Oskouei et al., "Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity, " Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 33, pp. 14022-14027, 2009.
57. D. Wang, F. Zhang, W. Shen et al., "Mesenchymal stem cell injection ameliorates the inducibility of ventricular arrhythmias after myocardial infarction in rats, " International Journal of Cardiology, vol. 152, no. 3, pp. 314-320, 2011.
58. J. M. Hare, J. H. Traverse, T. D. Henry et al., "A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction, " Journal of the American College of Cardiology, vol. 54, no. 24, pp. 2277-2286, 2009.
59. B. Trachtenberg, D. L. Velazquez, A. R. Williams et al., "Rationale and design of the transendocardial injection of autologous human cells (bone marrow or mesenchymal) in chronic ischemic left ventricular dysfunction and heart failure secondary to myocardial infarction (TAC-HFT) trial: A randomized, double-blind, placebo-controlled study of safety and efficacy, " American Heart Journal, vol. 161, no. 3, pp. 487-493, 2011.
60. J. M. Hare, "Translational development of mesenchymal stem cell therapy for cardiovascular diseases, " Texas Heart Institute Journal, vol. 36, no. 2, pp. 145-147, 2009.
61. C. Sanina and J. M. Hare, "Mesenchymal stem cells as a biological drug for heart disease: where are we with cardiac cellbased therapy" Circulation Research, vol. 117, no. 3, pp. 229-233, 2015.
62. T. Squillaro, G. Peluso, and U. Galderisi, "Clinical trials with mesenchymal stem cells: An update, " Cell Transplantation, vol. 25, no. 5, pp. 829-848, 2016.
63. A. B. Mathiasen, M. Haack-Sørensen, E. Jørgensen, and J. Kastrup, "Autotransplantation of mesenchymal stromal cells from bone-marrow to heart in patients with severe stable coronary artery disease and refractory angina-final 3-year follow-up, " International Journal of Cardiology, vol. 170, no. 2, pp. 246-251, 2013.
64. A. R. Williams, B. Trachtenberg, D. L. Velazquez et al., "Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling, " Circulation Research, vol. 108, no. 7, pp. 792-796, 2011.
65. J.-W. Lee, S.-H. Lee, Y.-J. Youn et al., "A randomized, openlabel, multicenter trial for the safety and efficacy of adult mesenchymal stem cells after acute myocardial infarction, " Journal of KoreanMedical Science, vol. 29, no. 1, pp. 23-31, 2014.
66. M. Gyöngyösi, W. Wojakowski, P. Lemarchand et al., "Metaanalysis of cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data, " Circulation Research, vol. 116, no. 8, pp. 1346-1360, 2015.
67. A. N. Kharlamov, A. E. Tyurnina, V. S. Veselova, O. P. Kovtun, V. Y. Shur, and J. L. Gabinsky, "Silica-gold nanoparticles for atheroprotectivemanagement of plaques: results of theNANOM-FIM trial, " Nanoscale, vol. 7, no. 17, pp. 8003-8015, 2015.
68. J. M. Hare, J. E. Fishman, G. Gerstenblith et al., "Comparison of allogeneic vs autologous bonemarrow-derivedmesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: The POSEIDON randomized trial, " The Journal of the AmericanMedical Association, vol. 308, no. 22, pp. 2369-2379, 2012.
69. A. W. Heldman, D. L. DiFede, J. E. Fishman et al., "Transendocardialmesenchymal stem cells and mononuclear bonemarrow cells for ischemic cardiomyopathy: The TAC-HFT randomized trial, " JAMA, vol. 311, no. 1, pp. 62-73, 2014.
70. V. Karantalis, D. L. Difede, G. Gerstenblith et al., "Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS) trial, " Circulation Research, vol. 114, no. 8, pp. 1302-1310, 2014.
71. T. Matsui, J. Tao, F. DelMonte et al., "Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo, " Circulation, vol. 104, no. 3, pp. 330-335, 2001.
72. A. A. Mangi, N. Noiseux, D. Kong et al., "Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts, " Nature Medicine, vol. 9, no. 9, pp. 1195-1201, 2003.
73. K. Tamama, V. H. Fan, L. G. Griffith, H. C. Blair, and A. Wells, "Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells, " Stem Cells, vol. 24, no. 3, pp. 686-695, 2006.
74. V. H. Fan, A. Au, K. Tamama et al., "Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells, " Stem Cells, vol. 25, no. 5, pp. 1241-1251, 2007.
75. H. L. Michalis Mastri and T. Lee, "Enhancing the efficacy of mesenchymal stem cell therapy, " World Journal of Stem Cells, vol. 6, no. 2, pp. 82-93, 2014.
76. D. S. Yoon, Y. H. Kim, H. S. Jung, S. Paik, and J. W. Lee, "Importance of Sox2 in maintenance of cell proliferation and multipotency of mesenchymal stem cells in low-density culture, " Cell Proliferation, vol. 44, no. 5, pp. 428-440, 2011.
77. T. M. Liu, Y. N. Wu, X. M. Guo, J. H. P. Hui, E. H. Lee, and B. Lim, "Effects of ectopic nanog and Oct4 overexpression on mesenchymal stem cells, " Stem Cells and Development, vol. 18, no. 7, pp. 1013-1022, 2009.
78. S.-M. Han, S.-H. Han, Y.-R. Coh et al., "Enhanced proliferation and differentiation of Oct4-And Sox2-overexpressing human adipose tissue mesenchymal stem cells, " Experimental and Molecular Medicine, vol. 46, no. 6, article no. e101, 2014.
79. Y. Komiya and R. Habas, "Wnt signal transduction pathways, " Organogenesis, vol. 4, no. 2, pp. 68-75, 2008.
80. R. Nusse, "Wnt signaling and stem cell control, " Cell Research, vol. 18, no. 5, pp. 523-527, 2008.
81. F. J. T. Staal and T. C. Luis, "Wnt signaling in hematopoiesis: crucial factors for self-renewal, proliferation, and cell fate decisions, " Journal of Cellular Biochemistry, vol. 109, no. 5, pp. 844-849, 2010.
82. G. M. Boland, G. Perkins, D. J. Hall, andR. S. Tuan, "Wnt 3apromotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells, " Journal of Cellular Biochemistry, vol. 93, no. 6, pp. 1210-1230, 2004.
83. Z. Zhu, J. Yin, J. Guan et al., "Lithium stimulates human bone marrow derived mesenchymal stem cell proliferation through GSK-3-dependent-catenin/Wnt pathway activation, " FEBS Journal, vol. 281, no. 23, pp. 5371-5389, 2014.
84. S. Guan, Z. Wang, F. Xin, and H. Xin, "Wnt5a is associated with the differentiation of bone marrow mesenchymal stem cells in vascular calcification by connecting with different receptors, " Molecular Medicine Reports, vol. 10, no. 4, pp. 1985-1991, 2014.
85. R. Bilkovski, D. M. Schulte, F. Oberhauser et al., "Role of Wnt-5a in the determination of human mesenchymal stem cells into preadipocytes, " The Journal of Biological Chemistry, vol. 285, no. 9, pp. 6170-6178, 2010.
86. L. Hong, G. Zhang, H. Sultana, Y. Yu, and Z. Wei, "The effects of 17-estradiol on enhancing proliferation of human bone marrow mesenchymal stromal cells in vitro, " Stem Cells and Development, vol. 20, no. 5, pp. 925-931, 2011.
87. Z. Cheng, L. Ou, X. Zhou et al., "Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance, " Molecular Therapy, vol. 16, no. 3, pp. 571-579, 2008.
88. S. Y. Oh, S.-J. Lee, Y. H. Jung, H. J. Lee, and H. J. Han, "Arachidonic acid promotes skin wound healing through induction of humanMSC migration by MT3-MMP-mediated fibronectin degradation, " Cell Death and Disease, vol. 6, no. 5, 2015.
89. T. J. Kean, L. Duesler, R. G. Young et al., "Development of a peptide-targeted, myocardial ischemia-homing, mesenchymal stem cell, " Journal of Drug Targeting, vol. 20, no. 1, pp. 23-32, 2012.
90. J. Liu, P. Zhu, P. Song et al., "Pretreatment of adipose derived stem cells with curcumin facilitates myocardial recovery via antiapoptosis and angiogenesis, " Stem Cells International, vol. 2015, Article ID638153, 12 pages, 2015.
91. X.-B. Liu, H. Chen, H.-Q. Chen et al., "Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation, " Journal of Zhejiang University: Science B, vol. 13, no. 8, pp. 616-623, 2012.
92. H. K. Haider and M. Ashraf, "Preconditioning and stem cell survival, " Journal of Cardiovascular Translational Research, vol. 3, no. 2, pp. 89-102, 2010.
93. B. Balana, C. Nicoletti, I. Zahanich et al., "5-Azacytidine induces changes in electrophysiological properties of human mesenchymal stem cells, " Cell Research, vol. 16, no. 12, pp. 949-960, 2006.
94. Y. Liu, J. Song, W. Liu, Y. Wan, X. Chen, and C. Hu, "Growth and differentiation of rat bone marrow stromal cells: does 5-azacytidine trigger their cardiomyogenic differentiation" Cardiovascular Research, vol. 58, no. 2, pp. 460-468, 2003.
95. H. Gai, E. L.-H. Leung, P. D. Costantino et al., "Generation and characterization of functional cardiomyocytes using induced pluripotent stem cells derived from human fibroblasts, " Cell Biology International, vol. 33, no. 11, pp. 1184-1193, 2009.
96. Z. Bin, L.-G. Sheng, Z.-C. Gang et al., "Efficient cardiomyocyte differentiation of embryonic stem cells by bone morphogenetic protein-2 combined with visceral endoderm-like cells, " Cell Biology International, vol. 30, no. 10, pp. 769-776, 2006.
97. J. Hou, A.-L. Lü, B.-W. Liu et al., "Combination of BMP-2 and 5-AZAis advantageous in rat bone marrow-derived mesenchymal stem cells differentiation into cardiomyocytes, " Cell Biology International, vol. 37, no. 12, pp. 1291-1299, 2013.
98. C. Liu, Y. Fan, L. Zhou et al., "Pretreatment of mesenchymal stem cells with angiotensin II enhances paracrine effects, angiogenesis, gap junction formation and therapeutic efficacy for myocardial infarction, " International Journal of Cardiology, vol. 188, no. 1, pp. 22-32, 2015.
99. J. H. Lee, J. M. Ryu, Y.-S. Han et al., "Fucoidan improves bioactivity and vasculogenic potential of mesenchymal stem cells in murine hind limb ischemia associated with chronic kidney disease, " Journal of Molecular and Cellular Cardiology, vol. 97, pp. 169-179, 2016.
100. M. T. Elnakish, F. Hassan, D. Dakhlallah, C. B. Marsh, I. A. Alhaider, and M. Khan, "Mesenchymal stem cells for cardiac regeneration: Translation to bedside reality, " Stem Cells International, vol. 2012, Article ID 646038, 14 pages, 2012.
101. M. Breitbach, T. Bostani, W. Roell et al., "Potential risks of bone marrow cell transplantation into infarcted hearts, " Blood, vol. 110, no. 4, pp. 1362-1369, 2007.
102. J. C. Bernhard and G. Vunjak-Novakovic, "Should we use cells, biomaterials, or tissue engineering for cartilage regeneration" Stem Cell Research andTherapy, vol. 7, no. 1, article 56, 2016.
103. K. J. Kim, Y. A. Joe, M. K. Kim et al., "Silica nanoparticles increase human adipose tissue-derived stem cell proliferation through ERK1/2 activation, " International Journal of Nanomedicine, vol. 10, pp. 2261-2272, 2015.
104. K. J. Kim, Y.-J. Jeon, J. H. Lee, and J.-W. Rhie, "The effect of silicon ion on proliferation and osteogenic differentiation of human ADSCs, " Korean Tissue Engineering and Regenerative Medicine Society, vol. 7, no. 2, pp. 171-177, 2010.
105. L. Ning, H. Malmström, and Y.-F. Ren, "Porous collagen-Hydroxyapatite scaffolds withmesenchymal stemcells for bone regeneration, " Journal of Oral Implantology, vol. 41, no. 1, pp. 45-49, 2015.
106. Y.-S. Zhang, J.-H. Gao, F. Lu, M. Zhu, and Y.-J. Liao, "Cellular compatibility of type collagen I scaffold and human adiposederived stemcells, "Nan Fang Yi Ke Da XueXue Bao, vol. 27, no. 2, pp. 223-225, 2007.
107. M. Ishii, R. Shibata, Y. Numaguchi et al., "Enhanced angiogenesis by transplantation of mesenchymal stem cell sheet created by a novel magnetic tissue engineering method, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 10, pp. 2210-2215, 2011.
108. I.-S. Yoon, C. W. Chung, J.-H. Sung et al., "Proliferation and chondrogenic differentiation of human adipose-derived mesenchymal stem cells in porous hyaluronic acid scaffold, " Journal of Bioscience and Bioengineering, vol. 112, no. 4, pp. 402-408, 2011.
109. R. Yao, R. Zhang, J. Luan, and F. Lin, "Alginate and alginate/ gelatin microspheres for human adipose-derived stem cell encapsulation and differentiation, " Biofabrication, vol. 4, no. 2, Article ID 025007, 2012.
110. N.-C. Cheng, S. Wang, and T.-H. Young, "The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities, " Biomaterials, vol. 33, no. 6, pp. 1748-1758, 2012.
111. J. R. Mauney, T. Nguyen, K. Gillen, C. Kirker-Head, J. M. Gimble, and D. L. Kaplan, "Engineering adipose-like tissue in vitro and in vivo utilizing human bone marrow and adiposederived mesenchymal stem cells with silk fibroin 3D scaffolds, " Biomaterials, vol. 28, no. 35, pp. 5280-5290, 2007.
112. H. Zhang, S.-J. Zhu, W. Wang, Y.-J. Wei, and S.-S. Hu, "Transplantation of microencapsulated genetically modified xenogeneic cells augments angiogenesis and improves heart function, " GeneTherapy, vol. 15, no. 1, pp. 40-48, 2008.
113. Y. Wang, G. Zhang, Y. Hou et al., "Transplantation of microencapsulated Schwann cells andmesenchymal stem cells augment angiogenesis and improve heart function, "Molecular and Cellular Biochemistry, vol. 366, no. 1-2, pp. 139-147, 2012.
114. J. M. Rosenstein, J. M. Krum, and C. Ruhrberg, "VEGF in the nervous system, " Organogenesis, vol. 6, no. 2, pp. 107-114, 2010.
115. J. H. Houtgraaf, R. de Jong, K. Monkhorst et al., "Feasibility of intracoronary GLP-1 eluting cellbead- infusion in acute myocardial infarction, " Cell Transplantation, vol. 22, no. 3, pp. 535-543, 2013.
116. M. F. Berry and J. Friedberg, "Chest wall/diaphragmatic complications, " Thoracic Surgery Clinics, vol. 16, no. 3, pp. 277-285, 2006.
117. H.-J. Wei, C.-H. Chen, W.-Y. Lee et al., "Bioengineered cardiac patch constructed from multilayered mesenchymal stem cells for myocardial repair, " Biomaterials, vol. 29, no. 26, pp. 3547-3556, 2008.
118. H.-W. Kang, S. J. Lee, I. K. Ko, C. Kengla, J. J. Yoo, and A. Atala, "A 3D bioprinting system to produce human-scale tissue constructs with structural integrity, " Nature Biotechnology, vol. 34, no. 3, pp. 312-319, 2016.
119. D. B. Kolesky, K. A. Homan, M. A. Skylar-Scott, and J. A. Lewis, "Three-dimensional bioprinting of thick vascularized tissues, " Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 12, pp. 3179-3184, 2016.