Mesenchymal stem cell injection ameliorates the inducibility of ventricular arrhythmias after myocardial infarction in rats

International Journal of Cardiology

Volumn 152, Issue 3, 2011, Pages 314-320

  Wang, Deguo ^a   Zhang, Fengxiang ^a   Shen, Wenzhi ^a   Chen, Minglong ^a   Yang, Bing ^a   Zhang, Yuzhen ^a   Cao, Kejiang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Acute Myocardial Infarction (AMI); Connexin 43 (Cx43); Mesenchymal stem cells (MSCs); Ventricular arrhythmias (VAs)

Indexed keywords

CARBOHYDRATE; CONNEXIN 43;

ACTIVATION TIME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CARDIOVASCULAR PARAMETERS; COLLAGEN METABOLISM; CONTROLLED STUDY; ELECTROSTIMULATION; FEMALE; HEART ELECTROPHYSIOLOGY; HEART INFARCTION; HEART MUSCLE FIBROSIS; HEART MUSCLE POTENTIAL; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EFFECTIVE REFRACTORY PERIOD; HEART VENTRICLE FIBRILLATION THRESHOLD; HEART VENTRICLE TACHYCARDIA; HISTOLOGY; MALE; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL TRANSPLANTATION;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MYOCARDIAL INFARCTION; RANDOM ALLOCATION; RATS; TACHYCARDIA, VENTRICULAR;

EID: 80055045664     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2010.07.025     Document Type: Article

References (36)

1. J.M. Pinto, and P.A. Boyden Electrical remodeling in ischemia and infarction Cardiovasc Res 42 2 May 1999 284 297
2. N. Dib, R.E. Michler, and F.D. Pagani Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year follow-up Circulation 112 12 Sep 20 2005 1748 1755
3. E. Macia, and P.A. Boyden Stem cell therapy is proarrhythmic Circulation 119 13 Apr 7 2009 1814 1823
4. W.T. Tse, J.D. Pendleton, W.M. Beyer, M.C. Egalka, and E.C. Guinan Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation Transplantation 75 3 Feb 15 2003 389 397
5. Chin SP, Poey AC, Wong CY, Chang SK, Teh W, Mohr TJ, et al. Cryopreserved mesenchymal stromal cell treatment is safe and feasible for severe dilated ischemic cardiomyopathy. Cytotherapy Jan 2010;12(1):31-7.
6. M.G. Chang, L. Tung, and R.B. Sekar Proarrhythmic potential of mesenchymal stem cell transplantation revealed in an in vitro coculture model Circulation 113 15 Apr 18 2006 1832 1841
7. H.N. Pak, M. Qayyum, and D.T. Kim Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a swine model of myocardial infarction J Cardiovasc Electrophysiol 14 8 Aug 2003 841 848
8. M.J. Price, C.C. Chou, and M. Frantzen Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties Int J Cardiol 111 2 Aug 10 2006 231 239
9. W.R. Mills, N. Mal, and M.J. Kiedrowski Stem cell therapy enhances electrical viability in myocardial infarction J Mol Cell Cardiol 42 2 Feb 2007 304 314
10. J.M. Hare, J.H. Traverse, and T.D. Henry A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction J Am Coll Cardiol 54 24 Dec 8 2009 2277 2286
11. J. Muller-Ehmsen, B. Krausgrill, and V. Burst Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction J Mol Cell Cardiol 41 5 Nov 2006 876 884
12. W. Dai, S.L. Hale, and B.J. Martin Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects Circulation 112 2 Jul 12 2005 214 223
13. M.R. Franz Current status of monophasic action potential recording: theories, measurements and interpretations Cardiovasc Res 41 1 Jan 1999 25 40
14. C. Waldeyer, L. Fabritz, and L. Fortmueller Regional, age-dependent, and genotype-dependent differences in ventricular action potential duration and activation time in 410 Langendorff-perfused mouse hearts Basic Res Cardiol 104 5 Sep 2009 523 533
15. M.J. Walker, M.J. Curtis, and D.J. Hearse The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion Cardiovasc Res 22 7 Jul 1988 447 455
16. J.F. Spear, E.N. Moore, and G. Gerstenblith Effect of lidocaine on the ventricular fibrillation threshold in the dog during acute ischemia and premature ventricular contractions Circulation 46 1 Jul 1972 65 73
17. M.F. Berry, A.J. Engler, and Y.J. Woo Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance Am J Physiol Heart Circ Physiol 290 6 Jun 2006 H2196 H2203
18. M.T. Kuhlmann, P. Kirchhof, and R. Klocke G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis J Exp Med 203 1 Jan 23 2006 87 97
19. W. Roell, T. Lewalter, and P. Sasse Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia Nature 450 7171 Dec 6 2007 819 824
20. S. Fernandes, J.C. Amirault, and G. Lande Autologous myoblast transplantation after myocardial infarction increases the inducibility of ventricular arrhythmias Cardiovasc Res 69 2 Feb 1 2006 348 358
21. S. Fukushima, A. Varela-Carver, and S.R. Coppen Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model Circulation 115 17 May 1 2007 2254 2261
22. D.G. Katritsis, P. Sotiropoulou, E. Giazitzoglou, E. Karvouni, and M. Papamichail Electrophysiological effects of intracoronary transplantation of autologous mesenchymal and endothelial progenitor cells Europace 9 3 Mar 2007 167 171
23. J.Y. Hahn, H.J. Cho, and H.J. Kang Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction J Am Coll Cardiol 51 9 Mar 4 2008 933 943
24. S.R. Coppen, S. Fukushima, and Y. Shintani A factor underlying late-phase arrhythmogenicity after cell therapy to the heart: global downregulation of connexin43 in the host myocardium after skeletal myoblast transplantation Circulation 118 14 Suppl Sep 30 2008 S138 S144
25. P.C. Ursell, P.I. Gardner, A. Albala, J.J. Fenoglio Jr., and A.L. Wit Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing Circ Res 56 3 Mar 1985 436 451
26. J.M. de Bakker, F.J. van Capelle, and M.J. Janse Slow conduction in the infarcted human heart. 'Zigzag' course of activation Circulation 88 3 Sep 1993 915 926
27. T. Kawara, R. Derksen, and J.R. de Groot Activation delay after premature stimulation in chronically diseased human myocardium relates to the architecture of interstitial fibrosis Circulation 104 25 Dec 18 2001 3069 3075
28. C. Mias, O. Lairez, and E. Trouche Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction Stem Cells 27 11 Jul 9 2009 2734 2743
29. J.A. Dixon, R.C. Gorman, and R.E. Stroud Mesenchymal cell transplantation and myocardial remodeling after myocardial infarction Circulation 120 11 Suppl Sep 15 2009 S220 S229
30. J.E. Saffitz, R.B. Schuessler, and K.A. Yamada Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias Cardiovasc Res 42 2 May 1999 309 317
31. D.E. Gutstein, G.E. Morley, and H. Tamaddon Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43 Circ Res 88 3 Feb 16 2001 333 339
32. S. Poelzing, and D.S. Rosenbaum Altered connexin43 expression produces arrhythmia substrate in heart failure Am J Physiol Heart Circ Physiol 287 4 Oct 2004 H1762 H1770
33. N.S. Peters, J. Coromilas, N.J. Severs, and A.L. Wit Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia Circulation 95 4 Feb 18 1997 988 996
34. T. Ohara, K. Ohara, and J.M. Cao Increased wave break during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction Circulation 103 10 Mar 13 2001 1465 1472
35. S. Baba, W. Dun, C. Cabo, and P.A. Boyden Remodeling in cells from different regions of the reentrant circuit during ventricular tachycardia Circulation 112 16 Oct 18 2005 2386 2396
36. A.J. Coats Ethical authorship and publishing Int J Cardiol 131 2 Jan 9 2009 149 150