Genetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritis

Rheumatology (United Kingdom)

Volumn 56, Issue 3, 2017, Pages 457-466

  Chang, Wan Chun ^a   Wu, Yeong Jian Jan ^b   Chung, Wen Hung ^b   Lee, Yun Shien ^c   Chin, See Wen ^a,b   Chen, Ting Jui ^a,d   Chang, Yu Sun ^e   Chen, Der Yuan ^f   Hung, Shuen Iu ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c MING CHUAN UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e CHANG GUNG UNIVERSITY   (Taiwan)

^f TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Gout; NLRP3 inflammasome; PPAR gamma coactivator 1B

Indexed keywords

COMPLEMENTARY DNA; CRYOPYRIN; GENOMIC DNA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR; URATE; URICOSURIC AGENT; CARRIER PROTEIN; IL1B PROTEIN, HUMAN; NLRP3 PROTEIN, HUMAN; PPARGC1A PROTEIN, HUMAN; PPARGC1B PROTEIN, HUMAN; TNF PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; ARTICLE; COMORBIDITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES MELLITUS; DIRECT SEQUENCING; ENZYME LINKED IMMUNOSORBENT ASSAY; ESTIMATED GLOMERULAR FILTRATION RATE; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE SILENCING; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENOTYPE; GOUT; HAN CHINESE; HAPLOTYPE; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; HYPERTENSION; HYPERURICEMIA; IMMUNOREGULATION; INFLAMMATION; KIDNEY FUNCTION; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; MISSENSE MUTATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SYNOVIOCYTE; TAIWAN; THP-1 CELL LINE; UPREGULATION; WILD TYPE; CASE CONTROL STUDY; CELL LINE; GENETIC VARIATION; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MONOCYTE; ODDS RATIO; POLYMERASE CHAIN REACTION; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, GOUTY; CARRIER PROTEINS; CASE-CONTROL STUDIES; CASPASE 1; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE KNOCKDOWN TECHNIQUES; GENETIC VARIATION; HUMANS; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; MONOCYTES; MUTATION, MISSENSE; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; ODDS RATIO; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR GAMMA; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SYNOVIOCYTES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; YOUNG ADULT;

EID: 85019990337     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kew337     Document Type: Article

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