Novel genes in human asthma based on a mouse model of allergic airway inflammation and human investigations

Allergy, Asthma and Immunology Research

Volumn 6, Issue 6, 2014, Pages 496-503

  Temesi, Gergely ^a   Virág, Viktor ^a   Hadadi, Éva ^a,b   Ungvári, Ildikó ^a   Fodor, Lili E ^a   Bikov, András ^a   Nagy, Adrienne ^c   Gálffy, Gabriella ^a   Tamási, Lilla ^a   Horváth, Ildikó ^a,d   Kiss, András ^c   Hullám, Gábor ^e   Gézsi, András ^a   Sárközy, Péter ^e   Antal, Péter ^e   Buzás, Edit ^a   Szalai, Csaba ^a,c,f  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c Heim Pal Children Hospital   (Hungary)

^d Ministry of National Resources   (Hungary)

^e BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^f Csertex Research Laboratory   (Hungary)

Author keywords

Animal; Asthma; Child; Disease model; Genetic association studies, gene expression; Sputum

Indexed keywords

OVALBUMIN; PEPTIDES AND PROTEINS; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; PROTEIN ITLN1; PROTEIN SCIN; UNCLASSIFIED DRUG;

ALLELE; ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; HUMAN GENOME; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SPUTUM; STATISTICAL SIGNIFICANCE;

EID: 84909585216     PISSN: 20927355     EISSN: 20927363     Source Type: Journal    
DOI: 10.4168/aair.2014.6.6.496     Document Type: Article

References (35)

1. Holgate ST. Pathogenesis of asthma. Clin Exp Allergy 2008;38:872-97.
2. Lemanske RF Jr, Busse WW. Asthma: clinical expression and molecular mechanisms. J Allergy Clin Immunol 2010;125:S95-102.
3. Braman SS. The global burden of asthma. Chest 2006;130:4S-12S.
4. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008;8:169-82.
5. Bierbaum S, Heinzmann A. The genetics of bronchial asthma in children. Respir Med 2007;101:1369-75.
6. Finkelman FD, Vercelli D. Advances in asthma, allergy mechanisms, and genetics in 2006. J Allergy Clin Immunol 2007;120:544-50.
7. Weiss ST, Raby BA, Rogers A. Asthma genetics and genomics 2009. Curr Opin Genet Dev 2009;19:279-82.
8. Zimmermann N, King NE, Laporte J, Yang M, Mishra A, Pope SM, Muntel EE, Witte DP, Pegg AA, Foster PS, Hamid Q, Rothenberg ME. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 2003;111:1863-74.
9. Karp CL, Grupe A, Schadt E, Ewart SL, Keane-Moore M, Cuomo PJ, Köhl J, Wahl L, Kuperman D, Germer S, Aud D, Peltz G, Wills-Karp M. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat Immunol 2000;1:221-6.
10. Tölgyesi G, Molnár V, Semsei AF, Kiszel P, Ungvári I, Pócza P, Wiener Z, Komlósi ZI, Kunos L, Gálffy G, Losonczy G, Seres I, Falus A, Szalai C. Gene expression profiling of experimental asthma reveals a possible role of paraoxonase-1 in the disease. Int Immunol 2009; 21:967-75.
11. Di Valentin E, Crahay C, Garbacki N, Hennuy B, Guéders M, Noël A, Foidart JM, Grooten J, Colige A, Piette J, Cataldo D. New asthma biomarkers: lessons from murine models of acute and chronic asthma. Am J Physiol Lung Cell Mol Physiol 2009;296:L185-97.
12. Ungvári I, Hadadi E, Virág V, Bikov A, Nagy A, Semsei AF, Gálffy G, Tamási L, Horváth I, Szalai C. Implication of BIRC5 in asthma pathogenesis. Int Immunol 2012;24:293-301.
13. Karolchik D, Hinrichs AS, Furey TS, Roskin KM, Sugnet CW, Haus-sler D, Kent WJ. The UCSC Table Browser data retrieval tool. Nucleic Acids Res 2004;32:D493-6.
14. International HapMap Project [Internet]. [place unknown]: International HapMap Project; [cited 2013 May 31]. Available from: http://hapmap.ncbi.nlm.nih.gov/cgi-perl/gbrowse/hapmap28_B36/.
15. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5.
16. Ungvári I, Hullám G, Antal P, Kiszel PS, Gézsi A, Hadadi é, Virág V, Hajós G, Millinghoffer A, Nagy A, Kiss A, Semsei áF, Temesi G, Melegh B, Kisfali P, Széll M, Bikov A, Gálffy G, Tamási L, Falus A, Szalai C. Evaluation of a partial genome screening of two asthma susceptibility regions using bayesian network based bayesian multilevel analysis of relevance. PLoS One 2012;7:e33573.
17. Tsitsiou E, Williams AE, Moschos SA, Patel K, Rossios C, Jiang X, Adams OD, Macedo P, Booton R, Gibeon D, Chung KF, Lindsay MA. Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma. J Allergy Clin Immunol 2012;129:95-103.
18. Tsaparas P, Mariño-Ramírez L, Bodenreider O, Koonin EV, Jordan IK. Global similarity and local divergence in human and mouse gene co-expression networks. BMC Evol Biol 2006;6:70.
19. Kuhn A, Luthi-Carter R, Delorenzi M. Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'. BMC Bioinformatics 2008;9:26.
20. Strand AD, Aragaki AK, Baquet ZC, Hodges A, Cunningham P, Holmans P, Jones KR, Jones L, Kooperberg C, Olson JM. Conservation of regional gene expression in mouse and human brain. PLoS Genet 2007;3:e59.
21. Song KH, Chiang JY. Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis. Hepatology 2006;43:117-25.
22. Jordan IK, Mariño-Ramírez L, Koonin EV. Evolutionary significance of gene expression divergence. Gene 2005;345:119-26.
23. Jordan IK, Mariño-Ramírez L, Wolf YI, Koonin EV. Conservation and coevolution in the scale-free human gene coexpression network. Mol Biol Evol 2004;21:2058-70.
24. Su AI, Cooke MP, Ching KA, Hakak Y, Walker JR, Wiltshire T, Orth AP, Vega RG, Sapinoso LM, Moqrich A, Patapoutian A, Hampton GM, Schultz PG, Hogenesch JB. Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A 2002;99:4465-70.
25. Yanai I, Graur D, Ophir R. Incongruent expression profiles between human and mouse orthologous genes suggest widespread neutral evolution of transcription control. OMICS 2004;8:15-24.
26. Ehre C, Rossi AH, Abdullah LH, De Pestel K, Hill S, Olsen JC, Davis CW. Barrier role of actin filaments in regulated mucin secretion from airway goblet cells. Am J Physiol Cell Physiol 2005;288:C46-56.
27. Davis CW, Dickey BF. Regulated airway goblet cell mucin secretion. Annu Rev Physiol 2008;70:487-512.
28. Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL, Ritchie MD; International Multiple Sclerosis Genetics Consortium. A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility. Genes Immun 2011;12:335-40.
29. Park SJ, Lee YC. Peroxisome proliferator-activated receptor gamma as a novel therapeutic target in asthma. J Asthma 2008;45:1-8.
30. Lee KS, Park SJ, Hwang PH, Yi HK, Song CH, Chai OH, Kim JS, Lee MK, Lee YC. PPAR-gamma modulates allergic inflammation thro-ugh up-regulation of PTEN. FASEB J 2005;19:1033-5.
31. Lee SH, Jang AS, Woo Park S, Park JS, Kim YK, Uh ST, Kim YH, Chung IY, Park BL, Shin HD, Park CS. Genetic effect of single-nucleotide polymorphisms in the PPARGC1B gene on airway hyperreactivitym in asthmatic patients. Clin Exp Allergy 2011;41:1533-44.
32. Tölgyesi G, Keszei M, Ungvári I, Nagy A, Falus A, Szalai C. Involvement of TNFalpha -308A promoter polymorphism in the development of asthma in children infected with Chlamydophila pneumoniae. Pediatr Res 2006;60:543-8.
33. Ungvári I, Tölgyesi G, Semsei AF, Nagy A, Radosits K, Keszei M, Kozma GT, Falus A, Szalai C. CCR5 Delta 32 mutation, Mycoplasma pneumoniae infection, and asthma. J Allergy Clin Immunol 2007; 119:1545-7.
34. Nagy A, Kozma GT, Keszei M, Treszl A, Falus A, Szalai C. The development of asthma in children infected with Chlamydia pneumoniae is dependent on the modifying effect of mannose-binding lectin. J Allergy Clin Immunol 2003;112:729-34.
35. Nagy A, Keszei M, Kis Z, Budai I, Tölgyesi G, Ungvári I, Falus A, Szalai C. Chlamydophila pneumoniae infection status is dependent on the subtypes of asthma and allergy. Allergy Asthma Proc 2007; 28:58-63.