-
1
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
Postow MA, Chesney J, Pavlick AC, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med. 2015;372:2006-2017.
-
(2015)
N Engl J Med.
, vol.372
, pp. 2006-2017
-
-
Postow, M.A.1
Chesney, J.2
Pavlick, A.C.3
-
2
-
-
84964341647
-
Association of pembrolizumab with tumor response and survival among patients with advanced melanoma
-
Ribas A, Hamid O, Daud A, et al. Association of pembrolizumab with tumor response and survival among patients with advanced melanoma. JAMA. 2016;315:1600-1609.
-
(2016)
JAMA.
, vol.315
, pp. 1600-1609
-
-
Ribas, A.1
Hamid, O.2
Daud, A.3
-
3
-
-
84928917822
-
Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma
-
Schadendorf D, Hodi FS, Robert C, et al. Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma. J Clin Oncol. 2015;33:1889-1894.
-
(2015)
J Clin Oncol.
, vol.33
, pp. 1889-1894
-
-
Schadendorf, D.1
Hodi, F.S.2
Robert, C.3
-
4
-
-
0024166189
-
Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report
-
Rosenberg SA, Packard BS, Aebersold PM, et al. Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report. N Engl J Med. 1988;319:1676-1680.
-
(1988)
N Engl J Med.
, vol.319
, pp. 1676-1680
-
-
Rosenberg, S.A.1
Packard, B.S.2
Aebersold, P.M.3
-
5
-
-
77951714425
-
Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients
-
Besser MJ, Shapira-Frommer R, Treves AJ, et al. Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients. Clin Cancer Res. 2010;16:2646-2655.
-
(2010)
Clin Cancer Res.
, vol.16
, pp. 2646-2655
-
-
Besser, M.J.1
Shapira-Frommer, R.2
Treves, A.J.3
-
6
-
-
84883472041
-
Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: intent-to-treat analysis and efficacy after failure to prior immunotherapies
-
Besser MJ, Shapira-Frommer R, Itzhaki O, et al. Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: intent-to-treat analysis and efficacy after failure to prior immunotherapies. Clin Cancer Res. 2013;19:4792-4800.
-
(2013)
Clin Cancer Res.
, vol.19
, pp. 4792-4800
-
-
Besser, M.J.1
Shapira-Frommer, R.2
Itzhaki, O.3
-
7
-
-
84980009912
-
Long-lasting complete responses in patients with metastatic melanoma after adoptive cell therapy with tumor-infiltrating lymphocytes and an attenuated IL2 regimen
-
Andersen R, Donia M, Ellebaek E, et al. Long-lasting complete responses in patients with metastatic melanoma after adoptive cell therapy with tumor-infiltrating lymphocytes and an attenuated IL2 regimen. Clin Cancer Res. 2016;22:3734-3745.
-
(2016)
Clin Cancer Res.
, vol.22
, pp. 3734-3745
-
-
Andersen, R.1
Donia, M.2
Ellebaek, E.3
-
8
-
-
84871207055
-
Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients
-
Radvanyi LG, Bernatchez C, Zhang M, et al. Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients. Clin Cancer Res. 2012;18:6758-6770.
-
(2012)
Clin Cancer Res.
, vol.18
, pp. 6758-6770
-
-
Radvanyi, L.G.1
Bernatchez, C.2
Zhang, M.3
-
9
-
-
84955573189
-
Adoptive cell therapy: a highly successful individualized therapy for melanoma with great potential for other malignancies
-
Verdegaal EM. Adoptive cell therapy: a highly successful individualized therapy for melanoma with great potential for other malignancies. Curr Opin Immunol. 2016;39:90-95.
-
(2016)
Curr Opin Immunol.
, vol.39
, pp. 90-95
-
-
Verdegaal, E.M.1
-
10
-
-
0037058993
-
Adoptive T cell therapy using antigen-specific CD8 + T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells
-
Yee C, Thompson JA, Byrd D, et al. Adoptive T cell therapy using antigen-specific CD8 + T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc Natl Acad Sci U S A. 2002;99:16168-16173.
-
(2002)
Proc Natl Acad Sci U S A.
, vol.99
, pp. 16168-16173
-
-
Yee, C.1
Thompson, J.A.2
Byrd, D.3
-
11
-
-
33749624177
-
Cancer regression in patients after transfer of genetically engineered lymphocytes
-
Morgan RA, Dudley ME, Wunderlich JR, et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science. 2006;314:126-129.
-
(2006)
Science.
, vol.314
, pp. 126-129
-
-
Morgan, R.A.1
Dudley, M.E.2
Wunderlich, J.R.3
-
12
-
-
79952304769
-
Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
-
Robbins PF, Morgan RA, Feldman SA, et al. Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol. 2011;29:917-924.
-
(2011)
J Clin Oncol.
, vol.29
, pp. 917-924
-
-
Robbins, P.F.1
Morgan, R.A.2
Feldman, S.A.3
-
13
-
-
84883704931
-
Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection
-
Schmitt TM, Aggen DH, Stromnes IM, et al. Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection. Blood. 2013;122:348-356.
-
(2013)
Blood.
, vol.122
, pp. 348-356
-
-
Schmitt, T.M.1
Aggen, D.H.2
Stromnes, I.M.3
-
14
-
-
84959333007
-
Induction of WT1-specific human CD8 + T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice
-
Najima Y, Tomizawa-Murasawa M, Saito Y, et al. Induction of WT1-specific human CD8 + T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice. Blood. 2016;127:722-734.
-
(2016)
Blood.
, vol.127
, pp. 722-734
-
-
Najima, Y.1
Tomizawa-Murasawa, M.2
Saito, Y.3
-
15
-
-
84899731823
-
Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma
-
Chodon T, Comin-Anduix B, Chmielowski B, et al. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clin Cancer Res. 2014;20:2457-2465.
-
(2014)
Clin Cancer Res.
, vol.20
, pp. 2457-2465
-
-
Chodon, T.1
Comin-Anduix, B.2
Chmielowski, B.3
-
16
-
-
84883157468
-
MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells
-
Leone P, Shin EC, Perosa F, Vacca A, Dammacco F, Racanelli V. MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells. J Natl Cancer Inst. 2013;105:1172-1187.
-
(2013)
J Natl Cancer Inst.
, vol.105
, pp. 1172-1187
-
-
Leone, P.1
Shin, E.C.2
Perosa, F.3
Vacca, A.4
Dammacco, F.5
Racanelli, V.6
-
17
-
-
84923118622
-
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
-
Kochenderfer JN, Dudley ME, Kassim SH, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol. 2015;33:540-549.
-
(2015)
J Clin Oncol.
, vol.33
, pp. 540-549
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Kassim, S.H.3
-
18
-
-
84908073316
-
Chimeric antigen receptor T cells for sustained remissions in leukemia
-
Maude SL, Frey N, Shaw PA, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014;371:1507-1517.
-
(2014)
N Engl J Med.
, vol.371
, pp. 1507-1517
-
-
Maude, S.L.1
Frey, N.2
Shaw, P.A.3
-
19
-
-
84896734231
-
EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss
-
Sampson JH, Choi BD, Sanchez-Perez L, et al. EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. Clin Cancer Res. 2014;20:972-984.
-
(2014)
Clin Cancer Res.
, vol.20
, pp. 972-984
-
-
Sampson, J.H.1
Choi, B.D.2
Sanchez-Perez, L.3
-
20
-
-
82955207691
-
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
-
Louis CU, Savoldo B, Dotti G, et al. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood. 2011;118:6050-6056.
-
(2011)
Blood.
, vol.118
, pp. 6050-6056
-
-
Louis, C.U.1
Savoldo, B.2
Dotti, G.3
-
22
-
-
84867577248
-
CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy
-
Sapoznik S, Ortenberg R, Galore-Haskel G, et al. CXCR1 as a novel target for directing reactive T cells toward melanoma: implications for adoptive cell transfer immunotherapy. Cancer Immunol Immunother. 2012;61:1833-1847.
-
(2012)
Cancer Immunol Immunother.
, vol.61
, pp. 1833-1847
-
-
Sapoznik, S.1
Ortenberg, R.2
Galore-Haskel, G.3
-
23
-
-
84903837615
-
Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer
-
Hartmann N, Giese NA, Giese T, et al. Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer. Clin Cancer Res. 2014;20:3422-3433.
-
(2014)
Clin Cancer Res.
, vol.20
, pp. 3422-3433
-
-
Hartmann, N.1
Giese, N.A.2
Giese, T.3
-
24
-
-
0035963379
-
Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction
-
Ochsenbein AF, Sierro S, Odermatt B, et al. Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature. 2001;411:1058-1064.
-
(2001)
Nature.
, vol.411
, pp. 1058-1064
-
-
Ochsenbein, A.F.1
Sierro, S.2
Odermatt, B.3
-
25
-
-
84952863049
-
Control of CD8 T-cell infiltration into tumors by vasculature and microenvironment
-
Peske JD, Woods AB, Engelhard VH. Control of CD8 T-cell infiltration into tumors by vasculature and microenvironment. Adv Cancer Res. 2015;128:263-307.
-
(2015)
Adv Cancer Res.
, vol.128
, pp. 263-307
-
-
Peske, J.D.1
Woods, A.B.2
Engelhard, V.H.3
-
26
-
-
84941366350
-
Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses
-
Ho PC, Bihuniak JD, Macintyre AN, et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell. 2015;162:1217-1228.
-
(2015)
Cell.
, vol.162
, pp. 1217-1228
-
-
Ho, P.C.1
Bihuniak, J.D.2
Macintyre, A.N.3
-
27
-
-
84941344937
-
Metabolic competition in the tumor microenvironment is a driver of cancer progression
-
Chang CH, Qiu J, O'Sullivan D, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell. 2015;162:1229-1241.
-
(2015)
Cell.
, vol.162
, pp. 1229-1241
-
-
Chang, C.H.1
Qiu, J.2
O'Sullivan, D.3
-
28
-
-
79960403269
-
Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor
-
Moon EK, Carpenito C, Sun J, et al. Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor. Clin Cancer Res. 2011;17:4719-4730.
-
(2011)
Clin Cancer Res.
, vol.17
, pp. 4719-4730
-
-
Moon, E.K.1
Carpenito, C.2
Sun, J.3
-
29
-
-
77955406159
-
Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
-
Shrimali RK, Yu Z, Theoret MR, Chinnasamy D, Restifo NP, Rosenberg SA. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res. 2010;70:6171-6180.
-
(2010)
Cancer Res.
, vol.70
, pp. 6171-6180
-
-
Shrimali, R.K.1
Yu, Z.2
Theoret, M.R.3
Chinnasamy, D.4
Restifo, N.P.5
Rosenberg, S.A.6
-
30
-
-
65449136307
-
A central role for induced regulatory T cells in tolerance induction in experimental colitis
-
Haribhai D, Lin W, Edwards B, et al. A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol. 2009;182:3461-3468.
-
(2009)
J Immunol.
, vol.182
, pp. 3461-3468
-
-
Haribhai, D.1
Lin, W.2
Edwards, B.3
-
31
-
-
12244285937
-
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo
-
Chen ML, Pittet MJ, Gorelik L, et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A. 2005;102:419-424.
-
(2005)
Proc Natl Acad Sci U S A.
, vol.102
, pp. 419-424
-
-
Chen, M.L.1
Pittet, M.J.2
Gorelik, L.3
-
32
-
-
4644237613
-
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
-
Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004;10:942-949.
-
(2004)
Nat Med.
, vol.10
, pp. 942-949
-
-
Curiel, T.J.1
Coukos, G.2
Zou, L.3
-
33
-
-
0041386189
-
CD4+CD25 + regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression
-
Sasada T, Kimura M, Yoshida Y, Kanai M, Takabayashi A. CD4+CD25 + regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer. 2003;98:1089-1099.
-
(2003)
Cancer.
, vol.98
, pp. 1089-1099
-
-
Sasada, T.1
Kimura, M.2
Yoshida, Y.3
Kanai, M.4
Takabayashi, A.5
-
34
-
-
68449099413
-
Regulatory T cells: major players in the tumor microenvironment
-
Beyer M, Schultze JL. Regulatory T cells: major players in the tumor microenvironment. Curr Pharm Des. 2009;15:1879-1892.
-
(2009)
Curr Pharm Des.
, vol.15
, pp. 1879-1892
-
-
Beyer, M.1
Schultze, J.L.2
-
35
-
-
84986296840
-
gammadelta T cells support pancreatic oncogenesis by restraining alphabeta T cell activation
-
Daley D, Zambirinis CP, Seifert L, et al. gammadelta T cells support pancreatic oncogenesis by restraining alphabeta T cell activation. Cell. 2016;166:1485-1499.
-
(2016)
Cell.
, vol.166
, pp. 1485-1499
-
-
Daley, D.1
Zambirinis, C.P.2
Seifert, L.3
-
36
-
-
84993929137
-
Suppressive role of myeloid-derived suppressor cells (MDSCs) in the microenvironment of breast cancer and targeted immunotherapies [published online ahead of print August 17, 2016]
-
Shou D, Wen L, Song Z, Yin J, Sun Q, Gong W. Suppressive role of myeloid-derived suppressor cells (MDSCs) in the microenvironment of breast cancer and targeted immunotherapies [published online ahead of print August 17, 2016]. Oncotarget. doi: 10.18632/oncotarget.11352.
-
Oncotarget.
-
-
Shou, D.1
Wen, L.2
Song, Z.3
Yin, J.4
Sun, Q.5
Gong, W.6
-
37
-
-
84862074482
-
MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN
-
Liu Y, Lai L, Chen Q, et al. MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN. J Immunol. 2012;188:5500-5510.
-
(2012)
J Immunol.
, vol.188
, pp. 5500-5510
-
-
Liu, Y.1
Lai, L.2
Chen, Q.3
-
38
-
-
84883609975
-
A mutual activation loop between breast cancer cells and myeloid-derived suppressor cells facilitates spontaneous metastasis through IL-6 trans-signaling in a murine model
-
Oh K, Lee OY, Shon SY, et al. A mutual activation loop between breast cancer cells and myeloid-derived suppressor cells facilitates spontaneous metastasis through IL-6 trans-signaling in a murine model. Breast Cancer Res. 2013;15:R79.
-
(2013)
Breast Cancer Res.
, vol.15
, pp. R79
-
-
Oh, K.1
Lee, O.Y.2
Shon, S.Y.3
-
39
-
-
84907029151
-
Noncanonical NF-kappaB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer
-
Yu J, Wang Y, Yan F, et al. Noncanonical NF-kappaB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer. J Immunol. 2014;193:2574-2586.
-
(2014)
J Immunol.
, vol.193
, pp. 2574-2586
-
-
Yu, J.1
Wang, Y.2
Yan, F.3
-
40
-
-
80053421470
-
Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice
-
Lu T, Ramakrishnan R, Altiok S, et al. Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice. J Clin Invest. 2011;121:4015-4029.
-
(2011)
J Clin Invest.
, vol.121
, pp. 4015-4029
-
-
Lu, T.1
Ramakrishnan, R.2
Altiok, S.3
-
41
-
-
84862500053
-
A Th1 cytokine-enriched microenvironment enhances tumor killing by activated T cells armed with bispecific antibodies and inhibits the development of myeloid-derived suppressor cells
-
Thakur A, Schalk D, Sarkar SH, Al-Khadimi Z, Sarkar FH, Lum LG. A Th1 cytokine-enriched microenvironment enhances tumor killing by activated T cells armed with bispecific antibodies and inhibits the development of myeloid-derived suppressor cells. Cancer Immunol Immunother. 2012;61:497-509.
-
(2012)
Cancer Immunol Immunother.
, vol.61
, pp. 497-509
-
-
Thakur, A.1
Schalk, D.2
Sarkar, S.H.3
Al-Khadimi, Z.4
Sarkar, F.H.5
Lum, L.G.6
-
42
-
-
84946912433
-
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
-
Peng D, Kryczek I, Nagarsheth N, et al. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature. 2015;527:249-253.
-
(2015)
Nature.
, vol.527
, pp. 249-253
-
-
Peng, D.1
Kryczek, I.2
Nagarsheth, N.3
-
43
-
-
20244366111
-
Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
-
Dudley ME, Wunderlich JR, Yang JC, et al. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol. 2005;23:2346-2357.
-
(2005)
J Clin Oncol.
, vol.23
, pp. 2346-2357
-
-
Dudley, M.E.1
Wunderlich, J.R.2
Yang, J.C.3
-
44
-
-
25844484607
-
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8 + T cells
-
Gattinoni L, Finkelstein SE, Klebanoff CA, et al. Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8 + T cells. J Exp Med. 2005;202:907-912.
-
(2005)
J Exp Med.
, vol.202
, pp. 907-912
-
-
Gattinoni, L.1
Finkelstein, S.E.2
Klebanoff, C.A.3
-
45
-
-
74349084455
-
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells
-
Wrzesinski C, Paulos CM, Kaiser A, et al. Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells. J Immunother. 2010;33:1-7.
-
(2010)
J Immunother.
, vol.33
, pp. 1-7
-
-
Wrzesinski, C.1
Paulos, C.M.2
Kaiser, A.3
-
46
-
-
79960299888
-
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
-
Rosenberg SA, Yang JC, Sherry RM, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res. 2011;17:4550-4557.
-
(2011)
Clin Cancer Res.
, vol.17
, pp. 4550-4557
-
-
Rosenberg, S.A.1
Yang, J.C.2
Sherry, R.M.3
-
47
-
-
84977573737
-
Randomized, prospective evaluation comparing intensity of lymphodepletion before adoptive transfer of tumor-infiltrating lymphocytes for patients with metastatic melanoma
-
Goff SL, Dudley ME, Citrin DE, et al. Randomized, prospective evaluation comparing intensity of lymphodepletion before adoptive transfer of tumor-infiltrating lymphocytes for patients with metastatic melanoma. J Clin Oncol. 2016;34:2389-2397.
-
(2016)
J Clin Oncol.
, vol.34
, pp. 2389-2397
-
-
Goff, S.L.1
Dudley, M.E.2
Citrin, D.E.3
-
48
-
-
79956215089
-
Blockade of CTLA-4 decreases the generation of multifunctional memory CD4 + T cells in vivo
-
Rudolph M, Hebel K, Miyamura Y, Maverakis E, Brunner-Weinzierl MC. Blockade of CTLA-4 decreases the generation of multifunctional memory CD4 + T cells in vivo. J Immunol. 2011;186:5580-5589.
-
(2011)
J Immunol.
, vol.186
, pp. 5580-5589
-
-
Rudolph, M.1
Hebel, K.2
Miyamura, Y.3
Maverakis, E.4
Brunner-Weinzierl, M.C.5
-
49
-
-
84940720838
-
Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma
-
Guislain A, Gadiot J, Kaiser A, et al. Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma. Cancer Immunol Immunother. 2015;64:1241-1250.
-
(2015)
Cancer Immunol Immunother.
, vol.64
, pp. 1241-1250
-
-
Guislain, A.1
Gadiot, J.2
Kaiser, A.3
-
50
-
-
84991510642
-
BRAF inhibition alleviates immune suppression in murine autochthonous melanoma
-
Steinberg SM, Zhang P, Malik BT, et al. BRAF inhibition alleviates immune suppression in murine autochthonous melanoma. Cancer Immunol Res. 2014;2:1044-1050.
-
(2014)
Cancer Immunol Res.
, vol.2
, pp. 1044-1050
-
-
Steinberg, S.M.1
Zhang, P.2
Malik, B.T.3
-
51
-
-
84885761143
-
Immunological consequences of selective BRAF inhibitors in malignant melanoma: neutralization of myeloid-derived suppressor cells
-
Schilling B, Paschen A. Immunological consequences of selective BRAF inhibitors in malignant melanoma: neutralization of myeloid-derived suppressor cells. Oncoimmunology. 2013;2:e25218.
-
(2013)
Oncoimmunology.
, vol.2
-
-
Schilling, B.1
Paschen, A.2
-
52
-
-
55249117972
-
Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor
-
Foster AE, Dotti G, Lu A, et al. Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor. J Immunother. 2008;31:500-505.
-
(2008)
J Immunother.
, vol.31
, pp. 500-505
-
-
Foster, A.E.1
Dotti, G.2
Lu, A.3
-
53
-
-
84902146901
-
Reversal of tumor immune inhibition using a chimeric cytokine receptor
-
Leen AM, Sukumaran S, Watanabe N, et al. Reversal of tumor immune inhibition using a chimeric cytokine receptor. Mol Ther. 2014;22:1211-1220.
-
(2014)
Mol Ther.
, vol.22
, pp. 1211-1220
-
-
Leen, A.M.1
Sukumaran, S.2
Watanabe, N.3
-
54
-
-
84865744445
-
CAR T cells transform to trucks: chimeric antigen receptor-redirected T cells engineered to deliver inducible IL-12 modulate the tumour stroma to combat cancer
-
Chmielewski M, Abken H. CAR T cells transform to trucks: chimeric antigen receptor-redirected T cells engineered to deliver inducible IL-12 modulate the tumour stroma to combat cancer. Cancer Immunol Immunother. 2012;61:1269-1277.
-
(2012)
Cancer Immunol Immunother.
, vol.61
, pp. 1269-1277
-
-
Chmielewski, M.1
Abken, H.2
-
55
-
-
84929433571
-
Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma
-
Zhang L, Morgan RA, Beane JD, et al. Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma. Clin Cancer Res. 2015;21:2278-2288.
-
(2015)
Clin Cancer Res.
, vol.21
, pp. 2278-2288
-
-
Zhang, L.1
Morgan, R.A.2
Beane, J.D.3
-
56
-
-
84921665150
-
A longitudinal study of CEACAM1 expression in melanoma disease progression
-
Zippel D, Barlev H, Ortenberg R, Barshack I, Schachter J, Markel G. A longitudinal study of CEACAM1 expression in melanoma disease progression. Oncol Rep. 2015;33:1314-1318.
-
(2015)
Oncol Rep.
, vol.33
, pp. 1314-1318
-
-
Zippel, D.1
Barlev, H.2
Ortenberg, R.3
Barshack, I.4
Schachter, J.5
Markel, G.6
-
57
-
-
84862564583
-
Novel immunotherapy for malignant melanoma with a monoclonal antibody that blocks CEACAM1 homophilic interactions
-
Ortenberg R, Sapir Y, Raz L, et al. Novel immunotherapy for malignant melanoma with a monoclonal antibody that blocks CEACAM1 homophilic interactions. Mol Cancer Ther. 2012;11:1300-1310.
-
(2012)
Mol Cancer Ther.
, vol.11
, pp. 1300-1310
-
-
Ortenberg, R.1
Sapir, Y.2
Raz, L.3
-
58
-
-
0036792506
-
Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions
-
Markel G, Wolf D, Hanna J, et al. Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions. J Clin Invest. 2002;110:943-953.
-
(2002)
J Clin Invest.
, vol.110
, pp. 943-953
-
-
Markel, G.1
Wolf, D.2
Hanna, J.3
-
59
-
-
58149302763
-
Dynamic expression of protective CEACAM1 on melanoma cells during specific immune attack
-
Markel G, Seidman R, Cohen Y, et al. Dynamic expression of protective CEACAM1 on melanoma cells during specific immune attack. Immunology. 2009;126:186-200.
-
(2009)
Immunology.
, vol.126
, pp. 186-200
-
-
Markel, G.1
Seidman, R.2
Cohen, Y.3
-
60
-
-
84984685190
-
Multiplex Cripsr/Cas9 genome editing to generate potent universal CART and PD1-deficient cells against leukemia
-
Ren J, Liu X, Fang C, Jiang S, June CH, Zhao Y. Multiplex Cripsr/Cas9 genome editing to generate potent universal CART and PD1-deficient cells against leukemia. Blood. 2015;126:4280-4280.
-
(2015)
Blood.
, vol.126
, pp. 4280
-
-
Ren, J.1
Liu, X.2
Fang, C.3
Jiang, S.4
June, C.H.5
Zhao, Y.6
-
61
-
-
84962163731
-
A chimeric switch-receptor targeting PD1 augments the efficacy of second-generation CAR T cells in advanced solid tumors
-
Liu X, Ranganathan R, Jiang S, et al. A chimeric switch-receptor targeting PD1 augments the efficacy of second-generation CAR T cells in advanced solid tumors. Cancer Res. 2016;76:1578-1590.
-
(2016)
Cancer Res.
, vol.76
, pp. 1578-1590
-
-
Liu, X.1
Ranganathan, R.2
Jiang, S.3
-
62
-
-
84885816614
-
Vemurafenib enhances MHC induction in BRAFV600E homozygous melanoma cells
-
Sapkota B, Hill CE, Pollack BP. Vemurafenib enhances MHC induction in BRAFV600E homozygous melanoma cells. Oncoimmunology. 2013;2:e22890.
-
(2013)
Oncoimmunology.
, vol.2
-
-
Sapkota, B.1
Hill, C.E.2
Pollack, B.P.3
-
63
-
-
84890207337
-
T cells expressing chimeric antigen receptors can cause anaphylaxis in humans
-
Maus MV, Haas AR, Beatty GL, et al. T cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer Immunol Res. 2013;1:26-31.
-
(2013)
Cancer Immunol Res.
, vol.1
, pp. 26-31
-
-
Maus, M.V.1
Haas, A.R.2
Beatty, G.L.3
-
64
-
-
48549087937
-
Toxicity and activity of a twice daily high-dose bolus interleukin 2 regimen in patients with metastatic melanoma and metastatic renal cell cancer
-
Acquavella N, Kluger H, Rhee J, et al. Toxicity and activity of a twice daily high-dose bolus interleukin 2 regimen in patients with metastatic melanoma and metastatic renal cell cancer. J Immunother. 2008;31:569-576.
-
(2008)
J Immunother.
, vol.31
, pp. 569-576
-
-
Acquavella, N.1
Kluger, H.2
Rhee, J.3
-
65
-
-
79959761214
-
Successful treatment of metastatic melanoma by adoptive transfer of blood-derived polyclonal tumor-specific CD4 + and CD8 + T cells in combination with low-dose interferon-alpha
-
Verdegaal EM, Visser M, Ramwadhdoebe TH, et al. Successful treatment of metastatic melanoma by adoptive transfer of blood-derived polyclonal tumor-specific CD4 + and CD8 + T cells in combination with low-dose interferon-alpha. Cancer Immunol Immunother. 2011;60:953-963.
-
(2011)
Cancer Immunol Immunother.
, vol.60
, pp. 953-963
-
-
Verdegaal, E.M.1
Visser, M.2
Ramwadhdoebe, T.H.3
-
66
-
-
84865079230
-
Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients
-
Ellebaek E, Iversen TZ, Junker N, et al. Adoptive cell therapy with autologous tumor infiltrating lymphocytes and low-dose Interleukin-2 in metastatic melanoma patients. J Transl Med. 2012;10:169.
-
(2012)
J Transl Med.
, vol.10
, pp. 169
-
-
Ellebaek, E.1
Iversen, T.Z.2
Junker, N.3
-
67
-
-
84997719834
-
Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning
-
Nelson MH, Bowers JS, Bailey SR, et al. Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning. J Immunother Cancer. 2016;4:6.
-
(2016)
J Immunother Cancer.
, vol.4
, pp. 6
-
-
Nelson, M.H.1
Bowers, J.S.2
Bailey, S.R.3
-
68
-
-
84920983137
-
miR-155 augments CD8 + T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic gammac cytokines
-
Ji Y, Wrzesinski C, Yu Z, et al. miR-155 augments CD8 + T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic gammac cytokines. Proc Natl Acad Sci U S A. 2015;112:476-481.
-
(2015)
Proc Natl Acad Sci U S A.
, vol.112
, pp. 476-481
-
-
Ji, Y.1
Wrzesinski, C.2
Yu, Z.3
-
69
-
-
84904097189
-
Current concepts in the diagnosis and management of cytokine release syndrome
-
Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood. 2014;124:188-195.
-
(2014)
Blood.
, vol.124
, pp. 188-195
-
-
Lee, D.W.1
Gardner, R.2
Porter, D.L.3
-
70
-
-
84940720703
-
Case report of a fatal serious adverse event upon administration of T cells transduced with a MART-1-specific T-cell receptor
-
van den Berg JH, Gomez-Eerland R, van de Wiel B, et al. Case report of a fatal serious adverse event upon administration of T cells transduced with a MART-1-specific T-cell receptor. Mol Ther. 2015;23:1541-1550.
-
(2015)
Mol Ther.
, vol.23
, pp. 1541-1550
-
-
van den Berg, J.H.1
Gomez-Eerland, R.2
van de Wiel, B.3
-
71
-
-
84977477922
-
Toxicities of chimeric antigen receptor T cells: recognition and management
-
Brudno JN, Kochenderfer JN. Toxicities of chimeric antigen receptor T cells: recognition and management. Blood. 2016;127:3321-3330.
-
(2016)
Blood.
, vol.127
, pp. 3321-3330
-
-
Brudno, J.N.1
Kochenderfer, J.N.2
-
72
-
-
84896335556
-
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
-
Davila ML, Riviere I, Wang X, et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med. 2014;6:224ra225.
-
(2014)
Sci Transl Med.
, vol.6
, pp. 224ra225
-
-
Davila, M.L.1
Riviere, I.2
Wang, X.3
-
73
-
-
84923019006
-
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
-
Lee DW, Kochenderfer JN, Stetler-Stevenson M, et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet. 2015;385:517-528.
-
(2015)
Lancet.
, vol.385
, pp. 517-528
-
-
Lee, D.W.1
Kochenderfer, J.N.2
Stetler-Stevenson, M.3
-
74
-
-
84940881287
-
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
-
Porter DL, Hwang WT, Frey NV, et al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Sci Transl Med. 2015;7:303ra139.
-
(2015)
Sci Transl Med.
, vol.7
, pp. 303ra139
-
-
Porter, D.L.1
Hwang, W.T.2
Frey, N.V.3
-
75
-
-
84924301768
-
Redirection of genetically engineered CAR-T cells using bifunctional small molecules
-
Kim MS, Ma JS, Yun H, et al. Redirection of genetically engineered CAR-T cells using bifunctional small molecules. J Am Chem Soc. 2015;137:2832-2835.
-
(2015)
J Am Chem Soc.
, vol.137
, pp. 2832-2835
-
-
Kim, M.S.1
Ma, J.S.2
Yun, H.3
-
76
-
-
84892772608
-
T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing
-
Kudo K, Imai C, Lorenzini P, et al. T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing. Cancer Res. 2014;74:93-103.
-
(2014)
Cancer Res.
, vol.74
, pp. 93-103
-
-
Kudo, K.1
Imai, C.2
Lorenzini, P.3
-
77
-
-
84878605813
-
Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity
-
Lamers CH, Sleijfer S, van Steenbergen S, et al. Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity. Mol Ther. 2013;21:904-912.
-
(2013)
Mol Ther.
, vol.21
, pp. 904-912
-
-
Lamers, C.H.1
Sleijfer, S.2
van Steenbergen, S.3
-
78
-
-
77950475517
-
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
-
Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther. 2010;18:843-851.
-
(2010)
Mol Ther.
, vol.18
, pp. 843-851
-
-
Morgan, R.A.1
Yang, J.C.2
Kitano, M.3
Dudley, M.E.4
Laurencot, C.M.5
Rosenberg, S.A.6
-
79
-
-
84873991752
-
Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
-
Morgan RA, Chinnasamy N, Abate-Daga D, et al. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother. 2013;36:133-151.
-
(2013)
J Immunother.
, vol.36
, pp. 133-151
-
-
Morgan, R.A.1
Chinnasamy, N.2
Abate-Daga, D.3
-
80
-
-
84880730689
-
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
-
Linette GP, Stadtmauer EA, Maus MV, et al. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. Blood. 2013;122:863-871.
-
(2013)
Blood.
, vol.122
, pp. 863-871
-
-
Linette, G.P.1
Stadtmauer, E.A.2
Maus, M.V.3
-
81
-
-
84987800356
-
Tandem CAR T cells targeting HER2 and IL13Ralpha2 mitigate tumor antigen escape
-
Hegde M, Mukherjee M, Grada Z, et al. Tandem CAR T cells targeting HER2 and IL13Ralpha2 mitigate tumor antigen escape. J Clin Invest. 2016;126:3036-3052.
-
(2016)
J Clin Invest.
, vol.126
, pp. 3036-3052
-
-
Hegde, M.1
Mukherjee, M.2
Grada, Z.3
-
82
-
-
84890174110
-
Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo
-
Lanitis E, Poussin M, Klattenhoff AW, et al. Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo. Cancer Immunol Res. 2013;1:43-53.
-
(2013)
Cancer Immunol Res.
, vol.1
, pp. 43-53
-
-
Lanitis, E.1
Poussin, M.2
Klattenhoff, A.W.3
-
83
-
-
84958214384
-
Precision tumor recognition by T cells with combinatorial antigen-sensing circuits
-
Roybal KT, Rupp LJ, Morsut L, et al. Precision tumor recognition by T cells with combinatorial antigen-sensing circuits. Cell. 2016;164:770-779.
-
(2016)
Cell.
, vol.164
, pp. 770-779
-
-
Roybal, K.T.1
Rupp, L.J.2
Morsut, L.3
-
84
-
-
84907373133
-
A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy
-
Philip B, Kokalaki E, Mekkaoui L, et al. A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy. Blood. 2014;124:1277-1287.
-
(2014)
Blood.
, vol.124
, pp. 1277-1287
-
-
Philip, B.1
Kokalaki, E.2
Mekkaoui, L.3
-
85
-
-
80051589534
-
A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
-
Wang X, Chang WC, Wong CW, et al. A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells. Blood. 2011;118:1255-1263.
-
(2011)
Blood.
, vol.118
, pp. 1255-1263
-
-
Wang, X.1
Chang, W.C.2
Wong, C.W.3
-
86
-
-
77955510549
-
Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans
-
Jensen MC, Popplewell L, Cooper LJ, et al. Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans. Biol Blood Marrow Transplant. 2010;16:1245-1256.
-
(2010)
Biol Blood Marrow Transplant.
, vol.16
, pp. 1245-1256
-
-
Jensen, M.C.1
Popplewell, L.2
Cooper, L.J.3
-
87
-
-
84908700977
-
The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells
-
Gargett T, Brown MP. The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells. Front Pharmacol. 2014;5:235.
-
(2014)
Front Pharmacol.
, vol.5
, pp. 235
-
-
Gargett, T.1
Brown, M.P.2
-
88
-
-
84976406873
-
Neoantigen landscape dynamics during human melanoma-T cell interactions
-
Verdegaal EM, de Miranda NF, Visser M, et al. Neoantigen landscape dynamics during human melanoma-T cell interactions. Nature. 2016;536:91-95.
-
(2016)
Nature.
, vol.536
, pp. 91-95
-
-
Verdegaal, E.M.1
de Miranda, N.F.2
Visser, M.3
-
89
-
-
84943329717
-
Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes
-
Cohen CJ, Gartner JJ, Horovitz-Fried M, et al. Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes. J Clin Invest. 2015;125:3981-3991.
-
(2015)
J Clin Invest.
, vol.125
, pp. 3981-3991
-
-
Cohen, C.J.1
Gartner, J.J.2
Horovitz-Fried, M.3
-
90
-
-
84959152038
-
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
-
Gros A, Parkhurst MR, Tran E, et al. Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients. Nat Med. 2016;22:433-438.
-
(2016)
Nat Med.
, vol.22
, pp. 433-438
-
-
Gros, A.1
Parkhurst, M.R.2
Tran, E.3
-
91
-
-
84985995114
-
Durable complete response from metastatic melanoma after transfer of autologous T cells recognizing 10 mutated tumor antigens
-
Prickett TD, Crystal JS, Cohen CJ, et al. Durable complete response from metastatic melanoma after transfer of autologous T cells recognizing 10 mutated tumor antigens. Cancer Immunol Res. 2016;4:669-678.
-
(2016)
Cancer Immunol Res.
, vol.4
, pp. 669-678
-
-
Prickett, T.D.1
Crystal, J.S.2
Cohen, C.J.3
-
92
-
-
84942903938
-
Multiplex genome-edited T-cell manufacturing platform for “off-the-shelf” adoptive T-cell immunotherapies
-
Poirot L, Philip B, Schiffer-Mannioui C, et al. Multiplex genome-edited T-cell manufacturing platform for “off-the-shelf” adoptive T-cell immunotherapies. Cancer Res. 2015;75:3853-3864.
-
(2015)
Cancer Res.
, vol.75
, pp. 3853-3864
-
-
Poirot, L.1
Philip, B.2
Schiffer-Mannioui, C.3
|