Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 21, 2017, Pages E4142-E4148

  Barajas, Jesus F ^a   Shakya, Gaurav ^a   Moreno, Gabriel ^a   Rivera, Heriberto ^b   Jackson, David R ^a   Topper, Caitlyn L ^a   Vagstad, Anna L ^c   La Clair, James J ^b   Townsend, Craig A ^c   Burkart, Michael D ^b   Tsai, Shiou Chuan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Aflatoxin; Atom replacement; Polyketide mimetics; Polyketide synthase; Product template

Indexed keywords

AFLATOXIN; CARBONYL DERIVATIVE; PHOSPHATE; POLYKETIDE; POLYKETIDE SYNTHASE; WATER; PANTETHEINE;

ADDITION REACTION; ARTICLE; ATOM; BIOMIMETICS; BIOSYNTHESIS; CONTROLLED STUDY; CRYSTALLOGRAPHY; IN VITRO STUDY; MOLECULAR DOCKING; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTON TRANSPORT; REGIOSELECTIVITY; CHEMISTRY; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

BIOMIMETICS; MUTAGENESIS, SITE-DIRECTED; PANTETHEINE; POLYKETIDE SYNTHASES; POLYKETIDES; PROTEIN CONFORMATION;

EID: 85019631508     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1609001114     Document Type: Article

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