Antidiabetogenic efficiency of menthol, improves glucose homeostasis and attenuates pancreatic β-cell apoptosis in streptozotocin–nicotinamide induced experimental rats through ameliorating glucose metabolic enzymes

Biomedicine and Pharmacotherapy

Volumn 92, Issue , 2017, Pages 229-239

  Muruganathan, Udaiyar ^a   Srinivasan, Subramani ^a,b   Vinothkumar, Veerasamy ^a  

^a ANNAMALAI UNIVERSITY   (India)

^b Government Arts College For Women   (India)

Author keywords

Apoptosis; Diabetes mellitus; Hepatic glucose metabolism; Menthol; Streptozotocin nicotinamide

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FRUCTOSE 6 PHOSPHATE; GLIBENCLAMIDE; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN; HEMOGLOBIN A1C; HEXOKINASE; INSULIN; MENTHOL; NICOTINAMIDE; PROTEIN BAX; PROTEIN BCL 2; PYRUVATE KINASE; STREPTOZOCIN; TERPENE; ANTIDIABETIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EXPERIMENTAL DIABETES MELLITUS; EXPERIMENTAL HYPERGLYCEMIA; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLYCOGEN LIVER LEVEL; GLYCOGEN METABOLISM; INSULIN BLOOD LEVEL; LIVER FUNCTION; LIVER INJURY; LIVER PROTECTION; MALE; MANAGED CARE; NONHUMAN; PANCREAS DISEASE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; HOMEOSTASIS; METABOLISM; PHYSIOLOGY; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; INSULIN-SECRETING CELLS; MALE; MENTHOL; NIACINAMIDE; RATS; RATS, WISTAR; STREPTOZOCIN; TREATMENT OUTCOME;

EID: 85019599435     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.05.068     Document Type: Article

References (46)

1. Zhang, X., Imperatore, G., Thomas, W., Cheng, Y.J., Lobelo, F., Norris, K., Devlin, H.M., Ali, M.K., Gruss, S., Bardenheier, B., Cho, P., Garcia de Quevedo, I., Mudaliar, U., Saaddine, J., Geiss, L.S., Gregg, E.W., Effect of lifestyle interventions on glucose regulation among adults without impaired glucose tolerance or diabetes: a systematic review and meta-analysis. Diabetes Res. Clin. Pract. 123 (2017), 149–164.
2. Sato, H., Nagashima, K., Ogura, M., Sato, Y., Tahara, Y., Ogura, K., Yamano, G., Sugizaki, K., Fujita, N., Tatsuoka, H., Usui, R., Mukai, E., Fujimoto, S., Inagaki, N., Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β-cells. J. Diabetes Investig. 7 (2016), 171–178.
3. International Diabetes Federation, IDF Diabetes Atlas. 7th ed., 2015, International Diabetes Federation, Brussels, Belgium Available at: http://www.idf.org/diabetesatlas (accessed 14.03.16).
4. Park, C.H., Lee, J.Y., Kim, M.Y., Shin, S.H., Roh, S.S., Choi, J.S., Chung, H.Y., Song, Y.O., Shin, Y.S., Yokozawa, T., Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats. Food Funct. 7 (2016), 3056–3063.
5. Donath, M.Y., Schumann, D.M., Faulenbach, M., Ellingsgaard, H., Perren, A., Ehses, J.A., Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Diabetes Care 31 (2008), 161–164.
6. Shahidi, F., Nutraceuticals and functional foods: whole versus processed foods. Trends Food Sci. Technol. 20 (2009), 376–387.
7. Vaddi, H.K., Ho, P.C., Chan, S.Y., Terpenes in propylene glycol as skin-penetration enhancers: permeation and partition of haloperidol, Fourier transform infrared spectroscopy, and differential scanning calorimetry. J. Pharm. Sci. 91 (2002), 1639–1651.
8. Patel, T., Ishiuji, Y., Yosipovitch, G., Menthol: a refreshing look at this ancient compound. J. Am. Acad. Dermatol. 57 (2007), 873–878.
9. Hajlaoui, H., Snoussi, M., Ben Jannet, H., Mighri, Z., Bakhrouf, A., Comparison of chemical composition and antimicrobial activities of Mentha longifolia L. ssp. longifolia essential oil from two Tunisian localities (Gabes and Sidi Bouzid). Ann. Microbiol. 58 (2008), 513–520.
10. Kim, S.H., Lee, S., Piccolo, S.R., Allen-Brady, K., Park, E.J., Chun, J.N., Kim, T.W., Cho, N.H., Kim, I.G., So, I., Jeon, J.H., Menthol induces cell-cycle arrest in PC-3 cells by down-regulating G2/M genes, including polo-like kinase1. BBRC 422 (2012), 436–441.
11. Raut, J.S., Shinde, R.B., Chauhan, N.M., Karuppayil, S.M., Terpenoids of plant origin inhibit morphogenesis, adhesion, and biofilm formation by Candida albicans. Biofouling 29 (2013), 87–96.
12. Baylac, S., Racine, P., Inhibition of 5-lipoxygenase by essential oils and other natural fragrant extracts. IJA 13 (2003), 138–142.
13. Trinder, P., Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem., 6, 1969, 24.
14. Bisse, E., Abragam, E.C., New less temperature sensitive, microchromatographic method for the separation and quantitation of glycosylated haemoglobin using a non cyanide buffer system. J. Chromatogr. 344 (1999), 81–91.
15. Brandstrup, N., Kirk, J.E., Bruni, C., The hexokinase and phosphoglucoisomerase activities of aortic and pulmonary artery tissue in individuals of various ages. J. Gerontol. 12 (1957), 166–171.
16. Bergmeyer, H.U., Glucose-6-Phosphate Dehydrogenase: Methods of Enzymatic Analysis, vol. 2, 1984, Verlag Chemie, Weinheim, Germany, 222–223.
17. Jamal, H., Ansari, W.H., Rizvi, S.J., Chalcones: differential effects on glycogen contents of liver, brain and spinal cord in rats. Biol. Med. 1 (2009), 107–115.
18. Koide, H., Oda, T., Pathological occurrence of glucose-6-phosphatase in serum in liver diseases. Clin. Chim. Acta 4 (1959), 554–561.
19. Gancedo, J.M., Gancedo, C., Fructose-1,6-diphosphatase, phosphor fructokinase and glucose-6-phosphate dehydrogenase from fermenting and non-fermenting yeasts. Arch. Mikrobiol. 176 (1971), 132–138.
20. Leloir, L.F., Goldemberg, S.H., Glycogen synthetase from rat liver. Methods Enzymol. 5 (1962), 145–147.
21. Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970), 680–685.
22. Lowry, O.H., Rosebrough, N.J., Farr, A.l., Randall, R.J., Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951), 265–275.
23. Bancroft, J.D., Stevens, A., Theory and Practice of Histological Techniques. 1990, Churchill Livingstone, Edinburgh, Great Britain.
24. Duncan, B.D., Multiple ranges tests for correlated and heteroscedastic means. Biometrics 13 (1957), 359–364.
25. Szkudelski, T., Zywert, A., Szkudelska, K., Metabolic disturbances and defects in insulin secretion in rats with streptozotocin–nicotinamide-induced diabetes. Physiol. Res. 62 (2013), 663–670.
26. Panahi, S., Tremblay, A., The potential role of yogurt in weight management and prevention of type 2 diabetes. J. Am. Coll. Nutr. 35 (2016), 717–731.
27. Chinedu, O., Ndodo, N.D., Ibrahim, K.G., The effect of cyclic monoterpene menthol on blood glucose, water and electrolyte excretion in rats. Online J. Med. Med. Sci. Res. 7 (2013), 86–89.
28. Murali, R., Saravanan, R., Antidiabetic effect of D-limonene, a monoterpene in streptozotocin-induced diabetic rats. Biomed. Prev. Nutr. 2 (2012), 269–275.
29. Barbalho, S.M.1, Damasceno, D.C., Spada, A.P., da Silva, V.S., Martuchi, K.A., Oshiiwa, M., Machado, F.M., Mendes, C.G., Metabolic profile of offspring from diabetic Wistar rats treated with Mentha piperita (peppermint). Evid. Based Complement. Alternat. Med., 2011, 2011, 430237.
30. McCoy, D.D., Zhou, L., Nguyen, A.K., Watts, A.G., Donovan, C.M., McKemy, D.D., Enhanced insulin clearance in mice lacking TRPM8 channels. Am. J. Physiol. Endocrinol. Metab. 305 (2013), 78–88.
31. Journigan, V.B., Zaveri, N.T., TRPM8 ion channel ligands for new therapeutic applications and as probes to study menthol pharmacology. Life Sci. 92 (2013), 425–437.
32. Nakagawa, Y., Nagasawa, M., Yamada, S., Hara, A., Mogami, H., Nikolaev, V.O., Lohse, M.J., Shigemura, N., Ninomiya, Y., Kojima, I., Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS ONE, 4, 2009, 5106.
33. Adam, S.H., Giribabu, N., Rao, P.V., Sayem, A.S., Arya, A., Panichayupakaranant, P., Korla, P.K., Salleh, N., Rhinacanthin C ameliorates hyperglycaemia, hyperlipidemia and pancreatic destruction in streptozotocin–nicotinamide induced adult male diabetic rats. Eur. J. Pharmacol. 771 (2016), 173–190.
34. Park, K., Lee, B.M., Hyun, K.H., Lee, D.H., Choi, H.H., Kim, H., Chong, W., Kim, K.B., Nam, S.Y., Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus. Bioorg. Med. Chem. 22 (2014), 2280–2293.
35. Balamurugan, R., Vendan, S.E., Aravinthan, A., Kim, J.H., Isolation and structural characterization of 2R, 3R taxifolin 3-O-rhamnoside from ethyl acetate extract of Hydnocarpus alpina and its hypoglycemic effect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats. Biochimie 111 (2015), 70–81.
36. Wang, J., Huang, Y., Li, K., Chen, Y., Vanegas, D., McLamore, E.S., Shen, Y., Leaf extract from Lithocarpus polystachyus Rehd. promote glycogen synthesis in T2DM mice. PLOS ONE, 11, 2016, 0166557.
37. Jiang, S.J., Dong, H., Li, J.B., Xu, L.J., Zou, X., Wang, K.F., Lu, F.E., Yi, P., Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats. World J. Gastroenterol. 21 (2015), 7777–7785.
38. Liu, T.Y., Shi, C.X., Gao, R., Sun, H.J., Xiong, X.Q., Ding, L., Chen, Q., Li, Y.H., Wang, J.J., Kang, Y.M., Zhu, G.Q., Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes. Clin. Sci. 129 (2015), 839–850.
39. Kovac, R., Rajkovic, V., Koledin, I., Matavulj, M., Acrylamide alters glycogen content and enzyme activities in the liver of juvenile rat. Acta Histochem. 117 (2015), 712–717.
40. Ahn, C., An, B.S., Jeung, E.B., Streptozotocin induces endoplasmic reticulum stress and apoptosis via disruption of calcium homeostasis in mouse pancreas. Mol. Cell. Endocrinol. 412 (2015), 302–308.
41. Roslan, J., Giribabu, N., Karim, K., Salleh, N., Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin–nicotinamide-induced adult male diabetic rats. Biomed. Pharmacother. 86 (2016), 570–582.
42. Arya, A., Al-Obaidi, M.M., Karim, R.B., Taha, H., Khan, A.K., Shahid, N., Sayem, A.S., Looi, C.Y., Mustafa, M.R., Mohd, M.A., Ali, H.M., Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function in streptozotocin–nicotinamide induced diabetic rats. J. Ethnopharmacol. 175 (2015), 229–240.
43. Koneri, R.B., Samaddar, S., Ramaiah, C.T., Antidiabetic activity of a triterpenoid saponin isolated from Momordica cymbalaria Fenzl, Indian. J. Exp. Biol. 52 (2014), 46–52.
44. Mustafa, H.N., The role of curcumin in streptozotocin-induced hepatic damage and the trans-differentiation of hepatic stellate cells. Tissue Cell 48 (2016), 81–88.
45. Akinola, O.B., Omotoso, G.O., Akinola, O.S., Dosumu, O.O., Adewoye, E.T., Effects of combined leaf extract of Vernonia amygdalina and Azadirachta indica on hepatic morphology and hepatotoxicity markers in streptozotocin-induced diabetic rats. Zhong Xi Yi Jie He Xue Bao 12 (2011), 1373–1379.
46. Janbaz, K.H., Gilani, A.H., Menthol prevents liver damage induced by paracetamol and CCl4. Pak. J. Biol. Sci. 5 (2002), 1101–1103.