메뉴 건너뛰기




Volumn 9, Issue 12, 2011, Pages 1373-1378

Effects of combined leaf extract of vernonia amygdalitis and azadirachta indica on hepatic morphology and hepatotoxicity markers in streptozotocin-induced diabetic rats

Author keywords

Azadirachta; Diabetes mellitus; Experimental; Hepatotoxicity; Oxidative stress; Plant extracts; Rats; Vernonia

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; AZADIRACHTA INDICA EXTRACT; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; METFORMIN; VERNONIA AMYGDALINA EXTRACT;

EID: 83755184201     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20111215     Document Type: Article
Times cited : (9)

References (23)
  • 3
    • 54949131340 scopus 로고    scopus 로고
    • National trends in treatment of type 2 diabetes mellitus, 1994-2007
    • Alexander GC, Sehgal NL, Moloney RM, Stafford RS. National trends in treatment of type 2 diabetes mellitus, 1994-2007. Arch Intern Med. 2008; 168(19): 2088-2094.
    • (2008) Arch Intern Med , vol.168 , Issue.19 , pp. 2088-2094
    • Alexander, G.C.1    Sehgal, N.L.2    Moloney, R.M.3    Stafford, R.S.4
  • 4
    • 70349623960 scopus 로고    scopus 로고
    • Vernonia amygdalina upregulates hepatic enzymes and improves liver microanatomy in experimental diabetes mellitus
    • Akinola OS, Akinola OB, Caxton-Martins EA. Vernonia amygdalina upregulates hepatic enzymes and improves liver microanatomy in experimental diabetes mellitus. Pharmacologyonline. 2009; 2: 1231-1242.
    • (2009) Pharmacologyonline , vol.2 , pp. 1231-1242
    • Akinola, O.S.1    Akinola, O.B.2    Caxton-Martins, E.A.3
  • 5
    • 77954182398 scopus 로고    scopus 로고
    • Chronic treatment with ethanolic leaf extract of Azadirachta indica ameliorates lesions of pancreatic islets in strepto-zotocin diabetes
    • Akinola OB, Caxton-Martins EA, Dini L. Chronic treatment with ethanolic leaf extract of Azadirachta indica ameliorates lesions of pancreatic islets in strepto-zotocin diabetes. Int J Morphol. 2010; 28(4): 292-302.
    • (2010) Int J Morphol , vol.28 , Issue.4 , pp. 292-302
    • Akinola, O.B.1    Caxton-Martins, E.A.2    Dini, L.3
  • 6
    • 48249116012 scopus 로고    scopus 로고
    • The antidiabetic efficacy of combined extracts from two continental plants: Azadirachta indica (A. Juss) (Neem) and Vernonia amygdalina (Del.) (African bitter leaf)
    • Ebong PE, Atangwho IJ, Eyong EU, Egbung GE. The antidiabetic efficacy of combined extracts from two continental plants: Azadirachta indica (A. Juss) (Neem) and Vernonia amygdalina (Del.) (African bitter leaf). Am J Biochem Biotechnol. 2008; 4(3): 239-244.
    • (2008) Am J Biochem Biotechnol , vol.4 , Issue.3 , pp. 239-244
    • Ebong, P.E.1    Atangwho, I.J.2    Eyong, E.U.3    Egbung, G.E.4
  • 7
    • 77953416903 scopus 로고    scopus 로고
    • Metformin reduces body weight gain and improves glucose intolerance in high-fat diet-fed C57BL/6J mice
    • Matsui Y, Hirasawa Y, Sugiura T, Toyoshi T, Kyuki K, Ito M. Metformin reduces body weight gain and improves glucose intolerance in high-fat diet-fed C57BL/6J mice. Biol Pharm Bull. 2010; 33(6): 963-970.
    • (2010) Biol Pharm Bull , vol.33 , Issue.6 , pp. 963-970
    • Matsui, Y.1    Hirasawa, Y.2    Sugiura, T.3    Toyoshi, T.4    Kyuki, K.5    Ito, M.6
  • 9
    • 66349129125 scopus 로고
    • A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases
    • Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957; 28 (1): 56-63.
    • (1957) Am J Clin Pathol , vol.28 , Issue.1 , pp. 56-63
    • Reitman, S.1    Frankel, S.2
  • 10
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95(2): 351-358.
    • (1979) Anal Biochem , vol.95 , Issue.2 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 11
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
    • Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967; 70(1): 158-169.
    • (1967) J Lab Clin Med , vol.70 , Issue.1 , pp. 158-169
    • Paglia, D.E.1    Valentine, W.N.2
  • 12
    • 70350129993 scopus 로고
    • An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma
    • Weichselbaum TE. An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma. Am J Clin Pathol. 1946; 10: 40-49.
    • (1946) Am J Clin Pathol , vol.10 , pp. 40-49
    • Weichselbaum, T.E.1
  • 13
    • 77956601047 scopus 로고    scopus 로고
    • Effect of Vernonia amygdalina and chlorpropamide on blood glucose
    • Osinubi AA. Effect of Vernonia amygdalina and chlorpropamide on blood glucose. Med J Islamic World Acad Sci. 2006; 16: 115-119.
    • (2006) Med J Islamic World Acad Sci , vol.16 , pp. 115-119
    • Osinubi, A.A.1
  • 17
    • 80052227277 scopus 로고    scopus 로고
    • Drug-induced liver injury: An update
    • Chau T. Drug-induced liver injury: an update. Med Bull. 2008; 13(3): 23-26.
    • (2008) Med Bull , vol.13 , Issue.3 , pp. 23-26
    • Chau, T.1
  • 18
    • 79959280879 scopus 로고    scopus 로고
    • In vivo anti-diabetic activity of the ethanolic crude extract of Sorbus decora CK Schneid. (Rosacea): A medicinal plant used by Canadian James Bay Cree Nations to treat symptoms related to diabetes
    • 2009 Nov 3. [Epub ahead of print]
    • Vianna R, Brault A, Martineau LC, Couture R, Arnason JT, Haddad PS. In vivo anti-diabetic activity of the ethanolic crude extract of Sorbus decora CK Schneid. (Rosacea): a medicinal plant used by Canadian James Bay Cree Nations to treat symptoms related to diabetes. Evid Based Complement Alternat Med. 2009 Nov 3. [Epub ahead of print]
    • Evid Based Complement Alternat Med
    • Vianna, R.1    Brault, A.2    Martineau, L.C.3    Couture, R.4    Arnason, J.T.5    Haddad, P.S.6
  • 20
    • 0037169941 scopus 로고    scopus 로고
    • Evaluation of prescribing practices: Risk of lactic acidosis with metformin therapy
    • Calabrese AT, Coley KC, DaPos SV, Swanson D, Rao RH. Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy. Arch Intern Med. 2002; 162(4): 434-437.
    • (2002) Arch Intern Med , vol.162 , Issue.4 , pp. 434-437
    • Calabrese, A.T.1    Coley, K.C.2    Dapos, S.V.3    Swanson, D.4    Rao, R.H.5
  • 21
    • 0344417048 scopus 로고    scopus 로고
    • Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin
    • Large V, Beylot M. Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin. Diabetes. 1999; 48 (6): 1251-1257.
    • (1999) Diabetes , vol.48 , Issue.6 , pp. 1251-1257
    • Large, V.1    Beylot, M.2
  • 22
    • 0027521967 scopus 로고
    • Phenformin-induced lactic acidosis: A forgotten adverse drug reaction
    • McGuinness ME, Talbert RL. Phenformin-induced lactic acidosis: a forgotten adverse drug reaction. Ann Phar-macother. 1993; 27(10): 1183-1187.
    • (1993) Ann Phar-macother , vol.27 , Issue.10 , pp. 1183-1187
    • McGuinness, M.E.1    Talbert, R.L.2
  • 23
    • 0025732948 scopus 로고
    • Role of oxidative stress in development of complications in diabetes
    • Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes. 1991; 40(4): 405-412.
    • (1991) Diabetes , vol.40 , Issue.4 , pp. 405-412
    • Baynes, J.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.