Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

World Journal of Gastroenterology

Volumn 21, Issue 25, 2015, Pages 7777-7785

  Jiang, Shu Jun ^a   Dong, Hui ^a   Li, Jing Bin ^a   Xu, Li Jun ^a   Zou, Xin ^a   Wang, Kai Fu ^a   Lu, Fu Er ^a   Yi, Ping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

AMPK; Berberine; Diabetes; Hepatic gluconeogenesis; LKB1; TORC2

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACTIVATING TRANSCRIPTION FACTOR 4; ANTIDIABETIC AGENT; BERBERINE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCINE DEHYDROGENASE (DECARBOXYLATING); HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN KINASE LKB1; STREPTOZOCIN; TRIACYLGLYCEROL; VASCULOTROPIN RECEPTOR 2; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; BIOLOGICAL MARKER; CRTC2 PROTEIN, RAT; GLUCOSE BLOOD LEVEL; PHOSPHOENOLPYRUVATE CARBOXYKINASE 1 (SOLUBLE) PROTEIN, RAT; PROTEIN SERINE THREONINE KINASE; RIBONUCLEOTIDE; SIGNAL PEPTIDE; STK11 PROTEIN, RAT; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CELL FUNCTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DYSLIPIDEMIA; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE TRANSLOCATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LIPID DIET; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ACTIVE TRANSPORT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMICALLY INDUCED; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; ENZYMOLOGY; HYPERLIPIDEMIAS; LIVER; METABOLISM; PHOSPHORYLATION; TIME FACTOR; WISTAR RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BERBERINE; BIOMARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GLUCONEOGENESIS; GLUCOSE-6-PHOSPHATASE; HYPERLIPIDEMIAS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPIDS; LIVER; MALE; METFORMIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS, WISTAR; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION; STREPTOZOCIN; TIME FACTORS; TRANS-ACTIVATORS; UP-REGULATION;

EID: 84936797739     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i25.7777     Document Type: Article

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