메뉴 건너뛰기




Volumn 140, Issue 5, 2017, Pages 1220-1230

Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model

Author keywords

Alzheimer's disease; blood brain barrier; dementia; neurofibrillary tangles; tau

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; RN2N ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TAU PROTEIN; UNCLASSIFIED DRUG; ANTIBODY; ISOPROTEIN;

EID: 85019548685     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awx052     Document Type: Article
Times cited : (145)

References (45)
  • 2
    • 77953812123 scopus 로고    scopus 로고
    • Neurons but not glial cells overexpress ubiquitin in the rat brain following focused ultrasound-induced opening of the blood-brain barrier
    • Alonso A, Reinz E, Fatar M, Jenne J, Hennerici MG, Meairs S. Neurons but not glial cells overexpress ubiquitin in the rat brain following focused ultrasound-induced opening of the blood-brain barrier. Neuroscience 2010; 169: 116-24.
    • (2010) Neuroscience , vol.169 , pp. 116-124
    • Alonso, A.1    Reinz, E.2    Fatar, M.3    Jenne, J.4    Hennerici, M.G.5    Meairs, S.6
  • 3
    • 80052638024 scopus 로고    scopus 로고
    • Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach
    • Amniai L, Lippens G, Landrieu I. Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach. Biochem Biophys Res Commun 2011; 412: 743-6.
    • (2011) Biochem Biophys Res Commun , vol.412 , pp. 743-746
    • Amniai, L.1    Lippens, G.2    Landrieu, I.3
  • 4
    • 0026551711 scopus 로고
    • The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region
    • Biernat J, Mandelkow EM, Schroter C, Lichtenberg-Kraag B, Steiner B, Berling B, et al. The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region. EMBO J 1992; 11: 1593-7.
    • (1992) EMBO J , vol.11 , pp. 1593-1597
    • Biernat, J.1    Mandelkow, E.M.2    Schroter, C.3    Lichtenberg-Kraag, B.4    Steiner, B.5    Berling, B.6
  • 5
    • 79960563632 scopus 로고    scopus 로고
    • Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
    • Boutajangout A, Ingadottir J, Davies P, Sigurdsson EM. Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. J Neurochem 2011; 118: 658-67.
    • (2011) J Neurochem , vol.118 , pp. 658-667
    • Boutajangout, A.1    Ingadottir, J.2    Davies, P.3    Sigurdsson, E.M.4
  • 6
    • 84896269359 scopus 로고    scopus 로고
    • Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles
    • Castillo-Carranza DL, Sengupta U, Guerrero-Munoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, et al. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J Neurosci 2014; 34: 4260-72.
    • (2014) J Neurosci , vol.34 , pp. 4260-4272
    • Castillo-Carranza, D.L.1    Sengupta, U.2    Guerrero-Munoz, M.J.3    Lasagna-Reeves, C.A.4    Gerson, J.E.5    Singh, G.6
  • 7
    • 79953699669 scopus 로고    scopus 로고
    • Chronic intranasal treatment with an anti-Abeta(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease
    • Cattepoel S, Hanenberg M, Kulic L, Nitsch RM. Chronic intranasal treatment with an anti-Abeta(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease. PLoS One 2011; 6: e18296.
    • (2011) PLoS One , vol.6 , pp. e18296
    • Cattepoel, S.1    Hanenberg, M.2    Kulic, L.3    Nitsch, R.M.4
  • 8
    • 0037414833 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding
    • Cho JH, Johnson GV. Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding. J Biol Chem 2003; 278: 187-93.
    • (2003) J Biol Chem , vol.278 , pp. 187-193
    • Cho, J.H.1    Johnson, G.V.2
  • 9
    • 71849102712 scopus 로고    scopus 로고
    • Molecules of various pharmacologically-relevant sizes can cross the ultrasoundinduced blood-brain barrier opening in vivo
    • Choi JJ, Wang S, Tung YS, Morrison B III, Konofagou EE. Molecules of various pharmacologically-relevant sizes can cross the ultrasoundinduced blood-brain barrier opening in vivo. Ultrasound Med Biol 2010; 36: 58-67.
    • (2010) Ultrasound Med Biol , vol.36 , pp. 58-67
    • Choi, J.J.1    Wang, S.2    Tung, Y.S.3    Morrison, B.4    Konofagou, E.E.5
  • 10
    • 84908377705 scopus 로고    scopus 로고
    • Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease
    • Collin L, Bohrmann B, Gopfert U, Oroszlan-Szovik K, Ozmen L, Gruninger F. Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease. Brain 2014; 137: 2834-46.
    • (2014) Brain , vol.137 , pp. 2834-2846
    • Collin, L.1    Bohrmann, B.2    Gopfert, U.3    Oroszlan-Szovik, K.4    Ozmen, L.5    Gruninger, F.6
  • 11
    • 84890282160 scopus 로고    scopus 로고
    • Antibody uptake into neurons occurs primarily via clathrin-dependent Fcgamma receptor endocytosis and is a prerequisite for acute tau protein clearance
    • Congdon EE, Gu J, Sait HB, Sigurdsson EM. Antibody uptake into neurons occurs primarily via clathrin-dependent Fcgamma receptor endocytosis and is a prerequisite for acute tau protein clearance. J Biol Chem 2013; 288: 35452-65.
    • (2013) J Biol Chem , vol.288 , pp. 35452-35465
    • Congdon, E.E.1    Gu, J.2    Sait, H.B.3    Sigurdsson, E.M.4
  • 12
    • 54049104444 scopus 로고    scopus 로고
    • Divergent phosphorylation pattern of tau in P301L tau transgenic mice
    • Deters N, Ittner LM, Gotz J. Divergent phosphorylation pattern of tau in P301L tau transgenic mice. Eur J Neurosci 2008; 28: 137-47.
    • (2008) Eur J Neurosci , vol.28 , pp. 137-147
    • Deters, N.1    Ittner, L.M.2    Gotz, J.3
  • 13
    • 84949233665 scopus 로고    scopus 로고
    • Anti-A beta single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease
    • Fernandez-Funez P, Zhang Y, Sanchez-Garcia J, de Mena L, Khare S, Golde TE, et al. Anti-A beta single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease. Hum Mol Genet 2015; 24: 6093-105.
    • (2015) Hum Mol Genet , vol.24 , pp. 6093-6105
    • Fernandez-Funez, P.1    Zhang, Y.2    Sanchez-Garcia, J.3    De Mena, L.4    Khare, S.5    Golde, T.E.6
  • 15
    • 0025600995 scopus 로고
    • Expression of separate isoforms of human tau protein: Correlation with the tau pattern in brain and effects on tubulin polymerization
    • Goedert M, Jakes R. Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J 1990; 9: 4225-30.
    • (1990) EMBO J , vol.9 , pp. 4225-4230
    • Goedert, M.1    Jakes, R.2
  • 16
    • 0027984739 scopus 로고
    • Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau protein
    • Goedert M, Jakes R, Crowther RA, Cohen P, Vanmechelen E, Vandermeeren M, et al. Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein. Biochem J 1994; 301 (Pt 3): 871-7.
    • (1994) Biochem J , vol.301 , pp. 871-877
    • Goedert, M.1    Jakes, R.2    Crowther, R.A.3    Cohen, P.4    Vanmechelen, E.5    Vandermeeren, M.6
  • 17
    • 84891864287 scopus 로고    scopus 로고
    • Open questions for Alzheimer's disease immunotherapy
    • Golde TE. Open questions for Alzheimer's disease immunotherapy. Alzheimers Res Ther 2014; 6: 3.
    • (2014) Alzheimers Res Ther , vol.6 , pp. 3
    • Golde, T.E.1
  • 18
    • 0035808361 scopus 로고    scopus 로고
    • Tau filament formation in transgenic mice expressing P301L tau
    • Gotz J, Chen F, Barmettler R, Nitsch RM. Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem 2001; 276: 529-34.
    • (2001) J Biol Chem , vol.276 , pp. 529-534
    • Gotz, J.1    Chen, F.2    Barmettler, R.3    Nitsch, R.M.4
  • 19
    • 84887837879 scopus 로고    scopus 로고
    • Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology
    • Gu J, Congdon EE, Sigurdsson EM. Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology. J Biol Chem 2013; 288: 33081-95.
    • (2013) J Biol Chem , vol.288 , pp. 33081-33095
    • Gu, J.1    Congdon, E.E.2    Sigurdsson, E.M.3
  • 20
    • 80052682729 scopus 로고    scopus 로고
    • Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation
    • Hanger DP, Noble W. Functional implications of glycogen synthase kinase-3-mediated tau phosphorylation. Int J Alzheimers Dis 2011; 2011: 352805.
    • (2011) Int J Alzheimers Dis , vol.2011 , pp. 352805
    • Hanger, D.P.1    Noble, W.2
  • 21
    • 84872587279 scopus 로고    scopus 로고
    • GSK3 and tau: Two convergence points in Alzheimer's disease
    • Hernandez F, Lucas JJ, Avila J. GSK3 and tau: two convergence points in Alzheimer's disease. J Alzheimers Dis 2013; 33 (Suppl 1): S141-4.
    • (2013) J Alzheimers Dis , vol.33 , pp. S141-S144
    • Hernandez, F.1    Lucas, J.J.2    Avila, J.3
  • 22
    • 84951816455 scopus 로고    scopus 로고
    • Current thinking on the mechanistic basis of Alzheimer's and implications for drug development
    • Ising C, Stanley M, Holtzman DM. Current thinking on the mechanistic basis of Alzheimer's and implications for drug development. Clin Pharmacol Ther 2015; 98: 469-71.
    • (2015) Clin Pharmacol Ther , vol.98 , pp. 469-471
    • Ising, C.1    Stanley, M.2    Holtzman, D.M.3
  • 23
    • 84923626096 scopus 로고    scopus 로고
    • Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice
    • Ittner A, Bertz J, Suh LS, Stevens CH, Gotz J, Ittner LM. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem 2015; 132: 135-45.
    • (2015) J Neurochem , vol.132 , pp. 135-145
    • Ittner, A.1    Bertz, J.2    Suh, L.S.3    Stevens, C.H.4    Gotz, J.5    Ittner, L.M.6
  • 24
    • 57349172663 scopus 로고    scopus 로고
    • Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia
    • Ittner LM, Fath T, Ke YD, Bi M, van Eersel J, Li KM, et al. Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proc Natl Acad Sci USA 2008; 105: 15997-6002.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15997-16002
    • Ittner, L.M.1    Fath, T.2    Ke, Y.D.3    Bi, M.4    Van Eersel, J.5    Li, K.M.6
  • 25
    • 77955322042 scopus 로고    scopus 로고
    • Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
    • Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 2010; 142: 387-97.
    • (2010) Cell , vol.142 , pp. 387-397
    • Ittner, L.M.1    Ke, Y.D.2    Delerue, F.3    Bi, M.4    Gladbach, A.5    Van Eersel, J.6
  • 26
    • 0026335705 scopus 로고
    • Construction of single-chain Fv derivatives monoclonal antibodies and their production in Escherichia coli
    • Johnson S, Bird RE. Construction of single-chain Fv derivatives monoclonal antibodies and their production in Escherichia coli. Methods Enzymol 1991; 203: 88-98.
    • (1991) Methods Enzymol , vol.203 , pp. 88-98
    • Johnson, S.1    Bird, R.E.2
  • 27
    • 77949915973 scopus 로고    scopus 로고
    • A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies
    • Jones ML, Seldon T, Smede M, Linville A, Chin DY, Barnard R, et al. A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies. J Immunol Methods 2010; 354: 85-90.
    • (2010) J Immunol Methods , vol.354 , pp. 85-90
    • Jones, M.L.1    Seldon, T.2    Smede, M.3    Linville, A.4    Chin, D.Y.5    Barnard, R.6
  • 28
    • 77956287949 scopus 로고    scopus 로고
    • Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease
    • Jordao JF, Ayala-Grosso CA, Markham K, Huang Y, Chopra R, McLaurin J, et al. Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease. PLoS One 2010; 5: e10549.
    • (2010) PLoS One , vol.5 , pp. e10549
    • Jordao, J.F.1    Ayala-Grosso, C.A.2    Markham, K.3    Huang, Y.4    Chopra, R.5    McLaurin, J.6
  • 29
    • 84873461276 scopus 로고    scopus 로고
    • Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice
    • Kohler C, Dinekov M, Gotz J. Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice. Neurobiol Aging 2013; 34: 1369-79.
    • (2013) Neurobiol Aging , vol.34 , pp. 1369-1379
    • Kohler, C.1    Dinekov, M.2    Gotz, J.3
  • 30
    • 84960921365 scopus 로고    scopus 로고
    • Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology
    • Koss DJ, Robinson L, Drever BD, Plucinska K, Stoppelkamp S, Veselcic P, et al. Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology. Neurobiol Dis 2016; 91: 105-23.
    • (2016) Neurobiol Dis , vol.91 , pp. 105-123
    • Koss, D.J.1    Robinson, L.2    Drever, B.D.3    Plucinska, K.4    Stoppelkamp, S.5    Veselcic, P.6
  • 32
    • 84924589138 scopus 로고    scopus 로고
    • Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model
    • Leinenga G, Gotz J. Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model. Sci Transl Med 2015; 7: 278ra33.
    • (2015) Sci Transl Med , vol.7 , pp. 278ra33
    • Leinenga, G.1    Gotz, J.2
  • 33
    • 33845639102 scopus 로고    scopus 로고
    • Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models
    • Levites Y, Smithson LA, Price RW, Dakin RS, Yuan B, Sierks MR, et al. Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. FASEB J 2006; 20: 2576-8.
    • (2006) FASEB J , vol.20 , pp. 2576-2578
    • Levites, Y.1    Smithson, L.A.2    Price, R.W.3    Dakin, R.S.4    Yuan, B.5    Sierks, M.R.6
  • 34
    • 84893529375 scopus 로고    scopus 로고
    • Profiling murine tau with 0N, 1N and 2N isoformspecific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus
    • Liu C, Gotz J. Profiling murine tau with 0N, 1N and 2N isoformspecific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus. PLoS One 2013; 8: e84849.
    • (2013) PLoS One , vol.8 , pp. e84849
    • Liu, C.1    Gotz, J.2
  • 35
    • 84964575878 scopus 로고    scopus 로고
    • Co-immunoprecipitation with tau isoform-specific antibodies reveals distinct protein interactions, and highlights a putative role for 2N tau in disease
    • Liu C, Song X, Nisbet R, Gotz J. Co-immunoprecipitation with tau isoform-specific antibodies reveals distinct protein interactions, and highlights a putative role for 2N tau in disease. J Biol Chem 2016a; 291: 8173-88.
    • (2016) J Biol Chem , vol.291 , pp. 8173-8188
    • Liu, C.1    Song, X.2    Nisbet, R.3    Gotz, J.4
  • 36
    • 84989237497 scopus 로고    scopus 로고
    • Focused ultrasound enhances central nervous system delivery of Bevacizumab for Malignant Glioma treatment
    • Liu HL, Hsu PH, Lin CY, Huang CW, Chai WY, Chu PC, et al. Focused ultrasound enhances central nervous system delivery of Bevacizumab for Malignant Glioma treatment. Radiology 2016b; 281: 99-108.
    • (2016) Radiology , vol.281 , pp. 99-108
    • Liu, H.L.1    Hsu, P.H.2    Lin, C.Y.3    Huang, C.W.4    Chai, W.Y.5    Chu, P.C.6
  • 37
    • 84885008285 scopus 로고    scopus 로고
    • Central amyloid-beta-specific single chain variable fragment ameliorates Abeta aggregation and neurotoxicity
    • Nisbet RM, Nigro J, Breheney K, Caine J, Hattarki MK, Nuttall SD. Central amyloid-beta-specific single chain variable fragment ameliorates Abeta aggregation and neurotoxicity. Protein Eng Des Sel 2013; 26: 571-80.
    • (2013) Protein Eng des Sel , vol.26 , pp. 571-580
    • Nisbet, R.M.1    Nigro, J.2    Breheney, K.3    Caine, J.4    Hattarki, M.K.5    Nuttall, S.D.6
  • 39
    • 1842431831 scopus 로고    scopus 로고
    • Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice
    • Pennanen L, Welzl H, D'Adamo P, Nitsch RM, Gotz J. Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice. Neurobiol Dis 2004; 15: 500-9.
    • (2004) Neurobiol Dis , vol.15 , pp. 500-509
    • Pennanen, L.1    Welzl, H.2    D'Adamo, P.3    Nitsch, R.M.4    Gotz, J.5
  • 41
    • 84900445093 scopus 로고    scopus 로고
    • IHC Profiler: An open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples
    • Varghese F, Bukhari AB, Malhotra R, De A. IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples. PLoS One 2014; 9: e96801.
    • (2014) PLoS One , vol.9 , pp. e96801
    • Varghese, F.1    Bukhari, A.B.2    Malhotra, R.3    De, A.4
  • 42
    • 56049116893 scopus 로고    scopus 로고
    • Peptide - Assisted traffic engineering for nonviral gene therapy
    • Vazquez E, Ferrer-Miralles N, Villaverde A. Peptide-assisted traffic engineering for nonviral gene therapy. Drug Discov Today 2008; 13: 1067-74.
    • (2008) Drug Discov Today , vol.13 , pp. 1067-1074
    • Vazquez, E.1    Ferrer-Miralles, N.2    Villaverde, A.3
  • 43
    • 34347207241 scopus 로고    scopus 로고
    • The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
    • Walf AA, Frye CA. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc 2007; 2: 322-8.
    • (2007) Nat Protoc , vol.2 , pp. 322-328
    • Walf, A.A.1    Frye, C.A.2
  • 44
    • 33745001453 scopus 로고    scopus 로고
    • Deglycosylated anti - Amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice
    • Wilcock DM, Alamed J, Gottschall PE, Grimm J, Rosenthal A, Pons J, et al. Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. J Neurosci 2006; 26: 5340-6.
    • (2006) J Neurosci , vol.26 , pp. 5340-5346
    • Wilcock, D.M.1    Alamed, J.2    Gottschall, P.E.3    Grimm, J.4    Rosenthal, A.5    Pons, J.6
  • 45
    • 84885783467 scopus 로고    scopus 로고
    • Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo
    • Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, et al. Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron 2013; 80: 402-14.
    • (2013) Neuron , vol.80 , pp. 402-414
    • Yanamandra, K.1    Kfoury, N.2    Jiang, H.3    Mahan, T.E.4    Ma, S.5    Maloney, S.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.