-
1
-
-
84876908676
-
Tau passive immunotherapy in mutant P301L mice: Antibody affinity versus specificity
-
d'Abramo C., Acker C. M., Jimenez H. T., and, Davies P., (2013) Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity. PLoS ONE 8, e62402.
-
(2013)
PLoS ONE
, vol.8
, pp. e62402
-
-
D'Abramo, C.1
Acker, C.M.2
Jimenez, H.T.3
Davies, P.4
-
2
-
-
0036850725
-
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein
-
Allen B., Ingram E., Takao M., et al,. (2002) Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J. Neurosci. 22, 9340-9351.
-
(2002)
J. Neurosci.
, vol.22
, pp. 9340-9351
-
-
Allen, B.1
Ingram, E.2
Takao, M.3
-
3
-
-
34548146119
-
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
-
Asuni A. A., Boutajangout A., Quartermain D., and, Sigurdsson E. M., (2007) Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J. Neurosci. 27, 9115-9129.
-
(2007)
J. Neurosci.
, vol.27
, pp. 9115-9129
-
-
Asuni, A.A.1
Boutajangout, A.2
Quartermain, D.3
Sigurdsson, E.M.4
-
4
-
-
82955194797
-
Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice
-
Bi M., Ittner A., Ke Y. D., Gotz J., and, Ittner L. M., (2011) Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS ONE 6, e26860.
-
(2011)
PLoS ONE
, vol.6
, pp. e26860
-
-
Bi, M.1
Ittner, A.2
Ke, Y.D.3
Gotz, J.4
Ittner, L.M.5
-
5
-
-
79960563632
-
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
-
Boutajangout A., Ingadottir J., Davies P., and, Sigurdsson E. M., (2011) Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. J. Neurochem. 118, 658-667.
-
(2011)
J. Neurochem.
, vol.118
, pp. 658-667
-
-
Boutajangout, A.1
Ingadottir, J.2
Davies, P.3
Sigurdsson, E.M.4
-
6
-
-
0029013727
-
Staging of Alzheimer's disease-related neurofibrillary changes
-
discussion 278-284
-
Braak H., and, Braak E., (1995) Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol. Aging, 16, 271-278; discussion 278-284.
-
(1995)
Neurobiol. Aging
, vol.16
, pp. 271-278
-
-
Braak, H.1
Braak, E.2
-
7
-
-
84896269359
-
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles
-
Castillo-Carranza D. L., Sengupta U., Guerrero-Munoz M. J., et al,. (2014) Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J. Neurosci. 34, 4260-4272.
-
(2014)
J. Neurosci.
, vol.34
, pp. 4260-4272
-
-
Castillo-Carranza, D.L.1
Sengupta, U.2
Guerrero-Munoz, M.J.3
-
8
-
-
80053202160
-
Passive immunization with anti-Tau antibodies in two transgenic models: Reduction of Tau pathology and delay of disease progression
-
Chai X., Wu S., Murray T. K., et al,. (2011) Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. J. Biol. Chem. 286, 34457-34467.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 34457-34467
-
-
Chai, X.1
Wu, S.2
Murray, T.K.3
-
9
-
-
0029031214
-
Molecular dissection of the paired helical filament
-
Goedert M., Spillantini M. G., Jakes R., Crowther R. A., Vanmechelen E., Probst A., Gotz J., Burki K., and, Cohen P., (1995) Molecular dissection of the paired helical filament. Neurobiol. Aging 16, 325-334.
-
(1995)
Neurobiol. Aging
, vol.16
, pp. 325-334
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Crowther, R.A.4
Vanmechelen, E.5
Probst, A.6
Gotz, J.7
Burki, K.8
Cohen, P.9
-
10
-
-
45749151056
-
Animal models of Alzheimer's disease and frontotemporal dementia
-
Gotz J., and, Ittner L. M., (2008) Animal models of Alzheimer's disease and frontotemporal dementia. Nat. Rev. Neurosci. 9, 532-544.
-
(2008)
Nat. Rev. Neurosci.
, vol.9
, pp. 532-544
-
-
Gotz, J.1
Ittner, L.M.2
-
11
-
-
0035808361
-
Tau filament formation in transgenic mice expressing P301L tau
-
Gotz J., Chen F., Barmettler R., and, Nitsch R. M., (2001a) Tau filament formation in transgenic mice expressing P301L tau. J. Biol. Chem. 276, 529-534.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 529-534
-
-
Gotz, J.1
Chen, F.2
Barmettler, R.3
Nitsch, R.M.4
-
12
-
-
0035943436
-
Formation of neurofibrillary tangles in P301 l tau transgenic mice induced by Abeta 42 fibrils
-
Gotz J., Chen F., van Dorpe J., and, Nitsch R. M., (2001b) Formation of neurofibrillary tangles in P301 l tau transgenic mice induced by Abeta 42 fibrils. Science 293, 1491-1495.
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
Van Dorpe, J.3
Nitsch, R.M.4
-
13
-
-
84857077700
-
Tau-targeted treatment strategies in Alzheimer's disease
-
Gotz J., Ittner A., and, Ittner L. M., (2012) Tau-targeted treatment strategies in Alzheimer's disease. Br. J. Pharmacol. 165, 1246-1259.
-
(2012)
Br. J. Pharmacol.
, vol.165
, pp. 1246-1259
-
-
Gotz, J.1
Ittner, A.2
Ittner, L.M.3
-
14
-
-
0026501888
-
Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau
-
Greenberg S. G., Davies P., Schein J. D., and, Binder L. I., (1992) Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. J. Biol. Chem. 267, 564-569.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 564-569
-
-
Greenberg, S.G.1
Davies, P.2
Schein, J.D.3
Binder, L.I.4
-
15
-
-
73049087785
-
Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice
-
Grueninger F., Bohrmann B., Czech C., Ballard T. M., Frey J. R., Weidensteiner C., von Kienlin M., and, Ozmen L., (2010) Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice. Neurobiol. Dis. 37, 294-306.
-
(2010)
Neurobiol. Dis.
, vol.37
, pp. 294-306
-
-
Grueninger, F.1
Bohrmann, B.2
Czech, C.3
Ballard, T.M.4
Frey, J.R.5
Weidensteiner, C.6
Von Kienlin, M.7
Ozmen, L.8
-
16
-
-
84887837879
-
Two novel tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce tau pathology
-
Gu J., Congdon E. E., and, Sigurdsson E. M., (2013) Two novel tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce tau pathology. J. Biol. Chem., 288, 33081-33095.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 33081-33095
-
-
Gu, J.1
Congdon, E.E.2
Sigurdsson, E.M.3
-
17
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
-
Haass C., and, Selkoe D. J., (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 8, 101-112.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
18
-
-
78751644048
-
Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease
-
Ittner L. M., and, Gotz J., (2011) Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease. Nat. Rev. Neurosci. 12, 65-72.
-
(2011)
Nat. Rev. Neurosci.
, vol.12
, pp. 65-72
-
-
Ittner, L.M.1
Gotz, J.2
-
19
-
-
57349172663
-
Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia
-
Ittner L. M., Fath T., Ke Y. D., Bi M., van Eersel J., Li K. M., Gunning P., and, Gotz J., (2008) Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proc. Natl Acad. Sci. USA 105, 15997-16002.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 15997-16002
-
-
Ittner, L.M.1
Fath, T.2
Ke, Y.D.3
Bi, M.4
Van Eersel, J.5
Li, K.M.6
Gunning, P.7
Gotz, J.8
-
20
-
-
68949105821
-
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease
-
Ittner L. M., Ke Y. D., and, Gotz J., (2009) Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J. Biol. Chem. 284, 20909-20916.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 20909-20916
-
-
Ittner, L.M.1
Ke, Y.D.2
Gotz, J.3
-
21
-
-
79959593757
-
Brief update on different roles of tau in neurodegeneration
-
Ittner A., Ke Y. D., van Eersel J., Gladbach A., Gotz J., and, Ittner L. M., (2011) Brief update on different roles of tau in neurodegeneration. IUBMB Life 63, 495-502.
-
(2011)
IUBMB Life
, vol.63
, pp. 495-502
-
-
Ittner, A.1
Ke, Y.D.2
Van Eersel, J.3
Gladbach, A.4
Gotz, J.5
Ittner, L.M.6
-
22
-
-
84871914752
-
Regulation of PTEN activity by p38delta-PKD1 signaling in neutrophils confers inflammatory responses in the lung
-
Ittner A., Block H., Reichel C. A., et al,. (2012) Regulation of PTEN activity by p38delta-PKD1 signaling in neutrophils confers inflammatory responses in the lung. J. Exp. Med. 209, 2229-2246.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 2229-2246
-
-
Ittner, A.1
Block, H.2
Reichel, C.A.3
-
23
-
-
84903552187
-
The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo
-
Ittner A. A., Bertz J., Chan T. Y., van Eersel J., Polly P., and, Ittner L. M., (2014) The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo. Diabetologia, 57, 1410-1419.
-
(2014)
Diabetologia
, vol.57
, pp. 1410-1419
-
-
Ittner, A.A.1
Bertz, J.2
Chan, T.Y.3
Van Eersel, J.4
Polly, P.5
Ittner, L.M.6
-
24
-
-
57649129018
-
Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation
-
Jeganathan S., Hascher A., Chinnathambi S., Biernat J., Mandelkow E. M., and, Mandelkow E., (2008) Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. J. Biol. Chem. 283, 32066-32076.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 32066-32076
-
-
Jeganathan, S.1
Hascher, A.2
Chinnathambi, S.3
Biernat, J.4
Mandelkow, E.M.5
Mandelkow, E.6
-
25
-
-
67649295517
-
Is passive immunization for Alzheimer's disease 'alive and well' or 'dead and buried'?
-
Jicha G. A., (2009) Is passive immunization for Alzheimer's disease 'alive and well' or 'dead and buried'? Expert. Opin. Biol. Ther. 9, 481-491.
-
(2009)
Expert. Opin. Biol. Ther.
, vol.9
, pp. 481-491
-
-
Jicha, G.A.1
-
26
-
-
67649983118
-
The tau of MARK: A polarized view of the cytoskeleton
-
Matenia D., and, Mandelkow E. M., (2009) The tau of MARK: a polarized view of the cytoskeleton. Trends Biochem. Sci. 34, 332-342.
-
(2009)
Trends Biochem. Sci.
, vol.34
, pp. 332-342
-
-
Matenia, D.1
Mandelkow, E.M.2
-
27
-
-
22544487815
-
FcgammaRIV: A novel FcR with distinct IgG subclass specificity
-
Nimmerjahn F., Bruhns P., Horiuchi K., and, Ravetch J. V., (2005) FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Immunity 23, 41-51.
-
(2005)
Immunity
, vol.23
, pp. 41-51
-
-
Nimmerjahn, F.1
Bruhns, P.2
Horiuchi, K.3
Ravetch, J.V.4
-
28
-
-
84883524853
-
The importance of tau phosphorylation for neurodegenerative diseases
-
Noble W., Hanger D. P., Miller C. C., and, Lovestone S., (2013) The importance of tau phosphorylation for neurodegenerative diseases. Front. Neurol. 4, 83.
-
(2013)
Front. Neurol.
, vol.4
, pp. 83
-
-
Noble, W.1
Hanger, D.P.2
Miller, C.C.3
Lovestone, S.4
-
29
-
-
84876873579
-
Immunotherapy for targeting tau pathology in Alzheimer's disease and tauopathies
-
Rosenmann H., (2013) Immunotherapy for targeting tau pathology in Alzheimer's disease and tauopathies. Curr. Alzheimer Res. 10, 217-228.
-
(2013)
Curr. Alzheimer Res.
, vol.10
, pp. 217-228
-
-
Rosenmann, H.1
-
30
-
-
33749614555
-
Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein
-
Rosenmann H., Grigoriadis N., Karussis D., Boimel M., Touloumi O., Ovadia H., and, Abramsky O., (2006) Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein. Arch. Neurol. 63, 1459-1467.
-
(2006)
Arch. Neurol.
, vol.63
, pp. 1459-1467
-
-
Rosenmann, H.1
Grigoriadis, N.2
Karussis, D.3
Boimel, M.4
Touloumi, O.5
Ovadia, H.6
Abramsky, O.7
-
31
-
-
84882793431
-
Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation
-
Rozenstein-Tsalkovich L., Grigoriadis N., Lourbopoulos A., Nousiopoulou E., Kassis I., Abramsky O., Karussis D., and, Rosenmann H., (2013) Repeated immunization of mice with phosphorylated-tau peptides causes neuroinflammation. Exp. Neurol. 248, 451-456.
-
(2013)
Exp. Neurol.
, vol.248
, pp. 451-456
-
-
Rozenstein-Tsalkovich, L.1
Grigoriadis, N.2
Lourbopoulos, A.3
Nousiopoulou, E.4
Kassis, I.5
Abramsky, O.6
Karussis, D.7
Rosenmann, H.8
-
32
-
-
0028978701
-
Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau
-
Seubert P., Mawal-Dewan M., Barbour R., et al,. (1995) Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau. J. Biol. Chem. 270, 18917-18922.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18917-18922
-
-
Seubert, P.1
Mawal-Dewan, M.2
Barbour, R.3
-
33
-
-
78349301194
-
Antibody therapy in neurodegenerative disease
-
Southwell A. L., and, Patterson P. H., (2010) Antibody therapy in neurodegenerative disease. Rev. Neurosci. 21, 273-287.
-
(2010)
Rev. Neurosci.
, vol.21
, pp. 273-287
-
-
Southwell, A.L.1
Patterson, P.H.2
-
34
-
-
0036676975
-
Roles of Fc receptors in autoimmunity
-
Takai T., (2002) Roles of Fc receptors in autoimmunity. Nat. Rev. Immunol. 2, 580-592.
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 580-592
-
-
Takai, T.1
-
35
-
-
84860531636
-
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: A suitable therapeutic approach
-
Troquier L., Caillierez R., Burnouf S., et al,. (2012) Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach. Curr. Alzheimer Res. 9, 397-405.
-
(2012)
Curr. Alzheimer Res.
, vol.9
, pp. 397-405
-
-
Troquier, L.1
Caillierez, R.2
Burnouf, S.3
-
36
-
-
0028935052
-
Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease
-
Vigo-Pelfrey C., Seubert P., Barbour R., et al,. (1995) Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease. Neurology 45, 788-793.
-
(1995)
Neurology
, vol.45
, pp. 788-793
-
-
Vigo-Pelfrey, C.1
Seubert, P.2
Barbour, R.3
-
37
-
-
84885783467
-
Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo
-
Yanamandra K., Kfoury N., Jiang H., Mahan T. E., Ma S., Maloney S. E., Wozniak D. F., Diamond M. I., and, Holtzman D. M., (2013) Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron, 80, 402-414.
-
(2013)
Neuron
, vol.80
, pp. 402-414
-
-
Yanamandra, K.1
Kfoury, N.2
Jiang, H.3
Mahan, T.E.4
Ma, S.5
Maloney, S.E.6
Wozniak, D.F.7
Diamond, M.I.8
Holtzman, D.M.9
-
38
-
-
84873939654
-
Plasma tau levels in Alzheimer's disease
-
Zetterberg H., Wilson D., Andreasson U., Minthon L., Blennow K., Randall J., and, Hansson O., (2013) Plasma tau levels in Alzheimer's disease. Alzheimers Res. Ther. 5, 9.
-
(2013)
Alzheimers Res. Ther.
, vol.5
, pp. 9
-
-
Zetterberg, H.1
Wilson, D.2
Andreasson, U.3
Minthon, L.4
Blennow, K.5
Randall, J.6
Hansson, O.7
|