메뉴 건너뛰기




Volumn 2, Issue 1, 2014, Pages 15-35

Advancing toward HIV-1 vaccine efficacy through the intersections of immune correlates

Author keywords

Clinical trials; HIV 1; Immune correlate; Immunity; Protection; Vaccine

Indexed keywords

DNA; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN A;

EID: 85019400427     PISSN: None     EISSN: 2076393X     Source Type: Journal    
DOI: 10.3390/vaccines2010015     Document Type: Review
Times cited : (38)

References (75)
  • 1
    • 13944254982 scopus 로고    scopus 로고
    • Rgp120 HIV Vaccine Study Group. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    • Flynn, N.M.; Forthal, D.N.; Harro, C.D.; Judson, F.N.; Mayer, K.H.; Para, M.F.; rgp120 HIV Vaccine Study Group. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J. Infect. Dis. 2005, 191, 654-665.
    • (2005) J. Infect. Dis , vol.191 , pp. 654-665
    • Flynn, N.M.1    Forthal, D.N.2    Harro, C.D.3    Judson, F.N.4    Mayer, K.H.5    Para, M.F.6
  • 2
    • 33845433434 scopus 로고    scopus 로고
    • Bangkok Vaccine Evaluation Group. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    • Pitisuttithum, P.; Gilbert, P.; Gurwith, M.; Heyward, W.; Martin, M.; van Griensven, F.; Hu, D.; Tappero, J.W.; Choopanya, K.; Bangkok Vaccine Evaluation Group. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J. Infect. Dis. 2006, 194, 1661-1671.
    • (2006) J. Infect. Dis , vol.194 , pp. 1661-1671
    • Pitisuttithum, P.1    Gilbert, P.2    Gurwith, M.3    Heyward, W.4    Martin, M.5    van Griensven, F.6    Hu, D.7    Tappero, J.W.8    Choopanya, K.9
  • 3
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the step study): A double-blind, randomised, placebo-controlled, test-of-concept trial
    • Buchbinder, S.P.; Mehrotra, D.V.; Duerr, A.; Fitzgerald, D.W.; Mogg, R.; Li, D.; Gilbert, P.B.; Lama, J.R.; Marmor, M.; Del Rio, C.; et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the step study): A double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 2008, 372, 1881-1893.
    • (2008) Lancet , vol.372 , pp. 1881-1893
    • Buchbinder, S.P.1    Mehrotra, D.V.2    Duerr, A.3    Fitzgerald, D.W.4    Mogg, R.5    Li, D.6    Gilbert, P.B.7    Lama, J.R.8    Marmor, M.9    Del Rio, C.10
  • 4
    • 79959301474 scopus 로고    scopus 로고
    • Safety and efficacy of the HVTN 503/Phambili study of a clade-b-based HIV-1 vaccine in South Africa: A double-blind, randomised, placebo-controlled test-of-concept phase 2b study
    • Gray, G.E.; Allen, M.; Moodie, Z.; Churchyard, G.; Bekker, L.G.; Nchabeleng, M.; Mlisana, K.; Metch, B.; de Bruyn, G.; Latka, M.H. et al. Safety and efficacy of the HVTN 503/Phambili study of a clade-b-based HIV-1 vaccine in South Africa: A double-blind, randomised, placebo-controlled test-of-concept phase 2b study. Lancet Infect. Dis. 2011, 11, 507-515.
    • (2011) Lancet Infect. Dis , vol.11 , pp. 507-515
    • Gray, G.E.1    Allen, M.2    Moodie, Z.3    Churchyard, G.4    Bekker, L.G.5    Nchabeleng, M.6    Mlisana, K.7    Metch, B.8    de Bruyn, G.9    Latka, M.H.10
  • 7
    • 13944250922 scopus 로고    scopus 로고
    • Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial
    • Gilbert, P.B.; Peterson, M.L.; Follmann, D.; Hudgens, M.G.; Francis, D.P.; Gurwith, M.; Heyward, W.L.; Jobes, D.V.; Popovic, V.; Self, S.G. et al. Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial. J. Infect. Dis. 2005, 191, 666-677.
    • (2005) J. Infect. Dis , vol.191 , pp. 666-677
    • Gilbert, P.B.1    Peterson, M.L.2    Follmann, D.3    Hudgens, M.G.4    Francis, D.P.5    Gurwith, M.6    Heyward, W.L.7    Jobes, D.V.8    Popovic, V.9    Self, S.G.10
  • 8
    • 34248168722 scopus 로고    scopus 로고
    • Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate
    • Forthal, D.N.; Gilbert, P.B.; Landucci, G.; Phan, T. Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate. J. Immunol. 2007, 178, 6596-6603.
    • (2007) J. Immunol , vol.178 , pp. 6596-6603
    • Forthal, D.N.1    Gilbert, P.B.2    Landucci, G.3    Phan, T.4
  • 9
    • 84867317902 scopus 로고    scopus 로고
    • Association of fcgamma receptor IIIa genotype with the rate of HIV infection after gp120 vaccination
    • Forthal, D.N.; Gabriel, E.E.; Wang, A.; Landucci, G.; Phan, T.B. Association of fcgamma receptor IIIa genotype with the rate of HIV infection after gp120 vaccination. Blood 2012, 120, 2836-2842.
    • (2012) Blood , vol.120 , pp. 2836-2842
    • Forthal, D.N.1    Gabriel, E.E.2    Wang, A.3    Landucci, G.4    Phan, T.B.5
  • 10
    • 83655192118 scopus 로고    scopus 로고
    • Comparing biomarkers as principal surrogate endpoints
    • Huang, Y.; Gilbert, P.B. Comparing biomarkers as principal surrogate endpoints. Biometrics 2011, 67, 1442-1451.
    • (2011) Biometrics , vol.67 , pp. 1442-1451
    • Huang, Y.1    Gilbert, P.B.2
  • 11
    • 85043045716 scopus 로고    scopus 로고
    • Immune-correlates analysis of the step HIV vaccine efficacy trial, a post-hoc analysis of HIV-specific and non-specific cellular immune responses
    • Barcelona, Spain, 7-10 October
    • Huang, Y.; Duerr, A.; Moodie, Z.; Frahm, N.; DeRosa, S.C.; McElrath, J.; Gilbert, P. Immune-correlates analysis of the step HIV vaccine efficacy trial, a post-hoc analysis of HIV-specific and non-specific cellular immune responses. In AIDS Vaccine, Barcelona, Spain, 7-10 October 2013.
    • (2013) AIDS Vaccine
    • Huang, Y.1    Duerr, A.2    Moodie, Z.3    Frahm, N.4    Derosa, S.C.5    McElrath, J.6    Gilbert, P.7
  • 15
    • 84884608718 scopus 로고    scopus 로고
    • Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial
    • Gottardo, R.; Bailer, R.T.; Korber, B.T.; Gnanakaran, S.; Phillips, J.; Shen, X.; Tomaras, G.D.; Turk, E.; Imholte, G.; Eckler, L. et al. Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial. PLoS One 2013, 8, e75665.
    • (2013) PLoS One , vol.8
    • Gottardo, R.1    Bailer, R.T.2    Korber, B.T.3    Gnanakaran, S.4    Phillips, J.5    Shen, X.6    Tomaras, G.D.7    Turk, E.8    Imholte, G.9    Eckler, L.10
  • 16
    • 84859166440 scopus 로고    scopus 로고
    • Evaluating immune correlates in HIV type 1 vaccine efficacy trials: What RV144 may provide
    • Rolland, M.; Gilbert, P. Evaluating immune correlates in HIV type 1 vaccine efficacy trials: What RV144 may provide. AIDS Res. Hum. Retroviruses 2012, 28, 400-404.
    • (2012) AIDS Res. Hum. Retroviruses , vol.28 , pp. 400-404
    • Rolland, M.1    Gilbert, P.2
  • 17
    • 38449106454 scopus 로고    scopus 로고
    • A framework for assessing immunological correlates of protection in vaccine trials
    • Qin, L.; Gilbert, P.B.; Corey, L.; McElrath, M.J.; Self, S.G. A framework for assessing immunological correlates of protection in vaccine trials. J. Infect. Dis. 2007, 196, 1304-1312.
    • (2007) J. Infect. Dis , vol.196 , pp. 1304-1312
    • Qin, L.1    Gilbert, P.B.2    Corey, L.3    McElrath, M.J.4    Self, S.G.5
  • 18
    • 47549116006 scopus 로고    scopus 로고
    • Vaccines: Correlates of vaccine-induced immunity
    • Plotkin, S.A. Vaccines: Correlates of vaccine-induced immunity. Clin. Infect. Dis. 2008, 47, 401-409.
    • (2008) Clin. Infect. Dis , vol.47 , pp. 401-409
    • Plotkin, S.A.1
  • 19
    • 84861057293 scopus 로고    scopus 로고
    • Nomenclature for immune correlates of protection after vaccination
    • Plotkin, S.A.; Gilbert, P.B. Nomenclature for immune correlates of protection after vaccination. Clin. Infect. Dis. 2012, 54, 1615-1617.
    • (2012) Clin. Infect. Dis , vol.54 , pp. 1615-1617
    • Plotkin, S.A.1    Gilbert, P.B.2
  • 20
    • 85043068684 scopus 로고    scopus 로고
    • Fred Hutchinson Cancer Research Center, and the Department of Biostatistics, University of Washington, Seattle, WA, USA. Unpublished observations
    • Gilbert, P. Vaccine and Infectious Disease and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, and the Department of Biostatistics, University of Washington, Seattle, WA, USA. Unpublished observations, 2013.
    • (2013) Vaccine and Infectious Disease and Public Health Sciences Divisions
    • Gilbert, P.1
  • 21
    • 41149170073 scopus 로고    scopus 로고
    • The 2-sample problem for failure rates depending on a continuous mark: An application to vaccine efficacy
    • Gilbert, P.B.; McKeague, I.W.; Sun, Y. The 2-sample problem for failure rates depending on a continuous mark: An application to vaccine efficacy. Biostatistics 2008, 9, 263-276.
    • (2008) Biostatistics , vol.9 , pp. 263-276
    • Gilbert, P.B.1    McKeague, I.W.2    Sun, Y.3
  • 22
    • 39849107041 scopus 로고    scopus 로고
    • Genome scanning tests for comparing amino acid sequences between groups
    • Gilbert, P.B.; Wu, C.; Jobes, D.V. Genome scanning tests for comparing amino acid sequences between groups. Biometrics 2008, 64, 198-207.
    • (2008) Biometrics , vol.64 , pp. 198-207
    • Gilbert, P.B.1    Wu, C.2    Jobes, D.V.3
  • 25
    • 84872809067 scopus 로고    scopus 로고
    • Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
    • Liao, H.X.; Bonsignori, M.; Alam, S.M.; McLellan, J.S.; Tomaras, G.D.; Moody, M.A.; Kozink, D.M.; Hwang, K.K.; Chen, X.; Tsao, C.Y. et al. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity 2013, 38, 176-186.
    • (2013) Immunity , vol.38 , pp. 176-186
    • Liao, H.X.1    Bonsignori, M.2    Alam, S.M.3    McLellan, J.S.4    Tomaras, G.D.5    Moody, M.A.6    Kozink, D.M.7    Hwang, K.K.8    Chen, X.9    Tsao, C.Y.10
  • 26
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup, R.A.; Safrit, J.T.; Cao, Y.; Andrews, C.A.; McLeod, G.; Borkowsky, W.; Farthing, C.; Ho, D.D. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 1994, 68, 4650-4655.
    • (1994) J. Virol , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3    Andrews, C.A.4    McLeod, G.5    Borkowsky, W.6    Farthing, C.7    Ho, D.D.8
  • 27
    • 16944365445 scopus 로고    scopus 로고
    • Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of ctl escape virus
    • Borrow, P.; Lewicki, H.; Wei, X.; Horwitz, M.S.; Peffer, N.; Meyers, H.; Nelson, J.A.; Gairin, J.E.; Hahn, B.H.; Oldstone, M.B. et al. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of ctl escape virus. Nat. Med. 1997, 3, 205-211.
    • (1997) Nat. Med , vol.3 , pp. 205-211
    • Borrow, P.1    Lewicki, H.2    Wei, X.3    Horwitz, M.S.4    Peffer, N.5    Meyers, H.6    Nelson, J.A.7    Gairin, J.E.8    Hahn, B.H.9    Oldstone, M.B.10
  • 29
  • 31
    • 72949117233 scopus 로고    scopus 로고
    • The immune response during acute HIV-1 infection: Clues for vaccine development
    • McMichael, A.J.; Borrow, P.; Tomaras, G.D.; Goonetilleke, N.; Haynes, B.F. The immune response during acute HIV-1 infection: Clues for vaccine development. Nat. Rev. 2010, 10, 11-23.
    • (2010) Nat. Rev , vol.10 , pp. 11-23
    • McMichael, A.J.1    Borrow, P.2    Tomaras, G.D.3    Goonetilleke, N.4    Haynes, B.F.5
  • 33
    • 77954617321 scopus 로고    scopus 로고
    • Long-term nonprogressive disease among untreated HIV-infected individuals: Clinical implications of understanding immune control of HIV
    • Migueles, S.A.; Connors, M. Long-term nonprogressive disease among untreated HIV-infected individuals: Clinical implications of understanding immune control of HIV. JAMA 2010, 304, 194-201.
    • (2010) JAMA , vol.304 , pp. 194-201
    • Migueles, S.A.1    Connors, M.2
  • 35
    • 79952701165 scopus 로고    scopus 로고
    • CD8(+)T-cell-mediated control of HIV-1 and SIV infection
    • Freel, S.A.; Saunders, K.O.; Tomaras, G.D. CD8(+)T-cell-mediated control of HIV-1 and SIV infection. Immunol. Res. 2011, 49, 135-146.
    • (2011) Immunol. Res , vol.49 , pp. 135-146
    • Freel, S.A.1    Saunders, K.O.2    Tomaras, G.D.3
  • 36
    • 84879614980 scopus 로고    scopus 로고
    • Unravelling the mechanisms of durable control of HIV-1
    • Walker, B.D.; Yu, X.G. Unravelling the mechanisms of durable control of HIV-1. Nat. Rev. Immunol. 2013, 13, 487-498.
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 487-498
    • Walker, B.D.1    Yu, X.G.2
  • 37
    • 84879320681 scopus 로고    scopus 로고
    • HIV controllers: A genetically determined or inducible phenotype?
    • Saez-Cirion, A.; Pancino, G. HIV controllers: A genetically determined or inducible phenotype? Immunol. Rev. 2013, 254, 281-294.
    • (2013) Immunol. Rev , vol.254 , pp. 281-294
    • Saez-Cirion, A.1    Pancino, G.2
  • 42
    • 84928586793 scopus 로고    scopus 로고
    • HIV vaccine raised infection risk
    • doi:10.1038/nature.2013.13971
    • Reardon, S. HIV vaccine raised infection risk. Nature 2013, doi:10.1038/nature.2013.13971.
    • (2013) Nature
    • Reardon, S.1
  • 45
    • 77955513770 scopus 로고    scopus 로고
    • Overview of step and phambili trial results: Two phase IIb test-of-concept studies investigating the efficacy of mrk adenovirus type 5 gag/pol/nef subtype b HIV vaccine
    • Gray, G.; Buchbinder, S.; Duerr, A. Overview of step and phambili trial results: Two phase IIb test-of-concept studies investigating the efficacy of mrk adenovirus type 5 gag/pol/nef subtype b HIV vaccine. Curr. Opin. HIV AIDS 2010, 5, 357-361.
    • (2010) Curr. Opin. HIV AIDS , vol.5 , pp. 357-361
    • Gray, G.1    Buchbinder, S.2    Duerr, A.3
  • 46
    • 84862904805 scopus 로고    scopus 로고
    • Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (step study)
    • Duerr, A.; Huang, Y.; Buchbinder, S.; Coombs, R.W.; Sanchez, J.; Del Rio, C.; Casapia, M.; Santiago, S.; Gilbert, P.; Corey, L. et al. Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (step study). J. Infect. Dis. 2012, 206, 258-266.
    • (2012) J. Infect. Dis , vol.206 , pp. 258-266
    • Duerr, A.1    Huang, Y.2    Buchbinder, S.3    Coombs, R.W.4    Sanchez, J.5    Del Rio, C.6    Casapia, M.7    Santiago, S.8    Gilbert, P.9    Corey, L.10
  • 48
    • 79952324470 scopus 로고    scopus 로고
    • Step Study Protocol Team. An ad5-vectored HIV-1 vaccine elicits cell-mediated immunity but does not affect disease progression in HIV-1-infected male subjects: Results from a randomized placebo-controlled trial (the step study)
    • Fitzgerald, D.W.; Janes, H.; Robertson, M.; Coombs, R.; Frank, I.; Gilbert, P.; Loufty, M.; Mehrotra, D.; Duerr, A.; Step Study Protocol Team. An ad5-vectored HIV-1 vaccine elicits cell-mediated immunity but does not affect disease progression in HIV-1-infected male subjects: Results from a randomized placebo-controlled trial (the step study). J. Infect. Dis. 2011, 203, 765-772.
    • (2011) J. Infect. Dis , vol.203 , pp. 765-772
    • Fitzgerald, D.W.1    Janes, H.2    Robertson, M.3    Coombs, R.4    Frank, I.5    Gilbert, P.6    Loufty, M.7    Mehrotra, D.8    Duerr, A.9
  • 49
    • 79952222105 scopus 로고    scopus 로고
    • Trivalent adenovirus type 5 HIV recombinant vaccine primes for modest cytotoxic capacity that is greatest in humans with protective HLA class I alleles
    • Migueles, S.A.; Rood, J.E.; Berkley, A.M.; Guo, T.; Mendoza, D.; Patamawenu, A.; Hallahan, C.W.; Cogliano, N.A.; Frahm, N.; Duerr, A. et al. Trivalent adenovirus type 5 HIV recombinant vaccine primes for modest cytotoxic capacity that is greatest in humans with protective HLA class I alleles. PLoS Pathog. 2011, 7, e1002002.
    • (2011) PLoS Pathog , vol.7
    • Migueles, S.A.1    Rood, J.E.2    Berkley, A.M.3    Guo, T.4    Mendoza, D.5    Patamawenu, A.6    Hallahan, C.W.7    Cogliano, N.A.8    Frahm, N.9    Duerr, A.10
  • 51
    • 84865437351 scopus 로고    scopus 로고
    • MrkAd5 HIV-1 gag/pol/nef vaccine-induced T-cell responses inadequately predict distance of breakthrough HIV-1 sequences to the vaccine or viral load
    • Janes, H.; Frahm, N.; DeCamp, A.; Rolland, M.; Gabriel, E.; Wolfson, J.; Hertz, T.; Kallas, E.; Goepfert, P.; Friedrich, D.P. et al. MrkAd5 HIV-1 gag/pol/nef vaccine-induced T-cell responses inadequately predict distance of breakthrough HIV-1 sequences to the vaccine or viral load. PLoS One 2012, 7, e43396.
    • (2012) PLoS One , vol.7
    • Janes, H.1    Frahm, N.2    Decamp, A.3    Rolland, M.4    Gabriel, E.5    Wolfson, J.6    Hertz, T.7    Kallas, E.8    Goepfert, P.9    Friedrich, D.P.10
  • 56
    • 84873051328 scopus 로고    scopus 로고
    • Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion
    • Alam, S.M.; Liao, H.X.; Tomaras, G.D.; Bonsignori, M.; Tsao, C.Y.; Hwang, K.K.; Chen, H.; Lloyd, K.E.; Bowman, C.; Sutherland, L. et al. Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion. J. Virol. 2013, 87, 1554-1568.
    • (2013) J. Virol , vol.87 , pp. 1554-1568
    • Alam, S.M.1    Liao, H.X.2    Tomaras, G.D.3    Bonsignori, M.4    Tsao, C.Y.5    Hwang, K.K.6    Chen, H.7    Lloyd, K.E.8    Bowman, C.9    Sutherland, L.10
  • 59
    • 79960342938 scopus 로고    scopus 로고
    • An HIV-1 gp120 envelope human monoclonal antibody that recognizes a c1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum
    • Ferrari, G.; Pollara, J.; Kozink, D.; Harms, T.; Drinker, M.; Freel, S.; Moody, M.A.; Alam, S.M.; Tomaras, G.D.; Ochsenbauer, C. et al. An HIV-1 gp120 envelope human monoclonal antibody that recognizes a c1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum. J. Virol. 2011, 85, 7029-7036.
    • (2011) J. Virol , vol.85 , pp. 7029-7036
    • Ferrari, G.1    Pollara, J.2    Kozink, D.3    Harms, T.4    Drinker, M.5    Freel, S.6    Moody, M.A.7    Alam, S.M.8    Tomaras, G.D.9    Ochsenbauer, C.10
  • 60
    • 84867902474 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    • Bonsignori, M.; Pollara, J.; Moody, M.A.; Alpert, M.D.; Chen, X.; Hwang, K.K.; Gilbert, P.B.; Huang, Y.; Gurley, T.C.; Kozink, D.M. et al. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J. Virol. 2012, 86, 11521-11532.
    • (2012) J. Virol , vol.86 , pp. 11521-11532
    • Bonsignori, M.1    Pollara, J.2    Moody, M.A.3    Alpert, M.D.4    Chen, X.5    Hwang, K.K.6    Gilbert, P.B.7    Huang, Y.8    Gurley, T.C.9    Kozink, D.M.10
  • 61
    • 57349127300 scopus 로고    scopus 로고
    • Initial B-cell responses to transmitted human immunodeficiency virus type 1: Virion-binding immunoglobulin IgM and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia
    • Tomaras, G.D.; Yates, N.L.; Liu, P.; Qin, L.; Fouda, G.G.; Chavez, L.L.; Decamp, A.C.; Parks, R.J.; Ashley, V.C.; Lucas, J.T. et al. Initial B-cell responses to transmitted human immunodeficiency virus type 1: Virion-binding immunoglobulin IgM and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. J. Virol. 2008, 82, 12449-12463.
    • (2008) J. Virol , vol.82 , pp. 12449-12463
    • Tomaras, G.D.1    Yates, N.L.2    Liu, P.3    Qin, L.4    Fouda, G.G.5    Chavez, L.L.6    Decamp, A.C.7    Parks, R.J.8    Ashley, V.C.9    Lucas, J.T.10
  • 69
    • 85043083708 scopus 로고    scopus 로고
    • Single cell transcriptomics: Measuring quality and quantity
    • Keystone Symposia, Keystone, CO, USA, 10-15 February
    • Roederer, M. Single cell transcriptomics: Measuring quality and quantity. In HIV-1 Vaccines/B Cell Development and Function, Keystone Symposia, Keystone, CO, USA, 10-15 February 2013.
    • (2013) HIV-1 Vaccines/B Cell Development and Function
    • Roederer, M.1
  • 72
    • 84855960921 scopus 로고    scopus 로고
    • Immunogenetics of spontaneous control of HIV
    • Carrington, M.; Walker, B.D. Immunogenetics of spontaneous control of HIV. Annu. Rev. Med. 2012, 63, 131-145.
    • (2012) Annu. Rev. Med , vol.63 , pp. 131-145
    • Carrington, M.1    Walker, B.D.2
  • 73
    • 85158921979 scopus 로고    scopus 로고
    • Vaccine Immunology
    • Plotkin, S.A., Orenstein, W.A., Offit, P.A., Eds.; Elsevier: Philadelphia, PA, USA
    • Siegrist, C. Vaccine Immunology. In Vaccines, Plotkin, S.A., Orenstein, W.A., Offit, P.A., Eds.; Elsevier: Philadelphia, PA, USA, 2008; pp. 17-36.
    • (2008) Vaccines , pp. 17-36
    • Siegrist, C.1
  • 74
    • 79952107221 scopus 로고    scopus 로고
    • Contributions of humoral and cellular immunity to vaccine-induced protection in humans
    • Amanna, I.J.; Slifka, M.K. Contributions of humoral and cellular immunity to vaccine-induced protection in humans. Virology 2011, 411, 206-215.
    • (2011) Virology , vol.411 , pp. 206-215
    • Amanna, I.J.1    Slifka, M.K.2
  • 75
    • 17644364706 scopus 로고    scopus 로고
    • Can successful vaccines teach us how to induce efficient protective immune responses?
    • Lambert, P.H.; Liu, M.; Siegrist, C.A. Can successful vaccines teach us how to induce efficient protective immune responses? Nat. Med. 2005, 11, S54-S62.
    • (2005) Nat. Med , vol.11
    • Lambert, P.H.1    Liu, M.2    Siegrist, C.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.