Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine

Journal of Clinical Investigation

Volumn 122, Issue 1, 2012, Pages 359-367

  Frahm, Nicole ^a,b   DeCamp, Allan C ^a   Friedrich, David P ^a   Carter, Donald K ^a   Defawe, Olivier D ^a   Kublin, James G ^a   Casimiro, Danilo R ^c   Duerr, Ann ^a   Robertson, Michael N ^c   Buchbinder, Susan P ^d   Huang, Yunda ^a   Spies, Gregory A ^a   De Rosa, Stephen C ^a,b   McElrath, M Juliana ^a,b  

^a USA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; PLACEBO;

ADENOVIRUS 5; ANTIBODY TITER; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS REACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; SEROTYPE; T LYMPHOCYTE;

ADENOVIRUSES, HUMAN; AIDS VACCINES; AMINO ACID SEQUENCE; ANTIGENS, VIRAL; GENETIC VECTORS; HIV ANTIGENS; HIV-1; HUMANS; IMMUNITY, CELLULAR; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SEROTYPING; T-LYMPHOCYTES; VACCINES, SYNTHETIC;

EID: 84855445252     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI60202     Document Type: Article

References (26)

1. McElrath MJ, et al. HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet. 2008;372(9653):1894-1905.
2. Priddy FH, et al. Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag/pol/nef vaccine in healthy adults. Clin Infect Dis. 2008;46(11):1769-1781. (Pubitemid 351706778)
3. Barouch DH. Novel adenovirus vector-based vaccines for HIV-1. Curr Opin HIV AIDS. 2010;5(5):386-390.
4. Smith CA, Woodruff LS, Rooney C, Kitchingman GR. Extensive cross-reactivity of adenovirus-specific cytotoxic T cells. Hum Gene Ther. 1998;9(10):1419-1427. (Pubitemid 28379081)
5. Leen AM, et al. Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications. Blood. 2004;103(3):1011-1019. (Pubitemid 38129564)
6. Calcedo R, Vandenberghe LH, Roy S, Somanathan S, Wang L, Wilson JM. Host immune responses to chronic adenovirus infections in human and non-human primates. J Virol. 2009;83(6):2623-2631.
7. Olive M, Eisenlohr L, Flomenberg N, Hsu S, Flomenberg P. The adenovirus capsid protein hexon contains a highly conserved human CD4+ T-cell epitope. Hum Gene Ther. 2002;13(10):1167-1178. (Pubitemid 34746697)
8. Tang J, et al. Adenovirus hexon T-cell epitope is recognized by most adults and is restricted by HLA DP4, the most common class II allele. Gene Ther. 2004;11(18):1408-1415. (Pubitemid 39263894)
9. Tang J, et al. Human CD8+ cytotoxic T cell responses to adenovirus capsid proteins. Virology. 2006;350(2):312-322. (Pubitemid 43928100)
10. Souberbielle BE, Russell WC. Human T cell proliferative response to polypeptides from adenovirus type 2. J Infect Dis. 1995;172(5):1421-1422.
11. McKelvey T, Tang A, Bett AJ, Casimiro DR, Chastain M. T-cell response to adenovirus hexon and DNA-binding protein in mice. Gene Ther. 2004;11(9):791-796. (Pubitemid 38659758)
12. Leen AM, et al. Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells. Blood. 2004;104(8):2432-2440. (Pubitemid 39331844)
13. Schmitz H, Wigand R, Heinrich W. Worldwide epidemiology of human adenovirus infections. Am J Epidemiol. 1983;117(4):455-466. (Pubitemid 13117425)
14. Obst R, van Santen HM, Mathis D, Benoist C. Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med. 2005;201(10):1555-1565. (Pubitemid 40721001)
15. Ravkov EV, Williams MA. The magnitude of CD4+ T cell recall responses is controlled by the duration of the secondary stimulus. J Immunol. 2009;183(4):2382-2389.
16. Kaech SM, Ahmed R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat Immunol. 2001;2(5):415-422. (Pubitemid 33706139)
17. Berk AJ. Adenoviridae: the viruses and their replication. In: Knipe DM, Howley PM, eds. Fields Virology. Vol. 1. Philadelphia, Pennsylvania, USA: Lippincott Williams and Wilkins; 2007:2355-2394.
18. O'Brien KL, et al. Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans. Nat Med. 2009;15(8):873-875.
19. Koup RA, et al. Replication-defective adenovirus vectors with multiple deletions do not induce measurable vector-specific T cells in human trials. J Virol. 2009;83(12):6318-6322.
20. Hutnick NA, et al. Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells. Nat Med. 2009;15(8):876-878.
21. Buchbinder SP, et al. Efficacy assessment of a cellmediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 2008;372(9653):1881-1893.
22. Aste-Amezaga M, et al. Quantitative adenovirus neutralization assays based on the secreted alkaline phosphatase reporter gene: application in epidemiologic studies and in the design of adenovector vaccines. Hum Gene Ther. 2004;15(3):293-304. (Pubitemid 38365918)
23. Catanzaro AT, et al. Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector. J Infect Dis. 2006;194(12):1638-1649. (Pubitemid 44901994)
24. Horton H, et al. Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination. J Immunol Methods. 2007;323(1):39-54. (Pubitemid 46722712)
25. Li F, et al. Peptide selection for human immunodeficiency virus type 1 CTL-based vaccine evaluation. Vaccine. 2006;24(47-48):6893-6904. (Pubitemid 46107181)
26. Hirotugu A. A new look at the statistical model identification. IEEE Transactions on Automatic Control. 1974;19(6):716-723.