PEGylation of a TLR2-agonist-based vaccine delivery system improves antigen trafficking and the magnitude of ensuing antibody and CD8+ T cell responses

Biomaterials

Volumn 137, Issue , 2017, Pages 61-72

  Sekiya, Toshiki ^a   Yamagishi, Junya ^b   Gray, John Henry V ^a   Whitney, Paul G ^a   Martinelli, Axel ^b   Zeng, Weiguang ^a   Wong, Chinn Yi ^a   Sugimoto, Chihiro ^b   Jackson, David C ^a,b   Chua, Brendon Y ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Antibody; Antigen trafficking; CD8 T cells; Polyethylene glycol; TLR2

Indexed keywords

ANTIBODIES; ANTIGENS; CYTOLOGY; GENE EXPRESSION; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYETHYLENES; VACCINES;

ANTIGEN PRESENTING CELLS; CD8 T-CELLS; CONCOMITANT REDUCTION; DENDRITIC CELLS (DCS); ELECTROSTATIC ASSOCIATION; PATHOGEN-ASSOCIATED MOLECULAR PATTERNS; TLR2; VACCINE DELIVERY SYSTEM;

T-CELLS;

CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; LIPOPEPTIDE; MACROGOL; MESSENGER RNA; TOLL LIKE RECEPTOR 2 AGONIST; TOLL LIKE RECEPTOR AGONIST; TRANSCRIPTOME; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VACCINE; DRUG CARRIER; IMMUNOLOGICAL ADJUVANT; OVALBUMIN; TLR2 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL MATURATION; CELLULAR IMMUNITY; COMPLEX FORMATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG SOLUBILITY; GENE EXPRESSION; HYDRODYNAMICS; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; LYMPH NODE; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VACCINATION; VACCINE IMMUNOGENICITY; AGONISTS; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; DRUG RELEASE; HUMAN; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; SOLUBILITY; SURFACE PROPERTY; TRANSGENIC MOUSE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODY FORMATION; ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; DENDRITIC CELLS; DRUG CARRIERS; DRUG LIBERATION; HUMANS; IMMUNITY, CELLULAR; LIPOPEPTIDES; MALE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; OVALBUMIN; POLYETHYLENE GLYCOLS; SOLUBILITY; SURFACE PROPERTIES; TOLL-LIKE RECEPTOR 2; TRANSCRIPTOME; VACCINES;

EID: 85019361962     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2017.05.018     Document Type: Article

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