Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies

Structure

Volumn 25, Issue 6, 2017, Pages 878-889.e5

  Lobner, Elisabeth ^a   Humm, Anne Sophie ^a,b   Göritzer, Kathrin ^a   Mlynek, Georg ^b   Puchinger, Martin G ^b   Hasenhindl, Christoph ^a   Rüker, Florian ^a   Traxlmayr, Michael W ^a   Djinović Carugo, Kristina ^b,c   Obinger, Christian ^a  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

binding stoichiometry; ErbB2; Fcab; Fcab HER2 structure; fluorescence correlation spectroscopy; HER2; IgG1 Fc; X ray crystallography

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; HOMODIMER; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; ERBB2 PROTEIN, HUMAN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; PERTUZUMAB; TRASTUZUMAB;

ANTIBODY COMBINING SITE; ANTIBODY LIBRARY; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISSOCIATION CONSTANT; ELECTROSPRAY MASS SPECTROMETRY; FC DOMAIN WITH ANTIGEN BINDING SITE; FLUORESCENCE CORRELATION SPECTROSCOPY; HEK293 CELL LINE; ISOTHERMAL TITRATION CALORIMETRY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY; BINDING SITE; CALORIMETRY; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MUTATION; PROCEDURES; PROTEIN DOMAIN; SIZE EXCLUSION CHROMATOGRAPHY; SPECTROFLUOROMETRY;

ANTIBODIES, MONOCLONAL, HUMANIZED; BINDING SITES; CALORIMETRY; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; MUTATION; PROTEIN CONFORMATION; PROTEIN DOMAINS; PROTEIN STABILITY; RECEPTOR, ERBB-2; SPECTROMETRY, FLUORESCENCE; TRASTUZUMAB;

EID: 85019346516     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2017.04.014     Document Type: Article

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