Coroglaucigenin enhances the radiosensitivity of human lung cancer cells through Nrf2/ROS pathway

Oncotarget

Volumn 8, Issue 20, 2017, Pages 32807-32820

  Sun, Meng ^a   Pan, Dong ^b,c   Chen, Yaxiong ^b,c   Li, Ya ^a   Gao, Kun ^a   Hu, Burong ^b,c  

^a LANZHOU UNIVERSITY   (China)

^b INSTITUTE OF MODERN PHYSICS   (China)

^c Orthopaedics Key Laboratory of Gansu Province   (China)

Author keywords

Calotropis gigantea; Coroglaucigenin; Human lung cancer; Nrf2 ROS; Radiosensitivity

Indexed keywords

3BETA,19 EPOXY 2ALPHA,3BETA,14BETA TRIHYDROXY 19 METHOXY 5ALPHA CARD 20(22) ENOLIDE; 6' O (3,5 DIMETHOXY 4 HYDROXYCINNAMOYL)DESGLUCOUZARIN; ALCOHOL; CALACTIN; CALOTROPAGENIN; CALOTROPIN; CALOTROPIS GIGANTEA EXTRACT; CARDENOLIDE DERIVATIVE; COROGLAUCIGENIN; DNA; RADIOSENSITIZING AGENT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UZARIGENIN; NFE2L2 PROTEIN, HUMAN; NQO1 PROTEIN, HUMAN; PLANT EXTRACT;

A-549 CELL LINE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BEAS 2B CELL LINE; CANCER RADIOTHERAPY; CELL SPECIFICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG SAFETY; DRUG STRUCTURE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LUNG CANCER; LUNG CANCER CELL LINE; LUNG CELL LINE; MTT ASSAY; NCI H446 CELL LINE; NCI H460 CELL LINE; OXIDATIVE STRESS; PLANT STEM; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; X IRRADIATION; CALOTROPIS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; LUNG TUMOR; METABOLISM; RADIATION RESPONSE;

A549 CELLS; CALOTROPIS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; PLANT EXTRACTS; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85019266914     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.16454     Document Type: Article

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