Autophagy inhibits C2-ceramide-mediated cell death by decreasing the reactive oxygen species levels in SH-SY5Y cells

Neuroscience Letters

Volumn 651, Issue , 2017, Pages 198-206

  Fan, Chenghe ^a,b   Liu, Yuanyuan ^a   Zhao, Mingming ^c   Zhan, Rui ^c   Cui, Wei ^a   Jin, Haiqiang ^a   Teng, Yuming ^a   Lv, Pu ^a   Zheng, Lemin ^c   Huang, Yining ^a,b  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b PEKING UNIVERSITY   (China)

^c Peking University Health Science Center   (China)

Author keywords

Apoptosis; Autophagy; C2 ceramide; Reactive oxygen species (ROS)

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CERAMIDE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; N-ACETYLSPHINGOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; SPHINGOSINE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL LINE; NEUROLOGIC DISEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; SH SY5Y CELL LINE; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; CELL DEATH; CELL PROLIFERATION; MAPK SIGNALING; METABOLISM; TUMOR CELL LINE;

AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; MAP KINASE SIGNALING SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SPHINGOSINE;

EID: 85019260144     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2017.03.006     Document Type: Article

References (34)

1. Morad, S.A., Cabot, M.C., Ceramide-orchestrated signalling in cancer cells. Nat. Rev. Cancer 13 (2013), 51–65.
2. Mencarelli, C., Martinez-Martinez, P., Ceramide function in the brain: when a slight tilt is enough. Cell. Mol. Life Sci. 70 (2013), 181–203.
3. Czubowicz, K., Strosznajder, R., Ceramide in the molecular mechanisms of neuronal cell death. The role of sphingosine-1-phosphate. Mol. Neurobiol. 50 (2014), 26–37.
4. Kim, N.H., Kim, K., Park, W.S., Son, H.S., Bae, Y., PKB/Akt inhibits ceramide-induced apoptosis in neuroblastoma cells by blocking apoptosis-inducing factor (AiF) translocation. J. Cell. Biochem. 102 (2007), 1160–1170.
5. Van Overloop, H., Denizot, Y., Baes, M., Van Veldhoven, P.P., On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. Biol. Chem. 388 (2007), 315–324.
6. Eldadah, B.A., Faden, A.I., Caspase pathways neuronal apoptosis, and CNS injury. J. Neurotrauma 17 (2000), 811–829.
7. Ohsumi, Y., Historical landmarks of autophagy research. Cell Res. 24 (2014), 9–23.
8. Menzies, F.M., Fleming, A., Rubinsztein, D.C., Compromised autophagy and neurodegenerative diseases. Nat. Rev. Neurosci. 16 (2015), 345–357.
9. Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J., Autophagy fights disease through cellular self-digestion. Nature 451 (2008), 1069–1075.
10. Yang, Z., Klionsky, D.J., Mammalian autophagy: core molecular machinery and signaling regulation. Curr. Opin. Cell Biol. 22 (2010), 124–131.
11. Caccamo, A., Majumder, S., Richardson, A., Strong, R., Oddo, S., Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J. Biol. Chem. 285 (2010), 13107–13120.
12. Sarkar, S., Rubinsztein, D.C., Huntington's disease: degradation of mutant huntingtin by autophagy. FEBS J. 275 (2008), 4263–4270.
13. Jaeger, P.A., Wyss-Coray, T., Beclin 1 complex in autophagy and Alzheimer disease. Arch. Neurol. 67 (2010), 1181–1184.
14. Yan, J.Q., Yuan, Y.H., Gao, Y.N., Huang, J.Y., Ma, K.L., Gao, Y., Zhang, W.Q., Guo, X.F., Chen, N.H., Overexpression of human E46K mutant alpha-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway. Mol. Neurobiol. 50 (2014), 685–701.
15. Scarlatti, F., Bauvy, C., Ventruti, A., Sala, G., Cluzeaud, F., Vandewalle, A., Ghidoni, R., Codogno, P., Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J. Biol. Chem. 279 (2004), 18384–18391.
16. Pattingre, S., Bauvy, C., Carpentier, S., Levade, T., Levine, B., Codogno, P., Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J. Biol. Chem. 284 (2009), 2719–2728.
17. Maryanovich, M., Gross, A., A ROS rheostat for cell fate regulation. Trends Cell Biol. 23 (2013), 129–134.
18. Lin, M.T., Beal, M.F., Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443 (2006), 787–795.
19. Wang, H., Gao, N., Li, Z., Yang, Z., Zhang, T., Autophagy alleviates melamine-induced cell death in PC12 cells via decreasing ROS Level. Mol. Neurobiol. 53 (2016), 1718–1729.
20. Azad, M.B., Chen, Y., Gibson, S.B., Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid. Redox Signal. 11 (2009), 777–790.
21. Jung, J.S., Ahn, Y.H., Moon, B.I., Kim, H.S., Exogenous C2 Ceramide suppresses matrix metalloproteinase gene expression by inhibiting ROS Production and MAPK signaling pathways in PMA-Stimulated human astroglioma cells. Int. J. Mol. Sci., 17, 2016, 477.
22. Liu, Y., Fan, C., Pu, L., Wei, C., Jin, H., Teng, Y., Zhao, M., Yu, A.C., Jiang, F., Shu, J., Li, F., Peng, Q., Kong, J., Pan, B., Zheng, L., Huang, Y., Phloretin induces cell cycle arrest and apoptosis of human glioblastoma cells through the generation of reactive oxygen species. J. Neurooncol. 128 (2016), 217–223.
23. Vucicevic, L., Misirkic-Marjanovic, M., Paunovic, V., Kravic-Stevovic, T., Martinovic, T., Ciric, D., Maric, N., Petricevic, S., Harhaji-Trajkovic, L., Bumbasirevic, V., Trajkovic, V., Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy 10 (2014), 2362–2378.
24. Mariño, G., Niso-Santano, M., Baehrecke, E.H., Kroemer, G., Self-consumption: the interplay of autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 15 (2014), 81–94.
25. Deroyer, C., Rénert, A.F., Merville, M.P., Fillet, M., New role for EMD (emerin) a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. Autophagy 10 (2014), 1229–1240.
26. Pattingre, S., Bauvy, C., Levade, T., Levine, B., Codogno, P., Ceramide-induced autophagy: to junk or to protect cells?. Autophagy 5 (2009), 558–560.
27. Du, T.T., Wang, L., Duan, C.L., Lu, L.L., Zhang, J.L., Gao, G., Qiu, X.B., Wang, X.M., Yang, H., GBA deficiency promotes SNCA/alpha-synuclein accumulation through autophagic inhibition by inactivated PPP2A. Autophagy 11 (2015), 1803–1820.
28. Jaramillo-Gomez, J., Nino, A., Arboleda, H., Arboleda, G., Overexpression of DJ-1 protects against C2-ceramide-induced neuronal death through activation of the PI3K/AKT pathway and inhibition of autophagy. Neurosci. Lett. 603 (2015), 71–76.
29. Arboleda, G., Cardenas, Y., Rodriguez, Y., Morales, L.C., Matheus, L., Arboleda, H., Differential regulation of AKT, MAPK and GSK3beta during C2-ceramide-induced neuronal death. Neurotoxicology 31 (2010), 687–693.
30. Chen, C.L., Lin, C.F., Chang, W.T., Huang, W.C., Teng, C.F., Lin, Y.S., Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood 111 (2008), 4365–4374.
31. Li, D.D., Wang, L.L., Deng, R., Tang, J., Shen, Y., Guo, J.F., Wang, Y., Xia, L.P., Feng, G.K., Liu, Q.Q., Huang, W.L., Zeng, Y.X., Zhu, X.F., The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene 28 (2009), 886–898.
32. Zhu, W., Wang, X., Zhou, Y., Wang, H., C2-ceramide induces cell death and protective autophagy in head and neck squamous cell carcinoma cells. Int. J. Mol. Sci. 15 (2014), 3336–3355.
33. Mohan, N., Banik, N.L., Ray, S.K., Combination of N-(4-hydroxyphenyl) retinamide and apigenin suppressed starvation-induced autophagy and promoted apoptosis in malignant neuroblastoma cells. Neurosci. Lett. 502 (2011), 24–29.
34. Jazvinšćak Jembrek, M., Hof, P.R., Šimić, G., Ceramides in Alzheimer's disease: key mediators of neuronal apoptosis induced by oxidative stress and Abeta accumulation. Oxid. Med. Cell. Longev., 2015, 2015, 346783.