-
1
-
-
37349004102
-
Parkinson disease
-
Spec No. Two, PMID:17911161
-
Thomas B, Beal MF. Parkinson disease. Hum Mol Genet 2007; 16 Spec No. Two:R183-94; PMID:17911161; http://dx.doi.org/10.1093/hmg/ddm159
-
(2007)
Hum Mol Genet
, vol.16
-
-
Thomas, B.1
Beal, M.F.2
-
2
-
-
80055082804
-
Parkinson disease and a-synuclein expression
-
PMID:21887711
-
Devine MJ, Gwinn K, Singleton A, Hardy J. Parkinson disease and a-synuclein expression. Mov Disord 2011; 26:2160-8; PMID:21887711; http://dx.doi.org/10.1002/mds.23948
-
(2011)
Mov Disord
, vol.26
, pp. 2160-2168
-
-
Devine, M.J.1
Gwinn, K.2
Singleton, A.3
Hardy, J.4
-
3
-
-
63149090431
-
Parkinson disease: From monogenic forms to genetic susceptibility factors
-
PMID:19297401
-
Lesage S, Brice A. Parkinson disease: from monogenic forms to genetic susceptibility factors. Hum Mol Genet 2009; 18:R48-59; PMID:19297401; http://dx.doi.org/10.1093/hmg/ddp012
-
(2009)
Hum Mol Genet
, vol.18
-
-
Lesage, S.1
Brice, A.2
-
4
-
-
40849120549
-
Glucocerebrosidase gene mutations: A risk factor for Lewy body disorders
-
PMID:18332251
-
Mata IF, Samii A, Schneer SH, Roberts JW, Griffith A, Leis BC, Schellenberg GD, Sidransky E, Bird TD, Leverenz JB, et al. Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders. Arch Neurol 2008; 65:379-82; PMID:18332251; http://dx.doi.org/10.1001/archneurol.2007.68
-
(2008)
Arch Neurol
, vol.65
, pp. 379-382
-
-
Mata, I.F.1
Samii, A.2
Schneer, S.H.3
Roberts, J.W.4
Griffith, A.5
Leis, B.C.6
Schellenberg, G.D.7
Sidransky, E.8
Bird, T.D.9
Leverenz, J.B.10
-
5
-
-
66249109910
-
Mutations for Gaucher disease confer high susceptibility to Parkinson disease
-
PMID:19433656
-
Mitsui J, Mizuta I, Toyoda A, Ashida R, Takahashi Y, Goto J, Fukuda Y, Date H, Iwata A, Yamamoto M, et al. Mutations for Gaucher disease confer high susceptibility to Parkinson disease. Arch Neurol 2009; 66:571-6; PMID:19433656; http://dx.doi.org/10.1001/archneurol.2009.72
-
(2009)
Arch Neurol
, vol.66
, pp. 571-576
-
-
Mitsui, J.1
Mizuta, I.2
Toyoda, A.3
Ashida, R.4
Takahashi, Y.5
Goto, J.6
Fukuda, Y.7
Date, H.8
Iwata, A.9
Yamamoto, M.10
-
6
-
-
70350319531
-
Multicenter analysis of glucocerebrosidase mutations in Parkinson disease
-
PMID:19846850
-
Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson disease. N Engl J Med 2009; 361:1651-61; PMID:19846850; http://dx.doi. org/10.1056/NEJMoa0901281
-
(2009)
N Engl J Med
, vol.361
, pp. 1651-1661
-
-
Sidransky, E.1
Nalls, M.A.2
Aasly, J.O.3
Aharon-Peretz, J.4
Annesi, G.5
Barbosa, E.R.6
Bar-Shira, A.7
Berg, D.8
Bras, J.9
Brice, A.10
-
7
-
-
79956324138
-
Large-scale screening of the Gaucher’s disease-related glucocerebrosidase gene in Europeans with Parkinson disease
-
PMID:20947659
-
Lesage S, Anheim M, Condroyer C, Pollak P, Durif F, Dupuits C, Viallet F, Lohmann E, Corvol JC, Honore A, et al. Large-scale screening of the Gaucher’s disease-related glucocerebrosidase gene in Europeans with Parkinson disease. Hum MolGenet 2011; 20:202-10; PMID:20947659; http://dx.doi.org/10.1093/hmg/ddq454
-
(2011)
Hum Molgenet
, vol.20
, pp. 202-210
-
-
Lesage, S.1
Anheim, M.2
Condroyer, C.3
Pollak, P.4
Durif, F.5
Dupuits, C.6
Viallet, F.7
Lohmann, E.8
Corvol, J.C.9
Honore, A.10
-
8
-
-
0038465682
-
The Metabolism of Glucocerebrosides. I. Purification and Properties of a Glucocerebroside-Cleaving Enzyme from Spleen Tissue
-
PMID:14253443
-
Brady RO, Kanfer J, Shapiro D. The Metabolism of Glucocerebrosides. I. Purification and Properties of a Glucocerebroside-Cleaving Enzyme from Spleen Tissue. J Biol Chem 1965; 240:39-43; PMID:14253443
-
(1965)
J Biol Chem
, vol.240
, pp. 39-43
-
-
Brady, R.O.1
Kanfer, J.2
Shapiro, D.3
-
9
-
-
42949118684
-
Gaucher disease: Mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)
-
PMID:18338393
-
Hruska KS, LaMarca ME, Scott CR, Sidransky E. Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA). Hum Mutat 2008; 29:567-83; PMID:18338393; http://dx. doi.org/10.1002/humu.20676
-
(2008)
Hum Mutat
, vol.29
, pp. 567-583
-
-
Hruska, K.S.1
Lamarca, M.E.2
Scott, C.R.3
Sidransky, E.4
-
10
-
-
33646837867
-
Increased incidence of Parkinson disease among relatives of patients with Gaucher disease
-
PMID:16651014
-
Halperin A, Elstein D, Zimran A. Increased incidence of Parkinson disease among relatives of patients with Gaucher disease. Blood Cells Mol Dis 2006; 36:426-8; PMID:16651014; http://dx.doi.org/10.1016/j.bcmd. 2006.02.004
-
(2006)
Blood Cells Mol Dis
, vol.36
, pp. 426-428
-
-
Halperin, A.1
Elstein, D.2
Zimran, A.3
-
11
-
-
34548726339
-
Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease
-
PMID:17875915
-
Clark LN, Ross BM, Wang Y, Mejia-Santana H, Harris J, Louis ED, Cote LJ, Andrews H, Fahn S, Waters C, et al. Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease. Neurology 2007; 69:1270-7; PMID:17875915; http://dx.doi.org/10.1212/01.wnl.0000276989.17578.02
-
(2007)
Neurology
, vol.69
, pp. 1270-1277
-
-
Clark, L.N.1
Ross, B.M.2
Wang, Y.3
Mejia-Santana, H.4
Harris, J.5
Louis, E.D.6
Cote, L.J.7
Rews, H.8
Fahn, S.9
Waters, C.10
-
12
-
-
60549098601
-
Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset
-
PMID:18987351
-
Nichols WC, Pankratz N, Marek DK, Pauciulo MW, Elsaesser VE, Halter CA, Rudolph A, Wojcieszek J, Pfeiffer RF, Foroud T. Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset. Neurology 2009; 72:310-6; PMID:18987351; http://dx.doi.org/10.1212/01.wnl.0000327823.81237.d1
-
(2009)
Neurology
, vol.72
, pp. 310-316
-
-
Nichols, W.C.1
Pankratz, N.2
Marek, D.K.3
Pauciulo, M.W.4
Elsaesser, V.E.5
Halter, C.A.6
Rudolph, A.7
Wojcieszek, J.8
Pfeiffer, R.F.9
Foroud, T.10
-
13
-
-
84858144224
-
Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers
-
PMID:22282650
-
Anheim M, Elbaz A, Lesage S, Durr A, Condroyer C, Viallet F, Pollak P, Bonaiti B, Bonaiti-Pellie C, Brice A. Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers. Neurology 2012; 78:417-20; PMID:22282650; http://dx.doi.org/10.1212/WNL.0b013e318245f476
-
(2012)
Neurology
, vol.78
, pp. 417-420
-
-
Anheim, M.1
Elbaz, A.2
Lesage, S.3
Durr, A.4
Condroyer, C.5
Viallet, F.6
Pollak, P.7
Bonaiti, B.8
Bonaiti-Pellie, C.9
Brice, A.10
-
14
-
-
3242703423
-
Neuropathology provides clues to the pathophysiology of Gaucher disease
-
PMID:15234332
-
Wong K, Sidransky E, Verma A, Mixon T, Sandberg GD, Wakefield LK, Morrison A, Lwin A, Colegial C, Allman JM, et al. Neuropathology provides clues to the pathophysiology of Gaucher disease. Mol Genet Metab 2004; 82:192-207; PMID:15234332; http://dx. doi.org/10.1016/jymgme.2004.04.011
-
(2004)
Mol Genet Metab
, vol.82
, pp. 192-207
-
-
Wong, K.1
Sidransky, E.2
Verma, A.3
Mixon, T.4
Sandberg, G.D.5
Wakefield, L.K.6
Morrison, A.7
Lwin, A.8
Colegial, C.9
Allman, J.M.10
-
15
-
-
84867036900
-
Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
-
PMID:23034917
-
Gegg ME, Burke D, Heales SJ, Cooper JM, Hardy J, Wood NW, Schapira AH. Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains. Ann Neurol 2012; 72:455-63; PMID:23034917; http://dx.doi.org/10.1002/ana.23614
-
(2012)
Ann Neurol
, vol.72
, pp. 455-463
-
-
Gegg, M.E.1
Burke, D.2
Heales, S.J.3
Cooper, J.M.4
Hardy, J.5
Wood, N.W.6
Schapira, A.H.7
-
16
-
-
79960009804
-
Gaucher disease glucocerebrosidase and a-synuclein form a bidirectional pathogenic loop in synucleinopathies
-
PMID:21700325
-
Mazzulli JR, Xu YH, Sun Y, Knight AL, McLean PJ, Caldwell GA, Sidransky E, Grabowski GA, Krainc D. Gaucher disease glucocerebrosidase and a-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 2011; 146:37-52; PMID:21700325; http://dx.doi.org/10.1016/j.cell.2011.06.001
-
(2011)
Cell
, vol.146
, pp. 37-52
-
-
Mazzulli, J.R.1
Xu, Y.H.2
Sun, Y.3
Knight, A.L.4
McLean, P.J.5
Caldwell, G.A.6
Sidransky, E.7
Grabowski, G.A.8
Krainc, D.9
-
17
-
-
79956199921
-
Saftig P,Woulfe J, et al. Acid b-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter a-synuclein processing
-
PMID:21472771
-
Cullen V, Sardi SP, Ng J, Xu YH, Sun Y, Tomlinson JJ, Kolodziej P, Kahn I, Saftig P,Woulfe J, et al. Acid b-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter a-synuclein processing. Ann Neurol 2011; 69:940-53; PMID:21472771; http://dx.doi.org/10.1002/ana.22400
-
(2011)
Ann Neurol
, vol.69
, pp. 940-953
-
-
Cullen, V.1
Sardi, S.P.2
Ng, J.3
Xu, Y.H.4
Sun, Y.5
Tomlinson, J.J.6
Kolodziej, P.7
Kahn, I.8
-
18
-
-
70350550208
-
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in a-synuclein models of Parkinson and Lewy body diseases
-
PMID:19864570
-
Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in a-synuclein models of Parkinson and Lewy body diseases. J Neurosci 2009; 29:13578-88; PMID:19864570; http://dx.doi.org/10.1523/JNEUROSCI.4390-09.2009
-
(2009)
J Neurosci
, vol.29
, pp. 13578-13588
-
-
Spencer, B.1
Potkar, R.2
Trejo, M.3
Rockenstein, E.4
Patrick, C.5
Gindi, R.6
Adame, A.7
Wyss-Coray, T.8
Masliah, E.9
-
19
-
-
0026786471
-
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation
-
Chen J,Martin BL, Brautigan DL, PMID:1325671
-
Chen J,Martin BL, Brautigan DL. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 1992; 257:1261-4; PMID:1325671; http://dx.doi.org/10.1126/science.1325671
-
(1992)
Science
, vol.257
, pp. 1261-1264
-
-
-
20
-
-
84859398214
-
Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A
-
PMID:22337773
-
Pitre A, Davis N, Paul M, Orr AW, Skalli O. Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A. Mol Biol Cell 2012; 23:1243-53; PMID:22337773; http://dx.doi.org/10.1091/mbc.E11-08-0685
-
(2012)
Mol Biol Cell
, vol.23
, pp. 1243-1253
-
-
Pitre, A.1
Davis, N.2
Paul, M.3
Orr, A.W.4
Skalli, O.5
-
21
-
-
84862501584
-
Carnosic acid modulates Akt/IKK/NF-kappaB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells
-
PMID:22453599
-
Kar S, Palit S, Ball WB, Das PK. Carnosic acid modulates Akt/IKK/NF-kappaB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells. Apoptosis 2012; 17:735-47; PMID:22453599; http://dx.doi.org/10.1007/s10495-012-0715-4
-
(2012)
Apoptosis
, vol.17
, pp. 735-747
-
-
Kar, S.1
Palit, S.2
Ball, W.B.3
Das, P.K.4
-
22
-
-
84867399176
-
DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3beta to downregulate b-catenin transcription target, osteopontin
-
PMID:22266849
-
Mitra A, Menezes ME, Pannell LK, Mulekar MS, Honkanen RE, Shevde LA, Samant RS. DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3beta to downregulate b-catenin transcription target, osteopontin. Oncogene 2012; 31:4472-83; PMID:22266849; http://dx.doi.org/101038/onc.2011.623
-
(2012)
Oncogene
, vol.31
, pp. 4472-4483
-
-
Mitra, A.1
Menezes, M.E.2
Pannell, L.K.3
Mulekar, M.S.4
Honkanen, R.E.5
Shevde, L.A.6
Samant, R.S.7
-
23
-
-
67650237693
-
Tap42- associated protein phosphatase type 2A negatively regulates induction of autophagy
-
PMID:19223769
-
Yorimitsu T, He C, Wang K, Klionsky DJ. Tap42- associated protein phosphatase type 2A negatively regulates induction of autophagy. Autophagy 2009; 5:616-24; PMID:19223769; http://dx.doi.org/104161/auto.5.5.8091
-
(2009)
Autophagy
, vol.5
, pp. 616-624
-
-
Yorimitsu, T.1
He, C.2
Wang, K.3
Klionsky, D.J.4
-
24
-
-
84862295360
-
Guidelines for the use and interpretation of assays for monitoring autophagy
-
PMID:22966490
-
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445-544; PMID:22966490; http://dx.doi.org/104161/auto.19496
-
(2012)
Autophagy
, vol.8
, pp. 445-544
-
-
Klionsky, D.J.1
Abdalla, F.C.2
Abeliovich, H.3
Abraham, R.T.4
Acevedo-Arozena, A.5
Adeli, K.6
Agholme, L.7
Agnello, M.8
Agostinis, P.9
Aguirre-Ghiso, J.A.10
-
25
-
-
33745859721
-
Autophagy, bafilomycin and cell death: The “a-B-cs" of plecomacrolideinduced neuroprotection
-
PMID:16874105
-
Shacka JJ, Klocke BJ, Roth KA. Autophagy, bafilomycin and cell death: the “a-B-cs" of plecomacrolideinduced neuroprotection. Autophagy 2006; 2:228-30; PMID:16874105; http://dx.doi.org/104161/auto.2703
-
(2006)
Autophagy
, vol.2
, pp. 228-230
-
-
Shacka, J.J.1
Klocke, B.J.2
Roth, K.A.3
-
26
-
-
2442485884
-
Ceramidemediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
-
PMID:14970205
-
Scarlatti F, Bauvy C, Ventruti A, Sala G, Cluzeaud F, Vandewalle A, Ghidoni R, Codogno P. Ceramidemediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem 2004; 279:18384-91; PMID:14970205; http://dx.doi.org/10.1074/jbc.M313561200
-
(2004)
J Biol Chem
, vol.279
, pp. 18384-18391
-
-
Scarlatti, F.1
Bauvy, C.2
Ventruti, A.3
Sala, G.4
Cluzeaud, F.5
Vandewalle, A.6
Ghidoni, R.7
Codogno, P.8
-
27
-
-
77950495123
-
Physiological significance of selective degradation of p62 by autophagy
-
PMID:20153326
-
Komatsu M, Ichimura Y. Physiological significance of selective degradation of p62 by autophagy. FEBS Lett 2010; 584:1374-8; PMID:20153326; http://dx.doi. org/10.1016/j.febslet.2010.02.017
-
(2010)
FEBS Lett
, vol.584
, pp. 1374-1378
-
-
Komatsu, M.1
Ichimura, Y.2
-
28
-
-
33947328858
-
Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation
-
PMID:17360897
-
Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, Lentz SR, Arning E, Bottiglieri T. Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. J Neurosci 2007; 27:2751-9; PMID:17360897; http://dx.doi.org/10.1523/ JNEUROSCI.3316-06.2007
-
(2007)
J Neurosci
, vol.27
, pp. 2751-2759
-
-
Sontag, E.1
Nunbhakdi-Craig, V.2
Sontag, J.M.3
Diaz-Arrastia, R.4
Ogris, E.5
Dayal, S.6
Lentz, S.R.7
Arning, E.8
Bottiglieri, T.9
-
29
-
-
84869014351
-
Disruption of protein quality control in Parkinson disease
-
PMID:22553500
-
Cook C, Stetler C, Petrucelli L. Disruption of protein quality control in Parkinson disease. Cold Spring Harb Perspect Med 2012; 2:a009423; PMID:22553500; http://dx.doi.org/10.1101/cshperspect.a009423
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Cook, C.1
Stetler, C.2
Petrucelli, L.3
-
30
-
-
38949096081
-
Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome
-
PMID:17986870
-
Ding WX, Yin XM. Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy 2008; 4:141-50; PMID:17986870; http://dx.doi.org/10.4161/auto.5190
-
(2008)
Autophagy
, vol.4
, pp. 141-150
-
-
Ding, W.X.1
Yin, X.M.2
-
31
-
-
67650087652
-
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson disease
-
PMID:19286695
-
Neumann J, Bras J, Deas E, O’Sullivan SS, Parkkinen L, Lachmann RH, Li A, Holton J, Guerreiro R, Paudel R, et al. Glucocerebrosidase mutations in clinical and pathologically proven Parkinson disease. Brain 2009; 132:1783-94; PMID:19286695; http://dx.doi.org/10.1093/brain/awp044
-
(2009)
Brain
, vol.132
, pp. 1783-1794
-
-
Neumann, J.1
Bras, J.2
Deas, E.3
O’Sullivan, S.S.4
Parkkinen, L.5
Lachmann, R.H.6
Li, A.7
Holton, J.8
Guerreiro, R.9
Paudel, R.10
-
32
-
-
36949031267
-
α-Synucleinopathy models and human neuropathology: Similarities and differences
-
PMID:17932682
-
Kahle PJ. α-Synucleinopathy models and human neuropathology: similarities and differences. Acta Neuropathol 2008; 115:87-95; PMID:17932682; http://dx.doi.org/10.1007/s00401-007-0302-x
-
(2008)
Acta Neuropathol
, vol.115
, pp. 87-95
-
-
Kahle, P.J.1
-
33
-
-
84875967929
-
Loss of b-glucocerebrosidase activity does not affect a-synuclein levels or lysosomal function in neuronal cells
-
PMID:23580063
-
Dermentzaki G, Dimitriou E, Xilouri M, Michelakakis H, Stefanis L. Loss of b-glucocerebrosidase activity does not affect a-synuclein levels or lysosomal function in neuronal cells. PLoS One 2013; 8:e60674; PMID:23580063; http://dx.doi.org/10.1371/journal. pone.0060674
-
(2013)
Plos One
, vol.8
-
-
Dermentzaki, G.1
Dimitriou, E.2
Xilouri, M.3
Michelakakis, H.4
Stefanis, L.5
-
34
-
-
84861595545
-
Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of a-synuclein and LRRK2 in the brain
-
PMID:22649237
-
Friedman LG, Lachenmayer ML, Wang J, He L, Poulose SM, Komatsu M, Holstein GR, Yue Z. Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of a-synuclein and LRRK2 in the brain. J Neurosci 2012; 32:7585-93; PMID:22649237; http://dx.doi.org/10.1523/JNEUROSCI.5809-11.2012
-
(2012)
J Neurosci
, vol.32
, pp. 7585-7593
-
-
Friedman, L.G.1
Lachenmayer, M.L.2
Wang, J.3
He, L.4
Poulose, S.M.5
Komatsu, M.6
Holstein, G.R.7
Yue, Z.8
-
35
-
-
84862598619
-
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway
-
PMID:22647715
-
Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlotzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, et al. Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Autophagy 2012; 8:754-66; PMID:22647715; http://dx.doi.org/10.4161/auto.19371
-
(2012)
Autophagy
, vol.8
, pp. 754-766
-
-
Klucken, J.1
Poehler, A.M.2
Ebrahimi-Fakhari, D.3
Schneider, J.4
Nuber, S.5
Rockenstein, E.6
Schlotzer-Schrehardt, U.7
Hyman, B.T.8
McLean, P.J.9
Masliah, E.10
-
36
-
-
84878811164
-
Mitochondria and quality control defects in a mouse model of Gaucher disease–links to Parkinson disease
-
PMID:23707074
-
Osellame LD, Rahim AA, Hargreaves IP, Gegg ME, Richard-Londt A, Brandner S, Waddington SN, Schapira AH, Duchen MR. Mitochondria and quality control defects in a mouse model of Gaucher disease–links to Parkinson disease. Cell Metab 2013; 17:941-53; PMID:23707074; http://dx.doi.org/10.1016/j.cmet.2013.04.014
-
(2013)
Cell Metab
, vol.17
, pp. 941-953
-
-
Osellame, L.D.1
Rahim, A.A.2
Hargreaves, I.P.3
Gegg, M.E.4
Richard-Londt, A.5
Brandner, S.6
Waddington, S.N.7
Schapira, A.H.8
Duchen, M.R.9
-
37
-
-
76349098949
-
Crosstalk between apoptosis and autophagy within the Beclin 1 interactome
-
PMID:20125189
-
Maiuri MC, Criollo A, Kroemer G. Crosstalk between apoptosis and autophagy within the Beclin 1 interactome. EMBO J 2010; 29:515-6; PMID:20125189; http://dx.doi.org/10.1038/emboj.2009.377
-
(2010)
EMBO J
, vol.29
, pp. 515-516
-
-
Maiuri, M.C.1
Criollo, A.2
Kroemer, G.3
-
38
-
-
84894528843
-
Reduced glucocerebrosidase is associated with increased a-synuclein in sporadic Parkinson disease
-
PMID:24477431
-
Murphy KE, Gysbers AM, Abbott SK, Tayebi N, Kim WS, Sidransky E, Cooper A, Garner B, Halliday GM. Reduced glucocerebrosidase is associated with increased a-synuclein in sporadic Parkinson disease. Brain 2014; 137:834-48; PMID:24477431; http://dx.doi.org/10.1093/brain/awt367
-
(2014)
Brain
, vol.137
, pp. 834-848
-
-
Murphy, K.E.1
Gysbers, A.M.2
Abbott, S.K.3
Tayebi, N.4
Kim, W.S.5
Sidransky, E.6
Cooper, A.7
Garner, B.8
Halliday, G.M.9
-
39
-
-
80052640576
-
Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments
-
PMID:20031277
-
Veeranna Yang DS, Lee JH, Vinod KY, Stavrides P, Amin ND, Pant HC, Nixon RA. Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiol Aging 2011; 32:2016-29; PMID:20031277; http://dx.doi.org/10.1016/j.neurobiolaging.2009.12.001
-
(2011)
Neurobiol Aging
, vol.32
, pp. 2016-2029
-
-
Veeranna Yang, D.S.1
Lee, J.H.2
Vinod, K.Y.3
Stavrides, P.4
Amin, N.D.5
Pant, H.C.6
Nixon, R.A.7
-
40
-
-
84870512554
-
PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins
-
PMID:22892312
-
Magnaudeix A, Wilson CM, Page G, Bauvy C, Codogno P, Leveque P, Labrousse F, Corre-Delage M, Yardin C, Terro F. PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins. Neurobiol Aging 2013; 34:770-90; PMID:22892312; http://dx.doi.org/10.1016/j.neurobiolaging.2012.06.026
-
(2013)
Neurobiol Aging
, vol.34
, pp. 770-790
-
-
Magnaudeix, A.1
Wilson, C.M.2
Page, G.3
Bauvy, C.4
Codogno, P.5
Leveque, P.6
Labrousse, F.7
Corre-Delage, M.8
Yardin, C.9
Terro, F.10
-
41
-
-
0037151038
-
A functional role for the B56 a-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function
-
PMID:11929874
-
Ruvolo PP, Clark W, Mumby M, Gao F, May WS. A functional role for the B56 a-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function. J Biol Chem 2002; 277:22847-52; PMID:11929874; http://dx.doi.org/10.1074/jbc.M201830200
-
(2002)
J Biol Chem
, vol.277
, pp. 22847-22852
-
-
Ruvolo, P.P.1
Clark, W.2
Mumby, M.3
Gao, F.4
May, W.S.5
-
42
-
-
0032520898
-
Bipotential roles of ceramide in the growth of hippocampal neurons: Promotion of cell survival and dendritic outgrowth in dose- and developmental stage-dependent manners
-
PMID:9545085
-
Mitoma J, Ito M, Furuya S, Hirabayashi Y. Bipotential roles of ceramide in the growth of hippocampal neurons: promotion of cell survival and dendritic outgrowth in dose- and developmental stage-dependent manners. J Neurosci Res 1998; 51:712-22;PMID:9545085;http://dx.doi.org/10.1002/(SICI)1097-4547(19980315)51:6%3c712:AIDJNR5%3e3.0.CO;2-E
-
(1998)
J Neurosci Res
, vol.51
, pp. 712-722
-
-
Mitoma, J.1
Ito, M.2
Furuya, S.3
Hirabayashi, Y.4
-
43
-
-
11844273281
-
Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau
-
PMID:15642345
-
Tsujio I, Zaidi T, Xu J, Kotula L, Grundke-Iqbal I, Iqbal K. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. FEBS Lett 2005; 579:363-72; PMID:15642345; http://dx.doi.org/10.1016/j.febslet.2004.11.097
-
(2005)
FEBS Lett
, vol.579
, pp. 363-372
-
-
Tsujio, I.1
Zaidi, T.2
Xu, J.3
Kotula, L.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
44
-
-
44849144122
-
I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A
-
PMID:18245083
-
Chen S, Li B, Grundke-Iqbal I, Iqbal K. I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. J Biol Chem 2008; 283:10513-21; PMID:18245083; http://dx.doi.org/10.1074/jbc.M709852200
-
(2008)
J Biol Chem
, vol.283
, pp. 10513-10521
-
-
Chen, S.1
Li, B.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
45
-
-
0035177048
-
Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen
-
PMID:11160832
-
Yu XX, Du X, Moreno CS, Green RE, Ogris E, Feng Q, Chou L, McQuoid MJ, Pallas DC. Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. Mol Biol Cell 2001; 12:185-99; PMID:11160832; http://dx.doi.org/10.1091/mbc.12.1.185
-
(2001)
Mol Biol Cell
, vol.12
, pp. 185-199
-
-
Yu, X.X.1
Du, X.2
Moreno, C.S.3
Green, R.E.4
Ogris, E.5
Feng, Q.6
Chou, L.7
McQuoid, M.J.8
Pallas, D.C.9
-
46
-
-
39949083195
-
PP2A holoenzyme assembly: In cauda venenum (the sting is in the tail)
-
PMID:18291659
-
Janssens V, Longin S, Goris J. PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail). Trends Biochem Sci 2008; 33:113-21; PMID:18291659; http://dx.doi.org/10.1016/j.tibs.2007.12.004
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 113-121
-
-
Janssens, V.1
Longin, S.2
Goris, J.3
-
47
-
-
5644293035
-
Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis
-
PMID:15535135
-
Sontag E, Hladik C, Montgomery L, Luangpirom A, Mudrak I, Ogris E, White CL, 3rd. Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol 2004; 63:1080-91; PMID:15535135
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 1080-1091
-
-
Sontag, E.1
Hladik, C.2
Montgomery, L.3
Luangpirom, A.4
Mudrak, I.5
Ogris, E.6
White, C.L.7
-
48
-
-
1842510667
-
Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology
-
PMID: 15099019
-
Sontag E, Luangpirom A, Hladik C, Mudrak I, Ogris E, Speciale S, White CL, 3rd. Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. J Neuropathol Exp Neurol 2004; 63:287-301; PMID: 15099019
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 287-301
-
-
Sontag, E.1
Luangpirom, A.2
Hladik, C.3
Mudrak, I.4
Ogris, E.5
Speciale, S.6
White, C.L.7
-
49
-
-
0041589248
-
Alpha-Synuclein is degraded by both autophagy and the proteasome
-
PMID:12719433
-
Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC. Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem 2003; 278:25009-13; PMID:12719433; http://dx.doi.org/10.1074/jbc.M300227200
-
(2003)
J Biol Chem
, vol.278
, pp. 25009-25013
-
-
Webb, J.L.1
Ravikumar, B.2
Atkins, J.3
Skepper, J.N.4
Rubinsztein, D.C.5
-
50
-
-
68449089023
-
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric a-synuclein
-
PMID:19628769
-
Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE. Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric a-synuclein. Am J Pathol 2009; 175:736-47; PMID:19628769; http://dx.doi.org/10.2353/ajpath.2009.080928
-
(2009)
Am J Pathol
, vol.175
, pp. 736-747
-
-
Yu, W.H.1
Dorado, B.2
Figueroa, H.Y.3
Wang, L.4
Planel, E.5
Cookson, M.R.6
Clark, L.N.7
Duff, K.E.8
-
51
-
-
84874487118
-
Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
-
PMID:23297226
-
Sardi SP, Clarke J, Viel C, Chan M, Tamsett TJ, Treleaven CM, Bu J, Sweet L, Passini MA, Dodge JC, et al. Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies. Proc Natl Acad Sci U S A 2013; 110:3537-42; PMID:23297226; http://dx.doi.org/10.1073/pnas.1220464110
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 3537-3542
-
-
Sardi, S.P.1
Clarke, J.2
Viel, C.3
Chan, M.4
Tamsett, T.J.5
Treleaven, C.M.6
Bu, J.7
Sweet, L.8
Passini, M.A.9
Dodge, J.C.10
-
52
-
-
84871720426
-
Membranebound a-synuclein interacts with glucocerebrosidase and inhibits enzyme activity
-
PMID:23266198
-
Yap TL, Velayati A, Sidransky E, Lee JC. Membranebound a-synuclein interacts with glucocerebrosidase and inhibits enzyme activity. Mol Genet Metab 2013; 108:56-64; PMID:23266198; http://dx.doi.org/10.1016/j.ymgme.2012.11.010
-
(2013)
Mol Genet Metab
, vol.108
, pp. 56-64
-
-
Yap, T.L.1
Velayati, A.2
Sidransky, E.3
Lee, J.C.4
-
53
-
-
0034663039
-
The A53T a-synuclein mutation increases iron-dependent aggregation and toxicity
-
PMID:10934254
-
Ostrerova-Golts N, Petrucelli L, Hardy J, Lee JM, Farer M, Wolozin B. The A53T a-synuclein mutation increases iron-dependent aggregation and toxicity. J Neurosci 2000; 20:6048-54; PMID:10934254
-
(2000)
J Neurosci
, vol.20
, pp. 6048-6054
-
-
Ostrerova-Golts, N.1
Petrucelli, L.2
Hardy, J.3
Lee, J.M.4
Farer, M.5
Wolozin, B.6
-
54
-
-
79953191736
-
A-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator
-
PMID:21310263
-
Zhu Y, Duan C, Lu L, Gao H, Zhao C, Yu S, Ueda K, Chan P, Yang H. a-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator. Int J Biochem Cell Biol 2011; 43:732-41; PMID:21310263; http://dx.doi.org/10.1016/j.biocel.2011.01.014
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 732-741
-
-
Zhu, Y.1
Duan, C.2
Lu, L.3
Gao, H.4
Zhao, C.5
Yu, S.6
Ueda, K.7
Chan, P.8
Yang, H.9
-
55
-
-
84880184556
-
Alpha-synuclein overexpression increases phospho-protein phosphatase 2A levels via formation of calmodulin/Src complex
-
PMID:23796501
-
Yang W, Wang X, Duan C, Lu L, Yang H. Alpha-synuclein overexpression increases phospho-protein phosphatase 2A levels via formation of calmodulin/Src complex. Neurochem Int 2013; 63:180-94; PMID:23796501; http://dx.doi.org/10.1016/j.neuint. 2013.06.010
-
(2013)
Neurochem Int
, vol.63
, pp. 180-194
-
-
Yang, W.1
Wang, X.2
Duan, C.3
Lu, L.4
Yang, H.5
-
56
-
-
70449158340
-
A simple method for the isolation and purification of total lipides from animal tissues
-
PMID:13428781
-
Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957; 226:497-509; PMID:13428781
-
(1957)
J Biol Chem
, vol.226
, pp. 497-509
-
-
Folch, J.1
Lees, M.2
Sloane Stanley, G.H.3
|