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Volumn 19, Issue 7, 2017, Pages 1313-1321

Thymidine Catabolism as a Metabolic Strategy for Cancer Survival

Author keywords

2 deoxy D ribose; glycolysis; thymidine; thymidine catabolism; thymidine phosphorylase

Indexed keywords

GLUCOSE 6 PHOSPHATE; LACTIC ACID; PHOSPHORIBOSYL PYROPHOSPHATE; SERINE; THYMIDINE; THYMIDINE PHOSPHORYLASE; CARBON; DEOXYRIBOSE;

EID: 85019195391     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.04.061     Document Type: Article
Times cited : (47)

References (37)
  • 1
    • 0024850677 scopus 로고
    • Isoenzymes of phosphoglucomutase from human red blood cells: isolation and kinetic properties
    • Accorsi, A., Piatti, E., Piacentini, M.P., Gini, S., Fazi, A., Isoenzymes of phosphoglucomutase from human red blood cells: isolation and kinetic properties. Prep. Biochem. 19 (1989), 251–271.
    • (1989) Prep. Biochem. , vol.19 , pp. 251-271
    • Accorsi, A.1    Piatti, E.2    Piacentini, M.P.3    Gini, S.4    Fazi, A.5
  • 3
    • 84965100853 scopus 로고    scopus 로고
    • Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling
    • Allen, E., Miéville, P., Warren, C.M., Saghafinia, S., Li, L., Peng, M.W., Hanahan, D., Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. Cell Rep. 15 (2016), 1144–1160.
    • (2016) Cell Rep. , vol.15 , pp. 1144-1160
    • Allen, E.1    Miéville, P.2    Warren, C.M.3    Saghafinia, S.4    Li, L.5    Peng, M.W.6    Hanahan, D.7
  • 5
    • 0033692793 scopus 로고    scopus 로고
    • Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors
    • Brown, N.S., Jones, A., Fujiyama, C., Harris, A.L., Bicknell, R., Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. Cancer Res. 60 (2000), 6298–6302.
    • (2000) Cancer Res. , vol.60 , pp. 6298-6302
    • Brown, N.S.1    Jones, A.2    Fujiyama, C.3    Harris, A.L.4    Bicknell, R.5
  • 8
    • 0031058350 scopus 로고    scopus 로고
    • The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo
    • Griffiths, L., Dachs, G.U., Bicknell, R., Harris, A.L., Stratford, I.J., The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo. Cancer Res. 57 (1997), 570–572.
    • (1997) Cancer Res. , vol.57 , pp. 570-572
    • Griffiths, L.1    Dachs, G.U.2    Bicknell, R.3    Harris, A.L.4    Stratford, I.J.5
  • 11
    • 84859436493 scopus 로고    scopus 로고
    • CoQ(10) deficiencies and MNGIE: two treatable mitochondrial disorders
    • Hirano, M., Garone, C., Quinzii, C.M., CoQ(10) deficiencies and MNGIE: two treatable mitochondrial disorders. Biochim. Biophys. Acta 1820 (2012), 625–631.
    • (2012) Biochim. Biophys. Acta , vol.1820 , pp. 625-631
    • Hirano, M.1    Garone, C.2    Quinzii, C.M.3
  • 12
    • 66349095388 scopus 로고    scopus 로고
    • Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry
    • Hirayama, A., Kami, K., Sugimoto, M., Sugawara, M., Toki, N., Onozuka, H., Kinoshita, T., Saito, N., Ochiai, A., Tomita, M., et al. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res. 69 (2009), 4918–4925.
    • (2009) Cancer Res. , vol.69 , pp. 4918-4925
    • Hirayama, A.1    Kami, K.2    Sugimoto, M.3    Sugawara, M.4    Toki, N.5    Onozuka, H.6    Kinoshita, T.7    Saito, N.8    Ochiai, A.9    Tomita, M.10
  • 13
    • 0014250428 scopus 로고
    • 2-deoxyribose gene-enzyme complex in Salmonella typhimurium. I. Isolation and enzymatic characterization of 2-deoxyribose-negative mutants
    • Hoffee, P.A., 2-deoxyribose gene-enzyme complex in Salmonella typhimurium. I. Isolation and enzymatic characterization of 2-deoxyribose-negative mutants. J. Bacteriol. 95 (1968), 449–457.
    • (1968) J. Bacteriol. , vol.95 , pp. 449-457
    • Hoffee, P.A.1
  • 14
    • 0038143237 scopus 로고    scopus 로고
    • Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3
    • Hotchkiss, K.A., Ashton, A.W., Schwartz, E.L., Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3. J. Biol. Chem. 278 (2003), 19272–19279.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19272-19279
    • Hotchkiss, K.A.1    Ashton, A.W.2    Schwartz, E.L.3
  • 16
    • 69349099903 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of 6-(2-aminoethyl)amino-5-chlorouracil, a novel small-molecule inhibitor of thymidine phosphorylase, in combination with the vascular endothelial growth factor-trap
    • Lu, H., Klein, R.S., Schwartz, E.L., Antiangiogenic and antitumor activity of 6-(2-aminoethyl)amino-5-chlorouracil, a novel small-molecule inhibitor of thymidine phosphorylase, in combination with the vascular endothelial growth factor-trap. Clin. Cancer Res. 15 (2009), 5136–5144.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5136-5144
    • Lu, H.1    Klein, R.S.2    Schwartz, E.L.3
  • 19
    • 0028957177 scopus 로고
    • Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase
    • Miyadera, K., Sumizawa, T., Haraguchi, M., Yoshida, H., Konstanty, W., Yamada, Y., Akiyama, S., Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase. Cancer Res. 55 (1995), 1687–1690.
    • (1995) Cancer Res. , vol.55 , pp. 1687-1690
    • Miyadera, K.1    Sumizawa, T.2    Haraguchi, M.3    Yoshida, H.4    Konstanty, W.5    Yamada, Y.6    Akiyama, S.7
  • 21
    • 0020424273 scopus 로고
    • Properties and activities of phosphoribomutase in the human leukemic cells
    • Nishida, Y., Miyamoto, T., Properties and activities of phosphoribomutase in the human leukemic cells. Int. J. Biochem. 14 (1982), 961–963.
    • (1982) Int. J. Biochem. , vol.14 , pp. 961-963
    • Nishida, Y.1    Miyamoto, T.2
  • 22
    • 0033613865 scopus 로고    scopus 로고
    • Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder
    • Nishino, I., Spinazzola, A., Hirano, M., Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Science 283 (1999), 689–692.
    • (1999) Science , vol.283 , pp. 689-692
    • Nishino, I.1    Spinazzola, A.2    Hirano, M.3
  • 24
    • 0001444987 scopus 로고
    • Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation
    • Potter, H., Weir, L., Leder, P., Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc. Natl. Acad. Sci. USA 81 (1984), 7161–7165.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 7161-7165
    • Potter, H.1    Weir, L.2    Leder, P.3
  • 25
    • 84886411355 scopus 로고    scopus 로고
    • Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: a metabolomics analysis
    • Saito, T., Sugimoto, M., Igarashi, K., Saito, K., Shao, L., Katsumi, T., Tomita, K., Sato, C., Okumoto, K., Nishise, Y., et al. Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: a metabolomics analysis. Metabolism 62 (2013), 1577–1586.
    • (2013) Metabolism , vol.62 , pp. 1577-1586
    • Saito, T.1    Sugimoto, M.2    Igarashi, K.3    Saito, K.4    Shao, L.5    Katsumi, T.6    Tomita, K.7    Sato, C.8    Okumoto, K.9    Nishise, Y.10
  • 27
    • 12144287351 scopus 로고    scopus 로고
    • Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy
    • Seeliger, H., Guba, M., Koehl, G.E., Doenecke, A., Steinbauer, M., Bruns, C.J., Wagner, C., Frank, E., Jauch, K.W., Geissler, E.K., Blockage of 2-deoxy-D-ribose-induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy. Clin. Cancer Res. 10 (2004), 1843–1852.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1843-1852
    • Seeliger, H.1    Guba, M.2    Koehl, G.E.3    Doenecke, A.4    Steinbauer, M.5    Bruns, C.J.6    Wagner, C.7    Frank, E.8    Jauch, K.W.9    Geissler, E.K.10
  • 30
    • 77949297718 scopus 로고    scopus 로고
    • Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles
    • Sugimoto, M., Wong, D.T., Hirayama, A., Soga, T., Tomita, M., Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics 6 (2010), 78–95.
    • (2010) Metabolomics , vol.6 , pp. 78-95
    • Sugimoto, M.1    Wong, D.T.2    Hirayama, A.3    Soga, T.4    Tomita, M.5
  • 31
    • 84857124407 scopus 로고    scopus 로고
    • Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis
    • Sugimoto, M., Kawakami, M., Robert, M., Soga, T., Tomita, M., Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis. Curr. Bioinform. 7 (2012), 96–108.
    • (2012) Curr. Bioinform. , vol.7 , pp. 96-108
    • Sugimoto, M.1    Kawakami, M.2    Robert, M.3    Soga, T.4    Tomita, M.5
  • 35
    • 84877888815 scopus 로고    scopus 로고
    • Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics
    • Trushina, E., Dutta, T., Persson, X.M., Mielke, M.M., Petersen, R.C., Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics. PLoS ONE, 8, 2013, e63644.
    • (2013) PLoS ONE , vol.8 , pp. e63644
    • Trushina, E.1    Dutta, T.2    Persson, X.M.3    Mielke, M.M.4    Petersen, R.C.5
  • 36
    • 84941278282 scopus 로고    scopus 로고
    • Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress
    • Uetaki, M., Tabata, S., Nakasuka, F., Soga, T., Tomita, M., Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress. Sci. Rep., 5, 2015, 13896.
    • (2015) Sci. Rep. , vol.5 , pp. 13896
    • Uetaki, M.1    Tabata, S.2    Nakasuka, F.3    Soga, T.4    Tomita, M.5
  • 37
    • 84988431514 scopus 로고    scopus 로고
    • Serine and one-carbon metabolism in cancer
    • Yang, M., Vousden, K.H., Serine and one-carbon metabolism in cancer. Nat. Rev. Cancer 16 (2016), 650–662.
    • (2016) Nat. Rev. Cancer , vol.16 , pp. 650-662
    • Yang, M.1    Vousden, K.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.