-
1
-
-
67349203545
-
Losing and finding a way at C: New promise for pharmacologic ascorbate in cancer treatment
-
Levine, M., Espey, M. G. and Chen, Q. Losing and finding a way at C: new promise for pharmacologic ascorbate in cancer treatment. Free Radic. Biol. Med. 47, 27-29, doi: 10.1016/j.freeradbiomed.2009.04.001 (2009).
-
(2009)
Free Radic. Biol. Med.
, vol.47
, pp. 27-29
-
-
Levine, M.1
Espey, M.G.2
Chen, Q.3
-
2
-
-
0006171777
-
Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer
-
Cameron, E. and Pauling, L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc. Natl. Acad. Sci. USA 73, 3685-3689 (1976).
-
(1976)
Proc. Natl. Acad. Sci. USA
, vol.73
, pp. 3685-3689
-
-
Cameron, E.1
Pauling, L.2
-
3
-
-
0012375577
-
Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer
-
Cameron, E. and Pauling, L. Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer. Proc. Natl. Acad. Sci. USA. 75, 4538-4542 (1978).
-
(1978)
Proc. Natl. Acad. Sci. USA.
, vol.75
, pp. 4538-4542
-
-
Cameron, E.1
Pauling, L.2
-
4
-
-
0018669229
-
Failure of high-dose Vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial
-
Creagan, E. T. et al. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N. Engl. J. Med. 301, 687-690, doi: 10.1056/NEJM197909273011303 (1979).
-
(1979)
N. Engl. J. Med.
, vol.301
, pp. 687-690
-
-
Creagan, E.T.1
-
5
-
-
0021955675
-
High-dose Vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison
-
Moertel, C. G. et al. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N. Engl. J. Med. 312, 137-141, doi: 10.1056/NEJM198501173120301 (1985).
-
(1985)
N. Engl. J. Med.
, vol.312
, pp. 137-141
-
-
Moertel, C.G.1
-
6
-
-
26444521256
-
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
-
Chen, Q. et al. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc. Natl. Acad. Sci. USA 102, 13604-13609, doi: 10.1073/pnas.0506390102 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13604-13609
-
-
Chen, Q.1
-
7
-
-
34547429599
-
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo
-
Chen, Q. et al. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc. Natl. Acad. Sci. USA. 104, 8749-8754, doi: 10.1073/pnas.0702854104 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA.
, vol.104
, pp. 8749-8754
-
-
Chen, Q.1
-
8
-
-
49649115940
-
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
-
Chen, Q. et al. Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc. Natl. Acad. Sci. USA 105, 11105-11109, doi: 10.1073/pnas.0804226105 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 11105-11109
-
-
Chen, Q.1
-
9
-
-
84866613772
-
Ascorbic acid: Chemistry, biology and the treatment of cancer
-
Du, J., Cullen, J. J. and Buettner, G. R. Ascorbic acid: Chemistry, biology and the treatment of cancer. Biochim. Biophys. Acta 1826, 443-457, doi: 10.1016/j.bbcan.2012.06.003 (2012).
-
(2012)
Biochim. Biophys. Acta
, vol.1826
, pp. 443-457
-
-
Du, J.1
Cullen, J.J.2
Buettner, G.R.3
-
10
-
-
77950296126
-
High dose of ascorbic acid induces cell death in mesothelioma cells
-
Takemura, Y. et al. High dose of ascorbic acid induces cell death in mesothelioma cells. Biochem. Biophys. Res. Commun. 394, 249-253, doi: 10.1016/j.bbrc.2010.02.012 (2010).
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.394
, pp. 249-253
-
-
Takemura, Y.1
-
11
-
-
33750510904
-
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
-
Takahashi, A. et al. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat. Cell Biol. 8, 1291-1297, doi: 10.1038/ncb1491 (2006).
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 1291-1297
-
-
Takahashi, A.1
-
12
-
-
74549157124
-
Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer
-
Du, J. et al. Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer. Clin. Cancer Res. 16, 509-520, doi: 10.1158/1078- 0432.CCR-09-1713 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 509-520
-
-
Du, J.1
-
13
-
-
0032498327
-
Growth suppression of malignant leukemia cell line in vitro by ascorbic acid (Vitamin C) and its derivatives
-
Roomi, M. W., House, D., Eckert-Maksic, M., Maksic, Z. B. and Tsao, C. S. Growth suppression of malignant leukemia cell line in vitro by ascorbic acid (vitamin C) and its derivatives. Cancer Lett. 122, 93-99 (1998).
-
(1998)
Cancer Lett.
, vol.122
, pp. 93-99
-
-
Roomi, M.W.1
House, D.2
Eckert-Maksic, M.3
Maksic, Z.B.4
Tsao, C.S.5
-
15
-
-
33746298246
-
Mechanisms of cytochrome c release from mitochondria
-
Garrido, C. et al. Mechanisms of cytochrome c release from mitochondria. Cell Death Differ. 13, 1423-1433 (2006).
-
(2006)
Cell Death Differ.
, vol.13
, pp. 1423-1433
-
-
Garrido, C.1
-
16
-
-
0037458619
-
Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol
-
Han, D., Antunes, F., Canali, R., Rettori, D. and Cadenas, E. Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J. Biol. Chem. 278, 5557-5563, doi: 10.1074/jbc.M210269200 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 5557-5563
-
-
Han, D.1
Antunes, F.2
Canali, R.3
Rettori, D.4
Cadenas, E.5
-
17
-
-
0034321934
-
H2O2-induced block of glycolysis as an active ADP-ribosylation reaction protecting cells from apoptosis
-
Colussi, C. et al. H2O2-induced block of glycolysis as an active ADP-ribosylation reaction protecting cells from apoptosis. FASEB J. 14, 2266-2276, doi: 10.1096/fj.00-0074com (2000).
-
(2000)
FASEB J.
, vol.14
, pp. 2266-2276
-
-
Colussi, C.1
-
18
-
-
79958152853
-
Superoxide dismutase in redox biology: The roles of superoxide and hydrogen peroxide
-
Buettner, G. R. Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide. Anticancer Agents Med. Chem. 11, 341-346 (2011).
-
(2011)
Anticancer Agents Med. Chem.
, vol.11
, pp. 341-346
-
-
Buettner, G.R.1
-
19
-
-
84858279403
-
Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy
-
Chen, P. et al. Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy. Anticancer Drugs 23, 437-444, doi: 10.1097/CAD.0b013e32834fd01f (2012).
-
(2012)
Anticancer Drugs
, vol.23
, pp. 437-444
-
-
Chen, P.1
-
20
-
-
84867335373
-
Enhanced antitumor activity of Vitamin C via p53 in cancer cells
-
Kim, J. et al. Enhanced antitumor activity of vitamin C via p53 in cancer cells. Free Radic. Biol. Med. 53, 1607-1615, doi: 10.1016/j.freeradbiomed.2012.07.079 (2012).
-
(2012)
Free Radic. Biol. Med.
, vol.53
, pp. 1607-1615
-
-
Kim, J.1
-
21
-
-
84884213220
-
SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment
-
Hong, S. W. et al. SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment. Oncogene 32, 1508-1517, doi: 10.1038/ onc.2012.176 (2013).
-
(2013)
Oncogene
, vol.32
, pp. 1508-1517
-
-
Hong, S.W.1
-
22
-
-
84905842358
-
Molecular expression and functional activity of Vitamin C specific transport system (SVCT2) in human breast cancer cells
-
Khurana, V., Kwatra, D., Pal, D. and Mitra, A. K. Molecular expression and functional activity of vitamin C specific transport system (SVCT2) in human breast cancer cells. Int. J. Pharm. 474, 14-24, doi: 10.1016/j.ijpharm.2014.07.056 (2014).
-
(2014)
Int. J. Pharm.
, vol.474
, pp. 14-24
-
-
Khurana, V.1
Kwatra, D.2
Pal, D.3
Mitra, A.K.4
-
23
-
-
84894593503
-
The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines
-
Sinnberg, T. et al. The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines. J. Cell. Mol. Med. 18, 530-541, doi: 10.1111/jcmm.12207 (2014).
-
(2014)
J. Cell. Mol. Med.
, vol.18
, pp. 530-541
-
-
Sinnberg, T.1
-
24
-
-
79251517382
-
Regulation of cancer cell metabolism
-
Cairns, R. A., Harris, I. S. and Mak, T. W. Regulation of cancer cell metabolism. Nat. Rev. Cancer 11, 85-95, doi: 10.1038/nrc2981 (2011).
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 85-95
-
-
Cairns, R.A.1
Harris, I.S.2
Mak, T.W.3
-
25
-
-
84874462054
-
Cancer metabolism: Key players in metabolic reprogramming
-
Soga, T. Cancer metabolism: key players in metabolic reprogramming. Cancer Sci. 104, 275-281, doi: 10.1111/cas.12085 (2013).
-
(2013)
Cancer Sci.
, vol.104
, pp. 275-281
-
-
Soga, T.1
-
26
-
-
66349095388
-
Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry
-
Hirayama, A. et al. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res. 69, 4918-4925, doi: 10.1158/0008-5472.CAN-08-4806 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 4918-4925
-
-
Hirayama, A.1
-
27
-
-
0030980641
-
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
-
Irani, K. et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275, 1649-1652 (1997).
-
(1997)
Science
, vol.275
, pp. 1649-1652
-
-
Irani, K.1
-
28
-
-
0036285034
-
C-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
-
Vafa, O. et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol. Cell 9, 1031-1044 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 1031-1044
-
-
Vafa, O.1
-
29
-
-
12444279265
-
On the origin of cancer cells
-
Warburg, O. On the origin of cancer cells. Science 123, 309-314 (1956).
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
30
-
-
78649711427
-
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
-
Levine, A. J. and Puzio-Kuter, A. M. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330, 1340-1344, doi: 10.1126/science.1193494 (2010).
-
(2010)
Science
, vol.330
, pp. 1340-1344
-
-
Levine, A.J.1
Puzio-Kuter, A.M.2
-
31
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden, M. G., Cantley, L. C. and Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033, doi: 10.1126/science.1160809 (2009).
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
32
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. and Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674, doi: 10.1016/j.cell.2011.02.013 (2011).
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
33
-
-
80053922625
-
Metabolic flux and the regulation of mammalian cell growth
-
Locasale, J. W. and Cantley, L. C. Metabolic flux and the regulation of mammalian cell growth. Cell metabolism 14, 443-451, doi: 10.1016/j.cmet.2011.07.014 (2011).
-
(2011)
Cell Metabolism
, vol.14
, pp. 443-451
-
-
Locasale, J.W.1
Cantley, L.C.2
-
34
-
-
0027230458
-
Association of glyceraldehyde-3-phosphate dehydrogenase expression with cell motility and metastatic potential of rat prostatic adenocarcinoma
-
Epner, D. E., Partin, A. W., Schalken, J. A., Isaacs, J. T. and Coffey, D. S. Association of glyceraldehyde-3-phosphate dehydrogenase expression with cell motility and metastatic potential of rat prostatic adenocarcinoma. Cancer Res. 53, 1995-1997 (1993).
-
(1993)
Cancer Res.
, vol.53
, pp. 1995-1997
-
-
Epner, D.E.1
Partin, A.W.2
Schalken, J.A.3
Isaacs, J.T.4
Coffey, D.S.5
-
35
-
-
0343619342
-
Glyceraldehyde-3-phosphate dehydrogenase gene expression in human breast cancer
-
Revillion, F., Pawlowski, V., Hornez, L. and Peyrat, J. P. Glyceraldehyde-3-phosphate dehydrogenase gene expression in human breast cancer. Eur. J. Cancer 36, 1038-1042 (2000).
-
(2000)
Eur. J. Cancer
, vol.36
, pp. 1038-1042
-
-
Revillion, F.1
Pawlowski, V.2
Hornez, L.3
Peyrat, J.P.4
-
36
-
-
0023608017
-
Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers
-
Tokunaga, K. et al. Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res. 47, 5616-5619 (1987).
-
(1987)
Cancer Res.
, vol.47
, pp. 5616-5619
-
-
Tokunaga, K.1
-
37
-
-
79954428147
-
Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells
-
Higashimura, Y. et al. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch. Biochem. Biophys. 509, 1-8, doi: 10.1016/j.abb.2011.02.011 (2011).
-
(2011)
Arch. Biochem. Biophys.
, vol.509
, pp. 1-8
-
-
Higashimura, Y.1
-
38
-
-
68049109441
-
Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry
-
Soga, T. et al. Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry. Anal. Chem. 81, 6165-6174, doi: 10.1021/ac900675k (2009).
-
(2009)
Anal. Chem.
, vol.81
, pp. 6165-6174
-
-
Soga, T.1
-
39
-
-
77949297718
-
Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles
-
Sugimoto, M., Wong, D. T., Hirayama, A., Soga, T. and Tomita, M. Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics: Official journal of the Metabolomic Society 6, 78-95, doi: 10.1007/s11306-009-0178-y (2010).
-
(2010)
Metabolomics: Official Journal of the Metabolomic Society
, vol.6
, pp. 78-95
-
-
Sugimoto, M.1
Wong, D.T.2
Hirayama, A.3
Soga, T.4
Tomita, M.5
|