Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells

Oncology Reports

Volumn 28, Issue 3, 2012, Pages 895-902

  Tabata, Sho ^a,b   Ikeda, Ryuji ^b   Yamamoto, Masatatu ^b   Furukawa, Tatsuhiko ^b   Kuramoto, Takuya ^a   Takeda, Yasuo ^b   Yamada, Katsushi ^b   Haraguchi, Misako ^b   Nishioka, Yasuhiko ^a   Sone, Saburo ^a   Akiyama, Shin Ichi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

2 deoxy D ribose; Interleukin 8; Reactive oxygen species; Thymidine phosphorylase; Thymidine phosphorylase inhibitor

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; HYDROGEN PEROXIDE; INTERLEUKIN 8; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; THYMIDINE; THYMIDINE PHOSPHORYLASE;

ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CELL LEVEL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; SQUAMOUS CELL CARCINOMA; UPREGULATION; UTERINE CERVIX CANCER;

ACETYLCYSTEINE; CELL LINE, TUMOR; FREE RADICAL SCAVENGERS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE-1; HUMANS; INTERLEUKIN-8; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; THYMIDINE PHOSPHORYLASE;

EID: 84865345573     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1887     Document Type: Article

References (24)

1. Furukawa T, Yoshimura A, Sumizawa T, et al: Angiogenic factor. Nature 356: 668, 1992.
2. Akiyama S, Furukawa T, Sumizawa T, Takebayashi Y, Nakajima Y, Shimaoka S and Haraguchi M: The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression. Cancer Sci 95: 851-857, 2004.
3. Miyadera K, Sumizawa T, Haraguchi M, Yoshida H, Konstanty W, Yamada Y and Akiyama S: Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase. Cancer Res 55: 1687-1690, 1995.
4. Matsushita S, Nitanda T, Furukawa T, et al: The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors. Cancer Res 59: 1911-1916, 1999.
5. Takao S, Akiyama S, Nakajo A, et al: Suppression of metastasis by thymidine phosphorylase inhibitor. Cancer Res 60: 5345-5348, 2000.
6. Haraguchi M, Miyadera K, Uemura K, et al: Angiogenic activity of enzymes. Nature 368: 198, 1994.
7. Kitazono M, Takebayashi Y, Ishitsuka K, et al: Prevention of hypoxia-induced apoptosis by the angiogenic factor, thymidine phosphprylase. Biochem Biophys Res Commun 253: 797-803, 1998.
8. Uchimiya H, Furukawa T, Okamoto M, et al: Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose. Cancer Res 62: 2834-2839, 2002.
9. Nakajima Y, Gotanda T, Uchimiya H, et al: Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose. Cancer Res 64: 1749-1801, 2004.
10. 3. J Biol Chem 278: 19272-19279, 2003.
11. Seeliger H, Guba M, Koehl GE, et al: Blockage of 2-deoxy-D-ribose induced angiogenesis with rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer under 5-fluorouracil therapy. Clin Cancer Res 10: 1843-1852, 2004.
12. Hoffee PA: 2-Deoxyribose gene-enzyme complex in Salmonella typhimurium I. Isolation and enzymatic characterization of 2-deoxyribose-negative mutants. J Bacteriol 95: 449-457, 1968.
13. Bijnsdorp IV, Azijli K, Jansen EE, et al: Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells. Biochem Pharmacol 80: 786-792, 2010.
14. Brown NS and Bicknell R: Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis (Review). Biochem J 334: 1-8, 1988.
15. Brown NS, Jones A, Fujiyama C, Harris AL and Bicknell R: Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. Cancer Res 60: 6298-6302, 2000.
16. Potter H, Weir L and Leder P: Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc Natl Acad Sci USA 81: 7161-7165, 1984.
17. Takebayashi Y, Yamada K, Miyadera K, et al: The activity and expression of thymidine phosphorylase in human solid tumours. Eur J Cancer 32A: 1227-1232, 1996.
18. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
19. Andersen JK: Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Biochem Biophys Methods 10: 203-209, 1984.
20. Tuvdendorj D, Oketani M, Ikeda R, et al: Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway. Hepatol Res 26: 47-54, 2003.
21. Fico A, Manganelli G, Cigliano L, et al: 2-Deoxy-d-ribose induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione. Free Radic Biol Med 45: 211-217, 2008.
22. Schmidt MM, Greb H, Koliwer-Brandl H, Kelm S and Dringen R: 2-Deoxyribose deprives cultured astrocytes of their glutathione. Neurochem Res 35: 1848-1856, 2010.
23. Brar SS, Kennedy TP, Sturrock AB, et al: NADPH oxidase promotes NF-κB activation and proliferation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 282: L782-L795, 2002.
24. Murayama T, Ohara Y, Obuchi M, Khabar KSA, Higashi H, Mukaida N and Matsushima K: Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-κB-binding sites of the interleukin-8 gene. J Virol 71: 5692-5695, 1997.