Inhibition of Metastasis of Tumor Cells Overexpressing Thymidine Phosphorylase by 2-Deoxy-L-Ribose

Cancer Research

Volumn 64, Issue 5, 2004, Pages 1794-1801

  Nakajima, Yuichi ^a   Gotanda, Takenari ^a   Uchimiya, Hiroshi ^a   Furukawa, Tatsuhiko ^a   Haraguchi, Misako ^a   Ikeda, Ryuji ^a   Sumizawa, Tomoyuki ^a   Yoshida, Hiroki ^a   Akiyama, Shin Ichi ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXYRIBOSE; 2 DEOXYRIBOSE 1 PHOSPHATE; CARBOHYDRATE DERIVATIVE; INTERLEUKIN 8; MESSENGER RNA; PHOSPHATE; TEGAFUR; THYMIDINE; THYMIDINE PHOSPHORYLASE; THYMINE; UNCLASSIFIED DRUG; VASCULOTROPIN; DEOXYRIBOSE; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INVASION; CATALYSIS; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEPHOSPHORYLATION; DRUG EFFICACY; ENDOTHELIUM CELL; GENE OVEREXPRESSION; GROWTH INHIBITION; HYPOXIA; LIVER METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEREOISOMERISM; TUMOR CELL; ANIMAL; DRUG COMBINATION; DRUG EFFECT; EXPERIMENTAL NEOPLASM; GENETICS; LIVER TUMOR; METASTASIS; NEOVASCULARIZATION (PATHOLOGY); PHYSIOLOGY;

ANIMALS; APOPTOSIS; DEOXYRIBOSE; DRUG THERAPY, COMBINATION; INTERLEUKIN-8; LIVER NEOPLASMS; MALE; MICE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; TEGAFUR; THYMIDINE PHOSPHORYLASE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 1642326603     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-2597     Document Type: Article

References (40)

1. Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med., 285: 1182-1186, 1971.
2. Senger, D. R., Perruzzi, C. A., Feder, J., and Dvorak, H. F. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res., 46: 5629-5632, 1986.
3. Schweigerer, L., Neufeld, G., Friedman, J., Abraham, J. A., Fiddes, J. C., and Gospodarowicz, D. Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. Nature (Lond.), 325: 257-259, 1987.
4. Rappolee, D. A., Mark, D., Banda, M. J., and Werb, Z. Wound macrophages express TGF-α and other growth factors in vivo: analysis by mRNA phenotyping. Science (Wash. DC), 241: 708-712, 1988.
5. Grant, D. S., Kleinman, H. K., Goldberg, I. D., Bhargava, M. M., Nickoloff, B. J., Kinsella, J. L., Polverini, P., and Rosen, E. M. Scatter factor induces blood vessel formation in vivo. Proc. Natl. Acad. Sci. USA, 90: 1937-1941, 1993.
6. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med., 1: 27-31, 1995.
7. Hanahan, D., and Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell, 86: 353-364, 1996.
8. Folkman, J. Anti-angiogenesis: new concept for therapy of solid tumors. Ann. Surg., 175: 409-416, 1972.
9. Furukawa, T., Yoshimura, A., Sumizawa, T., Haraguchi, M., Akiyama, S., Fukui, K., Ishizawa, M., and Yamada, Y. Angiogenic factor. Nature (Lond.), 356: 668, 1992.
10. Haraguchi, M., Miyadera, K., Uemura, K., Sumizawa, T., Furukawa, T., Yamada, K., Akiyama, S., and Yamada, Y. Angiogenic activity of enzymes. Nature (Lond.), 368: 198, 1994.
11. Matsushita, S., Nitanda, T., Furukawa, T., Sumizawa, T., Tani, A., Nishimoto, K., Akiba, S., Miyadera, K., Fukushima, M., Yamada, Y., Yoshida, H., Kanzaki, T., and Akiyama, S. The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors. Cancer Res., 59: 1911-1916, 1999.
12. Takebayashi, Y., Akiyama, S., Akiba, S., Yamada, K., Miyadera, K., Sumizawa, T., Yamada, Y., Murata, F., and Aikou, T. Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J. Natl. Cancer Inst., 88: 1110-1117, 1996.
13. Yonenaga, F., Takasaki, T., Ohi, Y., Sagara, Y., Akiba, S., Yoshinaka, H., Aikou, T., Miyadera, K., Akiyama, S., and Yoshida, H. The expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor is correlated to angiogenesis in breast cancer. Pathol. Int., 48: 850-856, 1998.
14. Shimaoka, S., Matsushita, S., Nitanda, T., Matsuda, A., Nioh, T., Suenaga, T., Nishimata, Y., Akiba, S., Akiyama, S., and Nishimata, H. The role of thymidine phosphorylase expression in the invasiveness of gastric carcinoma. Cancer (Phila.), 88: 2220-2227, 2000.
15. Giatromanolaki, A., Sivridis, E., Simopoulos, C., Polychronidis, A., Gatter, K. C., Harris, A. L., and Koukourakis, M. I. Thymidine phosphorylase expression in gallbladder adenocarcinomas. Int. J. Surg. Pathol., 10: 181-188, 2002.
16. Kitazono, M., Takebayashi, Y., Ishitsuka, K., Takao, S., Tani, A., Furukawa, T., Miyadera, K., Yamada, Y., Aikou, T., and Akiyama, S. Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase. Biochem. Biophys. Res. Commun., 253: 797-803, 1998.
17. Miyadera, K., Sumizawa, T., Haraguchi, M., Yoshida, H., Konstanty, W., Yamada, Y., and Akiyama, S. Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase. Cancer Res., 55: 1687-1690, 1995.
18. Uchimiya, H., Furukawa, T., Okamoto, M., Nakajima, Y., Matsushita, S., Ikeda, R., Gotanda, T., Haraguchi, M., Sumizawa, T., Ono, M., Kuwano, M., Kanzaki, T., and Akiyama, S. Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose. Cancer Res., 62: 2834-2839, 2002.
19. Ikeda, R., Furukawa, T., Kitazono, M., Ishitsuka, K., Okumura, H., Tani, A., Sumizawa, T., Haraguchi, M., Komatsu, M., Uchimiya, H., Ren, X. Q., Motoya, T., Motoya, T., Yamada, K., and Akiyama, S. Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-ribose. Biochem. Biophys. Res. Commun., 291: 806-812, 2002.
20. Klein, R. S., Lenzi, M., Lim, T. H., Hotchkiss, K. A., Wilson, P., and Schwartz, E. L. Novel 6-substituted uracil analogs as inhibitors of the angiogenic actions of thymidine phosphorylase. Biochem. Pharmacol., 62: 1257-1263, 2001.
21. Nishino, I., Spinazzola, A., and Hirano, M. Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Science (Wash. DC), 283: 689-692, 1999.
22. Nishino, I., Spinazzola, A., Papadimitriou, A., Hammans, S., Steiner, I., Hahn, C. D., Connolly, A. M., Verloes, A., Guimaraes, J., Maillard, I., Hamano, H., Donati, M. A., Semrad, C. E., Russell, J. A., Andreu, A. L., Hadjigeorgiou, G. M., Vu, T. H., Tadesse, S., Nygaard, T. G., Nonaka, I., Hirano, I., Bonilla, E., Rowland, L. P., DiMauro, S., and Hirano, M. Mitochondrial neurogastrointestinal encephalomyopathy: an autosomal recessive disorder due to thymidine phosphorylase mutations. Ann. Neurol., 47: 792-800, 2000.
23. Verweij, J. Rational design of new tumor activated cytotoxic agents. Oncology, 57: 9-15, 1999.
24. Haraguchi, M., Furukawa, T., Sumizawa, T., and Akiyama, S. Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites. Cancer Res., 53: 5680-5682, 1993.
25. Takao, S., Akiyama, S., Nakajo, A., Yoh, H., Kitazono, M., Natsugoe, S., Miyadera, K., Fukushima, M., Yamada, Y., and Aikou, T. Suppression of metastasis by thymidine phosphorylase inhibitor. Cancer Res., 60: 5345-5648, 2000.
26. Potter, H., Weir, L., and Leder, P. Enhancer-dependent expression of human κ immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc. Natl. Acad. Sci. USA, 81: 7161-7165, 1984.
27. Takebayashi, Y., Yamada, K., Miyadera, K., Sumizawa, T., Furukawa, T., Kinoshita, F., Aoki, D., Okumura, H., Yamada, Y., Akiyama, S., and Aikou, T. The activity and expression of thymidine phosphorylase in human solid tumors. Eur. J. Cancer, 32: 1227-1232, 1996.
28. Drixler, T. A., Rinkes, I. H., Ritchie, E. D., van Vroonhoven, T. J., Gebbink, M. F., and Voest, E. E. Continuous administration of angiostatin inhibits accelerated growth of colorectal liver metastases after partial hepatectomy. Cancer Res., 60: 1761-1765, 2000.
29. Guba, M., von Breitenbuch, P., Steinbauer, M., Koehl, G., Flegel, S., Hornung, M., Bruns, C. J., Zuelke, C., Farkas, S., Anthuber, M., Jauch, K. W., and Geissler, E. K. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat. Med., 8: 128-135, 2002.
30. Brown, N. S., and Bicknell, R. Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis. Biochem. J., 334: 1-8, 1998.
31. Ueda, M., Terai, Y., Kumagai, K., Ueki, K., Kanemura, M., and Ueki, M. Correlation between thymidine phosphorylase expression and invasion phenotype in cervical carcinoma cells. Int. J. Cancer, 91: 778-782, 2001.
32. Muro, H., Waguri-Nagaya, Y., Mukofujiwara, Y., Iwahashi, T., Otsuka, T., Matsui, N., Moriyama, A., Asai, K., and Kato, T. Autocrine induction of gliostatin/platelet-derived endothelial cell growth factor (GLS/PD-ECGF) and GLS-induced expression of matrix metalloproteinases in rheumatoid arthritis synoviocytes. Rheumatology (Oxford), 38: 1195-1202, 1999.
33. Haraguchi, M., Tsujimoto, H., Fukushima, M., Higuchi, I., Kuribayashi, H., Utsumi, H., Nakayama, A., Hashizume, Y., Hirato, J., Yoshida, H., Hara, H., Hamano, S., Kawaguchi, H., Furukawa, T., Miyazono, K., Ishikawa, F., Toyoshima, H., Kaname, T., Komatsu, M., Chen, Z. S., Gotanda, T., Tachiwada, T., Sumizawa, T., Miyadera, K., Osame, M., Yoshida, H., Noda, T., Yamada, Y., and Akiyama, S. Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Mol. Cell. Biol., 22: 5212-5221, 2002.
34. Tuchman, M., Stoeckeler, J. S., Kiang, D. T., O'Dea, R. F., Ramnaraine, M. L., and Mirkin, B. L. Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity. N. Engl. J. Med., 313: 245-249, 1985.
35. Brown, N. S., Jones, A., Fujiyama, C., Harris, A. L., and Bicknell, R. Thymidine phosphorylase induces carcinoma cell oxidative stress and promotes secretion of angiogenic factors. Cancer Res., 60: 6298-6302, 2000.
36. Li, A., Dubey, S., Varney, M. L., Dave, B. J., and Singh, R. K. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J. Immunol., 170: 3369-3376, 2003.
37. Ramjeesingh, R., Leung, R., and Siu, C. H. Interleukin-8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR1. FASEB J., 17: 1292-1294, 2003.
38. 3. J. Biol. Chem., 278: 19272-19279, 2003.
39. Vogel, T., Blake, D. A., Whikehart, D. R., Guo, N. H., Zabrenetzky, V. S., and Roberts, D. D. Specific simple sugars promote chemotaxis and chemokinesis of corneal endothelial cells. J. Cell Physiol., 157: 359-366, 1993.
40. Kim, C. H., and Kho, Y. H. Domain structure and multiplicity of raw-starch-digesting amylase from Bacillus circulans: extensive proteolysis with proteinase K, endopeptidase Glu-C and thermolysin. Biochim. Biophys. Acta, 1202: 200-206, 1993.