Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease

World Journal of Gastroenterology

Volumn 23, Issue 17, 2017, Pages 3150-3162

  Gelli, Chiara ^a,b   Tarocchi, Mirko ^b   Abenavoli, Ludovico ^c   Di Renzo, Laura ^a   Galli, Andrea ^b   De Lorenzo, Antonino ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Counseling; Diet; Life style; Mediterranean diet; Metabolic syndrome; Non alcoholic fatty liver disease; Nonalcoholic steatohepatitis; Therapeutic approach

Indexed keywords

ADULT; AGED; BLOOD; BODY WEIGHT LOSS; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; COUNSELING; DIAGNOSTIC IMAGING; ECHOGRAPHY; FEMALE; HUMAN; KINESIOTHERAPY; LIFESTYLE; LIVER; LIVER FUNCTION TEST; MALE; MEDITERRANEAN DIET; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; PROCEDURES; RISK FACTOR; RISK REDUCTION; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADULT; AGED; CARDIOVASCULAR DISEASES; COUNSELING; DIET, MEDITERRANEAN; EXERCISE THERAPY; FEMALE; HUMANS; LIFE STYLE; LIVER; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; RISK FACTORS; RISK REDUCTION BEHAVIOR; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; ULTRASONOGRAPHY; WAIST CIRCUMFERENCE; WAIST-HIP RATIO; WEIGHT LOSS;

EID: 85019143270     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v23.i17.3150     Document Type: Article

References (49)

1. Wah-Kheong C, Khean-Lee G. Epidemiology of a fast emerging disease in the Asia-Pacific region: non-alcoholic fatty liver disease. Hepatol Int 2013; 7: 65-71 [PMID: 26201622 DOI: 10.1007/s12072-012-9384-1]
2. Papamiltiadous ES, Roberts SK, Nicoll AJ, Ryan MC, Itsiopoulos C, Salim A, Tierney AC. A randomised controlled trial of a Mediterranean Dietary Intervention for Adults with Non Alcoholic Fatty Liver Disease (MEDINA): study protocol. BMC Gastroenterol 2016; 16: 14 [PMID: 26831892]
3. Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol 2010; 53: 372-384 [PMID: 20494470 DOI: 10.1016/j.jhep.2010.04.008]
4. European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL-EASDEASO Clinical Practice Guidelines for the management of nonalcoholic fatty liver disease. J Hepatol 2016; 64: 1388-1402 [PMID: 27062661 DOI: 10.1016/j.jhep.2015.11.004]
5. Levene AP, Goldin RD. The epidemiology, pathogenesis and histopathology of fatty liver disease. Histopathology 2012; 61: 141-152 [PMID: 22372457 DOI: 10.1111/j.1365-2559.2011.04145.x]
6. Moore JB. Non-alcoholic fatty liver disease: The hepatic consequence of obesity and the metabolic syndrome. Proc Nutr Soc 2010; 69: 211-220 [PMID: 20158939 DOI: 10.1017/S0029665110000030]
7. Lonardo A, Ballestri S, Marchesini G, Angulo P, Loria P. Nonalcoholic fatty liver disease: A precursor of the metabolic syndrome. Dig Liver Dis 2015; 47: 181-190 [PMID: 25739820 DOI: 10.1016/j.dld.2014.09.020]
8. Rector RS, Thyfault JP, Wei Y, Ibdah JA. Non-alcoholic fatty liver disease and the metabolic syndrome: an update. World J Gastroenterol 2008; 14: 185-192 [PMID: 18186553 DOI: 10.3748/wjg.14.185]
9. Tarantino G, Finelli C. What about non-alcoholic fatty liver disease as a new criterion to define metabolic syndrome? World J Gastroenterol 2013; 19: 3375-3384 [PMID: 23801829 DOI: 10.3748/wjg.v19.i22.3375]
10. Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, Landt CL, Harrison SA. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middleaged population utilizing ultrasound and liver biopsy: A prospective study. Gastroenterology 2011; 140: 124-131 [PMID: 20858492 DOI: 10.1053/j.gastro.2010.09.038]
11. Kaser S, Ebenbichler CF, Tilg H. Pharmacological and nonpharmacological treatment of non-alcoholic fatty liver disease. Int J Clin Pract 2010; 64: 968-983 [PMID: 20584230 DOI: 10.1111/j.1742-1241.2009.02327.x]
12. Del Ben M, Polimeni L, Baratta F, Pastori D, Loffredo L, Angelico F. Modern approach to the clinical management of non-alcoholic fatty liver disease. World J Gastroenterol 2014; 20: 8341-8350 [PMID: 25024593 DOI: 10.3748/wjg.v20.i26.8341]
13. Musso G, Gambino R, Cassader M, Pagano G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology 2010; 52: 79-104 [PMID: 20578268 DOI: 10.1002/hep.23623]
14. Musso G, Cassader M, Rosina F, Gambino R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of randomised trials. Diabetologia 2012; 55: 885-904 [PMID: 22278337 DOI: 10.1007/s00125-011-2446-4]
15. Zelber-Sagi S, Ratziu V, Oren R. Nutrition and physical activity in NAFLD: an overview of the epidemiological evidence. World J Gastroenterol 2011; 17: 3377-3389 [PMID: 21876630 DOI: 10.3748/wjg.v17.i29.3377]
16. Sofi F, Casini A. Mediterranean diet and non-alcoholic fatty liver disease: new therapeutic option around the corner? World J Gastroenterol 2014; 20: 7339-7346 [PMID: 24966604 DOI: 10.3748/wjg.v20.i23.7339]
17. Loria P, Adinolfi LE, Bellentani S, Bugianesi E, Grieco A, Fargion S, Gasbarrini A, Loguercio C, Lonardo A, Marchesini G, Marra F, Persico M, Prati D, Baroni GS. Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease. A decalogue from the Italian Association for the Study of the Liver (AISF) Expert Committee. Dig Liver Dis 2010; 42: 272-282 [PMID: 20171943 DOI: 10.1016/j.dld.2010.01.021]
18. Sofi F, Abbate R, Gensini GF, Casini A. Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr 2010; 92: 1189-1196 [PMID: 20810976 DOI: 10.3945/ajcn.2010.29673]
19. Sofi F, Macchi C, Abbate R, Gensini GF, Casini A. Mediterranean diet and health. Biofactors 2013; 39: 335-342 [PMID: 23553669 DOI: 10.1002/biof.1096]
20. Kastorini CM, Milionis HJ, Esposito K, Giugliano D, Goudevenos JA, Panagiotakos DB. The effect of Mediterranean diet on metabolic syndrome and its components: A meta-analysis of 50 studies and 534,906 individuals. J Am Coll Cardiol 2011; 57: 1299-1313 [PMID: 21392646 DOI: 10.1016/j.jacc.2010.09.073]
21. Kontogianni MD, Tileli N, Margariti A, Georgoulis M, Deutsch M, Tiniakos D, Fragopoulou E, Zafiropoulou R, Manios Y, Papatheodoridis G. Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease. Clin Nutr 2014; 33: 678-683 [PMID: 24064253 DOI: 10.1016/j.clnu.2013.08.014]
22. St George A, Bauman A, Johnston A, Farrell G, Chey T, George J. Independent effects of physical activity in patients with nonalcoholic fatty liver disease. Hepatology 2009; 50: 68-76 [PMID: 19444870 DOI: 10.1002/hep.22940]
23. Keating SE, Hackett DA, George J, Johnson NA. Exercise and non-alcoholic fatty liver disease: A systematic review and metaanalysis. J Hepatol 2012; 57: 157-166 [PMID: 22414768 DOI: 10.1016/j.jhep.2012.02.023]
24. Oliveira CP, de Lima Sanches P, de Abreu-Silva EO, Marcadenti A. Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease. J Diabetes Res 2016; 2016: 4597246 [PMID: 26770987 DOI: 10.1155/2016/4597246]
25. Perseghin G, Lattuada G, De Cobelli F, Ragogna F, Ntali G, Esposito A, Belloni E, Canu T, Terruzzi I, Scifo P, Del Maschio A, Luzi L. Habitual physical activity is associated with intrahepatic fat content in humans. Diabetes Care 2007; 30: 683-688 [PMID: 17327341 DOI: 10.2337/dc06-2032]
26. Church TS, Kuk JL, Ross R, Priest EL, Biltoft E, Blair SN. Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology 2006; 130: 2023-2030 [PMID: 16762625 DOI: 10.1053/j.gastro.2006.03.019]
27. Franz MJ, VanWormer JJ, Crain AL, Boucher JL, Histon T, Caplan W, Bowman JD, Pronk NP. Weight-loss outcomes: A systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up. J Am Diet Assoc 2007; 107: 1755-1767 [PMID: 17904936 DOI: 10.1016/j.jada.2007.07.017]
28. Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, Proietto J. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med 2011; 365: 1597-1604 [PMID: 22029981 DOI: 10.1056/NEJMoa1105816]
29. Centis E, Moscatiello S, Bugianesi E, Bellentani S, Fracanzani AL, Calugi S, Petta S, Dalle Grave R, Marchesini G. Stage of change and motivation to healthier lifestyle in non-alcoholic fatty liver disease. J Hepatol 2013; 58: 771-777 [PMID: 23201248 DOI: 10.1016/j.jhep.2012.11.031]
30. World Medical Association declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. JAMA 1997; 277: 925-926 [PMID: 9062334 DOI: 10.1001/jama.1997.03540350075038]
31. Altomare R, Cacciabaudo F, Damiano G, Palumbo VD, Gioviale MC, Bellavia M, Tomasello G, Lo Monte AI. The mediterranean diet: A history of health. Iran J Public Health 2013; 42: 449-457 [PMID: 23802101]
32. Bach-Faig A, Berry EM, Lairon D, Reguant J, Trichopoulou A, Dernini S, Medina FX, Battino M, Belahsen R, Miranda G, Serra-Majem L. Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutr 2011; 14: 2274-2284 [PMID: 22166184 DOI: 10.1017/S1368980011002515]
33. Kotronen A, Peltonen M, Hakkarainen A, Sevastianova K, Bergholm R, Johansson LM, Lundbom N, Rissanen A, Ridderstrale M, Groop L, Orho-Melander M, Yki-Järvinen H. Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology 2009; 137: 865-872 [PMID: 19524579 DOI: 10.1053/j.gastro.2009.06.005]
34. Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A, Tiribelli C. The Fatty Liver Index: A simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol 2006; 6: 33 [PMID: 17081293 DOI: 10.1186/1471-230X-6-33]
35. Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M, Galluzzo A. Visceral Adiposity Index: A reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care 2010; 33: 920-922 [PMID: 20067971 DOI: 10.2337/dc09-1825]
36. Panagiotakos DB, Pitsavos C, Arvaniti F, Stefanadis C. Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore. Prev Med 2007; 44: 335-340 [PMID: 17350085 DOI: 10.1016/j.ypmed.2006.12.009]
37. Montesi L, Caselli C, Centis E, Nuccitelli C, Moscatiello S, Suppini A, Marchesini G. Physical activity support or weight loss counseling for nonalcoholic fatty liver disease? World J Gastroenterol 2014; 20: 10128-10136 [PMID: 25110440 DOI: 10.3748/wjg.v20.i29.10128]
38. Dasarathy S, Dasarathy J, Khiyami A, Joseph R, Lopez R, McCullough AJ. Validity of real time ultrasound in the diagnosis of hepatic steatosis: A prospective study. J Hepatol 2009; 51: 1061-1067 [PMID: 19846234 DOI: 10.1016/j.jhep.2009.09.001]
39. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009; 120: 1640-1645 [PMID: 19805654 DOI: 10.1161/CIRCULATIONAHA.109.192644]
40. Mahady SE, George J. Exercise and diet in the management of nonalcoholic fatty liver disease. Metabolism 2016; 65: 1172-1182 [PMID: 26805014 DOI: 10.1016/j.metabol.2015.10.032]
41. Margariti A, Deutsch M, Manolakopoulos S, Tiniakos D, Papatheodoridis GV. The severity of histologic liver lesions is independent of body mass index in patients with nonalcoholic fatty liver disease. J Clin Gastroenterol 2013; 47: 280-286 [PMID: 23391869 DOI: 10.1097/MCG.0b013e31826be328]
42. Abenavoli L, Milic N, Di Renzo L, Preveden T, Medić-Stojanoska M, De Lorenzo A. Metabolic aspects of adult patients with nonalcoholic fatty liver disease. World J Gastroenterol 2016; 22: 7006-7016 [PMID: 27610012 DOI: 10.3748/wjg.v22.i31.7006]
43. Fraser A, Abel R, Lawlor DA, Fraser D, Elhayany A. A modified Mediterranean diet is associated with the greatest reduction in alanine aminotransferase levels in obese type 2 diabetes patients: results of a quasi-randomised controlled trial. Diabetologia 2008; 51: 1616-1622 [PMID: 18597068 DOI: 10.1007/s00125-008-1049-1]
44. Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003; 348: 2599-2608 [PMID: 12826634 DOI: 10.1056/NEJMoa025039]
45. Martínez-González MA, de la Fuente-Arrillaga C, Nunez-Cordoba JM, Basterra-Gortari FJ, Beunza JJ, Vazquez Z, Benito S, Tortosa A, Bes-Rastrollo M. Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study. BMJ 2008; 336: 1348-1351 [PMID: 18511765 DOI: 10.1136/bmj.39561.501007.BE]
46. Ryan MC, Itsiopoulos C, Thodis T, Ward G, Trost N, Hofferberth S, O'Dea K, Desmond PV, Johnson NA, Wilson AM. The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease. J Hepatol 2013; 59: 138-143 [PMID: 23485520 DOI: 10.1016/j.jhep.2013.02.012]
47. Tzima N, Pitsavos C, Panagiotakos DB, Chrysohoou C, Polychronopoulos E, Skoumas J, Stefanadis C. Adherence to the Mediterranean diet moderates the association of aminotransferases with the prevalence of the metabolic syndrome; the ATTICA study. Nutr Metab (Lond) 2009; 6: 30 [PMID: 19642977 DOI: 10.1186/1743-7075-6-30]
48. Walle P, Takkunen M, Männistö V, Vaittinen M, Lankinen M, Kärjä V, Käkelä P, Agren J, Tiainen M, Schwab U, Kuusisto J, Laakso M, Pihlajamäki J. Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity. Metabolism 2016; 65: 655-666 [PMID: 27085774 DOI: 10.1016/j.metabol.2016.01.011]
49. Ghaemi A, Taleban FA, Hekmatdoost A, Rafiei A, Hosseini V, Amiri Z, Homayounfar R, Fakheri H. How Much Weight Loss is Effective on Nonalcoholic Fatty Liver Disease? Hepat Mon 2013; 13: e15227 [PMID: 24358045 DOI: 10.5812/hepatmon.15227]