-
1
-
-
42049108822
-
Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas
-
Becher OJ, Hambardzumyan D, Fomchenko EI, Momota H, Mainwaring L, Bleau AM, et al. Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas. Cancer Res 2008; 68:2241-9.
-
(2008)
Cancer Res
, vol.68
, pp. 2241-2249
-
-
Becher, O.J.1
Hambardzumyan, D.2
Fomchenko, E.I.3
Momota, H.4
Mainwaring, L.5
Bleau, A.M.6
-
2
-
-
84856226955
-
The brain tumor microenvironment
-
Charles NA, Holland EC, Gilbertson R, Glass R, Kettenmann H. The brain tumor microenvironment. Glia 2012;60:502-14.
-
(2012)
Glia
, vol.60
, pp. 502-514
-
-
Charles, N.A.1
Holland, E.C.2
Gilbertson, R.3
Glass, R.4
Kettenmann, H.5
-
3
-
-
78650677818
-
Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth
-
Simmons GW, Pong WW, Emnett RJ, White CR, Gianino SM, Rodriguez FJ, et al. Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth. J Neuropathol Exp Neurol 2011;70:51-62.
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 51-62
-
-
Simmons, G.W.1
Pong, W.W.2
Emnett, R.J.3
White, C.R.4
Gianino, S.M.5
Rodriguez, F.J.6
-
4
-
-
84963964175
-
RNA sequencing of tumor-associated microglia reveals Ccl5 as a stromal chemokine critical for neurofibromatosis-1 glioma growth
-
Solga AC, Pong WW, Kim KY, Cimino PJ, Toonen JA, Walker J, et al. RNA sequencing of tumor-associated microglia reveals Ccl5 as a stromal chemokine critical for neurofibromatosis-1 glioma growth. Neoplasia 2015;17:776-88.
-
(2015)
Neoplasia
, vol.17
, pp. 776-788
-
-
Solga, A.C.1
Pong, W.W.2
Kim, K.Y.3
Cimino, P.J.4
Toonen, J.A.5
Walker, J.6
-
5
-
-
84953747412
-
The role of microglia and macrophages in glioma maintenance and progression
-
Hambardzumyan D, Gutmann DH, Kettenmann H. The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci 2016;19:20-7.
-
(2016)
Nat Neurosci
, vol.19
, pp. 20-27
-
-
Hambardzumyan, D.1
Gutmann, D.H.2
Kettenmann, H.3
-
6
-
-
84887481716
-
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
-
Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med 2013;19:1264-72.
-
(2013)
Nat Med
, vol.19
, pp. 1264-1272
-
-
Pyonteck, S.M.1
Akkari, L.2
Schuhmacher, A.J.3
Bowman, R.L.4
Sevenich, L.5
Quail, D.F.6
-
7
-
-
84966552295
-
Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: An Ivy Foundation Early Phase Clinical Trials Consortium phase II study
-
Butowski N, Colman H, De Groot JF, Omuro AM, Nayak L, Wen PY, et al. Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study. Neuro Oncol 2016;18:557-64.
-
(2016)
Neuro Oncol
, vol.18
, pp. 557-564
-
-
Butowski, N.1
Colman, H.2
De Groot, J.F.3
Omuro, A.M.4
Nayak, L.5
Wen, P.Y.6
-
8
-
-
0034093158
-
Flow cytometric characterization of tumor-associated macrophages in experimental gliomas
-
Badie B, Schartner JM. Flow cytometric characterization of tumor-associated macrophages in experimental gliomas. Neurosurgery 2000;46: 957-61.
-
(2000)
Neurosurgery
, vol.46
, pp. 957-961
-
-
Badie, B.1
Schartner, J.M.2
-
9
-
-
84929258477
-
Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells
-
Muller A, Brandenburg S, Turkowski K, Muller S, Vajkoczy P. Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells. Int J Cancer 2015;137:278-88.
-
(2015)
Int J Cancer
, vol.137
, pp. 278-288
-
-
Muller, A.1
Brandenburg, S.2
Turkowski, K.3
Muller, S.4
Vajkoczy, P.5
-
10
-
-
63849335831
-
Flow cytometry and in vitro analysis of human glioma-associated macrophages. Laboratory investigation
-
Parney IF, Waldron JS, Parsa AT. Flow cytometry and in vitro analysis of human glioma-associated macrophages. Laboratory investigation. J Neurosurg 2009;110:572-82.
-
(2009)
J Neurosurg
, vol.110
, pp. 572-582
-
-
Parney, I.F.1
Waldron, J.S.2
Parsa, A.T.3
-
11
-
-
84957810905
-
Glioblastoma: Defining tumor niches
-
Hambardzumyan D, Bergers G. Glioblastoma: defining tumor niches. Trends Cancer 2015;1:252-65.
-
(2015)
Trends Cancer
, vol.1
, pp. 252-265
-
-
Hambardzumyan, D.1
Bergers, G.2
-
12
-
-
0037963473
-
Blood monocytes consist of two principal subsets with distinct migratory properties
-
Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 2003;19: 71-82.
-
(2003)
Immunity
, vol.19
, pp. 71-82
-
-
Geissmann, F.1
Jung, S.2
Littman, D.R.3
-
13
-
-
84872765982
-
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
-
Yona S, Kim KW, Wolf Y,Mildner A, Varol D, Breker M, et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 2013;38:79-91.
-
(2013)
Immunity
, vol.38
, pp. 79-91
-
-
Yona, S.1
Kim, K.W.2
Wolf, Y.3
Mildner, A.4
Varol, D.5
Breker, M.6
-
14
-
-
70349291126
-
Modeling adult gliomas using RCAS/t-va technology
-
Hambardzumyan D, Amankulor NM, Helmy KY, Becher OJ, Holland EC. Modeling adult gliomas using RCAS/t-va technology. Transl Oncol 2009; 2:89-95.
-
(2009)
Transl Oncol
, vol.2
, pp. 89-95
-
-
Hambardzumyan, D.1
Amankulor, N.M.2
Helmy, K.Y.3
Becher, O.J.4
Holland, E.C.5
-
15
-
-
0034028817
-
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
-
Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 2000;20:4106-14.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 4106-4114
-
-
Jung, S.1
Aliberti, J.2
Graemmel, P.3
Sunshine, M.J.4
Kreutzberg, G.W.5
Sher, A.6
-
16
-
-
0035044016
-
Generation and analysis of mice lacking the chemokine fractalkine
-
Cook DN, Chen SC, Sullivan LM, Manfra DJ, Wiekowski MT, Prosser DM, et al. Generation and analysis of mice lacking the chemokine fractalkine. Mol Cell Biol 2001;21:3159-65.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3159-3165
-
-
Cook, D.N.1
Chen, S.C.2
Sullivan, L.M.3
Manfra, D.J.4
Wiekowski, M.T.5
Prosser, D.M.6
-
18
-
-
0032536531
-
Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice
-
Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL, et al. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 1998;187:601-8.
-
(1998)
J Exp Med
, vol.187
, pp. 601-608
-
-
Lu, B.1
Rutledge, B.J.2
Gu, L.3
Fiorillo, J.4
Lukacs, N.W.5
Kunkel, S.L.6
-
19
-
-
84919455244
-
Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain
-
Chen Z, Jalabi W, Hu W, Park HJ, Gale JT, Kidd GJ, et al. Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain. Nat Commun 2014;5:4486.
-
(2014)
Nat Commun
, vol.5
, pp. 4486
-
-
Chen, Z.1
Jalabi, W.2
Hu, W.3
Park, H.J.4
Gale, J.T.5
Kidd, G.J.6
-
20
-
-
77952310528
-
A human functional protein interaction network and its application to cancer data analysis
-
WuG, Feng X, Stein L. A human functional protein interaction network and its application to cancer data analysis. Genome Biol 2010;11:R53.
-
(2010)
Genome Biol
, vol.11
, pp. R53
-
-
Wu, G.1
Feng, X.2
Stein, L.3
-
21
-
-
79551587720
-
Cytoscape 2.8: New features for data integration and network visualization
-
Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 2011;27:431-2.
-
(2011)
Bioinformatics
, vol.27
, pp. 431-432
-
-
Smoot, M.E.1
Ono, K.2
Ruscheinski, J.3
Wang, P.L.4
Ideker, T.5
-
22
-
-
36448955070
-
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
-
Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, et al. Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci 2007;10:1544-53.
-
(2007)
Nat Neurosci
, vol.10
, pp. 1544-1553
-
-
Mildner, A.1
Schmidt, H.2
Nitsche, M.3
Merkler, D.4
Hanisch, U.K.5
Mack, M.6
-
23
-
-
34848863163
-
A rose by any other name? the potential consequences of microglial heterogeneity during CNS health and disease
-
Carson MJ, Bilousova TV, Puntambekar SS, Melchior B, Doose JM, Ethell IM. A rose by any other name? The potential consequences of microglial heterogeneity during CNS health and disease. Neurotherapeutics 2007;4:571-9.
-
(2007)
Neurotherapeutics
, vol.4
, pp. 571-579
-
-
Carson, M.J.1
Bilousova, T.V.2
Puntambekar, S.S.3
Melchior, B.4
Doose, J.M.5
Ethell, I.M.6
-
24
-
-
84928254123
-
A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury
-
Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong CH, Petri B, et al. A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury. J Exp Med 2015;212:447-56.
-
(2015)
J Exp Med
, vol.212
, pp. 447-456
-
-
Dal-Secco, D.1
Wang, J.2
Zeng, Z.3
Kolaczkowska, E.4
Wong, C.H.5
Petri, B.6
-
25
-
-
84855384345
-
The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood
-
Mizutani M, Pino PA, Saederup N, Charo IF, Ransohoff RM, Cardona AE. The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. J Immunol 2012;188: 29-36.
-
(2012)
J Immunol
, vol.188
, pp. 29-36
-
-
Mizutani, M.1
Pino, P.A.2
Saederup, N.3
Charo, I.F.4
Ransohoff, R.M.5
Cardona, A.E.6
-
26
-
-
0014851851
-
Studies on the chemotherapy of experimental brain tumors: Development of an experimental model
-
Ausman JI, Shapiro WR, Rall DP. Studies on the chemotherapy of experimental brain tumors: development of an experimental model. Cancer Res 1970;30:2394-400.
-
(1970)
Cancer Res
, vol.30
, pp. 2394-2400
-
-
Ausman, J.I.1
Shapiro, W.R.2
Rall, D.P.3
-
27
-
-
84934300728
-
Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis
-
Feng X, Szulzewsky F, Yerevanian A, Chen Z, Heinzmann D, Rasmussen RD, et al. Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis. Oncotarget 2015;6:15077-94.
-
(2015)
Oncotarget
, vol.6
, pp. 15077-15094
-
-
Feng, X.1
Szulzewsky, F.2
Yerevanian, A.3
Chen, Z.4
Heinzmann, D.5
Rasmussen, R.D.6
-
28
-
-
33745573660
-
Control of microglial neurotoxicity by the fractalkine receptor
-
Cardona AE, Pioro EP, Sasse ME, Kostenko V, Cardona SM, Dijkstra IM, et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 2006;9:917-24.
-
(2006)
Nat Neurosci
, vol.9
, pp. 917-924
-
-
Cardona, A.E.1
Pioro, E.P.2
Sasse, M.E.3
Kostenko, V.4
Cardona, S.M.5
Dijkstra, I.M.6
-
29
-
-
78149360132
-
Fate mapping analysis reveals that adultmicroglia derive from primitive macrophages
-
Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, et al. Fate mapping analysis reveals that adultmicroglia derive from primitive macrophages. Science 2010;330:841-5.
-
(2010)
Science
, vol.330
, pp. 841-845
-
-
Ginhoux, F.1
Greter, M.2
Leboeuf, M.3
Nandi, S.4
See, P.5
Gokhan, S.6
-
30
-
-
84893745524
-
Identification of a unique TGF-beta-dependent molecular and functional signature in microglia
-
Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, et al. Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci 2014;17:131-43.
-
(2014)
Nat Neurosci
, vol.17
, pp. 131-143
-
-
Butovsky, O.1
Jedrychowski, M.P.2
Moore, C.S.3
Cialic, R.4
Lanser, A.J.5
Gabriely, G.6
-
31
-
-
0030809822
-
Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
-
Boring L, Gosling J, Chensue SW, Kunkel SL, Farese RVJr, Broxmeyer HE, et al. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest 1997;100:2552-61.
-
(1997)
J Clin Invest
, vol.100
, pp. 2552-2561
-
-
Boring, L.1
Gosling, J.2
Chensue, S.W.3
Kunkel, S.L.4
Farese, R.V.5
Broxmeyer, H.E.6
-
32
-
-
79953324535
-
COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells
-
Fujita M, Kohanbash G, Fellows-Mayle W, Hamilton RL, Komohara Y, Decker SA, et al. COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells. Cancer Res 2011;71:2664-74.
-
(2011)
Cancer Res
, vol.71
, pp. 2664-2674
-
-
Fujita, M.1
Kohanbash, G.2
Fellows-Mayle, W.3
Hamilton, R.L.4
Komohara, Y.5
Decker, S.A.6
-
33
-
-
80052246111
-
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
-
Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci 2011;14:1142-9.
-
(2011)
Nat Neurosci
, vol.14
, pp. 1142-1149
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
McNagny, K.M.4
Rossi, F.M.5
-
34
-
-
84945470816
-
Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity
-
Shemer A, Jung S. Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity. Semin Immunopathol 2015; 37:613-23.
-
(2015)
Semin Immunopathol
, vol.37
, pp. 613-623
-
-
Shemer, A.1
Jung, S.2
-
35
-
-
36448994709
-
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
-
Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 2007;10:1538-43.
-
(2007)
Nat Neurosci
, vol.10
, pp. 1538-1543
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
Tetzlaff, W.4
Rossi, F.M.5
-
36
-
-
84898676953
-
Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain
-
Elmore MR, Najafi AR, Koike MA, Dagher NN, Spangenberg EE, Rice RA, et al. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron 2014;82:380-97.
-
(2014)
Neuron
, vol.82
, pp. 380-397
-
-
Elmore, M.R.1
Najafi, A.R.2
Koike, M.A.3
Dagher, N.N.4
Spangenberg, E.E.5
Rice, R.A.6
-
37
-
-
80355146868
-
Monocyte recruitment during infection and inflammation
-
Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol 2011;11:762-74.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 762-774
-
-
Shi, C.1
Pamer, E.G.2
-
38
-
-
84923068676
-
Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth
-
Zhou W, Ke SQ, Huang Z, Flavahan W, Fang X, Paul J, et al. Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol 2015;17:170-82.
-
(2015)
Nat Cell Biol
, vol.17
, pp. 170-182
-
-
Zhou, W.1
Ke, S.Q.2
Huang, Z.3
Flavahan, W.4
Fang, X.5
Paul, J.6
-
39
-
-
84962250196
-
New tools for studying microglia in the mouse and human CNS
-
Bennett ML, Bennett FC, Liddelow SA, Ajami B, Zamanian JL, Fernhoff NB, et al. New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci U S A 2016;113:E1738-46.
-
(2016)
Proc Natl Acad Sci U S A
, vol.113
, pp. E1738-E1746
-
-
Bennett, M.L.1
Bennett, F.C.2
Liddelow, S.A.3
Ajami, B.4
Zamanian, J.L.5
Fernhoff, N.B.6
-
40
-
-
22244464662
-
ATPmediates rapid microglial response to local brain injury invivo
-
Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, et al. ATPmediates rapid microglial response to local brain injury invivo. Nat Neurosci 2005;8:752-8.
-
(2005)
Nat Neurosci
, vol.8
, pp. 752-758
-
-
Davalos, D.1
Grutzendler, J.2
Yang, G.3
Kim, J.V.4
Zuo, Y.5
Jung, S.6
-
41
-
-
28544446111
-
Monocyte and macrophage heterogeneity
-
Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005;5:953-64.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 953-964
-
-
Gordon, S.1
Taylor, P.R.2
-
42
-
-
84893364090
-
Therapeutic inflammatory monocyte modulation using immune-modifying microparticles
-
Getts DR, Terry RL, Getts MT, Deffrasnes C, Muller M, van Vreden C, et al. Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Sci Transl Med 2014;6:219ra7.
-
(2014)
Sci Transl Med
, vol.6
, pp. 219ra7
-
-
Getts, D.R.1
Terry, R.L.2
Getts, M.T.3
Deffrasnes, C.4
Muller, M.5
Van Vreden, C.6
-
43
-
-
80052746486
-
Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy
-
Zhu X, Fujita M, Snyder LA, Okada H. Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy. J Neurooncol 2011;104: 83-92.
-
(2011)
J Neurooncol
, vol.104
, pp. 83-92
-
-
Zhu, X.1
Fujita, M.2
Snyder, L.A.3
Okada, H.4
-
44
-
-
84989941652
-
CCL2 produced by the glioma microenvironment is essential for the recruitment of regulatory T cells and myeloid-derived suppressor cells
-
Chang AL, Miska J, Wainwright DA, Dey M, Rivetta CV, Yu D, et al. CCL2 produced by the glioma microenvironment is essential for the recruitment of regulatory T cells and myeloid-derived suppressor cells. Cancer Res 2016;76:5671-82.
-
(2016)
Cancer Res
, vol.76
, pp. 5671-5682
-
-
Chang, A.L.1
Miska, J.2
Wainwright, D.A.3
Dey, M.4
Rivetta, C.V.5
Yu, D.6
-
46
-
-
34147164049
-
Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
-
Tsou CL, Peters W, Si Y, Slaymaker S, Aslanian AM, Weisberg SP, et al. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest 2007; 117:902-9.
-
(2007)
J Clin Invest
, vol.117
, pp. 902-909
-
-
Tsou, C.L.1
Peters, W.2
Si, Y.3
Slaymaker, S.4
Aslanian, A.M.5
Weisberg, S.P.6
|