메뉴 건너뛰기




Volumn 4, Issue JAN, 2017, Pages

Induced pluripotent stem cells for traumatic spinal cord injury

Author keywords

Induced pluripotent stem cell; IPS; Neural precursor cell; Spinal cord injury; Stem cell; Trauma

Indexed keywords


EID: 85018868464     PISSN: None     EISSN: 2296634X     Source Type: Journal    
DOI: 10.3389/fcell.2016.00152     Document Type: Review
Times cited : (63)

References (88)
  • 1
    • 76549260925 scopus 로고    scopus 로고
    • Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells
    • Aasen, T., and Izpisúa Belmonte, J. C. (2010). Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nat. Protoc. 5, 371-382. doi: 10.1038/nprot.2009.241
    • (2010) Nat. Protoc , vol.5 , pp. 371-382
    • Aasen, T.1    Izpisúa Belmonte, J.C.2
  • 2
    • 55749089875 scopus 로고    scopus 로고
    • Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
    • Aasen, T., Raya, A., Barrero, M. J., Garreta, E., Consiglio, A., Gonzalez, F., et al. (2008). Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat. Biotechnol. 26, 1276-1284. doi: 10.1038/nbt.1503
    • (2008) Nat. Biotechnol , vol.26 , pp. 1276-1284
    • Aasen, T.1    Raya, A.2    Barrero, M.J.3    Garreta, E.4    Consiglio, A.5    Gonzalez, F.6
  • 3
    • 84976448364 scopus 로고    scopus 로고
    • Concise review: bridging the gap: novel neuroregenerative and neuroprotective strategies in spinal cord injury
    • Ahuja, C. S., and Fehlings, M. (2016). Concise review: bridging the gap: novel neuroregenerative and neuroprotective strategies in spinal cord injury. Stem Cells Transl. Med. 5, 914-924. doi: 10.5966/sctm.2015-0381
    • (2016) Stem Cells Transl. Med , vol.5 , pp. 914-924
    • Ahuja, C.S.1    Fehlings, M.2
  • 4
    • 85010918251 scopus 로고    scopus 로고
    • Recent advances in managing a spinal cord injury secondary to trauma
    • F1000 Faculty Rev-1017
    • Ahuja, C. S., Martin, A. R., and Fehlings, M. (2016). Recent advances in managing a spinal cord injury secondary to trauma. F1000Res. 5:F1000 Faculty Rev-1017. doi: 10.12688/f1000research.7586.1
    • (2016) F1000Res , vol.5
    • Ahuja, C.S.1    Martin, A.R.2    Fehlings, M.3
  • 5
    • 84874682918 scopus 로고    scopus 로고
    • Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells
    • Araki, R., Uda, M., Hoki, Y., Sunayama, M., Nakamura, M., Ando, S., et al. (2013). Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells. Nature 494, 100-104. doi: 10.1038/nature11807
    • (2013) Nature , vol.494 , pp. 100-104
    • Araki, R.1    Uda, M.2    Hoki, Y.3    Sunayama, M.4    Nakamura, M.5    Ando, S.6
  • 6
    • 84978682966 scopus 로고    scopus 로고
    • Early intravenous delivery of human brain stromal cells modulates systemic inflammation and leads to vasoprotection in traumatic spinal cord injury
    • Badner, A., Vawda, R., Laliberte, A., Hong, J., Mikhail, M., Jose, A., et al. (2016). Early intravenous delivery of human brain stromal cells modulates systemic inflammation and leads to vasoprotection in traumatic spinal cord injury. Stem Cells Transl. Med. 5, 991-1003. doi: 10.5966/sctm.2015-0295
    • (2016) Stem Cells Transl. Med , vol.5 , pp. 991-1003
    • Badner, A.1    Vawda, R.2    Laliberte, A.3    Hong, J.4    Mikhail, M.5    Jose, A.6
  • 7
    • 80052157957 scopus 로고    scopus 로고
    • Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors
    • Ban, H., Nishishita, N., Fusaki, N., Tabata, T., Saeki, K., Shikamura, M., et al. (2011). Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors. Proc. Natl. Acad. Sci. U.S.A. 108, 14234-14239. doi: 10.1073/pnas.1103509108
    • (2011) Proc. Natl. Acad. Sci. U.S.A , vol.108 , pp. 14234-14239
    • Ban, H.1    Nishishita, N.2    Fusaki, N.3    Tabata, T.4    Saeki, K.5    Shikamura, M.6
  • 9
    • 45849112916 scopus 로고    scopus 로고
    • Adipose-derived stem cells: isolation, expansion and differentiation
    • Bunnell, B. A., Flaat, M., Gagliardi, C., Patel, B., and Ripoll, C. (2008). Adipose-derived stem cells: isolation, expansion and differentiation. Methods 45, 115-120. doi: 10.1016/j.ymeth.2008.03.006
    • (2008) Methods , vol.45 , pp. 115-120
    • Bunnell, B.A.1    Flaat, M.2    Gagliardi, C.3    Patel, B.4    Ripoll, C.5
  • 11
    • 85026837681 scopus 로고    scopus 로고
    • 'Dual-SMAD inhibition/WNT activation-based methods to induce neural crest and derivatives from human pluripotent stem cells'
    • ed. K. Turksen (New York, NY: Springer) (Accessed June 9, 2016)
    • Chambers, S. M., Mica, Y., Lee, G., Studer, L., and Tomishima, M. J. (2013). "Dual-SMAD inhibition/WNT activation-based methods to induce neural crest and derivatives from human pluripotent stem cells". in Human Embryonic Stem Cell Protocols, ed K. Turksen (New York, NY: Springer), 329-343. Available online at: http://link.springer.com/10.1007/7651_2013_59 (Accessed June 9, 2016)
    • (2013) Human Embryonic Stem Cell Protocols , pp. 329-343
    • Chambers, S.M.1    Mica, Y.2    Lee, G.3    Studer, L.4    Tomishima, M.J.5
  • 12
    • 84884826708 scopus 로고    scopus 로고
    • Transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts
    • Chen, J., Lin, M., Foxe, J. J., Pedrosa, E., Hrabovsky, A., Carroll, R., et al. (2013a). Transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts. PLoS ONE 8:e75682. doi: 10.1371/journal.pone.0075682
    • (2013) PLoS ONE , vol.8
    • Chen, J.1    Lin, M.2    Foxe, J.J.3    Pedrosa, E.4    Hrabovsky, A.5    Carroll, R.6
  • 13
    • 84871990064 scopus 로고    scopus 로고
    • H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
    • Chen, J., Liu, H., Liu, J., Qi, J., Wei, B., Yang, J., et al. (2013b). H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat. Genet. 45, 34-42. doi: 10.1038/ng.2491
    • (2013) Nat. Genet , vol.45 , pp. 34-42
    • Chen, J.1    Liu, H.2    Liu, J.3    Qi, J.4    Wei, B.5    Yang, J.6
  • 14
    • 84902128911 scopus 로고    scopus 로고
    • Identification of druggable cancer driver genes amplified across TCGA datasets
    • Chen, Y., McGee, J., Chen, X., Doman, T. N., Gong, X., Zhang, Y., et al. (2014). Identification of druggable cancer driver genes amplified across TCGA datasets. PLoS ONE 9:e98293. doi: 10.1371/journal.pone.0098293
    • (2014) PLoS ONE , vol.9
    • Chen, Y.1    McGee, J.2    Chen, X.3    Doman, T.N.4    Gong, X.5    Zhang, Y.6
  • 15
    • 34047158711 scopus 로고    scopus 로고
    • Contusion, dislocation, and distraction: primary hemorrhage and membrane permeability in distinct mechanisms of spinal cord injury
    • Choo, A. M., Liu, J., Lam, C. K., Dvorak, M., Tetzlaff, W., and Oxland, T. R. (2007). Contusion, dislocation, and distraction: primary hemorrhage and membrane permeability in distinct mechanisms of spinal cord injury. J. Neurosurg. Spine 6, 255-266. doi: 10.3171/spi.2007.6.3.255
    • (2007) J. Neurosurg. Spine , vol.6 , pp. 255-266
    • Choo, A.M.1    Liu, J.2    Lam, C.K.3    Dvorak, M.4    Tetzlaff, W.5    Oxland, T.R.6
  • 16
    • 69249208658 scopus 로고    scopus 로고
    • Pluripotent stem cells and disease modeling
    • Colman, A., and Dreesen, O. (2009). Pluripotent stem cells and disease modeling. Cell Stem Cell 5, 244-247. doi: 10.1016/j.stem.2009.08.010
    • (2009) Cell Stem Cell , vol.5 , pp. 244-247
    • Colman, A.1    Dreesen, O.2
  • 17
    • 33746914843 scopus 로고    scopus 로고
    • Astrocytes derived from glial-restricted precursors promote spinal cord repair
    • Davies, J. E., Huang, C., Proschel, C., Noble, M., Mayer-Proschel, M., and Davies, S. J. A. (2006). Astrocytes derived from glial-restricted precursors promote spinal cord repair. J. Biol. 5, 7. doi: 10.1186/jbiol35
    • (2006) J. Biol , vol.5 , pp. 7
    • Davies, J.E.1    Huang, C.2    Proschel, C.3    Noble, M.4    Mayer-Proschel, M.5    Davies, S.J.A.6
  • 18
    • 84992437517 scopus 로고    scopus 로고
    • Transplanted human stem cell-derived interneuron precursors mitigate mouse bladder dysfunction and central neuropathic pain after spinal cord injury
    • Fandel, T. M., Trivedi, A., Nicholas, C. R., Zhang, H., Chen, J., Martinez, A. F., et al. (2016). Transplanted human stem cell-derived interneuron precursors mitigate mouse bladder dysfunction and central neuropathic pain after spinal cord injury. Cell Stem Cell 19, 544-557. doi: 10.1016/j.stem.2016.08.020
    • (2016) Cell Stem Cell , vol.19 , pp. 544-557
    • Fandel, T.M.1    Trivedi, A.2    Nicholas, C.R.3    Zhang, H.4    Chen, J.5    Martinez, A.F.6
  • 20
    • 84861839572 scopus 로고    scopus 로고
    • Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells
    • Fujimoto, Y., Abematsu, M., Falk, A., Tsujimura, K., Sanosaka, T., Juliandi, B., et al. (2012). Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells. Stem Cells 30, 1163-1173. doi: 10.1002/stem.1083
    • (2012) Stem Cells , vol.30 , pp. 1163-1173
    • Fujimoto, Y.1    Abematsu, M.2    Falk, A.3    Tsujimura, K.4    Sanosaka, T.5    Juliandi, B.6
  • 21
    • 70349309622 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2
    • Giorgetti, A., Montserrat, N., Aasen, T., Gonzalez, F., Rodríguez-Pizà, I., Vassena, R., et al. (2009). Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell 5, 353-357. doi: 10.1016/j.stem.2009.09.008
    • (2009) Cell Stem Cell , vol.5 , pp. 353-357
    • Giorgetti, A.1    Montserrat, N.2    Aasen, T.3    Gonzalez, F.4    Rodríguez-Pizà, I.5    Vassena, R.6
  • 22
    • 79952258224 scopus 로고    scopus 로고
    • Somatic coding mutations in human induced pluripotent stem cells
    • Gore, A., Li, Z., Fung, H.-L., Young, J. E., Agarwal, S., Antosiewicz-Bourget, J., et al. (2011). Somatic coding mutations in human induced pluripotent stem cells. Nature 471, 63-67. doi: 10.1038/nature09805
    • (2011) Nature , vol.471 , pp. 63-67
    • Gore, A.1    Li, Z.2    Fung, H.-L.3    Young, J.E.4    Agarwal, S.5    Antosiewicz-Bourget, J.6
  • 23
    • 84875956144 scopus 로고    scopus 로고
    • Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells
    • Guha, P., Morgan, J. W., Mostoslavsky, G., Rodrigues, N. P., and Boyd, A. S. (2013). Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells. Cell Stem Cell 12, 407-412. doi: 10.1016/j.stem.2013.01.006
    • (2013) Cell Stem Cell , vol.12 , pp. 407-412
    • Guha, P.1    Morgan, J.W.2    Mostoslavsky, G.3    Rodrigues, N.P.4    Boyd, A.S.5
  • 24
    • 84924339474 scopus 로고    scopus 로고
    • Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's Disease
    • Hallett, P. J., Deleidi, M., Astradsson, A., Smith, G. A., Cooper, O., Osborn, T. M., et al. (2015). Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's Disease. Cell Stem Cell 16, 269-274. doi: 10.1016/j.stem.2015.01.018
    • (2015) Cell Stem Cell , vol.16 , pp. 269-274
    • Hallett, P.J.1    Deleidi, M.2    Astradsson, A.3    Smith, G.A.4    Cooper, O.5    Osborn, T.M.6
  • 25
    • 84862777308 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into neural stem cells by defined factors
    • Han, D. W., Tapia, N., Hermann, A., Hemmer, K., Höing, S., Araúzo-Bravo, M. J., et al. (2012). Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell 10, 465-472. doi: 10.1016/j.stem.2012.02.021
    • (2012) Cell Stem Cell , vol.10 , pp. 465-472
    • Han, D.W.1    Tapia, N.2    Hermann, A.3    Hemmer, K.4    Höing, S.5    Araúzo-Bravo, M.J.6
  • 26
    • 80555151610 scopus 로고    scopus 로고
    • Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell-derived astrocytes in a rat spinal cord injury model
    • Hayashi, K., Hashimoto, M., Koda, M., Naito, A. T., Murata, A., Okawa, A., et al. (2011). Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell-derived astrocytes in a rat spinal cord injury model. J. Neurosurg. Spine 15, 582-593. doi: 10.3171/2011.7.SPINE10775
    • (2011) J. Neurosurg. Spine , vol.15 , pp. 582-593
    • Hayashi, K.1    Hashimoto, M.2    Koda, M.3    Naito, A.T.4    Murata, A.5    Okawa, A.6
  • 27
    • 46949085597 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    • Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M., Chen, A. E., et al. (2008). Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat. Biotechnol. 26, 795-797. doi: 10.1038/nbt1418
    • (2008) Nat. Biotechnol , vol.26 , pp. 795-797
    • Huangfu, D.1    Maehr, R.2    Guo, W.3    Eijkelenboom, A.4    Snitow, M.5    Chen, A.E.6
  • 28
    • 84929916565 scopus 로고    scopus 로고
    • Motor neuron differentiation from pluripotent stem cells and other intermediate proliferative precursors that can be discriminated by lineage specific reporters
    • Jha, B. S., Rao, M., and Malik, N. (2015). Motor neuron differentiation from pluripotent stem cells and other intermediate proliferative precursors that can be discriminated by lineage specific reporters. Stem Cell Rev. 11, 194-204. doi: 10.1007/s12015-014-9541-0
    • (2015) Stem Cell Rev , vol.11 , pp. 194-204
    • Jha, B.S.1    Rao, M.2    Malik, N.3
  • 29
    • 84857496469 scopus 로고    scopus 로고
    • Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells
    • Ji, J., Ng, S. H., Sharma, V., Neculai, D., Hussein, S., Sam, M., et al. (2012). Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells. Stem Cells 30, 435-440. doi: 10.1002/stem.1011
    • (2012) Stem Cells , vol.30 , pp. 435-440
    • Ji, J.1    Ng, S.H.2    Sharma, V.3    Neculai, D.4    Hussein, S.5    Sam, M.6
  • 30
    • 84961905719 scopus 로고    scopus 로고
    • Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration
    • Kadoya, K., Lu, P., Nguyen, K., Lee-Kubli, C., Kumamaru, H., Yao, L., et al. (2016). Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration. Nat. Med. 22, 479-487. doi: 10.1038/nm.4066
    • (2016) Nat. Med , vol.22 , pp. 479-487
    • Kadoya, K.1    Lu, P.2    Nguyen, K.3    Lee-Kubli, C.4    Kumamaru, H.5    Yao, L.6
  • 31
    • 65649115029 scopus 로고    scopus 로고
    • Directed differentiation of human-induced pluripotent stem cells generates active motor neurons
    • Karumbayaram, S., Novitch, B. G., Patterson, M., Umbach, J. A., Richter, L., Lindgren, A., et al. (2009). Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells 27, 806-811. doi: 10.1002/stem.31
    • (2009) Stem Cells , vol.27 , pp. 806-811
    • Karumbayaram, S.1    Novitch, B.G.2    Patterson, M.3    Umbach, J.A.4    Richter, L.5    Lindgren, A.6
  • 32
    • 66049143859 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins
    • Kim, D., Kim, C.-H., Moon, J.-I., Chung, Y.-G., Chang, M.-Y., Han, B.-S., et al. (2009). Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 4, 472-476. doi: 10.1016/j.stem.2009.05.005
    • (2009) Cell Stem Cell , vol.4 , pp. 472-476
    • Kim, D.1    Kim, C.-H.2    Moon, J.-I.3    Chung, Y.-G.4    Chang, M.-Y.5    Han, B.-S.6
  • 33
    • 83255177149 scopus 로고    scopus 로고
    • Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells
    • Kim, K., Zhao, R., Doi, A., Ng, K., Unternaehrer, J., Cahan, P., et al. (2011). Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat. Biotechnol. 29, 1117-1119. doi: 10.1038/nbt.2052
    • (2011) Nat. Biotechnol , vol.29 , pp. 1117-1119
    • Kim, K.1    Zhao, R.2    Doi, A.3    Ng, K.4    Unternaehrer, J.5    Cahan, P.6
  • 34
    • 84871657149 scopus 로고    scopus 로고
    • Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity
    • Kobayashi, Y., Okada, Y., Itakura, G., Iwai, H., Nishimura, S., Yasuda, A., et al. (2012). Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity. PLoS ONE 7:e52787. doi: 10.1371/journal.pone.0052787
    • (2012) PLoS ONE , vol.7
    • Kobayashi, Y.1    Okada, Y.2    Itakura, G.3    Iwai, H.4    Nishimura, S.5    Yasuda, A.6
  • 35
    • 34347334446 scopus 로고    scopus 로고
    • CNS injury biomechanics and experimental models
    • LaPlaca, M. C., Simon, C. M., Prado, G. R., and Cullen, D. K. (2007). CNS injury biomechanics and experimental models. Prog. Brain Res. 161, 13-26. doi: 10.1016/S0079-6123(06)61002-9
    • (2007) Prog. Brain Res , vol.161 , pp. 13-26
    • LaPlaca, M.C.1    Simon, C.M.2    Prado, G.R.3    Cullen, D.K.4
  • 36
    • 67049164945 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells from human blood
    • Loh, Y.-H., Agarwal, S., Park, I.-H., Urbach, A., Huo, H., Heffner, G. C., et al. (2009). Generation of induced pluripotent stem cells from human blood. Blood 113, 5476-5479. doi: 10.1182/blood-2009-02-204800
    • (2009) Blood , vol.113 , pp. 5476-5479
    • Loh, Y.-H.1    Agarwal, S.2    Park, I.-H.3    Urbach, A.4    Huo, H.5    Heffner, G.C.6
  • 37
    • 84857136772 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells
    • Lujan, E., Chanda, S., Ahlenius, H., Südhof, T. C., and Wernig, M. (2012). Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc. Natl. Acad. Sci. U.S.A. 109, 2527-2532. doi: 10.1073/pnas.1121003109
    • (2012) Proc. Natl. Acad. Sci. U.S.A , vol.109 , pp. 2527-2532
    • Lujan, E.1    Chanda, S.2    Ahlenius, H.3    Südhof, T.C.4    Wernig, M.5
  • 38
    • 50849142559 scopus 로고    scopus 로고
    • A high-efficiency system for the generation and study of human induced pluripotent stem cells
    • Maherali, N., Ahfeldt, T., Rigamonti, A., Utikal, J., Cowan, C., and Hochedlinger, K. (2008). A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell 3, 340-345. doi: 10.1016/j.stem.2008.08.003
    • (2008) Cell Stem Cell , vol.3 , pp. 340-345
    • Maherali, N.1    Ahfeldt, T.2    Rigamonti, A.3    Utikal, J.4    Cowan, C.5    Hochedlinger, K.6
  • 39
    • 0033920448 scopus 로고    scopus 로고
    • Vascular events after spinal cord injury: contribution to secondary pathogenesis
    • Mautes, A. E. M., Weinzierl, M. R., Donovan, F., and Noble, L. J. (2000). Vascular events after spinal cord injury: contribution to secondary pathogenesis. Phys. Ther. 80, 673-687. doi: 10.1093/ptj/80.7.673
    • (2000) Phys. Ther , vol.80 , pp. 673-687
    • Mautes, A.E.M.1    Weinzierl, M.R.2    Donovan, F.3    Noble, L.J.4
  • 40
    • 84856539540 scopus 로고    scopus 로고
    • Efficient reprogramming of human cord blood CD34+ cells into induced pluripotent stem cells with OCT4 and SOX2 Alone
    • Meng, X., Neises, A., Su, R.-J., Payne, K. J., Ritter, L., Gridley, D. S., et al. (2012). Efficient reprogramming of human cord blood CD34+ cells into induced pluripotent stem cells with OCT4 and SOX2 Alone. Mol. Ther. 20, 408-416. doi: 10.1038/mt.2011.258
    • (2012) Mol. Ther , vol.20 , pp. 408-416
    • Meng, X.1    Neises, A.2    Su, R.-J.3    Payne, K.J.4    Ritter, L.5    Gridley, D.S.6
  • 41
    • 84928318940 scopus 로고    scopus 로고
    • Comparison and optimization of hiPSC forebrain cortical differentiation protocols
    • Muratore, C. R., Srikanth, P., Callahan, D. G., and Young-Pearse, T. L. (2014). Comparison and optimization of hiPSC forebrain cortical differentiation protocols. PLoS ONE 9:e105807. doi: 10.1371/journal.pone.0105807
    • (2014) PLoS ONE , vol.9
    • Muratore, C.R.1    Srikanth, P.2    Callahan, D.G.3    Young-Pearse, T.L.4
  • 42
    • 38049028459 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
    • Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., et al. (2008). Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 26, 101-106. doi: 10.1038/nbt1374
    • (2008) Nat. Biotechnol , vol.26 , pp. 101-106
    • Nakagawa, M.1    Koyanagi, M.2    Tanabe, K.3    Takahashi, K.4    Ichisaka, T.5    Aoi, T.6
  • 43
    • 85014251328 scopus 로고    scopus 로고
    • Spinal cord injury facts and figures at a glance
    • National Spinal Cord Injury Statistical Center (2014). Spinal cord injury facts and figures at a glance. J. Spinal Cord Med. 37, 355-356. doi: 10.1179/1079026814Z.000000000260
    • (2014) J. Spinal Cord Med , vol.37 , pp. 355-356
  • 44
    • 84877301288 scopus 로고    scopus 로고
    • Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development
    • Nicholas, C. R., Chen, J., Tang, Y., Southwell, D. G., Chalmers, N., Vogt, D., et al. (2013). Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell 12, 573-586. doi: 10.1016/j.stem.2013.04.005
    • (2013) Cell Stem Cell , vol.12 , pp. 573-586
    • Nicholas, C.R.1    Chen, J.2    Tang, Y.3    Southwell, D.G.4    Chalmers, N.5    Vogt, D.6
  • 45
    • 80053628732 scopus 로고    scopus 로고
    • Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice
    • Nori, S., Okada, Y., Yasuda, A., Tsuji, O., Takahashi, Y., Kobayashi, Y., et al. (2011). Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice. Proc. Natl. Acad. Sci. U.S.A. 108, 16825-16830. doi: 10.1073/pnas.1108077108
    • (2011) Proc. Natl. Acad. Sci. U.S.A , vol.108 , pp. 16825-16830
    • Nori, S.1    Okada, Y.2    Yasuda, A.3    Tsuji, O.4    Takahashi, Y.5    Kobayashi, Y.6
  • 46
    • 84882746714 scopus 로고    scopus 로고
    • Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model
    • Nutt, S. E., Chang, E.-A., Suhr, S. T., Schlosser, L. O., Mondello, S. E., Moritz, C. T., et al. (2013). Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model. Exp. Neurol. 248, 491-503. doi: 10.1016/j.expneurol.2013.07.010
    • (2013) Exp. Neurol , vol.248 , pp. 491-503
    • Nutt, S.E.1    Chang, E.-A.2    Suhr, S.T.3    Schlosser, L.O.4    Mondello, S.E.5    Moritz, C.T.6
  • 47
    • 84891833000 scopus 로고    scopus 로고
    • Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts
    • Orlova, V. V., Drabsch, Y., Freund, C., Petrus-Reurer, S., van den Hil, F. E., Muenthaisong, S., et al. (2014). Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts. Arterioscler. Thromb. Vasc. Biol. 34, 177-186. doi: 10.1161/ATVBAHA.113.302598
    • (2014) Arterioscler. Thromb. Vasc. Biol , vol.34 , pp. 177-186
    • Orlova, V.V.1    Drabsch, Y.2    Freund, C.3    Petrus-Reurer, S.4    van den Hil, F.E.5    Muenthaisong, S.6
  • 48
    • 50249098740 scopus 로고    scopus 로고
    • Generation of human-induced pluripotent stem cells
    • Park, I.-H., Lerou, P. H., Zhao, R., Huo, H., and Daley, G. Q. (2008). Generation of human-induced pluripotent stem cells. Nat. Protoc. 3, 1180-1186. doi: 10.1038/nprot.2008.92
    • (2008) Nat. Protoc , vol.3 , pp. 1180-1186
    • Park, I.-H.1    Lerou, P.H.2    Zhao, R.3    Huo, H.4    Daley, G.Q.5
  • 49
    • 84868145156 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated from human adipose-derived stem cells using a non-viral polycistronic plasmid in feeder-free conditions
    • Qu, X., Liu, T., Song, K., Li, X., and Ge, D. (2012). Induced pluripotent stem cells generated from human adipose-derived stem cells using a non-viral polycistronic plasmid in feeder-free conditions. PLoS ONE 7:e48161. doi: 10.1371/journal.pone.0048161
    • (2012) PLoS ONE , vol.7
    • Qu, X.1    Liu, T.2    Song, K.3    Li, X.4    Ge, D.5
  • 50
    • 79952560256 scopus 로고    scopus 로고
    • Intrinsic cell memory reinforces myogenic commitment of pericyte-derived iPSCs
    • Quattrocelli, M., Palazzolo, G., Floris, G., Schöffski, P., Anastasia, L., Orlacchio, A., et al. (2011). Intrinsic cell memory reinforces myogenic commitment of pericyte-derived iPSCs. J. Pathol. 223, 593-603. doi: 10.1002/path.2845
    • (2011) J. Pathol , vol.223 , pp. 593-603
    • Quattrocelli, M.1    Palazzolo, G.2    Floris, G.3    Schöffski, P.4    Anastasia, L.5    Orlacchio, A.6
  • 51
    • 84860171977 scopus 로고    scopus 로고
    • Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors
    • Ramos-Mejía, V., Montes, R., Bueno, C., Ayllón, V., Real, P. J., Rodríguez, R., et al. (2012). Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors. PLoS ONE 7:e35824. doi: 10.1371/journal.pone.0035824
    • (2012) PLoS ONE , vol.7
    • Ramos-Mejía, V.1    Montes, R.2    Bueno, C.3    Ayllón, V.4    Real, P.J.5    Rodríguez, R.6
  • 52
    • 9644254252 scopus 로고    scopus 로고
    • Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface
    • Red-Horse, K., Zhou, Y., Genbacev, O., Prakobphol, A., Foulk, R., McMaster, M., et al. (2004). Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J. Clin. Invest. 114, 744-754. doi: 10.1172/JCI200422991
    • (2004) J. Clin. Invest , vol.114 , pp. 744-754
    • Red-Horse, K.1    Zhou, Y.2    Genbacev, O.3    Prakobphol, A.4    Foulk, R.5    McMaster, M.6
  • 53
  • 54
    • 84863625049 scopus 로고    scopus 로고
    • Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor
    • Ring, K. L., Tong, L. M., Balestra, M. E., Javier, R., Andrews-Zwilling, Y., Li, G., et al. (2012). Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell 11, 100-109. doi: 10.1016/j.stem.2012.05.018
    • (2012) Cell Stem Cell , vol.11 , pp. 100-109
    • Ring, K.L.1    Tong, L.M.2    Balestra, M.E.3    Javier, R.4    Andrews-Zwilling, Y.5    Li, G.6
  • 55
    • 84872696866 scopus 로고    scopus 로고
    • Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization
    • Rowland, J. W., Lee, J. J., Salewski, R. P., Eftekharpour, E., van der Kooy, D., and Fehlings, M. G. (2011). Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization. Stem Cells Dev. 20, 1829-1845. doi: 10.1089/scd.2011.0214
    • (2011) Stem Cells Dev , vol.20 , pp. 1829-1845
    • Rowland, J.W.1    Lee, J.J.2    Salewski, R.P.3    Eftekharpour, E.4    van der Kooy, D.5    Fehlings, M.G.6
  • 56
    • 84872727619 scopus 로고    scopus 로고
    • The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway
    • Salewski, R. P., Buttigieg, J., Mitchell, R. A., van der Kooy, D., Nagy, A., and Fehlings, M. G. (2013). The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway. Stem Cells Dev. 22, 383-396. doi: 10.1089/scd.2012.0218
    • (2013) Stem Cells Dev , vol.22 , pp. 383-396
    • Salewski, R.P.1    Buttigieg, J.2    Mitchell, R.A.3    van der Kooy, D.4    Nagy, A.5    Fehlings, M.G.6
  • 57
    • 84936998347 scopus 로고    scopus 로고
    • Transplantation of induced pluripotent stem cell-derived neural stem cells mediate functional recovery following thoracic spinal cord injury through remyelination of axons
    • Salewski, R. P., Mitchell, R. A., Li, L., Shen, C., Milekovskaia, M., Nagy, A., et al. (2015). Transplantation of induced pluripotent stem cell-derived neural stem cells mediate functional recovery following thoracic spinal cord injury through remyelination of axons. Stem Cells Transl. Med. 4, 743-754. doi: 10.5966/sctm.2014-0236
    • (2015) Stem Cells Transl. Med , vol.4 , pp. 743-754
    • Salewski, R.P.1    Mitchell, R.A.2    Li, L.3    Shen, C.4    Milekovskaia, M.5    Nagy, A.6
  • 58
    • 84886389563 scopus 로고    scopus 로고
    • Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion
    • Sareen, D., O'Rourke, J. G., Meera, P., Muhammad, A. K. M. G., Grant, S., Simpkinson, M., et al. (2013). Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci. Transl. Med. 5, 208ra149. doi: 10.1126/scitranslmed.3007529
    • (2013) Sci. Transl. Med , vol.5
    • Sareen, D.1    O'Rourke, J.G.2    Meera, P.3    Muhammad, A.K.M.G.4    Grant, S.5    Simpkinson, M.6
  • 59
    • 84894433856 scopus 로고    scopus 로고
    • The potential for immunogenicity of autologous induced pluripotent stem cell-derived therapies
    • Scheiner, Z. S., Talib, S., and Feigal, E. G. (2014). The potential for immunogenicity of autologous induced pluripotent stem cell-derived therapies. J. Biol. Chem. 289, 4571-4577. doi: 10.1074/jbc. R113.509588
    • (2014) J. Biol. Chem , vol.289 , pp. 4571-4577
    • Scheiner, Z.S.1    Talib, S.2    Feigal, E.G.3
  • 60
    • 84870030633 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks
    • Shi, Y., Kirwan, P., and Livesey, F. J. (2012a). Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks. Nat. Protoc. 7, 1836-1846. doi: 10.1038/nprot.2012.116
    • (2012) Nat. Protoc , vol.7 , pp. 1836-1846
    • Shi, Y.1    Kirwan, P.2    Livesey, F.J.3
  • 61
    • 84862778046 scopus 로고    scopus 로고
    • Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
    • Shi, Y., Kirwan, P., Smith, J., Robinson, H. P. C., and Livesey, F. J. (2012b). Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Nat. Neurosci. 15, 477-486. doi: 10.1038/nn.3041
    • (2012) Nat. Neurosci , vol.15 , pp. 477-486
    • Shi, Y.1    Kirwan, P.2    Smith, J.3    Robinson, H.P.C.4    Livesey, F.J.5
  • 62
    • 84901416354 scopus 로고    scopus 로고
    • Concise review: evidence for CD34 as a common marker for diverse progenitors
    • Sidney, L. E., Branch, M. J., Dunphy, S. E., Dua, H. S., and Hopkinson, A. (2014). Concise review: evidence for CD34 as a common marker for diverse progenitors. Stem Cells 32, 1380-1389. doi: 10.1002/stem.1661
    • (2014) Stem Cells , vol.32 , pp. 1380-1389
    • Sidney, L.E.1    Branch, M.J.2    Dunphy, S.E.3    Dua, H.S.4    Hopkinson, A.5
  • 63
    • 29944443025 scopus 로고    scopus 로고
    • Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences
    • Smukler, S. R., Runciman, S. B., Xu, S., and van der Kooy, D. (2006). Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences. J. Cell Biol. 172, 79-90. doi: 10.1083/jcb.200508085
    • (2006) J. Cell Biol , vol.172 , pp. 79-90
    • Smukler, S.R.1    Runciman, S.B.2    Xu, S.3    van der Kooy, D.4
  • 64
    • 79955780736 scopus 로고    scopus 로고
    • Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
    • Subramanyam, D., Lamouille, S., Judson, R. L., Liu, J. Y., Bucay, N., Derynck, R., et al. (2011). Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat. Biotechnol. 29, 443-448. doi: 10.1038/nbt.1862
    • (2011) Nat. Biotechnol , vol.29 , pp. 443-448
    • Subramanyam, D.1    Lamouille, S.2    Judson, R.L.3    Liu, J.Y.4    Bucay, N.5    Derynck, R.6
  • 65
    • 70349446099 scopus 로고    scopus 로고
    • Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells
    • Sun, N., Panetta, N. J., Gupta, D. M., Wilson, K. D., Lee, A., Jia, F., et al. (2009). Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc. Natl. Acad. Sci. U.S.A. 106, 15720-15725. doi: 10.1073/pnas.0908450106
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 15720-15725
    • Sun, N.1    Panetta, N.J.2    Gupta, D.M.3    Wilson, K.D.4    Lee, A.5    Jia, F.6
  • 66
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., et al. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872. doi: 10.1016/j.cell.2007.11.019
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6
  • 67
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676. doi: 10.1016/j.cell.2006.07.024
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 68
    • 79960832807 scopus 로고    scopus 로고
    • A systematic review of cellular transplantation therapies for spinal cord injury
    • Tetzlaff, W., Okon, E. B., Karimi-Abdolrezaee, S., Hill, C. E., Sparling, J. S., Plemel, J. R., et al. (2011). A systematic review of cellular transplantation therapies for spinal cord injury. J. Neurotrauma 28, 1611-1682. doi: 10.1089/neu.2009.1177
    • (2011) J. Neurotrauma , vol.28 , pp. 1611-1682
    • Tetzlaff, W.1    Okon, E.B.2    Karimi-Abdolrezaee, S.3    Hill, C.E.4    Sparling, J.S.5    Plemel, J.R.6
  • 69
    • 0345227300 scopus 로고    scopus 로고
    • Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration
    • Tobias, C. A., Shumsky, J. S., Shibata, M., Tuszynski, M. H., Fischer, I., Tessler, A., et al. (2003). Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration. Exp. Neurol. 184, 97-113. doi: 10.1016/S0014-4886(03)00394-7
    • (2003) Exp. Neurol , vol.184 , pp. 97-113
    • Tobias, C.A.1    Shumsky, J.S.2    Shibata, M.3    Tuszynski, M.H.4    Fischer, I.5    Tessler, A.6
  • 70
    • 0035025619 scopus 로고    scopus 로고
    • Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism
    • Tropepe, V., Hitoshi, S., Sirard, C., Mak, T. W., Rossant, J., and van der Kooy, D. (2001). Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron 30, 65-78. doi: 10.1016/S0896-6273(01)00263-X
    • (2001) Neuron , vol.30 , pp. 65-78
    • Tropepe, V.1    Hitoshi, S.2    Sirard, C.3    Mak, T.W.4    Rossant, J.5    van der Kooy, D.6
  • 71
    • 77955454021 scopus 로고    scopus 로고
    • Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
    • Tsuji, O., Miura, K., Okada, Y., Fujiyoshi, K., Mukaino, M., Nagoshi, N., et al. (2010). Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc. Natl. Acad. Sci. U.S.A. 107, 12704-12709. doi: 10.1073/pnas.0910106107
    • (2010) Proc. Natl. Acad. Sci. U.S.A , vol.107 , pp. 12704-12709
    • Tsuji, O.1    Miura, K.2    Okada, Y.3    Fujiyoshi, K.4    Mukaino, M.5    Nagoshi, N.6
  • 72
    • 84978100730 scopus 로고    scopus 로고
    • Modulating the immune response in spinal cord injury
    • Ulndreaj, A., Chio, J. C. T., Ahuja, C. S., and Fehlings, M. G. (2016). Modulating the immune response in spinal cord injury. Expert Rev. Neurother. 16, 1127-1129. doi: 10.1080/14737175.2016.1207532
    • (2016) Expert Rev. Neurother , vol.16 , pp. 1127-1129
    • Ulndreaj, A.1    Chio, J.C.T.2    Ahuja, C.S.3    Fehlings, M.G.4
  • 73
    • 70350380887 scopus 로고    scopus 로고
    • Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells
    • Utikal, J., Maherali, N., Kulalert, W., and Hochedlinger, K. (2009). Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J. Cell Sci. 122, 3502-3510. doi: 10.1242/jcs.054783
    • (2009) J. Cell Sci , vol.122 , pp. 3502-3510
    • Utikal, J.1    Maherali, N.2    Kulalert, W.3    Hochedlinger, K.4
  • 74
    • 84856595816 scopus 로고    scopus 로고
    • Current stem cell treatments for spinal cord injury
    • Vawda, R., Wilcox, J., and Fehlings, M. (2012). Current stem cell treatments for spinal cord injury. Indian J. Orthop. 46, 10-18. doi: 10.4103/0019-5413.91629
    • (2012) Indian J. Orthop , vol.46 , pp. 10-18
    • Vawda, R.1    Wilcox, J.2    Fehlings, M.3
  • 75
    • 77958536106 scopus 로고    scopus 로고
    • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
    • Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y.-H., Li, H., Lau, F., et al. (2010). Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7, 618-630. doi: 10.1016/j.stem.2010.08.012
    • (2010) Cell Stem Cell , vol.7 , pp. 618-630
    • Warren, L.1    Manos, P.D.2    Ahfeldt, T.3    Loh, Y.-H.4    Li, H.5    Lau, F.6
  • 76
    • 0024395475 scopus 로고
    • Demyelination in spinal cord injury
    • Waxman, S. G. (1989). Demyelination in spinal cord injury. J. Neurol. Sci. 91, 1-14. doi: 10.1016/0022-510X(89)90072-5
    • (1989) J. Neurol. Sci , vol.91 , pp. 1-14
    • Waxman, S.G.1
  • 77
    • 0141705210 scopus 로고    scopus 로고
    • Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing
    • Whetstone, W. D., Hsu, J.-Y. C., Eisenberg, M., Werb, Z., and Noble-Haeusslein, L. J. (2003). Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J. Neurosci. Res. 74, 227-239. doi: 10.1002/jnr.10759
    • (2003) J. Neurosci. Res , vol.74 , pp. 227-239
    • Whetstone, W.D.1    Hsu, J.-Y.C.2    Eisenberg, M.3    Werb, Z.4    Noble-Haeusslein, L.J.5
  • 78
    • 84908040537 scopus 로고    scopus 로고
    • Neural precursor cell transplantation enhances functional recovery and reduces astrogliosis in bilateral compressive/contusive cervical spinal cord injury
    • Wilcox, J. T., Satkunendrarajah, K., Zuccato, J. A., Nassiri, F., and Fehlings, M. G. (2014). Neural precursor cell transplantation enhances functional recovery and reduces astrogliosis in bilateral compressive/contusive cervical spinal cord injury. Stem Cells Transl. Med. 3, 1148-1159. doi: 10.5966/sctm.2014-0029
    • (2014) Stem Cells Transl. Med , vol.3 , pp. 1148-1159
    • Wilcox, J.T.1    Satkunendrarajah, K.2    Zuccato, J.A.3    Nassiri, F.4    Fehlings, M.G.5
  • 79
    • 64749083939 scopus 로고    scopus 로고
    • piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
    • Woltjen, K., Michael, I. P., Mohseni, P., Desai, R., Mileikovsky, M., Hämäläinen, R., et al. (2009). piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458, 766-770. doi: 10.1038/nature07863
    • (2009) Nature , vol.458 , pp. 766-770
    • Woltjen, K.1    Michael, I.P.2    Mohseni, P.3    Desai, R.4    Mileikovsky, M.5    Hämäläinen, R.6
  • 80
    • 85015639659 scopus 로고    scopus 로고
    • Development of an inducible caspase-9 safety switch for pluripotent stem cell-based therapies
    • Wu, C., Hong, S. G., Winkler, T., Spencer, D. M., Jares, A., Ichwan, B., et al. (2014). Development of an inducible caspase-9 safety switch for pluripotent stem cell-based therapies. Mol. Ther. Methods Clin. Dev. 1:14053. doi: 10.1038/mtm.2014.53
    • (2014) Mol. Ther. Methods Clin. Dev , vol.1 , pp. 14053
    • Wu, C.1    Hong, S.G.2    Winkler, T.3    Spencer, D.M.4    Jares, A.5    Ichwan, B.6
  • 81
    • 67650095196 scopus 로고    scopus 로고
    • Elite and stochastic models for induced pluripotent stem cell generation
    • Yamanaka, S. (2009). Elite and stochastic models for induced pluripotent stem cell generation. Nature 460, 49-52. doi: 10.1038/nature08180
    • (2009) Nature , vol.460 , pp. 49-52
    • Yamanaka, S.1
  • 82
    • 65649116572 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells free of vector and transgene sequences
    • Yu, J., Hu, K., Smuga-Otto, K., Tian, S., Stewart, R., Slukvin, I. I., et al. (2009). Human induced pluripotent stem cells free of vector and transgene sequences. Science 324, 797-801. doi: 10.1126/science.1172482
    • (2009) Science , vol.324 , pp. 797-801
    • Yu, J.1    Hu, K.2    Smuga-Otto, K.3    Tian, S.4    Stewart, R.5    Slukvin, I.I.6
  • 83
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., et al. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920. doi: 10.1126/science.1151526
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3    Antosiewicz-Bourget, J.4    Frane, J.L.5    Tian, S.6
  • 84
    • 84878849645 scopus 로고    scopus 로고
    • Rapid single-step induction of functional neurons from human pluripotent stem cells
    • Zhang, Y., Pak, C., Han, Y., Ahlenius, H., Zhang, Z., Chanda, S., et al. (2013). Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron 78, 785-798. doi: 10.1016/j.neuron.2013.05.029
    • (2013) Neuron , vol.78 , pp. 785-798
    • Zhang, Y.1    Pak, C.2    Han, Y.3    Ahlenius, H.4    Zhang, Z.5    Chanda, S.6
  • 85
    • 79957807595 scopus 로고    scopus 로고
    • Immunogenicity of induced pluripotent stem cells
    • Zhao, T., Zhang, Z.-N., Rong, Z., and Xu, Y. (2011). Immunogenicity of induced pluripotent stem cells. Nature 474, 212-215. doi: 10.1038/nature10135
    • (2011) Nature , vol.474 , pp. 212-215
    • Zhao, T.1    Zhang, Z.-N.2    Rong, Z.3    Xu, Y.4
  • 86
    • 54949136146 scopus 로고    scopus 로고
    • Two supporting factors greatly improve the efficiency of human iPSC generation
    • Zhao, Y., Yin, X., Qin, H., Zhu, F., Liu, H., Yang, W., et al. (2008). Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 3, 475-479. doi: 10.1016/j.stem.2008.10.002
    • (2008) Cell Stem Cell , vol.3 , pp. 475-479
    • Zhao, Y.1    Yin, X.2    Qin, H.3    Zhu, F.4    Liu, H.5    Yang, W.6
  • 87
    • 72849137462 scopus 로고    scopus 로고
    • Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells
    • Zhou, W., and Freed, C. R. (2009). Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells. Stem Cells 27, 2667-2674. doi: 10.1002/stem.201
    • (2009) Stem Cells , vol.27 , pp. 2667-2674
    • Zhou, W.1    Freed, C.R.2
  • 88
    • 84894413040 scopus 로고    scopus 로고
    • Direct conversion of human fibroblasts into neuronal restricted progenitors
    • Zou, Q., Yan, Q., Zhong, J., Wang, K., Sun, H., Yi, X., et al. (2014). Direct conversion of human fibroblasts into neuronal restricted progenitors. J. Biol. Chem. 289, 5250-5260. doi: 10.1074/jbc. M113.516112
    • (2014) J. Biol. Chem , vol.289 , pp. 5250-5260
    • Zou, Q.1    Yan, Q.2    Zhong, J.3    Wang, K.4    Sun, H.5    Yi, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.