Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell-derived astrocytes in a rat spinal cord injury model: Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 15, Issue 6, 2011, Pages 582-593

  Hayashi, Koichi ^a   Hashimoto, Masayuki ^a   Koda, Masao ^a   Naito, Atsuhiko T ^a   Murata, Atsushi ^a   Okawa, Akihiko ^a   Takahashi, Kazuhisa ^a   Yamazaki, Masashi ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Astrocyte; Induced pluripotent stem cell; Neural stem cell; Neural stem sphere; Spinal cord injury

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; GREEN FLUORESCENT PROTEIN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; LOCOMOTION; MECHANICAL STIMULATION; MOUSE; NEURAL STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL; QUANTITATIVE ANALYSIS; RAT; SENSORIMOTOR FUNCTION; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; STIMULUS RESPONSE;

ANIMALS; ASTROCYTES; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CULTURE MEDIA, CONDITIONED; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GRAFT REJECTION; GRAFT SURVIVAL; GREEN FLUORESCENT PROTEINS; MICE; MICE, TRANSGENIC; NERVE REGENERATION; OLIGODENDROGLIA; PHYSICAL STIMULATION; PLURIPOTENT STEM CELLS; RATS; RECOVERY OF FUNCTION; SENSORY RECEPTOR CELLS; SPINAL CORD INJURIES;

EID: 80555151610     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2011.7.SPINE10775     Document Type: Article

References (38)

1. Bain G, Kitchens D, Yao M, Huettner JE, Gottlieb DI: Embryonic stem cells express neuronal properties in vitro. Dev Biol 168:342-357, 1995
2. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21, 1995
3. Cummings BJ, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, et al.: Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A 102:14069-14074, 2005 (Pubitemid 41377704)
4. Davies JE, Huang C, Proschel C, Noble M, Mayer-Proschel M, Davies SJ: Astrocytes derived from glial-restricted precursors promote spinal cord repair. J Biol 5:7, 2006
5. Davies JE, Pröschel C, Zhang N, Noble M, Mayer-Pröschel M, Davies SJ: Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury. J Biol 7:24, 2008
6. Davies SJ, Fitch MT, Memberg SP, Hall AK, Raisman G, Silver J: Regeneration of adult axons in white matter tracts of the central nervous system. Nature 390:680-683, 1997 (Pubitemid 28016354)
7. Davies SJ, Goucher DR, Doller C, Silver J: Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci 19:5810-5822, 1999 (Pubitemid 29327918)
8. Desclaux M, Teigell M, Amar L, Vogel R, Gimenez y Ribotta M, Privat A, et al.: A novel and efficient gene transfer strategy reduces glial reactivity and improves neuronal survival and axonal growth in vitro. PLoS ONE 4:e6227, 2009
9. Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV: Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci 24:2143-2155, 2004 (Pubitemid 38314546)
10. Fawcett JW, Asher RA: The glial scar and central nervous system repair. Brain Res Bull 49:377-391, 1999 (Pubitemid 29385505)
11. Hald A: Spinal astrogliosis in pain models: cause and effects. Cell Mol Neurobiol 29:609-619, 2009
12. Hofstetter CP, Holmström NA, Lilja JA, Schweinhardt P, Hao J, Spenger C, et al.: Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat Neurosci 8:346-353, 2005 (Pubitemid 40300192)
13. Hu BY, Du ZW, Zhang SC: Differentiation of human oligodendrocytes from pluripotent stem cells. Nat Protoc 4:1614-1622, 2009
14. Hu BY, Zhang SC: Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc 4:1295-1304, 2009
15. Iseda T, Nishio T, Kawaguchi S, Yamanoto M, Kawasaki T, Wakisaka S: Spontaneous regeneration of the corticospinal tract after transection in young rats: a key role of reactive astrocytes in making favorable and unfavorable conditions for regeneration. Neuroscience 126:365-374, 2004 (Pubitemid 38780812)
16. Iwanami A, Kaneko S, Nakamura M, Kanemura Y, Mori H, Kobayashi S, et al.: Transplantation of human neural stem cells for spinal cord injury in primates. J Neurosci Res 80:182-190, 2005 (Pubitemid 40676302)
17. Karimi-Abdolrezaee S, Eftekharpour E, Wang J, Schut D, Fehlings MG: Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord. J Neurosci 30:1657-1676, 2010
18. Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, Nakanishi S, et al.: Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 28:31-40, 2000
19. Keirstead HS, Nistor G, Bernal G, Totoiu M, Cloutier F, Sharp K, et al.: Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci 25:4694-4705, 2005 (Pubitemid 40664118)
20. Lemons ML, Howland DR, Anderson DK: Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantation. Exp Neurol 160:51-65, 1999
21. Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, et al.: Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. BMC Neurosci 10:122, 2009
22. Macias MY, Syring MB, Pizzi MA, Crowe MJ, Alexanian AR, Kurpad SN: Pain with no gain: allodynia following neural stem cell transplantation in spinal cord injury. Exp Neurol 201:335-348, 2006 (Pubitemid 44344226)
23. Mikami Y, Toda M, Watanabe M, Nakamura M, Toyama Y, Kawakami Y: A simple and reliable behavioral analysis of locomotor function after spinal cord injury in mice. Technical note. J Neurosurg 97 (1 Suppl):142-147, 2002 (Pubitemid 34686617)
24. Muramatsu S, Okuno T, Suzuki Y, Nakayama T, Kakiuchi T, Takino N, et al.: Multitracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson's disease. Synapse 63:541-548, 2009
25. Myer DJ, Gurkoff GG, Lee SM, Hovda DA, Sofroniew MV: Essential protective roles of reactive astrocytes in traumatic brain injury. Brain 129:2761-2772, 2006 (Pubitemid 44523749)
26. Nakamura M, Houghtling RA, MacArthur L, Bayer BM, Bregman BS: Differences in cytokine gene expression profile between acute and secondary injury in adult rat spinal cord. Exp Neurol 184:313-325, 2003 (Pubitemid 37444041)
27. Nakayama T, Inoue N: Neural stem sphere method: induction of neural stem cells and neurons by astrocyte-derived factors in embryonic stem cells in vitro. Methods Mol Biol 330:1-13, 2006
28. Nakayama T, Momoki-Soga T, Inoue N: Astrocyte-derived factors instruct differentiation of embryonic stem cells into neurons. Neurosci Res 46:241-249, 2003 (Pubitemid 36593287)
29. Nakayama T, Momoki-Soga T, Yamaguchi K, Inoue N: Efficient production of neural stem cells and neurons from embryonic stem cells. Neuroreport 15:487-491, 2004 (Pubitemid 38328146)
30. Nakayama T, Sai T, Otsu M, Momoki-Soga T, Inoue N: Astrocytogenesis of embryonic stem-cell-derived neural stem cells: default differentiation. Neuroreport 17:1519-1523, 2006 (Pubitemid 44359464)
31. Ogawa Y, Sawamoto K, Miyata T, Miyao S, Watanabe M, Nakamura M, et al.: Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J Neurosci Res 69:925-933, 2002 (Pubitemid 34984709)
32. Okabe S, Forsberg-Nilsson K, Spiro AC, Segal M, McKay RD: Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech Dev 59:89-102, 1996 (Pubitemid 26325462)
33. Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, et al.: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med 12:829-834, 2006 (Pubitemid 44050074)
34. Okuno T, Nakayama T, Konishi N, Michibata H, Wakimoto K, Suzuki Y, et al.: Self-contained induction of neurons from human embryonic stem cells. PLoS ONE 4:e6318, 2009
35. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al.: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872, 2007 (Pubitemid 350138099)
36. Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676, 2006 (Pubitemid 44233629)
37. Uchida K, Okano H, Hayashi T, Mine Y, Tanioka Y, Nomura T, et al.: Grafted swine neuroepithelial stem cells can form myelinated axons and both efferent and afferent synapses with xenogeneic rat neurons. J Neurosci Res 72:661-669, 2003 (Pubitemid 36666259)
38. Voskuhl RR, Peterson RS, Song B, Ao Y, Morales LB, Tiwari- Woodruff S, et al.: Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J Neurosci 29:11511-11522, 2009