Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice

Gastroenterology

Volumn 152, Issue 6, 2017, Pages 1419-1433.e5

  Tsoi, Ho ^a   Chu, Eagle S H ^a   Zhang, Xiang ^a   Sheng, Jianqiu ^b   Nakatsu, Geicho ^a   Ng, Siew C ^a   Chan, Anthony W H ^a   Chan, Francis K L ^a   Sung, Joseph J Y ^a   Yu, Jun ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Colon Cancer; Microbiota; Pathogen; Signal Transduction

Indexed keywords

ANTIBIOTIC AGENT; APOCYNIN; AZOXYMETHANE; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; ACETOPHENONE DERIVATIVE; BACTERIAL DNA; ENZYME INHIBITOR; REACTIVE OXYGEN METABOLITE; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADVANCED CANCER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CACO-2 CELL LINE; CELL PROLIFERATION; CHINA; CHOLESTEROL SYNTHESIS; COLON ADENOMA; COLON BIOPSY; COLON CARCINOGENESIS; COLON CELL; COLON EPITHELIUM; COLONOSCOPY; COLORECTAL CANCER; CONTROLLED STUDY; DYSPLASIA; EPITHELIUM CELL; ESCHERICHIA COLI; FECES; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; HONG KONG; HT-29 CELL LINE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INTESTINE TISSUE; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PEPTOSTREPTOCOCCUS ANAEROBIUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; ADENOMA; AGED; ANIMAL; BIOPSY; BIOSYNTHESIS; C57BL MOUSE; CASE CONTROL STUDY; CHEMICALLY INDUCED; COLON; COLON TUMOR; COMPLICATION; GENE EXPRESSION; GENETICS; GRAM POSITIVE INFECTION; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PATHOLOGY; PEPTOSTREPTOCOCCUS; UPREGULATION;

ACETOPHENONES; ADENOMA; AGED; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AZOXYMETHANE; BIOPSY; BIOSYNTHETIC PATHWAYS; CACO-2 CELLS; CASE-CONTROL STUDIES; CELL PROLIFERATION; CHOLESTEROL; COLON; COLONIC NEOPLASMS; DNA, BACTERIAL; ENZYME INHIBITORS; FECES; GENE EXPRESSION; GRAM-POSITIVE BACTERIAL INFECTIONS; HT29 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PEPTOSTREPTOCOCCUS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

EID: 85018829135     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2017.01.009     Document Type: Article

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