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Volumn 27, Issue 6, 2017, Pages 554-559

Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation

Author keywords

Antidepressants; Childhood trauma; Glucocorticoid receptor; HPA; Immunopsychiatry; mRNA; Psychoneuroimmunology.

Indexed keywords

BIOLOGICAL MARKER; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; ANTIINFLAMMATORY AGENT; AUTACOID; HYDROCORTISONE;

EID: 85018795239     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2017.04.001     Document Type: Review
Times cited : (281)

References (49)
  • 5
    • 84992415362 scopus 로고    scopus 로고
    • Genetic contributions of inflammation to depression
    • Barnes, J., Mondelli, V., Pariante, C.M., Genetic contributions of inflammation to depression. Neuropsychopharmacology 42:1 (2017), 81–98.
    • (2017) Neuropsychopharmacology , vol.42 , Issue.1 , pp. 81-98
    • Barnes, J.1    Mondelli, V.2    Pariante, C.M.3
  • 7
    • 84930350748 scopus 로고    scopus 로고
    • Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α
    • Baumeister, D., Akhtar, R., Ciufolini, S., Pariante, C.M., Mondelli, V., Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Mol. Psychiatry 21:5 (2016), 642–649.
    • (2016) Mol. Psychiatry , vol.21 , Issue.5 , pp. 642-649
    • Baumeister, D.1    Akhtar, R.2    Ciufolini, S.3    Pariante, C.M.4    Mondelli, V.5
  • 9
    • 77952551997 scopus 로고    scopus 로고
    • Antidepressants, but not antipsychotics, modulate GR function in human whole blood: an insight into molecular mechanisms
    • Carvalho, L.A., Garner, B.A., Dew, T., Fazakerley, H., Pariante, C.M., Antidepressants, but not antipsychotics, modulate GR function in human whole blood: an insight into molecular mechanisms. Eur. Neuropsychopharmacol. 20:6 (2010), 379–387.
    • (2010) Eur. Neuropsychopharmacol. , vol.20 , Issue.6 , pp. 379-387
    • Carvalho, L.A.1    Garner, B.A.2    Dew, T.3    Fazakerley, H.4    Pariante, C.M.5
  • 10
    • 57349088150 scopus 로고    scopus 로고
    • Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression
    • Carvalho, L.A., Juruena, M.F., Papadopoulos, A.S., Poon, L., Kerwin, R., Cleare, A.J., Pariante, C.M., Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression. Neuropsychopharmacology 33:13 (2008), 3182–3189.
    • (2008) Neuropsychopharmacology , vol.33 , Issue.13 , pp. 3182-3189
    • Carvalho, L.A.1    Juruena, M.F.2    Papadopoulos, A.S.3    Poon, L.4    Kerwin, R.5    Cleare, A.J.6    Pariante, C.M.7
  • 15
    • 71549168934 scopus 로고    scopus 로고
    • Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers
    • Danese, A., Moffitt, T.E., Harrington, H., Milne, B.J., Polanczyk, G., Pariante, C.M., Poulton, R., Caspi, A., Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch. Pediatr. Adolesc. Med. 163:12 (2009), 1135–1143.
    • (2009) Arch. Pediatr. Adolesc. Med. , vol.163 , Issue.12 , pp. 1135-1143
    • Danese, A.1    Moffitt, T.E.2    Harrington, H.3    Milne, B.J.4    Polanczyk, G.5    Pariante, C.M.6    Poulton, R.7    Caspi, A.8
  • 16
    • 42049086308 scopus 로고    scopus 로고
    • Elevated inflammation levels in depressed adults with a history of childhood maltreatment
    • Danese, A., Moffitt, T.E., Pariante, C.M., Ambler, A., Poulton, R., Caspi, A., Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch. Gen. Psychiatry 65:4 (2008), 409–415.
    • (2008) Arch. Gen. Psychiatry , vol.65 , Issue.4 , pp. 409-415
    • Danese, A.1    Moffitt, T.E.2    Pariante, C.M.3    Ambler, A.4    Poulton, R.5    Caspi, A.6
  • 17
    • 33846641772 scopus 로고    scopus 로고
    • Childhood maltreatment predicts adult inflammation in a life-course study
    • Danese, A., Pariante, C.M., Caspi, A., Taylor, A., Poulton, R., Childhood maltreatment predicts adult inflammation in a life-course study. Proc. Natl. Acad. Sci. USA 104:4 (2007), 1319–1324.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , Issue.4 , pp. 1319-1324
    • Danese, A.1    Pariante, C.M.2    Caspi, A.3    Taylor, A.4    Poulton, R.5
  • 19
    • 84973864175 scopus 로고    scopus 로고
    • Inflammatory insults and mental health consequences: does timing matter when it comes to depression?
    • Du Preez, A., Leveson, J., Zunszain, P.A., Pariante, C.M., Inflammatory insults and mental health consequences: does timing matter when it comes to depression?. Psychol. Med. 46:10 (2016), 2041–2057.
    • (2016) Psychol. Med. , vol.46 , Issue.10 , pp. 2041-2057
    • Du Preez, A.1    Leveson, J.2    Zunszain, P.A.3    Pariante, C.M.4
  • 22
    • 84873257915 scopus 로고    scopus 로고
    • Depression pathogenesis and treatment: what can we learn from blood mRNA expression?
    • Hepgul, N., Cattaneo, A., Zunszain, P.A., Pariante, C.M., Depression pathogenesis and treatment: what can we learn from blood mRNA expression?. BMC Med., 11, 2013, 28.
    • (2013) BMC Med. , vol.11 , pp. 28
    • Hepgul, N.1    Cattaneo, A.2    Zunszain, P.A.3    Pariante, C.M.4
  • 23
    • 84864534950 scopus 로고    scopus 로고
    • Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients
    • Hepgul, N., Pariante, C.M., Dipasquale, S., DiForti, M., Taylor, H., Marques, T.R., Morgan, C., Dazzan, P., Murray, R.M., Mondelli, V., Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients. Psychol. Med. 42:9 (2012), 1893–1901.
    • (2012) Psychol. Med. , vol.42 , Issue.9 , pp. 1893-1901
    • Hepgul, N.1    Pariante, C.M.2    Dipasquale, S.3    DiForti, M.4    Taylor, H.5    Marques, T.R.6    Morgan, C.7    Dazzan, P.8    Murray, R.M.9    Mondelli, V.10
  • 25
    • 53249132968 scopus 로고    scopus 로고
    • A revised role for P-glycoprotein in the brain distribution of dexamethasone, cortisol, and corticosterone in wild-type and ABCB1A/B-deficient mice
    • Mason, B.L., Pariante, C.M., Thomas, S.A., A revised role for P-glycoprotein in the brain distribution of dexamethasone, cortisol, and corticosterone in wild-type and ABCB1A/B-deficient mice. Endocrinology 149:10 (2008), 5244–5253.
    • (2008) Endocrinology , vol.149 , Issue.10 , pp. 5244-5253
    • Mason, B.L.1    Pariante, C.M.2    Thomas, S.A.3
  • 26
    • 80052731723 scopus 로고    scopus 로고
    • Desipramine treatment has minimal effects on the brain accumulation of glucocorticoids in P-gp-deficient and wild-type mice
    • Mason, B.L., Thomas, S.A., Lightman, S.L., Pariante, C.M., Desipramine treatment has minimal effects on the brain accumulation of glucocorticoids in P-gp-deficient and wild-type mice. Psychoneuroendocrinology 36:9 (2011), 1351–1360.
    • (2011) Psychoneuroendocrinology , vol.36 , Issue.9 , pp. 1351-1360
    • Mason, B.L.1    Thomas, S.A.2    Lightman, S.L.3    Pariante, C.M.4
  • 30
    • 84923300804 scopus 로고    scopus 로고
    • Psychoneuroimmunology or immunopsychiatry?
    • Pariante, C.M., Psychoneuroimmunology or immunopsychiatry?. Lancet Psychiatry 2:3 (2015), 197–199.
    • (2015) Lancet Psychiatry , vol.2 , Issue.3 , pp. 197-199
    • Pariante, C.M.1
  • 31
    • 84858445087 scopus 로고    scopus 로고
    • Central glucocorticoid receptor-mediated effects of the antidepressant, citalopram, in humans: a study using EEG and cognitive testing
    • Pariante, C.M., Alhaj, H.A., Arulnathan, V.E., Gallagher, P., Hanson, A., Massey, E., McAllister-Williams, R.H., Central glucocorticoid receptor-mediated effects of the antidepressant, citalopram, in humans: a study using EEG and cognitive testing. Psychoneuroendocrinology 37:5 (2012), 618–628.
    • (2012) Psychoneuroendocrinology , vol.37 , Issue.5 , pp. 618-628
    • Pariante, C.M.1    Alhaj, H.A.2    Arulnathan, V.E.3    Gallagher, P.4    Hanson, A.5    Massey, E.6    McAllister-Williams, R.H.7
  • 32
    • 0042168887 scopus 로고    scopus 로고
    • Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters
    • Pariante, C.M., Kim, R.B., Makoff, A., Kerwin, R.W., Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters. Br. J. Pharmacol. 139:6 (2003), 1111–1118.
    • (2003) Br. J. Pharmacol. , vol.139 , Issue.6 , pp. 1111-1118
    • Pariante, C.M.1    Kim, R.B.2    Makoff, A.3    Kerwin, R.W.4
  • 33
    • 50549092885 scopus 로고    scopus 로고
    • The HPA axis in major depression: classical theories and new developments
    • Pariante, C.M., Lightman, S.L., The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 31:9 (2008), 464–468.
    • (2008) Trends Neurosci. , vol.31 , Issue.9 , pp. 464-468
    • Pariante, C.M.1    Lightman, S.L.2
  • 34
    • 0141446215 scopus 로고    scopus 로고
    • The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones
    • Pariante, C.M., Hye, A., Williamson, R., Makoff, A., Lovestone, S., Kerwin, R.W., The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones. Neuropsychopharmacology 28:9 (2003), 1553–1561.
    • (2003) Neuropsychopharmacology , vol.28 , Issue.9 , pp. 1553-1561
    • Pariante, C.M.1    Hye, A.2    Williamson, R.3    Makoff, A.4    Lovestone, S.5    Kerwin, R.W.6
  • 35
    • 0035197083 scopus 로고    scopus 로고
    • Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters
    • Pariante, C.M., Makoff, A., Lovestone, S., Feroli, S., Heyden, A., Miller, A.H., Kerwin, R.W., Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters. Br. J. Pharmacol. 134:6 (2001), 1335–1343.
    • (2001) Br. J. Pharmacol. , vol.134 , Issue.6 , pp. 1335-1343
    • Pariante, C.M.1    Makoff, A.2    Lovestone, S.3    Feroli, S.4    Heyden, A.5    Miller, A.H.6    Kerwin, R.W.7
  • 36
    • 0035280252 scopus 로고    scopus 로고
    • Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    • Pariante, C.M., Miller, A.H., Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49:5 (2001), 391–404.
    • (2001) Biol. Psychiatry , vol.49 , Issue.5 , pp. 391-404
    • Pariante, C.M.1    Miller, A.H.2
  • 38
    • 0030760364 scopus 로고    scopus 로고
    • Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine
    • Pariante, C.M., Pearce, B.D., Pisell, T.L., Owens, M.J., Miller, A.H., Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Mol. Pharmacol. 52:4 (1997), 571–581.
    • (1997) Mol. Pharmacol. , vol.52 , Issue.4 , pp. 571-581
    • Pariante, C.M.1    Pearce, B.D.2    Pisell, T.L.3    Owens, M.J.4    Miller, A.H.5
  • 39
    • 0033305459 scopus 로고    scopus 로고
    • The proinflammatory cytokine, interleukin-1alpha, reduces glucocorticoid receptor translocation and function
    • Pariante, C.M., Pearce, B.D., Pisell, T.L., Sanchez, C.I., Po, C., Su, C., Miller, A.H., The proinflammatory cytokine, interleukin-1alpha, reduces glucocorticoid receptor translocation and function. Endocrinology 140:9 (1999), 4359–4366.
    • (1999) Endocrinology , vol.140 , Issue.9 , pp. 4359-4366
    • Pariante, C.M.1    Pearce, B.D.2    Pisell, T.L.3    Sanchez, C.I.4    Po, C.5    Su, C.6    Miller, A.H.7
  • 40
    • 1642553626 scopus 로고    scopus 로고
    • Do antidepressants regulate how cortisol affects the brain?
    • (Review. PubMed PMID: 14749091)
    • Pariante, C.M., Thomas, S.A., Lovestone, S., Makoff, A., Kerwin, R.W., Do antidepressants regulate how cortisol affects the brain?. Psychoneuroendocrinology 29:4 (2004), 423–447 (Review. PubMed PMID: 14749091).
    • (2004) Psychoneuroendocrinology , vol.29 , Issue.4 , pp. 423-447
    • Pariante, C.M.1    Thomas, S.A.2    Lovestone, S.3    Makoff, A.4    Kerwin, R.W.5
  • 41
    • 79960988646 scopus 로고    scopus 로고
    • Antenatal depression and offspring psychopathology: the influence of childhood maltreatment
    • Pawlby, S., Hay, D., Sharp, D., Waters, C.S., Pariante, C.M., Antenatal depression and offspring psychopathology: the influence of childhood maltreatment. Br. J. Psychiatry 199:2 (2011), 106–112.
    • (2011) Br. J. Psychiatry , vol.199 , Issue.2 , pp. 106-112
    • Pawlby, S.1    Hay, D.2    Sharp, D.3    Waters, C.S.4    Pariante, C.M.5
  • 42
    • 84873339503 scopus 로고    scopus 로고
    • Intergenerational transmission of maltreatment and psychopathology: the role of antenatal depression
    • Plant, D.T., Barker, E.D., Waters, C.S., Pawlby, S., Pariante, C.M., Intergenerational transmission of maltreatment and psychopathology: the role of antenatal depression. Psychol. Med. 43:3 (2013), 519–528.
    • (2013) Psychol. Med. , vol.43 , Issue.3 , pp. 519-528
    • Plant, D.T.1    Barker, E.D.2    Waters, C.S.3    Pawlby, S.4    Pariante, C.M.5
  • 43
    • 84941198027 scopus 로고    scopus 로고
    • Maternal depression during pregnancy and offspring depression in adulthood: role of child maltreatment
    • Plant, D.T., Pariante, C.M., Sharp, D., Pawlby, S., Maternal depression during pregnancy and offspring depression in adulthood: role of child maltreatment. Br. J. Psychiatry 207:3 (2015), 213–220.
    • (2015) Br. J. Psychiatry , vol.207 , Issue.3 , pp. 213-220
    • Plant, D.T.1    Pariante, C.M.2    Sharp, D.3    Pawlby, S.4
  • 44
    • 84994311166 scopus 로고    scopus 로고
    • Prenatal maternal depression is associated with offspring inflammation at 25 years: a prospective longitudinal cohort study
    • Plant, D.T., Pawlby, S., Sharp, D., Zunszain, P.A., Pariante, C.M., Prenatal maternal depression is associated with offspring inflammation at 25 years: a prospective longitudinal cohort study. Transl. Psychiatry, 6(11), 2016, e936.
    • (2016) Transl. Psychiatry , vol.6 , Issue.11 , pp. e936
    • Plant, D.T.1    Pawlby, S.2    Sharp, D.3    Zunszain, P.A.4    Pariante, C.M.5
  • 46
    • 76849103507 scopus 로고    scopus 로고
    • Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels
    • Su, K.P., Huang, S.Y., Peng, C.Y., Lai, H.C., Huang, C.L., Chen, Y.C., Aitchison, K.J., Pariante, C.M., Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels. Biol. Psychiatry 67:6 (2010), 550–557.
    • (2010) Biol. Psychiatry , vol.67 , Issue.6 , pp. 550-557
    • Su, K.P.1    Huang, S.Y.2    Peng, C.Y.3    Lai, H.C.4    Huang, C.L.5    Chen, Y.C.6    Aitchison, K.J.7    Pariante, C.M.8
  • 47
    • 84922681351 scopus 로고    scopus 로고
    • Omega-3 fatty acids in the prevention of interferon-alpha-induced depression: results from a randomized, controlled trial
    • Su, K.P., Lai, H.C., Yang, H.T., Su, W.P., Peng, C.Y., Chang, J.P., Chang, H.C., Pariante, C.M., Omega-3 fatty acids in the prevention of interferon-alpha-induced depression: results from a randomized, controlled trial. Biol. Psychiatry 76:7 (2014), 559–566.
    • (2014) Biol. Psychiatry , vol.76 , Issue.7 , pp. 559-566
    • Su, K.P.1    Lai, H.C.2    Yang, H.T.3    Su, W.P.4    Peng, C.Y.5    Chang, J.P.6    Chang, H.C.7    Pariante, C.M.8
  • 48
    • 34948826840 scopus 로고    scopus 로고
    • The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice
    • Yau, J.L., Noble, J., Thomas, S., Kerwin, R., Morgan, P.E., Lightman, S., Seckl, J.R., Pariante, C.M., The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice. Neuropsychopharmacology 32:12 (2007), 2520–2529.
    • (2007) Neuropsychopharmacology , vol.32 , Issue.12 , pp. 2520-2529
    • Yau, J.L.1    Noble, J.2    Thomas, S.3    Kerwin, R.4    Morgan, P.E.5    Lightman, S.6    Seckl, J.R.7    Pariante, C.M.8


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