Central glucocorticoid receptor-mediated effects of the antidepressant, citalopram, in humans: A study using EEG and cognitive testing

Psychoneuroendocrinology

Volumn 37, Issue 5, 2012, Pages 618-628

  Pariante, Carmine M ^a   Alhaj, Hamid A ^b   Arulnathan, Vijay Edmund ^b   Gallagher, Peter ^b   Hanson, Andy ^b   Massey, E ^b   McAllister Williams, R Hamish ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Antidepressants; Cortisol; Depression; Glucocorticoid receptor; Hypothalamic pituitary adrenal (HPA) axis; Spatial working memory

Indexed keywords

CITALOPRAM; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; PLACEBO;

ADULT; ALPHA RHYTHM; ARTICLE; COGNITION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; DRUG MECHANISM; DRUG RECEPTOR BINDING; ELECTROENCEPHALOGRAPHY; EXECUTIVE FUNCTION; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY DISORDER; NORMAL HUMAN; ORIENTING RESPONSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR DOWN REGULATION; SINGLE DRUG DOSE; WORKING MEMORY;

ADOLESCENT; ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CITALOPRAM; COGNITION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ELECTROENCEPHALOGRAPHY; HUMANS; HYDROCORTISONE; MALE; MEMORY, SHORT-TERM; RECEPTORS, GLUCOCORTICOID; YOUNG ADULT;

EID: 84858445087     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2011.08.011     Document Type: Article

References (58)

1. Alhaj H., Wisniewski G., McAllister-Williams R.H. The use of the EEG in measuring therapeutic drug action: focus on depression and antidepressants. J. Psychopharmacol. 2010, (November). 10.1177/0269881110388323.
2. American Electroencephalographic S. Guideline thirteen: guidelines for standard electrode position nomenclature. J. Clin. Neurophysiol. 1994, 11:111-113.
3. Anacker C., Zunszain P.A., Carvalho L.A., Pariante C.M. The glucocorticoid receptor: pivot of depression and of antidepressant treatment?. Psychoneuroendocrinology 2011, 36:415-425.
4. Anacker C., Zunszain P.A., Cattaneo A., Carvalho L.A., Garabedian M.J., Thuret S., Price J., Pariante C.M. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol. Psychiatry 2011, 16:738-750.
5. Annett M. The binomial distribution of right, mixed and left handedness. Q. J. Exp. Psychol. 1967, 19:327-333.
6. Augustyn M., Otczyk M., Budziszewska B., Jagla G., Nowak W., Basta-Kaim A., Jaworska-Feil L., Kubera M., Tetich M., Leskiewicz M., Lason W. Effects of some new antidepressant drugs on the glucocorticoid receptor-mediated gene transcription in fibroblast cells. Pharmacol. Rep. 2005, 57:766-773.
7. Beck A.T., Ward C.H., Mendelson M., Mock J., Erbaugh J. An inventory for measuring depression. Arch. Gen. Psychiatry 1961, 4:561-571.
8. Binder E.B. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 2009, 34(Suppl 1):S186-S195.
9. Briggs G.G., Nebes R.D. Patterns of hand preference in a student population. Cortex 1975, 11:230-238.
10. Budziszewska B., Jaworska-Feil L., Kajta M., Lason W. Antidepressant drugs inhibit glucocorticoid receptor-mediated gene transcription - a possible mechanism. Br. J. Pharmacol. 2000, 130:1385-1393.
11. Carvalho L.A., Juruena M.F., Papadopoulos A.S., Poon L., Kerwin R., Cleare A.J., Pariante C.M. Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression. Neuropsychopharmacology 2008, 33:3182-3189.
12. Carvalho L.A., Pariante C.M. In vitro modulation of the glucocorticoid receptor by antidepressants. Stress 2008, 11:411-424.
13. Carvalho L.A., Garner B.A., Dew T., Fazakerley H., Pariante C.M. Antidepressants, but not antipsychotics, modulate GR function in human whole blood: an insight into molecular mechanisms. Eur. Neuropsychopharmacol. 2010, 20:379-387.
14. Claes S. Glucocorticoid receptor polymorphisms in major depression. Ann. N.Y. Acad. Sci. 2009, 1179:216-228.
15. Doerr J.P., Spiegelhalder K., Petzold F., Feige B., Hirscher V., Kaufmann R., Riemann D., Voderholzer U. Impact of escitalopram on nocturnal sleep, day-time sleepiness and performance compared to amitriptyline: a randomized, double-blind, placebo-controlled study in healthy male subjects. Pharmacopsychiatry 2010, 43:166-173.
16. Fan J., McCandliss B.D., Sommer T., Raz A., Posner M.I. Testing the efficiency and independence of attentional networks. J. Cogn. Neurosci. 2002, 14:340-347.
17. Feigenbaum J.D., Polkey C.E., Morris R.G. Deficits in spatial working memory after unilateral temporal lobectomy in man. Neuropsychologia 1996, 34:163-176.
18. Flores B.H., Kenna H., Keller J., Solvason H.B., Schatzberg A.F. Clinical and biological effects of mifepristone treatment for psychotic depression. Neuropsychopharmacology 2006, 31:628-636.
19. Gallagher P., Reid K.S., Ferrier I.N. Neuropsychological functioning in health and mood disorder: modulation by glucocorticoids and their receptors. Psychoneuroendocrinology 2009, 34(Suppl. 1):S196-S207.
20. Heiske A., Jesberg J., Krieg J.C., Vedder H. Differential effects of antidepressants on glucocorticoid receptors in human primary blood cells and human monocytic u-937 cells. Neuropsychopharmacology 2003, 28:807-817.
21. Heydendael W., Jacobson L. Widespread hypothalamic-pituitary-adrenocortical axis-relevant and mood-relevant effects of chronic fluoxetine treatment on glucocorticoid receptor gene expression in mice. Eur. J. Neurosci. 2010, 31:892-902.
22. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 2000, 23:477-501.
23. Ising M., Horstmann S., Kloiber S., Lucae S., Binder E.B., Kern N., Kunzel H.E., Pfennig A., Uhr M., Holsboer F. Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?. Biol. Psychiatry 2007, 62:47-54.
24. Juruena M.F., Cleare A.J., Papadopoulos A.S., Poon L., Lightman S., Pariante C.M. Different responses to dexamethasone and prednisolone in the same depressed patients. Psychopharmacology (Berl.) 2006, 189:225-235.
25. Juruena M.F., Pariante C.M., Papadopoulos A.S., Poon L., Lightman S., Cleare A.J. Prednisolone suppression test in depression: prospective study of the role of HPA axis dysfunction in treatment resistance. Br. J. Psychiatry 2009, 194:342-349.
26. Juruena M.F., Cleare A.J., Papadopoulos A.S., Poon L., Lightman S., Pariante C.M. The prednisolone suppression test in depression: dose-response and changes with antidepressant treatment. Psychoneuroendocrinology 2010, 35:1486-1491.
27. Kerlik J., Penesova A., Vlcek M., Imrich R., Vogeser M., Radikova Z. Comparison of salivary cortisol and calculated free plasma cortisol during low-dose ACTH test in healthy subjects. Clin. Biochem. 2010, 43:764-767.
28. Kragh-Sorensen P., Overo K.F., Petersen O.L., Jensen K., Parnas W. The kinetics of citalopram: single and multiple dose studies in man. Acta Pharmacol. Toxicol. (Copenh) 1981, 48:53-60.
29. Lupien S.J., Gillin C.J., Hauger R.L. Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans. Behav. Neurosci. 1999, 113:420-430.
30. McAllister-Williams R.H., Ferrier I.N., Young A.H. Mood and neuropsychological function in depression: the role of corticosteroids and serotonin. Psychol. Med. 1998, 28:573-584.
31. Miller A.H., Vogt G.J., Pearce B.D. The phosphodiesterase type 4 inhibitor, rolipram, enhances glucocorticoid receptor function. Neuropsychopharmacology 2002, 27:939-948.
32. Okugawa G., Omori K., Suzukawa J., Fujiseki Y., Kinoshita T., Inagaki C. Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones. J. Neuroendocrinol. 1999, 11:887-895.
33. Oranje B., Wienberg M., Glenthoj B.Y. A single high dose of escitalopram disrupts sensory gating and habituation, but not sensorimotor gating in healthy volunteers. Psychiatry Res. 2011, 186:431-436.
34. Otczyk M., Mulik K., Budziszewska B., Jaworska-Feil L., Basta-Kaim A., Kubera M., Jagla G., Nowak W., Lason W. Effect of some antidepressants on the low corticosterone concentration-induced gene transcription in LMCAT fibroblast cells. J. Physiol. Pharmacol. 2008, 59:153-162.
35. Otte C., Wust S., Zhao S., Pawlikowska L., Kwok P.Y., Whooley M.A. Glucocorticoid receptor gene and depression in patients with coronary heart disease: the Heart and Soul Study-2009 Curt Richter Award Winner. Psychoneuroendocrinology 2009, 34:1574-1581.
36. Otte C., Hinkelmann K., Moritz S., Yassouridis A., Jahn H., Wiedemann K., Kellner M. Modulation of the mineralocorticoid receptor as add-on treatment in depression: a randomized, double-blind, placebo-controlled proof-of-concept study. J. Psychiatr. Res. 2010, 44:339-346.
37. Pariante C.M., Pearce B.D., Pisell T.L., Owens M.J., Miller A.H. Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Mol. Pharmacol. 1997, 52:571-581.
38. Pariante C.M., Makoff A., Lovestone S., Feroli S., Heyden A., Miller A.H., Kerwin R.W. Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters. Br. J. Pharmacol. 2001, 134:1335-1343.
39. Pariante C.M., Hye A., Williamson R., Makoff A., Lovestone S., Kerwin R.W. The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones. Neuropsychopharmacology 2003, 28:1553-1561.
40. Pariante C.M., Kim R.B., Makoff A., Kerwin R.W. Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters. Br. J. Pharmacol. 2003, 139:1111-1118.
41. Pariante C.M., Papadopoulos A.S., Poon L., Cleare A.J., Checkley S.A., English J., Kerwin R.W., Lightman S. Four days of citalopram increase suppression of cortisol secretion by prednisolone in healthy volunteers. Psychopharmacology (Berl) 2004, 177:200-206.
42. Pariante C.M. The glucocorticoid receptor: part of the solution or part of the problem?. J. Psychopharmacol. 2006, 20:79-84.
43. Pariante C.M., Lightman S.L. The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 2008, 31:464-468.
44. Pariante C.M. Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids. Ann. N.Y. Acad. Sci. 2009, 1179:144-152.
45. Pepin M.C., Beaulieu S., Barden N. Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neuronal cultures. Brain Res. Mol. Brain Res. 1989, 6:77-83.
46. Posner M.I., Petersen S.E. The attention system of the human brain. Ann. Rev. Neurosci. 1990, 13:25-42.
47. Pringle A., Browning M., Cowen P.J., Harmer C.J. A cognitive neuropsychological model of antidepressant drug action. Prog. Neuropsychopharmacol. Biol. Psychiatry 2011, 35:1586-1592.
48. Raison C.L., Miller A.H. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am. J. Psychiatry 2003, 160:1554-1565.
49. Reul J.M., Stec I., Soder M., Holsboer F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology 1993, 133:312-320.
50. Schatzberg A.F., Lindley S. Glucocorticoid antagonists in neuropsychotic disorders. Eur. J. Pharmacol. 2008, 583:358-364.
51. Schule C., Baghai T.C., Eser D., Rupprecht R. Hypothalamic-pituitary-adrenocortical system dysregulation and new treatment strategies in depression. Expert Rev. Neurother. 2009, 9:1005-1019.
52. Semlitsch H.V., Anderer P., Schuster P., Presslich O. A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP. Psychophysiology 1986, 23:695-703.
53. Tops M., Wijers A.A., van Staveren A.S., Bruin K.J., den Boer J.A., Meijman T.F., Korf J. Acute cortisol administration modulates EEG alpha asymmetry in volunteers: relevance to depression. Biol. Psychology 2005, 69:181-193.
54. Tylee A., Walters P. Onset of action of antidepressants. BMJ 2007, 334:911-912.
55. van Asselen M., Kessels R.P., Wester A.J., Postma A. Spatial working memory and contextual cueing in patients with Korsakoff amnesia. J. Clin. Exp. Neuropsychol. 2005, 27:645-655.
56. Yau J.L., Noble J., Hibberd C., Seckl J.R. Short-term administration of fluoxetine and venlafaxine decreases corticosteroid receptor mRNA expression in the rat hippocampus. Neurosci. Let. 2001, 306:161-164.
57. Young E.A., Lopez J.F., Murphy-Weinberg V., Watson S.J., Akil H. Mineralocorticoid receptor function in major depression. Arch. Gen. Psychiatry 2003, 60:24-28.
58. Zobel A.W., Nickel T., Sonntag A., Uhr M., Holsboer F., Ising M. Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. A prospective study. J. Psychiatr. Res. 2001, 35:83-94.