High plasma hemopexin activity is an independent risk factor for late graft failure in renal transplant recipients

Transplant International

Volumn 23, Issue 8, 2010, Pages 805-812

  Krikken, Jan A ^a   Van Ree, Rutger M ^a   Klooster, Astrid ^a   Seelen, Marcus A ^a   Borghuis, Theo ^a   Lems, Simon P M ^a   Schouten, Jan P ^a   Bakker, Winston W ^a   Gans, Rijk O B ^a   Navis, Gerjan ^a   Bakker, Stephan J L ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

chronic allograft nephropathy; hemopexin; inflammation; kidney transplantation

Indexed keywords

C REACTIVE PROTEIN; CITRIC ACID; HEMOPEXIN; CREATININE;

ADULT; ARTICLE; DIASTOLIC BLOOD PRESSURE; FEMALE; FOLLOW UP; GRAFT FAILURE; HUMAN; INDEPENDENT VARIABLE; KIDNEY GRAFT; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; RISK FACTOR; BLOOD; CHRONIC DISEASE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOLOGY; KIDNEY TRANSPLANTATION; LONGITUDINAL STUDY; METABOLISM; MIDDLE AGED; NEPHRITIS; PREDICTIVE VALUE; PREVALENCE; PROSPECTIVE STUDY; STATISTICS AND NUMERICAL DATA; TIME;

ADULT; CHRONIC DISEASE; CREATININE; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HEMOPEXIN; HUMANS; KIDNEY TRANSPLANTATION; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; NEPHRITIS; PREDICTIVE VALUE OF TESTS; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS;

EID: 77954473208     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2010.01055.x     Document Type: Article

References (21)

1. Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 2000 342 : 605 612. (Pubitemid 30118412)
2. Kreis HA, Ponticelli C. Causes of late renal allograft loss: chronic allograft dysfunction, death, and other factors. Transplantation 2001 71 : SS5 SS9.
3. Massy ZA, Guijarro C, Wiederkehr MR, Ma JZ, Kasiske BL. Chronic renal allograft rejection: immunologic and nonimmunologic risk factors. Kidney Int 1996 49 : 518 524. (Pubitemid 26051834)
4. Joosten SA, Sijpkens YW, van Kooten C, Paul LC. Chronic renal allograft rejection: pathophysiologic considerations. Kidney Int 2005 68 : 1 13. (Pubitemid 43181359)
5. Vazquez MA, Jeyarajah DR, Kielar ML, Lu CY. Long-term outcomes of renal transplantation: a result of the original endowment of the donor kidney and the inflammatory response to both alloantigens and injury. Curr Opin Nephrol Hypertens 2000 9 : 643 648.
6. Cheung PK, Klok PA, Baller JF, Bakker WW. Induction of experimental proteinuria in vivo following infusion of human plasma hemopexin. Kidney Int 2000 57 : 1512 1520.
7. Lennon R, Singh A, Welsh GI, et al. Hemopexin induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes. J Am Soc Nephrol 2008 19 : 2140 2149.
8. Bakker WW, van Dael CM, Pierik LJ, et al. Altered activity of plasma hemopexin in patients with minimal change disease in relapse. Pediatr Nephrol 2005 20 : 1410 1415.
9. Marinkovic S, Jahreis GP, Wong GG, Baumann H. IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo. J Immunol 1989 142 : 808 812. (Pubitemid 19093910)
10. van Ree RM, Oterdoom LH, de Vries AP, et al. Elevated levels of C-reactive protein independently predict accelerated deterioration of graft function in renal transplant recipients. Nephrol Dial Transplant 2007 22 : 246 253.
11. van Ree RM, de Vries AP, Oterdoom LH, et al. Abdominal obesity and smoking are important determinants of C-reactive protein in renal transplant recipients. Nephrol Dial Transplant 2005 20 : 2524 2531.
12. Bakker WW, Borghuis T, Harmsen MC, et al. Protease activity of plasma hemopexin. Kidney Int 2005 68 : 603 610. (Pubitemid 43323115)
13. de Leeuw K, Sanders JS, Stegeman C, Smit A, Kallenberg CG, Bijl M. Accelerated atherosclerosis in patients with Wegener's granulomatosis. Ann Rheum Dis 2005 64 : 753 759. (Pubitemid 40559304)
14. Altman DG, Lausen B, Sauerbrei W, Schumacher M. Dangers of using "optimal" cutpoints in the evaluation of prognostic factors. J Natl Cancer Inst 1994 86 : 829 835. (Pubitemid 2100935)
15. Tolosano E, Altruda F. Hemopexin: structure, function, and regulation. DNA Cell Biol 2002 21 : 297 306. (Pubitemid 34594543)
16. Kapojos JJ, van den Berg A, van Goor H, et al. Production of hemopexin by TNF-alpha stimulated human mesangial cells. Kidney Int 2003 63 : 1681 1686. (Pubitemid 36513313)
17. Camborieux L, Bertrand N, Swerts JP. Changes in expression and localization of hemopexin and its transcripts in injured nervous system: a comparison of central and peripheral tissues. Neuroscience 1998 82 : 1039 1052. (Pubitemid 27502049)
18. Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage? J Am Soc Nephrol 2006 17 : 2974 2984. (Pubitemid 44707757)
19. Russo LM, Sandoval RM, McKee M, et al. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int 2007 71 : 504 513. (Pubitemid 46398675)
20. Hilliard LM, Osicka TM, Clavant SP, Robinson PJ, Nikolic-Paterson DJ, Comper WD. Characterization of the urinary albumin degradation pathway in the isolated perfused rat kidney. J Lab Clin Med 2006 147 : 36 44.
21. Strong KJ, Osicka TM, Comper WD. Urinary-peptide excretion by patients with and volunteers without diabetes. J Lab Clin Med 2005 145 : 239 246. (Pubitemid 40719930)