Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Nature

Volumn 527, Issue 7576, 2015, Pages 100-104

  Zhang, Lin ^a,b   Zhang, Siyuan ^a,c   Yao, Jun ^a   Lowery, Frank J ^a,b   Zhang, Qingling ^a   Huang, Wen Chien ^a   Li, Ping ^a   Li, Min ^a   Wang, Xiao ^a   Zhang, Chenyu ^a   Wang, Hai ^a   Ellis, Kenneth ^a   Cheerathodi, Mujeeburahiman ^a   McCarty, Joseph H ^a   Palmieri, Diane ^d   Saunus, Jodi ^e   Lakhani, Sunil ^e,f,g   Huang, Suyun ^a   Sahin, Aysegul A ^a   Aldape, Kenneth D ^a   Steeg, Patricia S ^d   Yu, Dihua ^a,b,h   more..

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF NOTRE DAME   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f UNIVERSITY OF QUEENSLAND   (Australia)

^g ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^h CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; AIF1 PROTEIN, HUMAN; DNA BINDING PROTEIN; MESSENGER RNA; PTEN PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; BRAIN; CANCER; GENE EXPRESSION; PROTEIN; RNA; RODENT; SECRETION; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BONE MARROW CELL; BRAIN METASTASIS; CANCER GROWTH; CANCER PATIENT; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; EPIGENETICS; EXOSOME; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR MICROENVIRONMENT; ADAPTATION; ANIMAL; BRAIN; BRAIN TUMOR; CYTOLOGY; DEFICIENCY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; MOLECULAR EVOLUTION; PATHOLOGY; SECONDARY; SECRETION (PROCESS); TUMOR SUPPRESSOR GENE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ASTROCYTES; BRAIN; BRAIN NEOPLASMS; CELL PROLIFERATION; CHEMOKINE CCL2; DNA-BINDING PROTEINS; DOWN-REGULATION; EVOLUTION, MOLECULAR; EXOSOMES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MICE; MICRORNAS; PTEN PHOSPHOHYDROLASE; RNA, MESSENGER; TUMOR MICROENVIRONMENT; TUMOR SUPPRESSOR PROTEINS;

EID: 84946559154     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature15376     Document Type: Article

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